CN216396903U - Drawing device of paper chip aquogel valve - Google Patents
Drawing device of paper chip aquogel valve Download PDFInfo
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- CN216396903U CN216396903U CN202122936601.1U CN202122936601U CN216396903U CN 216396903 U CN216396903 U CN 216396903U CN 202122936601 U CN202122936601 U CN 202122936601U CN 216396903 U CN216396903 U CN 216396903U
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Abstract
The utility model belongs to the technical field of paper chip preparation, and particularly relates to a drawing device for a paper chip hydrogel valve. The drawing device comprises a writing robot, a micro-flow pump, an injector needle cylinder, a tetrafluoro capillary, a luer male connector and a dispensing needle head; fixing the syringe cylinder on the micro flow pump, wherein the syringe cylinder is filled with a solution for drawing a hydrogel valve; connecting the tail end of the needle cylinder with one end of the tetrafluoro capillary, connecting the other end of the tetrafluoro capillary with one end of the luer male connector, and connecting the other end of the luer male connector with the dispensing needle head; the dispensing needle head is fixed on a cantilever of the writing robot. Writing robot and micro-flow pumpThe combination mode adds the water gel valve in the specific area of paper tape, and the precision can be controlled at 0.05 mm min‑1The moving distance can reach 30 cm, and the requirement for manufacturing a large number of paper chips can be met after the same batch of hydrogel valves are prepared.
Description
Technical Field
The utility model belongs to the technical field of paper chip preparation, and particularly relates to a drawing device for a paper chip hydrogel valve.
Background
Paper chips are generally called Paper-based Microfluidic analytical devices (μ PADs) or Paper-based Microfluidic devices (paps), and have received much attention since being developed in 2007. Compared with the traditional microfluidic analysis equipment and the traditional microfluidic chip, the device has the advantages of low cost, easiness in storage, convenience in transportation, simplicity in operation and the like. In recent years, the method has good commercial application and prospect in the aspects of food detection, pesticide residue, environmental detection and the like.
When a paper chip is used as a carrier of the detection device, a hydrogel valve is often required to be drawn at the forefront end of the paper chip. In the prior art, a hydrogel valve is generally drawn by using a micro-flow pump, when a dispensing needle head is fixed on the micro-flow pump, the moving precision of the micro-flow pump can be accurate to 0.01 mm, but the area length of sodium alginate prepared at one time is less than 11cm, and the moving distance is too short, so that the number of paper chips prepared at one time is limited, and the requirement for manufacturing a large number of paper chips cannot be met.
SUMMERY OF THE UTILITY MODEL
Aiming at the technical problem, the utility model provides a drawing device for a paper chip hydrogel valve. By adopting a method of combining a micro-flow pump and a dispensing needle, a gel valve is drawn on a paper tape, the moving distance can reach 30 cm, and the length of a sodium alginate strip prepared by one-time experiment can meet the requirement of manufacturing a large number of paper chips.
The utility model is realized by the following technical scheme:
a drawing device of a paper chip hydrogel valve comprises a writing robot, a microflow pump, an injector needle cylinder, a tetrafluoro capillary tube, a luer male connector and a dispensing needle head; the writing robot and the micro-flow pump are combined, so that the moving speed of the dispensing needle head and the flow rate of the solution can be controlled.
Fixing the syringe cylinder on the micro flow pump, wherein the syringe cylinder is filled with a solution for drawing a hydrogel valve; the solution can flow out at a constant speed by fixing the needle cylinder on the micro-flow pump;
connecting the tail end of the needle cylinder with one end of the tetrafluoro capillary, connecting the other end of the tetrafluoro capillary with one end of the luer male connector, and connecting the other end of the luer male connector with the dispensing needle head; the dispensing needle head is fixed on a cantilever of the writing robot.
Further, a tool is placed on the object stage of the writing robot. So that the flatness of the loading platform of the writing robot meets the requirement;
further, paper for preparing the paper chip is placed on the tool and fixed by a magnet.
The distance between a dispensing needle head and paper used for preparing a paper chip is controlled to be a certain distance (such as 1 mm) by a pen-dropping mechanical arm of the writing robot, before moving and drawing, a solution is titrated for a certain time in advance, so that the solution flow rate is stable and the liquid output is uniform, and a hydrogel valve is drawn on the paper after the solution flow rate is stable.
Further, the tetrafluoro capillary is made of Polytetrafluoroethylene (PTFE) and has the following model: the inner diameter is 0.5mm, and the outer diameter is 0.9 mm; the luer male connector is 1/16 inches, and the engineering structure writing robot is Chunzhen CZ 6890A.
The utility model has the beneficial technical effects that:
the utility model provides a drawing device for a paper chip hydrogel valve, which is characterized in that a writing robot and a micro-flow pump are combined to add the hydrogel valve in a specific area of a paper tape, and the precision can be controlled within 0.05 mm min-1Although the precision is not as good as that of a micro-flow pump, the moving distance can reach 30 cm, and the requirement for manufacturing a large number of paper chips can be met after the preparation of the same batch of hydrogel valves is finished.
Drawings
FIG. 1 is a schematic structural diagram of a drawing apparatus for a paper chip hydrogel valve according to an embodiment of the present invention;
reference numerals: 1. a microflow pump; 2. an injector syringe; 3. a tetrafluoro capillary tube; 4. a luer male connector; 5. a writing robot; 6. and (6) dispensing a needle head.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is described in further detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the utility model and are not intended to limit the utility model.
On the contrary, the utility model is intended to cover alternatives, modifications, equivalents and alternatives which may be included within the spirit and scope of the utility model as defined by the appended claims. Furthermore, in the following detailed description of the present invention, certain specific details are set forth in order to provide a better understanding of the present invention. It will be apparent to one skilled in the art that the present invention may be practiced without these specific details.
The embodiment of the utility model provides a drawing device of a paper chip hydrogel valve, which comprises a writing robot, a micro-flow pump, an injector syringe, a tetrafluoro capillary, a luer male connector and a dispensing needle head; the writing robot and the micro-flow pump are combined, so that the moving speed of the dispensing needle head and the flow rate of the solution can be controlled.
Fixing the syringe cylinder on the micro flow pump, wherein the syringe cylinder is filled with a solution for drawing a hydrogel valve; the solution can flow out at a constant speed by fixing the needle cylinder on the micro-flow pump;
connecting the tail end of the needle cylinder with one end of the tetrafluoro capillary, connecting the other end of the tetrafluoro capillary with one end of the luer male connector, and connecting the other end of the luer male connector with the dispensing needle head; the dispensing needle head is fixed on a cantilever of the writing robot.
In this embodiment, a tool is placed on the stage of the writing robot. So that the flatness of the loading platform of the writing robot meets the requirement;
in this example, the paper used for preparing the paper chip was placed on the tool and fixed by a magnet.
The distance between a dispensing needle head and paper used for preparing a paper chip is controlled to be a certain distance (such as 1 mm) by a pen-dropping mechanical arm of the writing robot, before moving and drawing, a solution is titrated for a certain time in advance, so that the solution flow rate is stable and the liquid output is uniform, and a hydrogel valve is drawn on the paper after the solution flow rate is stable.
In this embodiment, the tetrafluoro capillary is made of PTFE, and has the following types: the inner diameter is 0.5mm, and the outer diameter is 0.9 mm; the luer male connector is 1/16 inches, and the engineering structure writing robot is Chunzhen CZ 6890A.
Preparation of hydrogels and microfluidic Ca Using the rendering device provided in the above example2+The method for detecting the paper chip by the ions comprises the following steps:
selecting paper for preparing the paper chip;
drawing a hydrogel valve in a specific area for preparing paper chip paper, wherein the hydrogel valve is a sodium alginate separation band formed on the paper, and sodium alginate is uniformly distributed on the sodium alginate separation band;
cutting paper containing the sodium alginate barrier tape into paper tapes with consistent specifications; preferably, the width of the cut paper tape is 2 Mm;
preparing hydrophobic layer on the surface of the paper belt to realize hydrophobization of the surface of the paper belt to obtain Ca2+Ion detection paper chip.
In this embodiment, the method of mapping a hydrogel valve comprises:
1) preparing an oxygen-free sodium alginate solution with the mass fraction of 2%;
preferably, the preparation method of the oxygen-free sodium alginate solution comprises the following steps: 1) adding 0.8g of sodium alginate solution into 39.2g of deoxidized water, and shaking at the constant temperature of 90 ℃ for 12 hours to prepare the sodium alginate solution with the mass fraction of 2%. 2) And (3) opening the cover of the prepared sodium alginate solution, placing the prepared sodium alginate solution in a vacuum drying box, and vacuumizing and deoxidizing for 1 hour to obtain an oxygen-free sodium alginate solution.
2) Controlling the dispensing needle head to uniformly and uniformly drip out the deoxidized sodium alginate;
3) after the dispensing needle head can uniformly drip out the sodium alginate solution at a constant speed, the dispensing needle head is controlled to move at a constant speed on paper to form a sodium alginate barrier belt, so that the amount of the sodium alginate in any area with the same area on the same sodium alginate barrier belt is ensured to be the same.
Preferably, in step 3), a writing robot and a micro-flow pump are combined to control the moving speed of the dispensing needle and the flow rate of the solution, specifically:
sucking an oxygen-free sodium alginate solution into a needle cylinder of an injector, fixing the needle cylinder on a micro-flow pump to realize uniform outflow of the oxygen-free sodium alginate solution, connecting a tetrafluoro capillary tube at the tail end of the needle cylinder, connecting one end of a luer male joint with the tetrafluoro capillary tube, connecting a dispensing needle head with the other end of the luer male joint, and finally fixing the dispensing needle head on a cantilever of a writing robot; preferably, the middle part of the tetrafluoro capillary is fixed to prevent the tetrafluoro capillary from shaking and generating errors in the experimental process, and particularly, the tetrafluoro capillary can be penetrated into a cylindrical pen holder and fixed by glue or other fixing modes.
Placing a tool for preparing a high-precision sensor on the object stage of the writing robot so as to enable the flatness of the object stage of the writing robot to meet the requirement;
after placing the frock at writing robot's cargo platform, place the paper and fix with magnet on the frock, the distance control that the pen arm that falls of control writing robot will glue syringe needle and paper is removed at certain distance (as 1 mm) and is drawn before, let solution titrate the certain time in advance for the solution velocity of flow is stabilized and is gone out the liquid even, carries out preparation sodium alginate barrier tape on the paper after the solution velocity of flow is stable, accomplishes the interpolation of aquogel valve.
In the traditional technology, the dispensing needle head is fixed on the micro-flow pump, and the moving speed can be accurate to 0.01 mm min-1However, the upper limit of the moving speed is low, and the moving distance is limited (less than 11 cm), which limits the number of paper chips prepared in one experiment. In the utility model, a writing robot and a micro-flow pump are combined to add the hydrogel valve in a specific area of the paper tape, and the precision can be controlled within 0.05 mm min-1Although the precision is not as good as that of a micro-flow pump, the moving distance can reach 30 cm, and the requirement for manufacturing a large number of paper chips can be met after the preparation of the same batch of hydrogel valves is finished.
Claims (4)
1. A drawing device of a paper chip hydrogel valve is characterized by comprising a writing robot, a microflow pump, a syringe needle cylinder, a tetrafluoro capillary, a luer male connector and a dispensing needle head;
fixing the syringe cylinder on the micro flow pump, wherein the syringe cylinder is filled with a solution for drawing a hydrogel valve;
connecting the tail end of the needle cylinder with one end of the tetrafluoro capillary, connecting the other end of the tetrafluoro capillary with one end of the luer male connector, and connecting the other end of the luer male connector with the dispensing needle head; the dispensing needle head is fixed on a cantilever of the writing robot.
2. The drawing device of the paper chip hydrogel valve according to claim 1, wherein a tool is placed on the stage of the writing robot.
3. The device for drawing the hydrogel valve with the paper chip as claimed in claim 2, wherein the paper for preparing the paper chip is placed on the tool and fixed by a magnet.
4. The drawing device of the paper chip hydrogel valve according to claim 1, wherein the polytetrafluoroethylene capillary is Polytetrafluoroethylene (PTFE) and has the following model: the inner diameter is 0.5mm, and the outer diameter is 0.9 mm; the luer male connector is model 1/16 inches.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202122936601.1U CN216396903U (en) | 2021-11-26 | 2021-11-26 | Drawing device of paper chip aquogel valve |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202122936601.1U CN216396903U (en) | 2021-11-26 | 2021-11-26 | Drawing device of paper chip aquogel valve |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN216396903U true CN216396903U (en) | 2022-04-29 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202122936601.1U Active CN216396903U (en) | 2021-11-26 | 2021-11-26 | Drawing device of paper chip aquogel valve |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN216396903U (en) |
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2021
- 2021-11-26 CN CN202122936601.1U patent/CN216396903U/en active Active
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