CN216573635U - Separation and purification device for medicine bud compound and intermediate thereof - Google Patents
Separation and purification device for medicine bud compound and intermediate thereof Download PDFInfo
- Publication number
- CN216573635U CN216573635U CN202123303160.8U CN202123303160U CN216573635U CN 216573635 U CN216573635 U CN 216573635U CN 202123303160 U CN202123303160 U CN 202123303160U CN 216573635 U CN216573635 U CN 216573635U
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- box
- pipe
- centrifuge tube
- cleaning
- case lid
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- 238000000746 purification Methods 0.000 title claims abstract description 32
- 239000003814 drug Substances 0.000 title claims abstract description 31
- 150000001875 compounds Chemical class 0.000 title claims abstract description 25
- 238000000926 separation method Methods 0.000 title claims abstract description 14
- 230000007246 mechanism Effects 0.000 claims abstract description 45
- 239000000463 material Substances 0.000 claims abstract description 14
- 239000012528 membrane Substances 0.000 claims abstract description 9
- 230000003204 osmotic effect Effects 0.000 claims abstract description 7
- 238000004140 cleaning Methods 0.000 claims description 28
- 239000007921 spray Substances 0.000 claims description 18
- 239000000543 intermediate Substances 0.000 claims description 13
- 229920000742 Cotton Polymers 0.000 claims description 12
- 238000007789 sealing Methods 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- 238000005507 spraying Methods 0.000 claims description 2
- 239000012535 impurity Substances 0.000 abstract description 15
- 238000005119 centrifugation Methods 0.000 abstract description 4
- 230000000694 effects Effects 0.000 description 8
- 239000007788 liquid Substances 0.000 description 5
- 238000010586 diagram Methods 0.000 description 4
- 238000000034 method Methods 0.000 description 3
- 239000002893 slag Substances 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000007876 drug discovery Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 230000001418 larval effect Effects 0.000 description 1
- 150000002611 lead compounds Chemical class 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 230000000171 quenching effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
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- Centrifugal Separators (AREA)
Abstract
The utility model discloses a separation and purification device for medicine seedling head compound and midbody thereof, including box and case lid, be connected through the tower knot between box and the case lid, the inside bottom of box is equipped with slewing mechanism, and the box is equipped with the centrifuge tube through slewing mechanism, and centrifuge tube week side is equipped with the osmotic membrane to be equipped with spacing guiding mechanism between centrifuge tube and the box lateral wall, the both ends symmetry of box is equipped with row's material pipe, and centrifuge tube bottom one side is equipped with the scum pipe, and the scum pipe is linked together with row's material pipe, and the symmetry is equipped with the handle on the case lid, and the case lid has wiper mechanism, wiper mechanism and centrifuge tube phase-match. The utility model discloses an above-mentioned mechanism mutually support, can guarantee that the centrifuge tube can wash it automatically after finishing using, facilitate the use to can avoid impurity to remain at the inner wall, influence next centrifugation and use, avoid causing the pollution to the medicine of next purification, improve the purity of medicine.
Description
Technical Field
The utility model relates to a medicine purification technical field specifically is a separation and purification device that is used for medicine seedling head compound and midbody thereof.
Background
The miaow-headed compound is a compound with preliminary activity on a specific target or action link, belongs to an early drug discovery stage in the process of researching and developing new drugs, and is from the miaow-headed compound to a lead compound and then to candidate molecules, so a large amount of research and development and manufacturing are needed, wherein the miaow-headed compound is processed by processes of raw material feeding, dissolution, reaction, quenching, layering, extraction, concentration, purification, drying, target products and the like.
And current add man-hour to the first compound of seedling, often need separate purification, and then get rid of the impurity in midbody or the compound, when the in-process of actual purification is adopting centrifugal mode to carry out preliminary purification filtration, the inside impurity of its centrifuge bowl can be attached to on the inner wall, still has its bottom, and is comparatively troublesome when wasing, washs not thoroughly then can influence next use, can cause the pollution to the medicine of purification, influences purity.
SUMMERY OF THE UTILITY MODEL
An object of the utility model is to provide a separation and purification device that is used for medicine first compound of seedling and midbody to solve the problem that proposes among the above-mentioned background art.
In order to achieve the above object, the utility model provides a following technical scheme: the utility model provides a separation and purification device for medicine bud of seedling compound and midbody, including box and case lid, be connected through the tower knot between box and the case lid, the inside bottom of box is equipped with slewing mechanism, the box is equipped with the centrifuge bowl through slewing mechanism, centrifuge bowl week side is equipped with the osmotic membrane to be equipped with spacing guiding mechanism between centrifuge bowl and the box lateral wall, the both ends symmetry of box is equipped with row material pipe, centrifuge bowl bottom one side is equipped with the scum pipe, the scum pipe is linked together with row material pipe, the symmetry is equipped with the handle on the case lid, the case lid has wiper mechanism, wiper mechanism and centrifuge bowl phase-match.
Preferably, for the convenience wash equipment, and then do not influence next use, wiper mechanism is including setting up the scavenge pipe at the case lid middle part, and inside the scavenge pipe ran through the case lid and extended to the centrifuge bowl, the scavenge pipe was equipped with the spray pipe through expansion hose to be connected through electric putter between spray pipe and the case lid, the equidistance is equipped with the shower nozzle under the spray pipe.
Preferably, in order to guarantee the cleaning performance, let the washing more thorough, wiper mechanism is equipped with the clearance cotton including setting up the scraper blade at the spray tube tip on the scraper blade, and the clearance cotton is laminated mutually with the centrifuge tube inner wall.
Preferably, a sealing gasket is arranged between the box cover and the centrifugal cylinder in order to improve the sealing performance of the centrifugal cylinder and improve the purification effect.
Preferably, in order to facilitate the outflow of the liquid medicine, the bottom end inside the box body is provided with a flow guide table, and the lower end of the flow guide table is flush with the discharge pipe.
Preferably, in order to drive the centrifugal cylinder to rotate and further perform centrifugal purification on the liquid medicine, the rotating mechanism comprises a motor arranged inside the flow guide table, the output end of the motor is provided with a rotating shaft, and the rotating shaft penetrates through the flow guide table and extends to the outside to be connected with the centrifugal cylinder.
Preferably, in order to improve the stability when rotating, the limiting guide mechanism comprises a limiting sliding groove arranged on the inner wall of the box body, arc-shaped limiting sliding blocks are arranged in the limiting sliding groove at equal intervals, and the arc-shaped limiting sliding blocks are connected with the outer side wall of the centrifugal cylinder.
Compared with the prior art, the beneficial effects of the utility model are that:
(1) the cleaning mechanism is arranged below the box cover, so that when the centrifugal cylinder rotates during equipment use, the inner part of the centrifugal cylinder can be scraped through cleaning cotton on the scraper, impurities are prevented from being attached to the inner wall, the centrifugal cylinder is convenient to clean, after the centrifugal cylinder is used, the inner centrifugal cylinder can be cleaned through the cleaning pipe, the centrifugal cylinder can be thoroughly cleaned through the scraper, the centrifugal cylinder can be automatically cleaned after the centrifugal cylinder is used, the centrifugal cylinder is convenient to use, the impurities can be prevented from remaining on the inner wall to influence next centrifugal use, the next purified medicine is prevented from being polluted, and the purity of the medicine is improved;
(2) through mutually supporting of slewing mechanism and spacing guiding mechanism, can take the centrifuge bowl to rotate, and then can carry out centrifugal purification to inside medicine, the liquid medicine is discharged through the osmotic membrane, discharges through row's material roller, and inside impurity stayed the centrifuge bowl, spacing guiding mechanism can guarantee the stability of centrifuge bowl when the rotation, improves centrifugal efficiency, guarantees centrifugal effect.
Drawings
Fig. 1 is a schematic structural diagram of an internal part of a separation and purification device for a pharmaceutical head compound and an intermediate thereof according to the present invention;
fig. 2 is a schematic structural diagram of a cleaning mechanism in a separation and purification device for a pharmaceutical head compound and an intermediate thereof according to the present invention;
FIG. 3 is a schematic view of a part of the structure of a cleaning mechanism in a separation and purification device for a pharmaceutical head compound and its intermediate provided by the present invention;
FIG. 4 is a schematic structural diagram of a centrifuge tube in a separation and purification apparatus for pharmaceutical larval compounds and intermediates thereof according to the present invention;
fig. 5 is a schematic structural diagram of a separation and purification device for a pharmaceutical head compound and its intermediate provided by the present invention.
In the figure: 1. a box body; 2. a box cover; 3. a handle; 4. cleaning the pipe; 5. a centrifugal cylinder; 6. a permeable membrane; 7. a discharge pipe; 8. a flow guide table; 9. a motor; 10. a rotating shaft; 11. a slag discharge pipe; 12. an arc-shaped limiting slide block; 13. a gasket; 14. cleaning cotton; 15. a squeegee; 16. an electric push rod; 17. a spray tube; 18. a spray head; 19. a flexible hose; 20. a limiting chute; 21. and (6) buckling the tower.
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.
The first embodiment is as follows:
referring to fig. 1-5, the present invention provides an embodiment: the utility model provides a separation purification device for medicine seedling head compound and midbody thereof, including box 1 and case lid 2, be connected through tower knot 21 between box 1 and the case lid 2, 1 inside bottom of box is equipped with slewing mechanism, box 1 is equipped with centrifuge tube 5 through slewing mechanism, centrifuge tube 5 week side is equipped with osmotic membrane 6, and be equipped with spacing guiding mechanism between centrifuge tube 5 and the box 1 lateral wall, the both ends symmetry of box 1 is equipped with row material pipe 7, 5 bottom one side of centrifuge tube is equipped with scum pipe 11, be equipped with the solenoid valve on the scum pipe 11, can avoid impurity to enter into row material pipe 7 through scum pipe 11 when centrifuging, and influence the effect of separation purification, scum pipe 11 is linked together with row material pipe 7, the symmetry is equipped with handle 3 on case lid 2, case lid 2 has wiper mechanism, wiper mechanism and centrifuge tube 5 phase-match.
Through mutually supporting of above-mentioned mechanism, can be when equipment uses, when centrifuge tube 5 rotates, can scrape inside through clearance cotton 14 on the scraper blade 15, avoid impurity to adhere to on the inner wall, convenient washing, after finishing using, can wash inside centrifuge tube 5 through scavenge pipe 4, deuterogamy scraper blade 15 can carry out rinse thoroughly to centrifuge tube 5, can guarantee that centrifuge tube 5 can wash it automatically after finishing using, facilitate the use, and can avoid impurity to remain at the inner wall, influence next centrifugation use, avoid causing the pollution to the medicine of next purification, improve the purity of medicine.
Example two:
referring to fig. 1-5, the cleaning mechanism includes a cleaning tube 4 disposed in the middle of the case cover 2, the cleaning tube 4 penetrates the case cover 2 and extends into the centrifuge tube 5, the cleaning tube 4 is provided with a spray tube 17 through a flexible hose 19, the spray tube 17 is connected with the case cover 2 through an electric push rod 16, spray heads 18 are disposed at equal intervals under the spray tube 17, the cleaning mechanism further includes a scraper 15 disposed at the end of the spray tube 17, cleaning cotton 14 is disposed on the scraper 15, the cleaning cotton 14 is attached to the inner wall of the centrifuge tube 5, and a sealing gasket 13 is disposed between the case cover 2 and the centrifuge tube 5 to prevent the drug from escaping through the open end of the centrifuge tube 5 and ensure the purification effect.
Can wash centrifugal cylinder 5 inside through wiper mechanism, the clearance cotton 14 on shower nozzle 18 and the scraper blade 15 under the spray tube 17 mutually supports, and rethread centrifugal cylinder 5 rotates, can carry out thorough washing to its inside, guarantees the cleaning performance, avoids impurity to remain at the inner wall, does not influence next use, and improve equipment avoids the medicine to receive the pollution when the purification to the effect of medicine purification.
Example three:
referring to fig. 1-5, a flow guiding table 8 is disposed at the bottom end inside the box body 1, a lower end of the flow guiding table 8 is flush with the discharge pipe 7, the rotating mechanism includes a motor 9 disposed inside the flow guiding table 8, an output end of the motor 9 is provided with a rotating shaft 10, the rotating shaft 10 penetrates through the flow guiding table 8 and extends to the outside to be connected with the centrifugal cylinder 5, the limiting guide mechanism includes a limiting chute 20 disposed on an inner wall of the box body 1, arc-shaped limiting sliders 12 are disposed in the limiting chute 20 at equal intervals, and the arc-shaped limiting sliders 12 are connected with an outer side wall of the centrifugal cylinder 5.
Through the mutually supporting of slewing mechanism and spacing guiding mechanism, can take centrifuge tube 5 to rotate, and then can carry out centrifugal purification to inside medicine, the liquid medicine is discharged through osmotic membrane 6, discharge through row material pipe 7, impurity is stayed inside centrifuge tube 5, spacing guiding mechanism can guarantee centrifuge tube 5 stability when rotating, improve centrifugal efficiency, guarantee centrifugal effect, water conservancy diversion platform 8 can conveniently discharge through osmotic membrane 6 exhaust medicine fast through row material pipe 7, simultaneously can conveniently when wasing inside residue enters into row material pipe 7 through row slag pipe 11 fast and discharges, high durability and convenient use.
The working principle is as follows: when the centrifugal purification device is used, the medicine to be purified is put into the centrifugal cylinder 5, the box cover 2 is covered by the handle 3 and is fixedly connected with the box body 1 through the tower buckle 21, meanwhile, the sealing gasket 13 under the box cover 2 seals the centrifugal cylinder 5 to prevent the medicine from spilling out through the opening of the centrifugal cylinder 5, the purification effect can be ensured, at the moment, the motor 9 rotates to drive the centrifugal cylinder 5 on the rotating shaft 10 to rotate, meanwhile, the arc-shaped limiting slide block 12 on the centrifugal cylinder 5 slides in the limiting slide groove 20 to ensure the stability of the rotation of the centrifugal cylinder 5, the shaking during the rotation is avoided, at the moment, under the action of centrifugal force, the liquid medicine is discharged through the permeable membrane 6, quickly enters the discharge pipe 7 through the flow guide table 8 to be collected, impurities can be in the centrifugal cylinder 5, and simultaneously, the cleaning cotton 14 on the scraper 15 can scrape the inner wall by matching with the rotation of the centrifugal cylinder 5, the subsequent cleaning is convenient, and after the centrifugation is finished, when the impurities in the inner part need to be cleaned, the motor 9 continues to rotate, meanwhile, water is introduced through the cleaning pipe 4 and is sprayed out through a spray head 18 on a spray pipe 17, and then the cleaning is carried out by matching with a scraper 15 and cleaning cotton 14, meanwhile, the flexible hose 19 can be extended along with the extension of the electric push rod 16, the scraper 15 on the spraying pipe 17 is driven to move downwards, the inner wall can be cleaned by matching with the centrifugal cylinder 5, meanwhile, the electromagnetic valve on the slag discharge pipe 11 is opened, impurities can be discharged through the electromagnetic valve, collected through the discharge pipe 7 and mutually matched through the mechanisms, can ensure that the centrifugal cylinder 5 can be automatically cleaned after use, is convenient to use, and can avoid impurity to remain at the inner wall, influence next centrifugation and use, avoid causing the pollution to the medicine of next purification, improve the purity of medicine.
It is obvious to a person skilled in the art that the invention is not restricted to details of the above-described exemplary embodiments, but that it can be implemented in other specific forms without departing from the spirit or essential characteristics of the invention. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein. Any reference sign in a claim should not be construed as limiting the claim concerned.
Claims (7)
1. A separation and purification device for a medicine miao tou compound and an intermediate thereof comprises a box body (1) and a box cover (2), and is characterized in that: box (1) with it is connected to detain (21) through the tower between case lid (2), the inside bottom of box (1) is equipped with slewing mechanism, box (1) is equipped with centrifuge tube (5) through slewing mechanism, centrifuge tube (5) week side is equipped with osmotic membrane (6), and centrifuge tube (5) with be equipped with spacing guiding mechanism between box (1) the lateral wall, the both ends symmetry of box (1) is equipped with row material pipe (7), centrifuge tube (5) bottom one side is equipped with scum pipe (11), scum pipe (11) with it is linked together to arrange material pipe (7), the symmetry is equipped with handle (3) on case lid (2), case lid (2) have wiper mechanism, wiper mechanism with centrifuge tube (5) phase-match.
2. The apparatus for separating and purifying pharmaceutical miaow compounds and intermediates thereof as claimed in claim 1, wherein: the cleaning mechanism comprises a cleaning pipe (4) arranged in the middle of a box cover (2), the cleaning pipe (4) penetrates through the box cover (2) and extends to the interior of a centrifugal cylinder (5), a spray pipe (17) is arranged on the cleaning pipe (4) through a telescopic hose (19), the spray pipe (17) is connected with the box cover (2) through an electric push rod (16), and spray heads (18) are arranged under the spray pipe (17) at equal intervals.
3. The apparatus for separating and purifying pharmaceutical miaow compounds and intermediates thereof as claimed in claim 2, wherein: the cleaning mechanism further comprises a scraper (15) arranged at the end part of the spraying pipe (17), cleaning cotton (14) is arranged on the scraper (15), and the cleaning cotton (14) is attached to the inner wall of the centrifugal cylinder (5).
4. The apparatus for separating and purifying pharmaceutical miaow compounds and intermediates thereof as claimed in claim 2, wherein: a sealing gasket (13) is arranged between the box cover (2) and the centrifugal cylinder (5).
5. The apparatus for separating and purifying pharmaceutical miaow compounds and intermediates thereof as claimed in claim 1, wherein: the bottom end in box (1) is equipped with water conservancy diversion platform (8), water conservancy diversion platform (8) low end with arrange material pipe (7) and level mutually.
6. The apparatus for separating and purifying pharmaceutical miaow compounds and intermediates thereof as claimed in claim 5, wherein: the rotating mechanism comprises a motor (9) arranged inside the flow guide table (8), a rotating shaft (10) is arranged at the output end of the motor (9), and the rotating shaft (10) penetrates through the flow guide table (8) and extends to the outside to be connected with the centrifugal cylinder (5).
7. The apparatus for separating and purifying pharmaceutical miaow compounds and intermediates thereof as claimed in claim 1, wherein: the limiting guide mechanism comprises a limiting sliding groove (20) arranged on the inner wall of the box body (1), arc-shaped limiting sliding blocks (12) are arranged in the limiting sliding groove (20) at equal intervals, and the arc-shaped limiting sliding blocks (12) are connected with the outer side wall of the centrifugal cylinder (5).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202123303160.8U CN216573635U (en) | 2021-12-25 | 2021-12-25 | Separation and purification device for medicine bud compound and intermediate thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202123303160.8U CN216573635U (en) | 2021-12-25 | 2021-12-25 | Separation and purification device for medicine bud compound and intermediate thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN216573635U true CN216573635U (en) | 2022-05-24 |
Family
ID=81617844
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202123303160.8U Active CN216573635U (en) | 2021-12-25 | 2021-12-25 | Separation and purification device for medicine bud compound and intermediate thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN216573635U (en) |
-
2021
- 2021-12-25 CN CN202123303160.8U patent/CN216573635U/en active Active
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