CN2164792Y - Heart rate variation spectrum analyser - Google Patents
Heart rate variation spectrum analyser Download PDFInfo
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- CN2164792Y CN2164792Y CN 93225827 CN93225827U CN2164792Y CN 2164792 Y CN2164792 Y CN 2164792Y CN 93225827 CN93225827 CN 93225827 CN 93225827 U CN93225827 U CN 93225827U CN 2164792 Y CN2164792 Y CN 2164792Y
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- amplifier
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- rate variability
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Abstract
The utility model relates to an electronic medical analytical instrument which is exclusively used for heart rate variation spectrum analysis, and is composed of a microcomputer, an electro-cardio and respiratory wave signal pre-amplifier, a multifunctional interface, a display, a printer, etc., concentrated on a case and forming an integrative complete machine. The multifunctional interface card is composed of an analog-to-digital converter, a programmed control amplifier, a two-way digital-to-analog converter, an exterior triggering steady-state circuit of a pulse detector, etc., which are connected; detecting and analyzing software is developed on the microcomputer. The instrument has simple structure, easy use, and complete function, can record electro-cardio R-R interval rapidly and accurately and calculate various parameters, and can be used as the reference of disease prognosis and curative effect judgment.
Description
This utility model is a kind of electron medical treatment analytical tool, especially a kind of spectral analysis of heart rate variability instrument.
As everyone knows, cardiovascular indicators such as blood pressure, electrocardio etc. all have cyclic fluctuation.Since the seventies, Chinese scholars is to have done many work aspect the heart rate variability in research electrocardio R-R cycle (RRI) undulatory property, the high and low frequency range that has now drawn in comparatively clear conclusions: the Cardiac RR I fluctuation is relevant with parasympathetic nervous, and its low-frequency range is main relevant with sympathetic activity.Along with development of computer, make the more deep practical value that also demonstrates it more and more of Cardiac RR I undulatory property research.But this technology only is confined to use in the scientific research at present, and the experimenter utilizes equipment such as existing amplifier, A/D interface, computer mostly at hand, and the required program of establishment laboratory is finished spectral analysis of heart rate variability.These equipment are numerous and diverse, use trouble, bring very big inconvenience to applying the spectral analysis of heart rate variability method.The appearance of the spectral analysis of heart rate variability instrument that people wait in expectation special.
The purpose of this utility model is to design a kind of spectral analysis of heart rate variability instrument simple in structure, easy to use.
This utility model comprises several sections such as microcomputer, two road preamplifiers, versatile interface, display, printer and analysis software.Adopt 80286 or 80386 in this utility model as main frame, expanding thereon has two road preamplifiers and versatile interface, and the three is combined in the cabinet, becomes the complete machine integral structure.Analysis software has functions such as heart rate, respiration detection, experiment control and spectrum analysis.One the tunnel as ecg signal amplifier in two road preamplifiers, be used to handle input ecg signal, another road is used to handle the respiratory wave signal as the respiratory wave signal amplifier, and versatile interface is connected to form through circuit by A/D converter, program control (intelligence) amplifier, D/A, pulse detection window, external trigger steady-state circuit.Preamplifier, versatile interface and microcomputer join together with cable.
Further specify structure of the present utility model below in conjunction with accompanying drawing:
Fig. 1 is a complete machine structure sketch map of the present utility model: 1. preamplifier, 2. versatile interface card, 3. hard disk, 4. floppy disk, 5. printer, 6. display
Fig. 2 is the ECG preamplifier electrical schematic diagram, and it is formed by connecting through circuit by following components and parts:
AD620A is a first order amplifier; R1 is a gain resistor, and this stage gain is 10;
Resistance R 7, capacitor C 8-C12 forms the High frequency filter network;
A3 is a post-amplifier; R10, R12-R16 are gain resistor;
W is the floatingpotential device;
A2, A4 are emitter follower;
A2-A4 all adopts the uA741 operational amplifier;
A, B termination electrocardioelectrode, the C termination is gone into body ground, and out connects versatile interface.
Fig. 3 is a respiratory wave preamplifier electrical schematic diagram, and it is formed by connecting through circuit by following components and parts:
AD620A is a first order amplifier, and R17 is a gain resistor, and this stage gain is 10
Resistance R 18, capacitor C 13.C17 is that high frequency is considered wave network
A6 is a post-amplifier, and R20, R22-R26 are gain resistor
W is the floatingpotential device
A5-A7 is an emitter follower;
A5-A7 all adopts the uA741 operational amplifier;
D, E are the tonotransducer signal input part; F, G are the tonotransducer feeder ear;
H is a ground connection
Fig. 4 is the versatile interface block diagram, and it is made of following circuit:
7. programmable amplifier
8. gain control circuit
9. displacement control circuit
10. passage gating
11. pulse detection window
12. last threshold level control circuit
13. following threshold level control circuit
14. impulse register
15. two ways/weighted-voltage D/A converter
16. passage gating
17. A/D converter
18. port decoding
19. be the junction point of preamplifier output with versatile interface
20.PC machine bus
21. port decoding exports each port to
22. external trigger steady-state circuit
Fig. 5 is the intelligent amplifier electrical schematic diagram
A8-A12 is the LM324 operational amplifier
Thereby the gain of A9 is by programme-control, and program is imported data in integrated circuit 74LS273, makes the different resistance (R27-R30) of integrated circuit 4051 gatings the gain of change A9
A10 is the 1:1 amplifier, the output of its positive termination DAC0832, and program makes the output level of A10 produce corresponding mobile to the different data of DAC0832 input
I, J are respectively the selection signal of integrated circuit 74LS273 and DAC0832, from the port decoder
R31 R33 R35 is a coupling resistance, and R32 is an earth resistance, and R34 is a feedback resistance, and R36 is a coupling resistance, and R37 0832 is a load resistance
Fig. 6 is a pulse detection window electrical schematic diagram
Q1, Q2(D/A) threshold level up and down of control impuls detection window
A13 A14(LM339) is threshold level comparator up and down
G1, G2, G3, G4 are gate circuit
Q5, Q6 are monostable circuit
A13, A14, G1, G2, Q4-Q6 forms the pulse detection window
A15, A16 are 0832 output loading coupling resistance, the output amplitude of may command 0832
When rising edge of a pulse was crossed down threshold level, the A13 upset triggered Q6(P10), Q6(P12) output low level makes Q5(D D-flip flop, 7474) put 1.When threshold level was crossed in pulse, the A4 upset triggered Q4(P2), Q4(P13) the output high level makes the Q5 return-to-zero.
When the trailing edge of pulse crosses threshold level, A13 overturns once more, trigger Q4(P10), when Q4(P5) the output high level makes the state of Q5 export (Pout exports impulse register to) as if the G4 output low level, then trigger Q6(P2), Q6(P13) the output high level makes the Q5 return-to-zero, to wait for the detection of next arteries and veins.
Q1, Q2 is subjected to programme-control, and A0, B0 are respectively the gating signal of the two, from the port decoder.
Other circuit in the versatile interface are common circuit.
The first order of preamplifier adopts high impedance, low noise AD620A instrument amplifier, in ECG preamplifier, for overcoming the high impedance of signal source, improves quality of signals effectively, has added drive circuit between human body grounding and instrument ground.
The key technical indexes of preamplifier is as follows:
1. input impedance＞1 megohm
2. time constant is established 0.001S, 0.03S, 0.1S, 0.3S, five grades of 2S (being fixed as 2S in putting before respiratory wave)
3. high-frequency fluctuation is established 10Hz, 30Hz, 100Hz, 300Hz, five grades of 1000Hz
4. gain establishes 20,50,100,200,500 5 grades
The key technical indexes of versatile interface can be selected as follows:
1. A/D converter 17 adopts AD7574,8 of word lengths, changing voltage 0-5V, conversion time 15uS, the maximum sample rate of single channel is 50KHz, the sampling interval is by program setting.
2. programmable amplifier 7 has buffering and amplifies and the DC compensation effect, and input impedance is 100 kilohms, and amplification establishes * 1, * 2, * 4, * 8 fourth gear, dc offset range is ± 4V amplification and DC compensation Keyboard Control.
3. two road D/A switch, transducer 15 adopts DAC0832,8 of word lengths, the full amplitude of output is 8V.
4. the judgment threshold of pulse detection window 11 can be regulated with keyboard in the scope of 0-8V, and all pulse peaks above threshold value are detected.Whether program understands pulse detection by the status register 14 on the inquiry versatile interface card, if having, then does step-by-step counting and handles.Electrocardio R-R detects with pulse detection window 11 at interval in the program, and the respiratory frequency software detection
But stable trigger circuit when needed triggering signal make program and other instrument simultaneously operating.
In this instrument, program adopts TURBOC language and assembler language to write, and has stronger processing capability in real time; Image adopts the VGA mode to show, and is clear attractive in appearance, and in experimentation, electrocardio and respiratory wave dynamically show on screen, and be simple and clear; Primary RRI data can be deposited, so that check in the future; The program function Keyboard Control is used very convenient.
Program adopts Time Series Method to try to achieve the power spectrum of RRI, and the sequence that this method is strong to randomness, length is short is more feasible than FFT method commonly used, can analyze the regularity of RRI fluctuation more accurately.The solution procedure of RRI power spectrum is: detecting earlier 256 (or 512) electrocardio R-R intervals constitutes a Serial No., tries to achieve the linear predictor coefficient ai of autoregression model (AR) then with the Burg algorithm, and then tries to achieve its power spectrum by conversion.
Has comparability between the measured in order to make, program has been made normalized with the parameter about frequency and spectrum amplitude according to measured's heart rate, wherein the method that spectrum amplitude is made normalized with heart rate is tried to achieve the absolute value of spectrum amplitude, particularly useful to passing judgment on the neuro extent of damage, be to be better than external conventional method part.
The physiological significance of each parameter of Cardiac RR I spectrum analysis is as follows:
One, the dispersion degree of total variability (variance) prompting cardiac cycle
Normal value: quiet 1227.7-2367.5
Mental arithmetic 1068.6-1969.8
Meaning: increase-autonomic center tonicity instability
Attenuating-autonomic center integration function goes down
Two, LF, HF, LF+HF and LF/HF
Normal value: quiet LF 35.86-49.26(normalized unit)
29.09-67.58(absolute value)
HF 50.99-64.47(normalized unit)
39.05-105.35(absolute value)
LF+HF 73.33-167.73(absolute value)
LF／HF 0.6219－1.1334
Mental arithmetic LF 59.88-73.85(normalized unit)
38.46-82.68(absolute value)
HF 26.20-40.15(normalized unit)
15.99-55.70(absolute value)
LF+HF 56.66-136.16(absolute value)
LF／HF 1.7885－3.9134
Meaning: the LF(low-frequency component) and the HF(radio-frequency component) value prompting sympathetic nerve and parasympathetic active state.LF/HF value when quiet can be in order to pass judgment on the relative potence to the cardiovascular activity domination of sympathetic nerve and parasympathetic nervous.LF/HF value increase prompting sympathetic nerve central tonicity is higher or the parasympathetic nervous central tonicity is relatively low; LF/HF value attenuating prompting sympathetic nerve central tonicity is lower or the parasympathetic nervous central tonicity is higher relatively.The decline prompting vegetative nerve function of the absolute magnitude of high and low frequency goes down.
Three, stress the time LF/HF change percentage rate
Normal value: 153.5%-342.4%
Meaning: increase-sympathetic nerve excessive reactivity
Attenuating-sympathetic nerve reactivity is lower
Four, LF/LF peak and HF/HF peak reflection LF(low-frequency component) and the HF(radio-frequency component) frequency range
Normal value: quiet LF/LF peak 8.8049-12.3443
HF／HF peak 5.8320－11.7578
Mental arithmetic LF/LF peak 9.9482-13.4194
HF／HF peak 9.2736－13.9773
Meaning: increase-frequency content is too disperseed
Attenuating-frequency content is too concentrated
Embodiment:
One, to healthy population do stress forward and backward heart rate variability frequency spectrum normal value investigation.
1. healthy people 131 people (men and women half and half, the range of age 20-65 year) are test heart rate variability frequency spectrum under rest state, and test result shows:
(1) healthy people's vegetative nerve active state can be divided into according to the value of LF/HF that the sympathetic nervous center irritability is preponderated and the fan walks central excitation two classes of preponderating.Test data shows that above-mentioned two types of pacts respectively account for half, and is many with the sympathetic nervous center irritability tool of preponderating in greater than 40 years old crowd, and it is many then to walk the central excitation tool of preponderating with the fan in less than 40 years old crowd.
(2) gross area of total variability of cardiac cycle and LF and HF reduces with the increase at age, illustrates that human body vegetative nerve integration function reduces with the growth at age.
(3) healthy people's heart rate variability frequency spectrum no significant difference between the men and women.
Annotate 1: the range of normal value of frequency spectrum parameter is tabulated at preamble
Annotate 2: the testee is testing taboo clothes stimulant substance or beverage in first three hour; Test
The time emotion loosen; Test cabinet is kept quite
2. (96 give cold stimulation to give the certain stimulation of above 131 testees, the mental arithmetic of 35 doing mathematics topics) tests its heart rate variability frequency spectrum again, gained result and rest state are relatively, find that LF increases, HF reduces relatively, and LF/HF increases, and illustrates that normal person's sympathetic nervous center reactivity under stress situation is bigger, make the sympathetic nervous center irritability obviously greater than the irritability of being confused away maincenter, and the heart rate variability frequency spectrum is changed.
The normal person stress forward and backward LF/HF variation percentage rate be 251 ± 58%.
Two, the patient of uremia being done stress forward and backward heart rate variability spectrum measurement.
(1) patient of uremia 26 examples (male 21 examples, women 5 examples; Chronic nephritis 22 examples wherein, chronic pyelonephritis 1 example, polycystic kidney 2 examples, heritability nephropathy 1 example, the range of age is in 22-64 year) heart rate variability frequency spectrum major parameter during test when rest state and mental arithmetic is as follows:
Total variability peace and quiet 603.23 ± 106.34
Mental arithmetic 421.12 ± 64.37
LF+HF peace and quiet 26.71 ± 6.60
Mental arithmetic 15.81 ± 3.13
LF/HF variation percentage rate is 3.34 ± 15.73(%) before and after the mental arithmetic
Above parameter and normal person's group are made other significance test of difference in means, and P illustrates that all less than 0.001 uremia's patient's amphotonia obviously reduces than the normal person, and stress ability also obviously reduces.
Three, hypertension, diabetes, patient neurasthenia being done stress forward and backward heart rate variability spectrum measurement.
Test result shows: diabetic is stress forward and backward heart rate variability spectral change situation similar to the patient of uremia, all shows as amphotonia and obviously reduces, and stress ability also obviously reduces.When hypertensive patient and patient neurasthenia then show as peace and quiet the sympathetic nervous center irritability increase and stress unusual.
Claims (6)
1, a kind of spectral analysis of heart rate variability instrument, comprise microcomputer, two road preamplifiers, several sections such as versatile interface, display, printer and analysis software, it is characterized in that hardware expansion as microcomputer, in the preamplifier a road is as ecg signal amplifier, and one the tunnel as the respiratory wave signal amplifier; Versatile interface is connected to form through circuit by A/D converter, programmable amplifier, D/A, pulse detector, external trigger steady-state circuit.
2, spectral analysis of heart rate variability instrument according to claim 1, it is characterized in that ECG preamplifier is connected to form by following component circuitry: with the first order amplifier of AD620A instrument amplifier formation, the human body grounding drive circuit that constitutes by resistance R 2, R3, R4, R6 and capacitor C 1, resistance R 7, the High frequency filter network that capacitor C 8～C12 forms, capacitor C 2, C3～C7, resistance R 8, the low frequency filtering network that R9 forms, post-amplifier A3, floatingpotential device W, emitter follower A2, A4, and gain resistor R1, R10, R12～R16.
3, spectral analysis of heart rate variability instrument according to claim 1, it is characterized in that the respiratory wave preamplifier is connected to form by following component circuitry: with the first order amplifier of AD620A instrument amplifier formation, by resistance R 18, the High frequency filter network that capacitor C 13～C17 forms, post-amplifier A6, floatingpotential device, emitter follower A5～A7, and gain resistor R17, R20, R22～R26.
4, spectral analysis of heart rate variability instrument according to claim 1 is characterized in that versatile interface is made of following circuit: programmable amplifier 7, gain control circuit 8, displacement control circuit 9, pulse detection window 11, last threshold level control circuit 12, following threshold level control circuit 13, impulse register 14, two ways/weighted-voltage D/A converter 15, A/D converter 17, port decoding 18, two ways/weighted-voltage D/A converter 19, PC bus 20, passage gating 10,16.
5, according to claim 2,3 described spectral analysis of heart rate variability instruments, the input impedance that it is characterized in that two road preamplifiers is 1 megohm; Time constant is made as five grades of 0.01S, 0.03S, 0.1S, 0.3S, 2S; High-frequency fluctuation is made as five grades of 10Hz, 30Hz, 100Hz, 300Hz, 1000Hz, and gain is made as 20,50,100,200,500 5 grades.
6, spectral analysis of heart rate variability instrument according to claim 4 is characterized in that the technical parameter design of versatile interface is as follows:
(1) A/D converter adopts the AD7574 of 8 word lengths, changing voltage 0-5V, conversion time 15uS, the maximum sample rate of single channel is 50KHz;
(2) input impedance of programmable amplifier is 100 kilohms, amplification is made as * 1, * 2, * 4, * 8 fourth gear, dc offset range is ± 4V;
(3) two road D/A switch adopt the DAC0832 of 8 word lengths, and the full amplitude of output is 8V;
(4) judgment threshold of pulse detection window is regulated with keyboard in the 0-8V scope.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93225827 CN2164792Y (en) | 1993-06-04 | 1993-06-04 | Heart rate variation spectrum analyser |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93225827 CN2164792Y (en) | 1993-06-04 | 1993-06-04 | Heart rate variation spectrum analyser |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN2164792Y true CN2164792Y (en) | 1994-05-18 |
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ID=33803549
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 93225827 Expired - Fee Related CN2164792Y (en) | 1993-06-04 | 1993-06-04 | Heart rate variation spectrum analyser |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN2164792Y (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997022296A1 (en) * | 1995-12-18 | 1997-06-26 | Xiangsheng Wang | System and method for testing the function of the autonomic nervous system |
| CN102512139A (en) * | 2011-11-29 | 2012-06-27 | 乔德才 | Maximal oxygen uptake testing and evaluating apparatus |
-
1993
- 1993-06-04 CN CN 93225827 patent/CN2164792Y/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997022296A1 (en) * | 1995-12-18 | 1997-06-26 | Xiangsheng Wang | System and method for testing the function of the autonomic nervous system |
| CN102512139A (en) * | 2011-11-29 | 2012-06-27 | 乔德才 | Maximal oxygen uptake testing and evaluating apparatus |
| CN102512139B (en) * | 2011-11-29 | 2015-10-21 | 乔德才 | A kind of maximal oxygen uptake assessment instrument |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |