CN216366701U

CN216366701U - Raw material extraction equipment of chiral medicine

Info

Publication number: CN216366701U
Application number: CN202123040982.1U
Authority: CN
Inventors: 郭玉波; 张琦; 牛宪森
Original assignee: Shandong Longchen Pharmaceutical Co ltd
Current assignee: Shandong Longchen Pharmaceutical Co ltd
Priority date: 2021-12-06
Filing date: 2021-12-06
Publication date: 2022-04-26
Anticipated expiration: 2031-12-06

Abstract

The utility model relates to the technical field of chiral drug processing, and particularly discloses a raw material extraction device for chiral drugs, which comprises an outer cylinder, wherein an inner cylinder is arranged on the inner side of the outer cylinder, a heating component is arranged between the outer cylinder and the inner cylinder, a rotating shaft is rotatably arranged on the inner side of the inner cylinder, the lower position of one end of the rotating shaft sequentially penetrates through the inner cylinder and the outer cylinder, a rotating mechanism is arranged at the end part of the rotating shaft, a fixed seat is sleeved on the outer side of the rotating shaft, a stirring mechanism is arranged on the outer side of the fixed seat, a conical hopper is movably sleeved on the outer side of the rotating shaft, stirring rods are sleeved in the middle of the outer side of the conical hopper at equal intervals along the circumferential direction, the bottom end of the conical hopper is slidably inserted into the inner side of the fixed seat, a plurality of groups of water seepage holes are arranged at the bottom of the inner side of the conical hopper, fixed blocks are arranged at both ends of the inner side of the conical hopper, the utility model can separate chiral drugs, and then, the extraction is carried out, and the extraction mode is more automatic, time-saving and labor-saving.

Description

Raw material extraction equipment of chiral medicine

Technical Field

The utility model relates to the technical field of chiral drug processing, and particularly discloses a raw material extraction device for a chiral drug.

Background

Chiral drugs refer to a pair of enantiomers which are physical and mirror images of each other and obtained by introducing a chiral center into a drug molecular structure. The physical and chemical properties of each pair of chemically pure enantiomers are different (not only in optical rotation), and can be named as R-type or S-type, D-type or L-type, levorotatory or dextrorotatory according to different naming rules, so that the improvement is needed, the resolution methods reported so far comprise mechanical resolution, chemical resolution, microbial resolution, seed crystal crystallization and the like, the simplest chemical resolution method is the most common and most basic effective method, and the most simple chemical resolution method comprises the steps of firstly enabling a racemate consisting of equivalent amounts of levorotatory and dextrorotatory isomers to react with another pure optical isomer (levorotatory isomer or dextrorotatory isomer) to generate two diastereomers with different physical and chemical properties, then utilizing different solubilities of the physical properties, dissolving the other crystal, separating the crystal by filtering, and purifying the diastereoisomers by a recrystallization method, this pure optical isomer is then removed to give the pure levorotatory or dextrorotatory isomer.

The equipment for extracting chiral medicine raw materials in the prior art is too complex to operate, is not convenient for taking out the purified raw materials, wastes time and labor, and needs to be improved.

SUMMERY OF THE UTILITY MODEL

The utility model aims to solve the defects in the background art and provides a raw material extraction device for chiral medicines.

In order to achieve the above purpose, the utility model provides a raw material extraction device of chiral drugs, which comprises an outer cylinder, wherein an inner cylinder is arranged on the inner side of the outer cylinder, a heating component is arranged between the outer cylinder and the inner cylinder, a rotating shaft is rotatably arranged on the inner side of the inner cylinder, the lower part of one end of the rotating shaft sequentially penetrates through the inner cylinder and the outer cylinder, a rotating mechanism is arranged at the end part of the rotating shaft, a fixed seat is sleeved on the outer side of the rotating shaft, a stirring mechanism is arranged on the outer side of the fixed seat, a conical hopper is movably sleeved on the outer side of the rotating shaft, stirring rods are sleeved in the middle of the outer side of the conical hopper at equal intervals along the circumferential direction, the bottom end of the conical hopper is inserted into the inner side of the fixed seat in a sliding manner, a plurality of groups of water seepage holes are arranged at the bottom of the inner side of the conical hopper, fixed blocks are arranged at the two ends of the inner side of the conical hopper, connecting rods are respectively provided with a connecting rod, and a lifting mechanism is arranged on the outer sides of the two connecting rods, and the inner sides of the outer barrel and the inner barrel are provided with a discharging mechanism together.

Preferably, the heating assembly comprises a heating pipe fixedly sleeved on the outer side of the inner cylinder, one end of the heating pipe is connected with a connecting seat, and the connecting seat extends to the position below the outer side of the outer cylinder.

Preferably, the rotating mechanism comprises a motor fixedly installed at the bottom of the outer side of the outer cylinder, and an output shaft of the motor is fixedly connected with the end part of the rotating shaft.

Preferably, stirring mechanism includes the swivel mount of suit in the fixing base outside, the tip of swivel mount and the outside movable contact that the toper is all just the outside and the inner tube inner wall sliding fit of swivel mount, the outside of pivot and the below cover that is close to the fixing base are equipped with and are stirred the work or material rest.

Preferably, the lifting mechanism comprises a mounting seat fixedly mounted on the outer wall of one side of the outer barrel, a hydraulic cylinder is clamped on the inner side of the mounting seat, a round frame is movably arranged above the telescopic end of the hydraulic cylinder, the bottom end of the round frame is movably contacted with the telescopic end, and the top ends of the two connecting rods are fixedly connected to the bottom end of the round frame.

Preferably, the discharge mechanism comprises a drain pipe, and one end of the drain pipe penetrates through the inner sides of the outer cylinder and the inner cylinder and is communicated with the inner sides of the outer cylinder and the inner cylinder.

Compared with the prior art, the utility model has the following beneficial effects: the toper fill activity interlude in the outside of pivot through setting up, when slewing mechanism drives the pivot and rotates, the toper of slip suit in the pivot outside is fought and can together follow and rotate, can separate the solvent and the raw materials of pouring the inner tube from this, under heating element's effect, heat the purification to it, come the circle frame through elevating system at last, the connecting rod, the toper is fought the outside that isostructure monolithic movement to the inner tube, the infiltration hole that sees through the inboard bottom of toper fill comes to filter liquid, then take out the crystal, and convenient for operation, time saving and labor saving.

Drawings

FIG. 1 is a schematic view of the overall structure of the present invention;

FIG. 2 is a partial cross-sectional view of a heating assembly of the present invention;

FIG. 3 is a sectional view showing the inner structure of the inner cylinder according to the present invention;

FIG. 4 is another perspective view of the inner structure of the inner barrel of the present invention.

In the figure: 1. an outer cylinder; 2. a round frame; 3. a rotating shaft; 4. an inner barrel; 5. a mounting seat; 6. a hydraulic cylinder; 7. a drain pipe; 8. a motor; 9. heating a tube; 10. a connecting rod; 11. a fixed seat; 12. a fixed block; 13. a conical hopper; 14. a rotating frame; 15. a material stirring frame; 16. a stirring rod.

Detailed Description

In order that the above objects, features and advantages of the present invention can be more clearly understood, a more particular description of the utility model will be rendered by reference to the appended drawings.

In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention, however, the present invention may be practiced in other ways than those specifically described herein, and thus the present invention is not limited to the specific embodiments disclosed below.

As shown in fig. 1-4, a raw material extraction apparatus for chiral drugs comprises an outer cylinder 1, an inner cylinder 4 is installed on the inner side of the outer cylinder 1, a heating component is arranged between the outer cylinder 1 and the inner cylinder 4, a rotating shaft 3 is rotatably installed on the inner side of the inner cylinder 4, a rotating mechanism is arranged at the end of the rotating shaft 3, a fixing seat 11 is sleeved on the outer side of the rotating shaft 3, a stirring mechanism is arranged on the outer side of the fixing seat 11, a tapered bucket 13 is movably sleeved on the outer side of the rotating shaft 3, stirring rods 16 are sleeved in the middle of the outer side of the tapered bucket 13 at equal intervals along the circumferential direction, the bottom end of the tapered bucket 13 is slidably inserted into the inner side of the fixing seat 11, a plurality of groups of water seepage holes are arranged at the bottom of the inner side of the tapered bucket 13, fixing blocks 12 are installed at both ends of the inner side of the tapered bucket 13, connecting rods 10 are installed on the inner sides of both fixing blocks 12, and a lifting mechanism is arranged on the outer sides of both connecting rods 10, the inner sides of the outer cylinder 1 and the inner cylinder 4 are provided with a discharging mechanism together.

Can heat up the liquid of inside in the outside of inner tube 4 through the heating element who sets up, then separation effect with higher speed, the toper through setting up is fought 13 and can be filtered liquid on the one hand in the inboard of inner tube 4, remains the crystal, and on the other hand can be convenient for get the material, is convenient for be connected the toper through connecting rod 10 with the elevating system in the outside through the fixed block 12 that sets up.

Heating element includes that fixed suit is in the heating pipe 9 in the inner tube 4 outside, and 9 one end of heating pipe is connected with the connecting seat, and the connecting seat extends to the outside below position department of urceolus 1, is connected with the connecting seat through the heating pipe 9 that sets up, then is connected its back with outside power, can make heating pipe 9 begin to work for reheat inner tube 4 promotes the speed of separation purification.

The rotating mechanism comprises a motor 8 fixedly arranged at the bottom of the outer side of the outer barrel 1, an output shaft of the motor 8 is fixedly connected with the end part of the rotating shaft 3, and the motor 8 is connected with a power supply and then can drive the rotating shaft 3 to rotate at the inner side of the inner barrel 4, so that the structure at the outer side of the rotating shaft 3 rotates at the inner side of the inner barrel 4.

Stirring mechanism includes the swivel mount 14 of suit in the fixing base 11 outside, and the tip of swivel mount 14 and the outside movable contact of toper fill 13 and the outside and the 4 inner walls of inner tube of swivel mount 14 slide to be laminated, and the outside of pivot 3 and the below cover that is close to fixing base 11 are equipped with and are stirred work or material rest 15, stirs work or material rest 15 and swivel mount 14 and all accelerates the rotation efficiency in 4 inboard bottoms of inner tube to accelerate separation rate.

Elevating system includes mount pad 5 of fixed mounting on the outer wall of 1 one side of urceolus, pneumatic cylinder 6 has been clamped to the inboard of mount pad 5, the top activity of the flexible end of pneumatic cylinder 6 is provided with circle frame 2, the bottom and the flexible end movable contact of circle frame 2, two connecting rod 10 top fixed connection are in the bottom of circle frame 2, can rise in the outside through the pneumatic cylinder 6 that sets up and support and move in the outside one end of circle frame 2, circle frame 2 can drive connecting rod 10 immediately, fixed block 12 isotructure, rise the toper 13 from the inboard of inner tube 4, take out the crystal at last.

The discharging mechanism comprises a water discharging pipe 7, one end of the water discharging pipe 7 penetrates through the inner sides of the outer barrel 1 and the inner barrel 4 and is communicated with the inner sides of the outer barrel and the inner barrel, and waste water after later-stage use can be discharged through the arranged water discharging pipe 7.

The working principle is as follows: during the use, put into the inside of inner tube 4 with the solvent of catalytic purification together with the raw materials, then connect power drive motor 8 and begin work, motor 8 drives pivot 3, swivel mount 14, it is rotatory in the inside of inner tube 4 to stir work or material rest 15, slide the suit from one end top and also contact with swivel mount 14 in the toper fill 13 outside of fixing base 11 inboard, the suit is in the outside of pivot 3, also can rotate simultaneously, under heating element's effect, the effect that makes the inside raw materials of inner tube 4 can separate is better, come round mount 2 through elevating system at last, connecting rod 10, toper fill 13 isotructures bodily movement to the outside top position of inner tube 4, see through the infiltration hole of toper fill 13 inboard bottom and filter liquid, then take out the crystal, and convenient for operation, time and labor saving.

In the present invention, the terms "mounting," "connecting," "fixing," and the like are used in a broad sense, for example, "connecting" may be a fixed connection, a detachable connection, or an integral connection; may be directly connected or indirectly connected through an intermediate. The specific meanings of the above terms in the present invention can be understood by those skilled in the art according to specific situations.

In the description herein, the appearances of the phrases "one embodiment," "some embodiments," "a specific embodiment," or the like, in various places throughout this specification are not necessarily all referring to the same embodiment or example, but rather to the same embodiment or example. In this specification, the schematic representations of the terms used above do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.

The foregoing shows and describes the general principles, essential features, and advantages of the utility model. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are merely illustrative of the principles of the utility model, but that various changes and modifications may be made without departing from the spirit and scope of the utility model, which fall within the scope of the utility model as claimed. The scope of the utility model is defined by the appended claims and equivalents thereof.

Claims

1. The raw material extraction equipment for the chiral medicine comprises an outer barrel (1) and is characterized in that an inner barrel (4) is installed on the inner side of the outer barrel (1), a heating component is arranged between the outer barrel (1) and the inner barrel (4), a rotating shaft (3) is installed on the inner side of the inner barrel (4) in a rotating mode, the lower position of one end of the rotating shaft (3) penetrates through the inner barrel (4) and the outer barrel (1) in sequence, a rotating mechanism is arranged at the end of the rotating shaft, a fixing seat (11) is sleeved on the outer side of the rotating shaft (3), a stirring mechanism is arranged on the outer side of the fixing seat (11), a conical hopper (13) is movably sleeved on the outer side of the rotating shaft (3), stirring rods (16) are sleeved on the middle of the outer side of the conical hopper (13) at equal intervals in the circumferential direction, the bottom end of the conical hopper (13) is inserted into the inner side of the fixing seat (11) in a sliding mode, and a plurality of groups of water seepage holes are formed in the bottom of the inner side of the conical hopper (13), fixed block (12), two are all installed at toper fill (13) inboard both ends connecting rod (10), two are all installed to the inboard of fixed block (12) connecting rod (10) outside is provided with elevating system, the inboard of urceolus (1) and inner tube (4) is provided with row material mechanism jointly.

2. The raw material extraction equipment for chiral drugs according to claim 1, wherein the heating assembly comprises a heating tube (9) fixedly sleeved outside the inner barrel (4), and one end of the heating tube (9) is connected with a connecting seat extending to a position below the outer side of the outer barrel (1).

3. The raw material extracting apparatus for chiral drugs according to claim 1, wherein the rotating mechanism comprises a motor (8) fixedly installed at the bottom of the outer side of the outer cylinder (1), and the output shaft of the motor (8) is fixedly connected with the end of the rotating shaft (3).

4. The raw material extraction equipment for the chiral drug according to claim 1, wherein the stirring mechanism comprises a rotating frame (14) sleeved outside the fixed seat (11), the end of the rotating frame (14) is in movable contact with the outer side of the conical hopper (13), the outer side of the rotating frame (14) is in sliding fit with the inner wall of the inner cylinder (4), and a stirring frame (15) is sleeved outside the rotating shaft (3) and below the fixed seat (11).

5. The raw material extraction equipment for the chiral drug according to claim 1, wherein the lifting mechanism comprises a mounting seat (5) fixedly mounted on the outer wall of one side of the outer cylinder (1), a hydraulic cylinder (6) is clamped inside the mounting seat (5), a round frame (2) is movably arranged above the telescopic end of the hydraulic cylinder (6), the bottom end of the round frame (2) is movably contacted with the telescopic end, and the top ends of the two connecting rods (10) are fixedly connected to the bottom end of the round frame (2).

6. The raw material extracting apparatus for chiral drugs according to claim 1, wherein the discharging mechanism comprises a water discharging pipe (7), and one end of the water discharging pipe (7) passes through the inner sides of the outer barrel (1) and the inner barrel (4) and the inner parts of the water discharging pipe (7) are communicated with each other.