CN216458927U

CN216458927U - Micro-fluidic chip box

Info

Publication number: CN216458927U
Application number: CN202122771346.XU
Authority: CN
Inventors: 吴刚
Original assignee: Maiana Shanghai Instrument Technology Co ltd
Current assignee: Maiana Shanghai Instrument Technology Co ltd
Priority date: 2021-11-12
Filing date: 2021-11-12
Publication date: 2022-05-10
Anticipated expiration: 2031-11-12

Abstract

The utility model discloses a microfluidic chip box, which comprises a box body, a microfluidic chip and a box cover; the box body is provided with an accommodating cavity with an opening at one end, the bottom of the accommodating cavity is provided with a chip groove and an annular groove, the annular groove is wound on the outer side of the chip groove, the box body is provided with at least two liquid inlets and at least one liquid outlet, and the liquid inlets and the liquid outlets are both communicated with the chip groove; the micro-fluidic chip is accommodated in the chip groove, a micro-channel is arranged in the micro-fluidic chip, a first opening and at least one second opening are formed in the micro-fluidic chip, the first opening is communicated with the second opening through the micro-channel, the first opening is correspondingly connected with the liquid inlet, and the second opening is correspondingly connected with the liquid outlet; the box cover covers the opening of the box body, and an annular clamping strip is arranged on the box cover and clamped in the annular groove. The utility model is provided with a swirling flow structure, is not only used for screening low-flow-rate nano-drug prescriptions within the flow rate range of 1-20ml/min at the early stage, but also solves the problem of process amplification more breakthroughs, and the highest flow rate can be supported to 120 ml/min.

Description

Micro-fluidic chip box

Technical Field

The utility model relates to the field of microfluid liquid flowing and mixing, in particular to a microfluidic chip box.

Background

Microfluidics is a technology that uses microchannels (tens to hundreds of microns in size) to precisely control and manipulate microscale fluids or minute volumes of fluids, especially for micron and submicron structures.

The early concept of microfluidics was to fabricate a gas chromatograph on a silicon wafer using photolithography, and then extend it to microfluidic capillary electrophoresis devices and microreactors. One of the important features of microfluidics is the unique fluid properties in microscale environments, such as laminar flow and droplets. With these unique fluidic phenomena, microfluidics can achieve a range of microfabrication and micromanipulation that are difficult to accomplish with conventional methods. At present, microfluidics is considered to have great development potential and wide application prospect in biological and medical research.

However, the current common fluidic chip boxes are relatively complex in manufacturing structure and relatively high in cost, and some fluidic chip boxes can only be used once, so that great waste is caused, and high research and development cost is brought to research and development units or personnel.

Therefore, aiming at the technical characteristics, the patent provides a new technical scheme.

SUMMERY OF THE UTILITY MODEL

In order to solve the technical problems in the prior art, the utility model provides a microfluidic chip cartridge with simple structure, convenient use and better quality, and the specific technical scheme is as follows:

a microfluidic chip cartridge comprises

The liquid inlet and the liquid outlet are communicated with the chip groove;

the micro-fluidic chip is accommodated in the chip groove, a micro-channel is arranged in the micro-fluidic chip, at least one first opening and at least one second opening are formed in the micro-fluidic chip, the first opening is communicated with the second opening through the micro-channel, the first opening is correspondingly connected with the liquid inlet, and the second opening is correspondingly connected with the liquid outlet;

the box cover covers the opening of the box body, an annular clamping strip is arranged on the box cover and clamped in the annular groove.

As a preferable scheme of the microfluidic chip cartridge of the present invention, the structure of the microchannel includes a T-shaped structure, a Y-shaped structure, a cross-shaped structure, an SHM fish bone structure, a tesla structure, and a swirling flow structure.

As a preferable embodiment of the microfluidic chip cartridge of this patent, the microchannel includes at least one inlet microchannel and at least one mixing microchannel.

As a preferable scheme of the microfluidic chip cartridge of this patent, the mixing microchannel is a linear microchannel, and/or a surrounding microchannel, and/or a curved microchannel, and/or a swirling microchannel;

the liquid inlet micro-channel is a linear micro-channel, and/or a surrounding micro-channel, and/or a curve micro-channel, and/or a swirling micro-channel.

As an optimized proposal of the micro-fluidic chip box, the mixing micro-channel is a swirling flow mixing micro-channel which is formed by a plurality of S-shaped micro-channel structures which are sequentially connected end to end.

As a preferred scheme of the microfluidic chip cartridge of this patent, the first opening corresponds to the liquid inlet microchannel one to one, one end of the liquid inlet microchannel is communicated with the first opening, the other end of the liquid inlet microchannel is communicated with one end of the mixing microchannel, and the other end of the mixing microchannel is communicated with the second opening;

the first opening and the second opening are both located on the same side of the microfluidic chip.

As a preferable scheme of the microfluidic chip cartridge of the present patent, the microfluidic chip cartridge further comprises a sealing structure, wherein the first opening and the liquid inlet are provided with a sealing structure, and the second opening and the liquid outlet are provided with a sealing structure;

the inlet is provided with hollow inlet column, the liquid outlet is provided with hollow play liquid post, it all extends towards the direction of keeping away from the box body with play liquid post to advance the liquid post.

As the preferred scheme of this patent micro-fluidic chip box, chip tank bottom sets up spacing post, set up spacing hole on the micro-fluidic chip, spacing post holds in spacing downthehole.

As the preferred scheme of this patent micro-fluidic chip box, the box body is the fixedly connected with handle end still, the handle end is located the one end of liquid outlet is kept away from to the box body, at least one side surface of handle end is provided with a plurality of archs.

As a preferable scheme of the microfluidic chip cartridge of the present patent, the number of the liquid inlet microchannels is at least two, and the shape and the inner diameter of at least two liquid inlet microchannels are the same, or

The at least two inlet microchannels have different shapes and/or different inner diameter sizes.

As this patent a preferred scheme of micro-fluidic chip box, seal structure is the sealing washer, two at least feed liquor seal grooves and play liquid seal groove have been seted up to the chip tank bottom, the feed liquor seal groove has all been held the sealing washer with play liquid seal groove, first opening passes through the sealing washer and the inlet is inconsistent, the second opening passes through the sealing washer and the liquid outlet is inconsistent.

Compared with the prior art, the microfluidic chip cartridge disclosed by the patent at least has one or more of the following beneficial effects:

(1) the microfluidic chip cartridge of the present invention is provided with a microchannel, and the shape (including straight line, curve, circular, rotational flow or other), structure (including T-shaped structure, Y-shaped structure, cross-shaped structure, SHM fish bone structure, tesla structure, rotational flow structure or other structures, etc.) and inner diameter of the microchannel are set to control the flow rate and flow velocity of the liquid, and the operation of mixing, and/or coating, and/or proportion configuration, and/or separation, and/or sorting, and/or purification, etc. of the mixed liquid, so as to obtain an ideal preparation product.

(2) The microfluidic chip cartridge is provided with a micro channel, and is suitable for experiments or small-batch product manufacturing and accurate preparation of target products; meanwhile, the process amplification can be carried out, and the method is applied to production, which is a place difficult to realize by other microfluidic chip boxes. The microfluidic chip box disclosed by the patent can be used for screening low-flow-rate nano-drug prescriptions within the flow rate range of 1-20ml/min at the early stage, the problem of process amplification is solved more breakthroughs, and the highest flow rate can be up to 120 ml/min.

(3) The micro-fluidic chip cartridge provided by the patent has the structure of a micro-channel including but not limited to a T-shaped structure, a Y-shaped structure, a cross-shaped structure, an SHM structure (i.e., a fishbone structure), a tesla structure, and the like according to requirements; the preferable swirling flow structure can reach high flow rate of 120ml/min, and the prepared microfluid mixed liquid has better encapsulation efficiency and dispersibility.

(4) This patent micro-fluidic chip box, it sets up the sealing washer, realize that the first export and the second export of micro-fluidic chip respectively with between the inlet and the liquid outlet of box body sealing connection, prevent that liquid from spilling leaks, not only influence the experimental result, and can pollute raw materials or the result of preparation once more.

(5) This patent micro-fluidic chip box, it sets up spacing post, not only can play spacing and fixed action to micro-fluidic chip, prevents that micro-fluidic chip from sliding dislocation in the chip groove, and has the foolproof effect, prevents that micro-fluidic chip from installing in the opposite direction, causes micro-fluidic chip box unable the use.

(6) This patent micro-fluidic chip box, it sets up the handle end for hand handle end promotes micro-fluidic chip box in the box body inslot, or promotes micro-fluidic chip box, so that the buckle has micro-fluidic chip box's supporting subject to rotate, sets up the arch, can play anti-skidding effect, the operation of being convenient for.

Additional aspects and advantages of the utility model will be set forth in part in the description which follows and, in part, will be obvious from the description, or may be learned by practice of the utility model.

Drawings

In order to more clearly illustrate the technical solution of the present invention, the drawings needed for the description of the embodiments or the prior art will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art to obtain other drawings without creative efforts.

Fig. 1 is an exploded view of the microfluidic chip cartridge according to the present embodiment;

FIG. 2 is a schematic perspective view of a microfluidic chip cartridge according to this embodiment;

FIG. 3 is a schematic view of the A-direction plan structure of FIG. 2;

FIG. 4 is a schematic view of the cross-sectional structure of FIG. 2 taken along the line B;

FIG. 5 is a schematic perspective view of a box according to the present embodiment;

FIG. 6 is a schematic perspective view of another perspective view of the case according to the embodiment;

fig. 7 is a schematic perspective view of a microfluidic chip according to the present embodiment;

fig. 8 is a schematic perspective view of another view of the microfluidic chip according to the present embodiment;

fig. 9 is a schematic perspective view of the box cover according to this embodiment.

The device comprises a box body 21, a micro-fluidic chip 22, a micro-fluidic chip 23, a box cover 211, a containing cavity 2111, a chip groove 2112, an annular groove 2113, a liquid inlet sealing groove 2114, a liquid outlet sealing groove 2115, a limiting column 2116, an inner annular convex strip 2117, an outer annular convex strip 2117, a liquid inlet 212, a liquid inlet 2121, a liquid outlet 213, a liquid outlet 2131, a liquid outlet column 214, a handle end 2141, a bulge 2141, a 221 liquid inlet micro-channel, a 2211 first liquid inlet micro-channel, a 2212 second liquid inlet micro-channel, a 222 mixing micro-channel, a 223 first opening, a 224 second opening, a 226 limiting hole, a 231 annular clamping strip, a 232 fixing groove and a 241 sealing ring.

Detailed Description

Reference will now be made in detail to embodiments of the present invention, examples of which are illustrated in the accompanying drawings, wherein like or similar reference numerals refer to the same or similar elements or elements having the same or similar function throughout. The embodiments described below with reference to the drawings are illustrative and intended to be illustrative of the utility model and are not to be construed as limiting the utility model. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

In the description of the present invention, it should be understood that the terms "upper", "lower", "top", "bottom", "one end", "one side", "the other side", and the like indicate orientations or positional relationships based on those shown in the drawings, and are only for convenience in describing the present invention and simplifying the description, but do not indicate or imply that the device or element referred to must have a specific orientation, be constructed in a specific orientation, and be operated, and thus, should not be construed as limiting the present invention. In the description of the present invention, "a plurality" means two or more unless specifically defined otherwise.

In the description of the present invention, unless otherwise expressly specified or limited, the terms "disposed," "provided," "connected," "disposed," "fixed," and the like are to be construed broadly, e.g., as meaning fixedly connected, detachably connected, or integral to; can be mechanically or electrically connected; the terms may be directly connected or indirectly connected through an intermediate medium, and may be specifically understood in the two elements.

Examples

The microfluidic chip cartridge of the embodiment is mainly applied to microfluidic equipment, raw material liquid is connected to a liquid inlet, the flow and the flow speed of different raw material liquid are controlled, a target product is prepared, and the target product is collected. The micro-fluidic device comprises a device shell, wherein the device shell comprises an opening and a containing cavity, a supporting main body is arranged in the containing cavity, a box body groove is formed in the supporting main body, the micro-fluidic chip box is buckled in the box body groove in a buckling mode, a liquid conveying device is arranged below a liquid inlet of the micro-fluidic chip box, and a liquid receiving device is arranged below a liquid outlet of the micro-fluidic chip box.

The following technical scheme of the microfluidic chip cartridge is illustrated by taking the application to microfluidic equipment as an example:

referring to fig. 1 to 9, as shown in fig. 1 to 9, a microfluidic chip cartridge includes a cartridge body 21, a microfluidic chip 22, and a cartridge cover 23;

the box body 21 is provided with an accommodating cavity 211 with an opening at one end, a chip groove 2111 and an annular groove 2112 are arranged at the bottom of the accommodating cavity 211, the annular groove 2112 is wound outside the chip groove 2111, the chip groove 2111 and the annular groove 2112 are arranged at intervals, namely the chip groove 2111 is not communicated with the annular groove 2112, the box body 21 is provided with at least two liquid inlets 212 and at least one liquid outlet 213, and the liquid inlets 212 and the liquid outlets 213 are communicated with the chip groove 2111; in an example, the liquid inlet 212 is provided with a hollow liquid inlet column 2121, the liquid outlet 213 is provided with a hollow liquid outlet column 2131, the liquid inlet column 2121 and the liquid outlet column 2131 both extend towards a direction away from the box body 21, and the liquid inlet column 2121 and the liquid outlet column 2131 are both integrally connected with the box body 21; preferably, the liquid inlet 212 and the liquid outlet 213 are circular, and the liquid inlet column 2121 and the liquid outlet column 2131 are cylindrical. In the example, the bottom of the box 21 is provided with an inner annular rib 2116 and an outer annular rib 2117, the inner annular rib 2116 and the outer annular rib 2117 are coaxially arranged, an annular groove 2112 is formed between the inner annular rib 2116 and the outer annular rib 2117, and the inner annular rib 2116 surrounds a chip groove 2111.

Preferably, the box body 21 is further fixedly connected with a handle end 214, the handle end 214 is located at one end of the box body 21 far away from the liquid outlet 213, at least one side surface of the handle end 214 is provided with a plurality of protrusions 2141, the protrusions 2141 are preferably circular arc-shaped protrusions, and of course, the protrusions may be in any other shapes. In an example, the protrusions 2141 are arranged in an array. Set up handle end 214 for hand handle end promotes micro-fluidic chip box in the box body inslot, or promotes micro-fluidic chip box, so that the buckle has micro-fluidic chip box's support subject to rotate, sets up the arch can play the antiskid effect, the operation of being convenient for, but the arch is not limited to arc, or is not limited to the arch, can also set up concave-convex line on handle end surface, as long as can play increase frictional force again can not produce all in the protective scope of this patent of damage to the adversary. In an example, the handle end 214 is provided with a plurality of protrusions 2141 on both side surfaces. In an example, an end of the handle end 214 away from the accommodating cavity 211 is arc-shaped, and an axis of the arc-shaped is parallel to the accommodating cavity 211.

The microfluidic chip 22 is accommodated in the chip slot 2111, and a micro-channel is arranged in the microfluidic chip 22, and the structure of the micro-channel includes, but is not limited to, a T-shaped structure, a Y-shaped structure, a cross-shaped structure, an SHM structure (i.e., a fishbone structure), a tesla structure, a swirling flow structure, and the like as required. In an example, the structure of the micro-channel is preferably a swirling flow structure, and experiments prove that the swirling flow structure can greatly improve the flow velocity and has better encapsulation efficiency and dispersibility. The micro flow channel comprises at least two liquid inlet micro flow channels 221 and at least one mixed micro flow channel 222, at least two first openings 223 and at least one second opening 224 are arranged on the micro flow chip 22, the first openings 223 correspond to the liquid inlet micro flow channels 221 one by one, the first openings correspond to the liquid inlets one by one, the second openings correspond to the liquid outlets, one end of each liquid inlet micro flow channel 221 is communicated with the first opening 223, the other end of each liquid inlet micro flow channel 221 is communicated with one end of the mixed micro flow channel 222, and the other end of the mixed micro flow channel 222 is communicated with the second opening 224; in an example, the inner diameter of the chip groove 2111 corresponds to the outer diameter of the microfluidic chip 22, and the first opening 223 and the second opening 224 are both disposed on the same side of the microfluidic chip 22. The material of the microfluidic chip 22 includes, but is not limited to, polymers, including, but not limited to, cyclic olefin polymer (cop), cyclic olefin copolymer (coc), polydimethylsiloxane (pdms), and the like, stainless steel, PEEK, and the like, and the microfluidic chip 22 is manufactured by a method including, but not limited to, injection molding, precision machining, and other material processing methods, and the microfluidic chip channel is encapsulated by a process including, but not limited to, ultrasonic bonding, thermal compression bonding, laser welding, cold/thermal compression bonding, and the like.

The box cover 23 covers the opening of the box body 21, the box cover 23 props against the microfluidic chip 22 in the chip groove, an annular clamping strip 231 is arranged on the box cover 23, and the annular clamping strip 231 is clamped in the annular groove 2112. In an example, the inner side of the annular clamping strip 231 is provided with an inclined surface which can play a role of sealing, so that the annular clamping strip 231 is ultrasonically welded and sealed in the annular groove 2112. At least two fixing grooves 232 are formed in the box cover 23, when the microfluidic chip box is installed on equipment, the microfluidic chip box can be fixed on the equipment through the fixing grooves, and the fixing grooves play a role in positioning and fixing. The device is provided with a box body groove, the side wall of the box body groove is provided with a protruding structure, the protruding structure corresponds to the fixing groove, and when the microfluidic chip box is inserted into the box body groove, the protruding structure is buckled in the fixing groove.

The mixing microchannel includes but is not limited to a linear microchannel, and/or a surrounding microchannel, and/or a curved microchannel, and/or a swirling-flow microchannel. In an example, the mixing microchannel 222 is a swirling flow type microchannel, the swirling flow type microchannel is a swirling flow mixing microchannel formed by sequentially connecting a plurality of S-shaped microchannel structures end to end, and two adjacent S-shaped microchannel structures may be connected smoothly or in a staggered manner along the flow direction of the raw material liquid, may be staggered within the previous S-shaped microchannel structure, or may be staggered outside the previous S-shaped microchannel structure. In the example, the latter S-type micro flow channel structure is dislocated inside the former S-type micro flow channel structure, as shown in fig. 7. The mixing microchannel enables mixing, and/or coating, and/or proportioning, and/or separation, and/or sorting, and/or purification of the raw liquid. By setting the shape and structure of the micro-channel and the inner diameter of the micro-channel, the micro-channel can perform operations such as mixing, and/or coating, and/or proportion configuration, and/or separation, and/or sorting, and/or purification and the like on two or more raw material liquids, so as to achieve the purpose of experimental preparation.

The liquid inlet micro-channel comprises but is not limited to a linear micro-channel, and/or a surrounding micro-channel, and/or a curved micro-channel, and/or a swirling micro-channel. In an example, the liquid inlet micro-channel is a linear micro-channel. The inlet microchannel comprises a first inlet microchannel 2211 and a second inlet microchannel 2212, and the shape and the inner diameter of the first inlet microchannel 2211 and the second inlet microchannel 2212 can be the same or different. The flow and the flow speed of the raw material liquid can be controlled by setting the shape and the inner diameter size of the liquid inlet micro-channel, so that different raw material liquids can be mixed to achieve better mixing effect, coating effect or the like.

In a preferred embodiment, a sealing structure is further included, a sealing structure is disposed between the first opening 223 and the liquid inlet 212, and a sealing structure is disposed between the second opening 224 and the liquid outlet 213. In an example, the sealing structure is a sealing ring 241, the bottom of the chip slot 2111 is provided with at least two liquid inlet sealing grooves 2113 and liquid outlet sealing grooves 2114, the sealing rings 241 are accommodated in the liquid inlet sealing grooves 2113 and the liquid outlet sealing grooves 2114, the first opening 223 is abutted to the liquid inlet 212 through the sealing ring 241, and the second opening 224 is abutted to the liquid outlet 213 through the sealing ring 241. Of course, the sealing ring 241 in the liquid inlet sealing groove 2113 may be the same as or different from the sealing ring 241 in the liquid outlet sealing groove 2114, the sealing ring 241 in the liquid inlet sealing groove 2113 is matched with the liquid inlet sealing groove 2113, and the sealing ring 241 in the liquid outlet sealing groove 2114 is matched with the liquid outlet sealing groove 2114. In an example, the liquid inlet sealing groove 2113 is disposed coaxially with the liquid inlet 212, the liquid outlet sealing groove 2114 is disposed coaxially with the liquid outlet 213, the inner diameter of the liquid inlet sealing groove 2113 is greater than the inner diameter of the liquid inlet 212, the inner diameter of the liquid outlet sealing groove 2114 is greater than the inner diameter of the liquid outlet 213, the outer diameter of the sealing ring 241 in the liquid inlet sealing groove 2113 is greater than the inner diameter of the first opening 223, and the outer diameter of the sealing ring 241 in the liquid outlet sealing groove 2114 is greater than the inner diameter of the second opening 224; realize that first export and the second export of micro-fluidic chip are sealing connection between inlet and the liquid outlet of box body respectively, prevent that liquid from spilling hourglass, not only influence the experimental result, and can pollute raw materials or the result of preparing once more.

In another preferred embodiment, the chip groove 2111 is provided with a retaining post 2115 at the bottom, the microfluidic chip 22 is provided with a through retaining hole 226, and the retaining post 2115 is accommodated in the retaining hole 226. The position of the microfluidic chip 22 in the chip groove can be limited by the limiting columns and the limiting holes 226, so that the first openings are correspondingly communicated with the liquid inlets one by one, the second openings are correspondingly communicated with the liquid outlets, dislocation is avoided, the situations of liquid leakage or blockage and the like are avoided, and the effect of fixing the microfluidic chip 22 can be achieved.

Preferably, the microfluidic chip cartridge is mainly used for mixing materials and generating liquid drops, and particularly for preparing nano-drugs, nano-carriers and microspheres. Nano-drugs include, but are not limited to, nucleic acid drugs including, but not limited to, mRNA, siRNA, cyclic RNA, self-replicating RNA, etc., small molecule nano-drugs including, but not limited to, paclitaxel liposome, doxorubicin liposome, etc., nano-carriers including, but not limited to, Lipid Nanoparticles (LNPs), polymers, polypeptides, proteins, etc.; microspheres include, but are not limited to, PLGA microspheres, gel microspheres, embolic microspheres, and the like.

The process preparation condition of packaging mRNA drugs by a classical LNP prescription is tested by respectively using a traditional separately-built microfluidic control device and microfluidic equipment developed by the company, the LNP selected in the prescription is a classical Dlin-MC3 prescription (dissolved in 100% medicinal ethanol), the package is luciferase mRNA (Luc mRNA) dissolved in an injection water buffer solution with a certain PH value, and the specific prescription concentration is not published for confidentiality reasons.

Table 1 micro-fluidic device and traditional separately built micro-fluidic device for preparing classic LNP prescription packaged mRNA medicine

The PDI represents the polymer dispersity index, and the data result proves that the drug dispersity of the mRNA wrapped by the LNP prescription prepared by the microfluidic chip box is better, the encapsulation efficiency is higher, the microfluidic chip box and microfluidic equipment can provide a high flow rate of 120ml/min in match, so that the production process amplification is favorably realized, the effective practicability of the microfluidic chip box is stronger, the use is more convenient and faster, the efficiency is higher, and the popularization and the use are favorably realized.

All the technical features of the above components can be freely combined without conflict, and moreover, the structural change, the modification and the modification of the components are also within the protection scope of the patent.

The microfluidic chip box disclosed by the patent has the beneficial effects that:

(1) the microfluidic chip cartridge of the present invention is provided with a microchannel, and the shape (including a straight line, a curve, a circular shape, a rotational flow shape or others), the structure (including a T-shaped structure, a Y-shaped structure, a cross-shaped structure, an SHM fish bone structure, a tesla structure, a rotational flow structure or others) and the inner diameter of the microchannel are set to control the flow rate and the flow velocity of the liquid, and the operations of mixing, and/or coating, and/or proportion configuration, and/or separation, and/or sorting, and/or purification, etc. of the mixed liquid, so as to obtain an ideal preparation product, especially a nano-coating for preparing a nucleic acid drug or a vaccine.

(5) This patent micro-fluidic chip box, it sets up spacing post, can play spacing and fixed action to micro-fluidic chip, avoids micro-fluidic chip to slide the dislocation and the condition such as weeping or jam appear.

In the description herein, references to the description of the term "one embodiment," "some embodiments," "an example," "a specific example" or "some examples" or the like are intended to mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the utility model. In this specification, the schematic representations of the terms used above are not necessarily intended to refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples. Furthermore, various embodiments or examples described in this specification can be combined and combined by one skilled in the art.

While embodiments of the present invention have been shown and described above, it is to be understood that the above embodiments are exemplary and not to be construed as limiting the present invention, and that changes, modifications and variations may be made therein by those of ordinary skill in the art within the scope of the present invention.

Claims

1. A microfluidic chip cartridge, comprising;

the chip packaging box comprises a box body (21), wherein the box body (21) is provided with a containing cavity (211) with an opening at one end, a chip groove (2111) and an annular groove (2112) are arranged at the bottom of the containing cavity (211), the annular groove (2112) is wound on the outer side of the chip groove (2111), at least one liquid inlet (212) and at least one liquid outlet (213) are formed in the box body (21), and the liquid inlet (212) and the liquid outlet (213) are communicated with the chip groove (2111);

the micro-fluidic chip (22), the micro-fluidic chip (22) is accommodated in the chip groove (2111), a micro-channel is arranged in the micro-fluidic chip (22), at least one first opening (223) and at least one second opening (224) are arranged on the micro-fluidic chip (22), the first opening (223) is communicated with the second opening (224) through the micro-channel, the first opening (223) is correspondingly connected with the liquid inlet, and the second opening is correspondingly connected with the liquid outlet;

the box cover (23), lid (23) lid fits the opening part of box body (21), be provided with annular card strip (231) on lid (23), annular card strip (231) block in annular groove (2112).

2. The microfluidic chip cartridge according to claim 1, wherein the structure of the microchannel comprises a T-shaped structure, a Y-shaped structure, a cross-shaped structure, an SHM fishbone structure, a tesla structure, and a swirling flow structure.

3. A microfluidic chip cartridge according to claim 2, wherein the microchannels comprise at least one inlet microchannel (221) and at least one mixing microchannel (222).

4. The microfluidic chip cartridge according to claim 3, wherein the mixing microchannel is a linear microchannel, and/or a circumferential microchannel, and/or a curved microchannel, and/or a swirling microchannel;

5. The microfluidic chip cartridge according to claim 4, wherein the mixing microchannel (222) is a swirling-flow microchannel, and the swirling-flow microchannel is a swirling-flow microchannel in which a plurality of S-type microchannels are connected end to end in sequence.

6. A microfluidic chip cartridge according to claim 3, wherein the first opening (223) corresponds to a liquid inlet microchannel (221) one-to-one, one end of the liquid inlet microchannel (221) is connected to the first opening (223), the other end of the liquid inlet microchannel (221) is connected to one end of the mixing microchannel (222), and the other end of the mixing microchannel (222) is connected to the second opening (224).

7. The microfluidic chip cartridge according to claim 1, further comprising a sealing structure, wherein the first opening (223) and the liquid inlet (212) are provided with a sealing structure, and the second opening (224) and the liquid outlet (213) are provided with a sealing structure;

the liquid inlet (212) is provided with a hollow liquid inlet column (2121), the liquid outlet (213) is provided with a hollow liquid outlet column (2131), and the liquid inlet column (2121) and the liquid outlet column (2131) both extend towards the direction far away from the box body (21).

8. The microfluidic chip cartridge according to claim 1, wherein a position-limiting post (2115) is disposed at the bottom of the chip groove (2111), a position-limiting hole (226) is disposed on the microfluidic chip (22), and the position-limiting post (2115) is accommodated in the position-limiting hole (226);

the box body (21) is further fixedly connected with a handle end (214), the handle end (214) is located at one end, far away from the liquid outlet (213), of the box body (21), and at least one side surface of the handle end (214) is provided with a plurality of protrusions (2141).

9. The microfluidic chip cartridge according to claim 3, wherein the at least two inlet microchannels have the same shape and inner diameter, or

10. The microfluidic chip cartridge according to claim 7, wherein the sealing structure is a sealing ring (241), the bottom of the chip groove (2111) is provided with at least two liquid inlet sealing grooves (2113) and liquid outlet sealing grooves (2114), the sealing ring (241) is contained in each of the liquid inlet sealing groove (2113) and the liquid outlet sealing groove (2114), the first opening (223) is abutted to the liquid inlet (212) through the sealing ring (241), and the second opening (224) is abutted to the liquid outlet (213) through the sealing ring (241).