CN216538438U

CN216538438U - Heating device of deer heart blood polypeptide synthesizer

Info

Publication number: CN216538438U
Application number: CN202122766127.2U
Authority: CN
Inventors: 李虹瑾
Original assignee: JILIN CHINA AND SOUTH KOREA ANIMAL SCIENCE RESEARCH INSTITUTE; Changchun University of Science and Technology
Current assignee: JILIN CHINA AND SOUTH KOREA ANIMAL SCIENCE RESEARCH INSTITUTE; Changchun University of Science and Technology
Priority date: 2021-11-09
Filing date: 2021-11-09
Publication date: 2022-05-17
Anticipated expiration: 2031-11-09

Abstract

The utility model discloses a heating device of a deer heart blood polypeptide synthesizer, and relates to the technical field of polypeptide synthesis; the device is provided with a spray head, a third water pipe, an annular water pipe and the like; after the deer heart blood polypeptide synthesis is finished, the first water pump or the second water pump is opened, water in the wastewater collection box or the water tank is introduced into the reaction kettle, and substances adhered to the inner wall are washed, so that the adverse effect on products when the polypeptide is synthesized again due to bacterial breeding caused by not washing the reaction kettle is prevented; in addition, the stirring rod is driven by the rotating shaft to rotate in the reaction kettle, so that the synthesis rate of the polypeptide can be improved; the cleaning water in the reaction kettle can comprehensively clean the interior of the reaction kettle through the rotation of the stirring rod, so that the cleaning efficiency is improved; still can in time dry reation kettle after the washing, prevent in the reation kettle because of the moist metal parts such as agitating unit that lead to rust, perhaps lead to mildening and rot etc. in the reation kettle, cause adverse effect to synthesizing polypeptide once more.

Description

Heating device of deer heart blood polypeptide synthesizer

Technical Field

The utility model relates to the technical field of polypeptide synthesis, in particular to a heating device of a deer heart blood polypeptide synthesizer.

Background

The utility model discloses a temperature control device of a polypeptide synthesizer, which belongs to the technical field of temperature control of the polypeptide synthesizer and comprises a base, wherein a nitrogen bottle, a nitrogen heater, a nitrogen collecting bottle, a reaction area, a wastewater collecting box and a water tank are sequentially arranged on the top end of the base from left to right, a fourth pipeline is arranged on the nitrogen heater, one end of the fourth pipeline is connected to the nitrogen bottle, the other end of the fourth pipeline is connected to the reaction area, a heating box is surrounded on the outer side of the reaction area, heating wires are arranged at the bottom end of the heating box, a top cover is arranged on the top end of the reaction area, a third pipeline is arranged on the top end of the top cover, and one end of the third pipeline is connected to the nitrogen collecting bottle. The utility model achieves the aims of rapid temperature control, accurate temperature control and high-efficiency polypeptide synthesis by matching the electric heating box and the nitrogen cylinder.

Above-mentioned device is in polypeptide synthesis in-process, because of can adjusting the regulation temperature in the polypeptide synthesis process, consequently can increase the synthetic rate of polypeptide, but after polypeptide synthesis, need wash the material of adhesion at the reaction zone inner wall to keep the cleanness of reaction zone, avoid leading to breeding the bacterium or causing and milden and rot because of the reaction zone is unclean, and produce adverse effect to polypeptide synthesis next time.

SUMMERY OF THE UTILITY MODEL

The utility model aims to overcome the defects of the prior art and provide a heating device of a deer heart blood polypeptide synthesizer; it can wash reation kettle after polypeptide synthesis to keep reation kettle's cleanness, and then when guaranteeing to synthesize polypeptide once more, can not produce adverse effect because of reation kettle is unclean to polypeptide synthesis.

The purpose of the utility model is realized by the following technical scheme:

a heating device of a deer heart blood polypeptide synthesizer comprises a base, wherein a reaction kettle, a wastewater collection box and a water tank are arranged at the top end of the base, a heating box is arranged around the outer wall of the reaction kettle, a water containing cavity is arranged around the inside of the heating box, an electric heating wire is arranged at the bottom of the heating box, one side of the heating box is communicated with a first water pipe, one end, away from the heating box, of the first water pipe is communicated with the wastewater collection box, and one side, away from the first water pipe, of the wastewater collection box is communicated with the water tank through a second water pipe; the top end of the reaction kettle is provided with a top cover, the top cover is movably connected with the top end of the reaction kettle through a connecting device, the connecting device comprises an annular block and an annular groove, the annular block is annularly arranged at the bottom end of the top cover, the annular groove is annularly arranged at the top end of the reaction kettle, and the annular block is clamped with the annular groove; a plurality of spray heads are uniformly distributed on the circumference of the inner top surface of the top cover, the tops of the spray heads are communicated with third water pipes, the top ends of the third water pipes penetrate through the top cover and are communicated with an annular water pipe arranged at the top end of the top cover together, one side of the annular water pipe is sequentially communicated with a first hose and a second hose, one end, away from the annular water pipe, of the first hose is connected with a first water pump, and one end, away from the first hose, of the first water pump is communicated with the wastewater collection box; one end of the second hose, which is far away from the annular water pipe, is communicated with a water inlet pipe, one end of the water inlet pipe is communicated with the water containing cavity, the other end of the water inlet pipe is connected with a second water pump, and the second water pump is communicated with the water tank; a first valve is arranged at one end of the water inlet pipe close to the heating box, and a second valve is arranged on the second hose; a stirring device is coaxially arranged in the reaction kettle, the stirring device comprises a rotating shaft, a stirring rod and a motor, the rotating shaft is coaxially arranged in the reaction kettle, the bottom of the rotating shaft and the inner bottom surface of the reaction kettle are arranged in a clearance mode, the top of the rotating shaft penetrates through the top cover and is fixedly connected with the output end of the motor arranged at the top end of the top cover, and the stirring rod is uniformly distributed on the outer wall of the rotating shaft; a temperature sensor and a pressure sensor are arranged in the reaction kettle; the side wall of the reaction kettle is communicated with a water outlet pipe, and the water outlet pipe is provided with a third valve; the top end of the reaction kettle is communicated with an air outlet pipe, and the air outlet pipe is provided with a fourth valve.

Further, reation kettle's outside still is provided with the hair-dryer, the hair-dryer sets up the top surface of base, the hair-dryer intercommunication has the air-supply line and goes out the tuber pipe, it keeps away from to go out the tuber pipe the one end of hair-dryer with the outlet duct intercommunication.

Furthermore, the air outlet pipe is in threaded connection with the air outlet pipe.

Furthermore, a filter cartridge is arranged on the air outlet pipe.

Further, the bottom of base is provided with the support column.

Furthermore, the bottom end of the support column is provided with a non-slip mat.

Furthermore, hydraulic telescopic rods are arranged on two sides of the base, and universal wheels are fixedly connected to the bottom ends of the hydraulic telescopic rods.

Further, a handle is arranged at the top of the top cover.

Compared with the prior art, the utility model has the following beneficial effects:

1. the device is provided with a spray head, a third water pipe, an annular water pipe, a first hose, a second hose and the like. Can open first water pump or second water pump after deer heart blood polypeptide synthesis ends, let in reation kettle through the water with in waste water collecting box or the water tank inside, wash the material of adhesion on the inner wall, prevent to cause bacterial growing because of not rinsing reation kettle, and then when synthesizing polypeptide once more, cause adverse effect to the product.

2. Is provided with a stirring device comprising a rotating shaft, a stirring rod and a motor. In the polypeptide reaction process, the stirring rod is driven by the rotating shaft to rotate in the reaction kettle, so that the synthesis rate of the polypeptide can be improved; in the reation kettle cleaning process, through the rotation of puddler, can make inside washing water of reation kettle can carry out comprehensive cleanness to reation kettle inside, improve the cleaning efficiency.

3. An exhaust fan and other devices are arranged. Can in time dry reation kettle after the washing, prevent in the reation kettle because of the moist metal parts such as agitating unit that lead to rust, perhaps lead to mildening and rot etc. in the reation kettle, cause adverse effect to synthesizing polypeptide once more.

Drawings

FIG. 1 is a schematic sectional view in front view;

FIG. 2 is a schematic top view of the present invention;

FIG. 3 is a schematic cross-sectional view of the present invention in a top view;

in the figure: 100-base, 200-reaction kettle, 300-wastewater collection box, 400-water tank, 210-heating box, 220-electric heating wire, 230-first water pipe, 240-second water pipe, 500-top cover, 250-annular block, 260-annular groove, 510-spray head, 520-third water pipe, 530-annular water pipe, 540-first hose, 560-first water pump, 550-second hose, 570-water inlet pipe, 580-second water pump, 571-first valve, 551-second valve, 610-rotating shaft, 620-stirring rod, 630-motor, 270-water outlet pipe, 271-third valve, 740-air outlet pipe, 741-fourth valve, 710-blower, 720-air inlet pipe, 730-air outlet pipe, 750-filter cartridge, 760-support column, 770-universal wheel, 780-handle and 211-water containing cavity.

Detailed Description

The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to fig. 1 to 3 in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Example 1

In the prior art, the disclosed temperature control device for the polypeptide synthesizer can increase the synthesis rate of polypeptide due to the fact that the temperature can be adjusted in the polypeptide synthesis process, but after the polypeptide synthesis is finished, substances adhered to the inner wall of a reaction area need to be cleaned so as to keep the reaction area clean, and adverse effects on the next polypeptide synthesis caused by bacteria breeding or mildew due to unclean reaction area are avoided.

A heating device of a deer heart blood polypeptide synthesizer comprises a base 100, wherein the top end of the base 100 is provided with a reaction kettle 200, a wastewater collection box 300 and a water tank 400, the outer wall of the reaction kettle 200 is surrounded with a heating box 210, the interior of the heating box 210 is surrounded with a water containing cavity 211, the bottom of the heating box 210 is provided with a heating wire 220, one side of the heating box 210 is communicated with a first water pipe 230, one end of the first water pipe 230, which is far away from the heating box 210, is communicated with the wastewater collection box 300, and one side of the wastewater collection box 300, which is far away from the first water pipe 230, is communicated with the water tank 400 through a second water pipe 240; the top end of the reaction kettle 200 is provided with a top cover 500, the top cover 500 is movably connected with the top end of the reaction kettle 200 through a connecting device, the connecting device comprises an annular block 250 and an annular groove 260, the annular block 250 is annularly arranged at the bottom end of the top cover 500, the annular groove 260 is annularly arranged at the top end of the reaction kettle 200, and the annular block 250 is clamped with the annular groove 260; a plurality of spray heads 510 are uniformly distributed on the circumference of the inner top surface of the top cover 500, the tops of the spray heads 510 are communicated with third water pipes 520, the top ends of the third water pipes 520 penetrate through the top cover 500 and are communicated with an annular water pipe 530 arranged at the top end of the top cover 500 together, one side of the annular water pipe 530 is communicated with a first hose 540 and a second hose 550 in sequence, one end of the first hose 540, far away from the annular water pipe 530, is connected with a first water pump 560, and one end of the first water pump 560, far away from the first hose 540, is communicated with the wastewater collection tank 300; one end of the second hose 550, which is far away from the annular water pipe 530, is communicated with a water inlet pipe 570, one end of the water inlet pipe 570 is communicated with the water containing cavity 211, the other end of the water inlet pipe 570 is connected with a second water pump 580, and the second water pump 580 is communicated with the water tank 400; a first valve 571 is arranged at one end of the water inlet pipe 570 close to the heating box 210, and a second valve 551 is arranged on the second hose 550; a stirring device is coaxially arranged in the reaction kettle 200, the stirring device comprises a rotating shaft 610, a stirring rod 620 and a motor 630, the rotating shaft 610 is coaxially arranged in the reaction kettle 200, the bottom of the rotating shaft 610 and the inner bottom surface of the reaction kettle 200 are arranged in a clearance manner, the top of the rotating shaft 610 penetrates through the top cover 500 and is fixedly connected with the output end of the motor 630 arranged at the top end of the top cover 500, and the stirring rods 620 are uniformly distributed on the outer wall of the rotating shaft 610; a temperature sensor and a pressure sensor are arranged in the reaction kettle 200; the side wall of the reaction kettle 200 is communicated with a water outlet pipe 270, and the water outlet pipe 270 is provided with a third valve 271; the top end of the reaction kettle 200 is communicated with an air outlet pipe 740, and the air outlet pipe 740 is provided with a fourth valve 741.

In the specific implementation, the raw material for synthesizing the deer heart blood polypeptide is placed in the reaction kettle 200, then the second valve 551 is closed, the first valve 571 is opened, the second water pump 580 is opened, under the action of the second water pump 580, the water in the water tank 400 sequentially enters the water containing cavity in the heating tank 210 along the second water pump 580 and the water inlet pipe 570, after the water is added, the second water pump 580 is turned off, the electric heating wire 220 is turned on to heat the water in the water containing cavity, and the water is used as a medium, heating the reaction kettle 200 to provide the synthesis speed of the deer heart blood polypeptide, simultaneously detecting the temperature and the pressure in the reaction kettle 200 in real time with precision by a temperature sensor and a pressure sensor, further ensuring that the temperature in the reaction kettle 200 is matched with the temperature in the polypeptide synthesis process, improving the synthesis speed to the maximum extent, reducing the occurrence of side reactions and improving the synthesis yield of the polypeptide; if the pressure in the reaction kettle 200 is too strong, the fourth valve 741 can be adjusted to discharge the excessive gas along the gas outlet 740, so as to ensure the safe and efficient reaction in the reaction kettle 200. In addition, during the synthesis reaction, the motor 630 needs to be turned on, and the rotating shaft 610 and the stirring rod 620 synchronously rotate under the action of the motor 630, so that the synthesis rate of the polypeptide is further improved. After the polypeptide synthesis reaction is finished, the product is taken out, and then the reaction kettle 200 needs to be cleaned. In the concrete operation, the water in the water containing cavity flows into the waste water collecting tank 300, and then the first water pump 560 is turned on, so that the hot water in the waste water collecting tank 300 flows into the spraying reaction kettle 200 along the first hose 540, the annular water pipe 530, the third water pipe 520 and the plurality of spray heads 510, because the hot water has better dissolving effect on the substances adhered to the inner wall of the reaction kettle 200, thereby improving the cleaning efficiency, discharging the cleaned wastewater along the water outlet pipe 270 directly, after the water in the wastewater collection tank 300 is used up, the first water pump 560 and the first valve 571 are closed, the second water pump 580 and the second valve 551 are opened, under the action of the second water pump 580, the water in the water tank 400 flows to the interior of the plurality of spray heads 510 along the water inlet pipe 570, the second hose 550, the annular water pipe 530, and the third water pipe 520 in sequence, and sprayed into the reaction kettle 200 to realize the secondary washing of the reaction kettle 200 and improve the cleanliness. In addition, because of a plurality of shower nozzles 510 are the circumference setting, can satisfy the purpose that washes the material furthest of reation kettle 200 inner wall adhesion, in addition, at abluent in-process, need open motor 630, under the effect of motor 630, can make axis of rotation 610 drive puddler 620 and rotate, and then make washing water can rotate in reation kettle, and then reation kettle 200 can all-round washing, further realize the purpose to reation kettle 200's clean purpose and the purpose that improves the cleaning efficiency, avoid existing for a long time because of residual substance, lead to fostering the bacterium in reation kettle 200, produce adverse effect to the synthesis of polypeptide next time. In addition, because the top cover 500 is clamped with the annular groove 260 through the annular block 250, the top cover 500 can be freely taken and placed while the sealing performance of the reaction kettle 200 is improved, and after the cover is conveniently taken and placed, daily maintenance or replacement is carried out on devices inside the reaction kettle 200 such as the spray head 510 and the stirring rod 620.

Example 2

On the basis of embodiment 1, the outside of the reaction kettle 200 is further provided with a blower 710, the blower 710 is arranged on the top surface of the base 100, the blower 710 is communicated with an air inlet pipe 720 and an air outlet pipe 730, and one end of the air outlet pipe 730 far away from the blower 710 is communicated with an air outlet pipe 740. Further, the air outlet pipe 740 is in threaded connection with the air outlet pipe 730. Further, a filter cartridge 750 is arranged on the air outlet pipe 740. Further, a support column 760 is provided at the bottom of the base 100. Further, the bottom end of the supporting column 760 is provided with a non-slip mat. Furthermore, hydraulic telescopic rods are arranged on two sides of the base 100, and universal wheels 770 are fixedly connected to the bottom ends of the hydraulic telescopic rods. Further, a handle 780 is provided on the top of the top cover 500.

During the concrete implementation, because of the washing back in reation kettle 200, there is a large amount of water to remain, if not dry it, then humid environment can lead to the metal device in reation kettle 200 to rust or produce bad consequence such as mildenes and rot in reation kettle 200, consequently, after finishing cleaning, need open hair-dryer 710, under the effect of hair-dryer 710, can make in wind gets into reation kettle 200 along air-out pipe 730, outlet duct 740 for the evaporation of reation kettle 200 water improves its drying rate. Further, outlet duct 740 and play tuber pipe 730 threaded connection are convenient for dismantle both. Further, be provided with cartridge filter 750 on the outlet duct 740, can filter the air that gets into reation kettle 200, prevent that the impurity in the air from causing the pollution to reation kettle 200. Further, the bottom of the base 100 is provided with a support column 760, which can support the synthesizer heating device, and meanwhile, the non-slip mat at the bottom end of the support column 760 can enhance the stability of the heating device. Further, the both sides of base 100 are provided with hydraulic telescoping rod, and hydraulic telescoping rod's bottom fixedly connected with universal wheel 770 when needs remove heating device, starts hydraulic telescoping rod, pastes universal wheel 770 ground, removes heating device through universal wheel 770, and the operation is convenient and the practicality is strong. Further, the top of the top cover 500 is provided with a handle 780, so that the top cover 500 can be conveniently opened or closed through the handle 780, and the practicability is improved.

In the description of this patent, it is to be understood that the terms "center," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," and the like are used in the orientations and positional relationships indicated in FIG. 1 to facilitate the description of the patent and to simplify the description, but are not intended to indicate or imply that the referenced device or element must have a particular orientation, be constructed and operated in a particular orientation, and are not to be considered limiting of the patent.

The foregoing is illustrative of the preferred embodiments of this invention, and it is to be understood that the utility model is not limited to the precise form disclosed herein and that various other combinations, modifications, and environments may be resorted to, falling within the scope of the concept as disclosed herein, either as described above or as apparent to those skilled in the relevant art. And that modifications and variations may be effected by those skilled in the art without departing from the spirit and scope of the utility model as defined by the appended claims.

Claims

1. A heating device of a deer heart blood polypeptide synthesizer is characterized in that: the reaction kettle comprises a base (100), wherein a reaction kettle (200), a wastewater collection box (300) and a water tank (400) are arranged at the top end of the base (100), a heating box (210) is arranged on the outer wall of the reaction kettle (200) in a surrounding manner, a water containing cavity (211) is arranged in the heating box (210) in a surrounding manner, an electric heating wire (220) is arranged at the bottom of the heating box (210), a first water pipe (230) is communicated with one side of the heating box (210), one end, far away from the heating box (210), of the first water pipe (230) is communicated with the wastewater collection box (300), and one side, far away from the first water pipe (230), of the wastewater collection box (300) is communicated with the water tank (400) through a second water pipe (240); the top end of the reaction kettle (200) is provided with a top cover (500), the top cover (500) is movably connected with the top end of the reaction kettle (200) through a connecting device, the connecting device comprises an annular block (250) and an annular groove (260), the annular block (250) is annularly arranged at the bottom end of the top cover (500), the annular groove (260) is annularly arranged at the top end of the reaction kettle (200), and the annular block (250) is clamped with the annular groove (260); a plurality of spray heads (510) are uniformly distributed on the circumference of the inner top surface of the top cover (500), the tops of the spray heads (510) are communicated with third water pipes (520), the top ends of the third water pipes (520) penetrate through the top cover (500) and are communicated with an annular water pipe (530) arranged at the top end of the top cover (500), one side of the annular water pipe (530) is sequentially communicated with a first hose (540) and a second hose (550), one end, far away from the annular water pipe (530), of the first hose (540) is connected with a first water pump (560), and one end, far away from the first hose (540), of the first water pump (560) is communicated with the wastewater collection box (300); one end, far away from the annular water pipe (530), of the second hose (550) is communicated with a water inlet pipe (570), one end of the water inlet pipe (570) is communicated with the water containing cavity (211), the other end of the water inlet pipe (570) is connected with a second water pump (580), and the second water pump (580) is communicated with the water tank (400); a first valve (571) is arranged at one end, close to the heating box (210), of the water inlet pipe (570), and a second valve (551) is arranged on the second hose (550); a stirring device is coaxially arranged in the reaction kettle (200), the stirring device comprises a rotating shaft (610), a stirring rod (620) and a motor (630), the rotating shaft (610) is coaxially arranged in the reaction kettle (200), the bottom of the rotating shaft (610) and the inner bottom surface of the reaction kettle (200) are arranged in a clearance mode, the top of the rotating shaft (610) penetrates through the top cover (500) and is fixedly connected with the output end of the motor (630) arranged at the top end of the top cover (500), and the stirring rod (620) is uniformly distributed on the outer wall of the rotating shaft (610); a temperature sensor and a pressure sensor are arranged in the reaction kettle (200); the side wall of the reaction kettle (200) is communicated with a water outlet pipe (270), and the water outlet pipe (270) is provided with a third valve (271); the top end of the reaction kettle (200) is communicated with an air outlet pipe (740), and the air outlet pipe (740) is provided with a fourth valve (741).

2. The heating device of the deer heart blood polypeptide synthesizer according to claim 1, characterized in that: the outside of reation kettle (200) still is provided with hair-dryer (710), hair-dryer (710) set up the top surface of base (100), hair-dryer (710) intercommunication has air-supply line (720) and goes out tuber pipe (730), it keeps away from to go out tuber pipe (730 the one end of hair-dryer (710) with outlet duct (740) intercommunication.

3. The heating device of the deer heart blood polypeptide synthesizer according to claim 2, characterized in that: the air outlet pipe (740) is in threaded connection with the air outlet pipe (730).

4. The heating device of the deer heart blood polypeptide synthesizer according to claim 2, characterized in that: and a filter cartridge (750) is arranged on the air outlet pipe (740).

5. The heating device of the deer heart blood polypeptide synthesizer according to claim 1, characterized in that: the bottom of the base (100) is provided with a supporting column (760).

6. The heating device of the deer heart blood polypeptide synthesizer according to claim 5, characterized in that: the bottom end of the supporting column (760) is provided with a non-slip mat.

7. The heating device of the deer heart blood polypeptide synthesizer according to claim 1, characterized in that: the two sides of the base (100) are provided with hydraulic telescopic rods, and the bottom ends of the hydraulic telescopic rods are fixedly connected with universal wheels (770).

8. The heating device of the deer heart blood polypeptide synthesizer according to claim 1, characterized in that: the top of the top cover (500) is provided with a handle (780).