CN216317726U

CN216317726U - Novel oral swab

Info

Publication number: CN216317726U
Application number: CN202122652373.5U
Authority: CN
Inventors: 王晓静; 王继英; 张岩; 李庆华
Original assignee: Institute of Hematology and Blood Diseases Hospital of CAMS and PUMC
Current assignee: Institute of Hematology and Blood Diseases Hospital of CAMS and PUMC
Priority date: 2021-11-02
Filing date: 2021-11-02
Publication date: 2022-04-19
Anticipated expiration: 2031-11-02

Abstract

The utility model discloses a novel oral swab, which belongs to the technical field of medical instruments and comprises a swab body, wherein the swab body comprises a sampling plate and a connecting rod, the sampling plate comprises a first surface and a second surface, the first surface and the second surface are provided with the same scraping parts, and the scraping parts are used for scraping oral epithelial mucosal cells; the connecting rod includes along its length direction first end and second end, and the first end of connecting rod is equipped with the sampling board, and connecting rod length direction sets up along sampling board length direction. The novel oral swab disclosed by the utility model can improve the scraping amount of oral epithelial mucosal cells, so that the yield and the integrity of DNA are improved, the consumption of the oral swab is reduced, and the detection cost is saved.

Description

Novel oral swab

Technical Field

The utility model belongs to the technical field of medical instruments, and particularly relates to a novel oral swab.

Background

The oral mucosa has the characteristics of vigorous metabolism, quick renewal and easy shedding, and consists of a plurality of layers of cells, wherein a basal layer has vigorous division capability, and the cells shed from the upper skin have complete genome DNA as other histiocytes, so that the cells of the oral epithelial mucosa become important inspection materials for DNA inspection at present. The collection oral cavity epithelium mucosa cell adopts the oral cavity swab to accomplish more when gathering oral cavity epithelium mucosa cell, and the oral cavity swab appearance is similar to ordinary medical cotton swab, is equipped with the sampling head that the nylon flocking was made in the one end of branch, and during the patient sampling, usually stretch into the oral cavity with the sampling head end, makes a round trip to wipe with great effort many times at the oral cavity wall, gathers oral cavity both sides epithelium mucosa cell, then the cell that is infected with on the enrichment swab, draws DNA and carries out the low reaches experiment. In the collection process, the oral epithelial mucosal cells are not easy to stay in the sampling head, each patient usually needs to use a plurality of oral swabs to scrape the epithelial mucosal cells on two sides of the oral cavity respectively, so that the consumption of the oral swabs is large, and even if the oral swabs are used, the finally obtained cells are not large, so that the yield of the extracted DNA is low (usually less than 1 ug). Furthermore, the low cell size results in poor integrity of the extracted DNA, i.e., the DNA is available in small long fragments, most of which are short fragments (usually less than 1 kb). For downstream experiments such as paternity testing, which require shorter DNA fragments, such samples with poor DNA integrity may meet experimental requirements, but if the downstream experiments require long fragment DNA amplification (e.g., greater than 5kb), such samples with poor DNA integrity may not meet experimental requirements. Thus, there is a need for an oral swab that improves DNA yield and integrity.

Disclosure of Invention

The utility model is provided for solving the problems in the prior art, and aims to provide a novel oral swab which can improve the scraping amount of oral epithelial mucosal cells, further improve the yield and the integrity of DNA, reduce the consumption of the oral swab and save the detection cost.

In order to achieve the above object, the present invention provides a novel oral swab, including a swab body, the swab body including: the sampling plate comprises a first surface and a second surface, wherein the first surface and the second surface are provided with the same scraping parts which are used for scraping oral epithelial mucosal cells; the connecting rod, including following its length direction first end and second end, the first end of connecting rod is equipped with the sampling board, connecting rod length direction follows the setting of sampling board length direction.

Further, the scraping part comprises a plurality of parallel grooves, and the grooves are arranged along the length direction of the sampling plate, or along the width direction of the sampling plate, or inclined to the length direction of the sampling plate.

Further, the scraping part comprises a plurality of parallel bulges, and the bulges are arranged along the length direction of the sampling plate, or along the width direction of the sampling plate, or inclined to the length direction of the sampling plate.

Furthermore, a folding groove is formed in the connecting rod and is formed in the first end side.

Further, the swab body still includes the handle, the second end of connecting rod is located to the handle, the handle includes relative first side and the second side that sets up, first side and second side are equipped with the same operation groove, the operation groove of first side with the operation groove of second side sets up relatively, the operation groove is used for holding the finger.

Further, the mouth swab further comprises a protection plate arranged at the second end side of the connecting rod, and the axis of the connecting rod is collinear with the axis of the protection plate.

Further, the protection shield package rubbing board body, the plate body is equipped with the edge plate body diameter direction and its width match in the mounting hole of connecting rod diameter, the length direction's of mounting hole one end is located the plate body middle part, the length direction's of mounting hole the other end is open end, a plate body side is equipped with the draw-in groove along its diameter direction, the draw-in groove adopts logical groove structure, the draw-in groove width with handle thickness phase-match.

The utility model discloses a novel oral swab, compared with a sampling head in the prior art, the first surface or the second surface of the sampling plate has larger contact area with oral epithelial mucosa, and a scraping part on the sampling plate can improve the scraping amount of oral epithelial mucosa cells, thereby being beneficial to improving the yield and integrity of DNA and meeting higher downstream experiment requirements; the first surface and the second surface of the sampling plate can be respectively used for collecting epithelial mucosal cells on two sides of the oral cavity, and the collection of the epithelial mucosal cells on the two sides of the oral cavity can be completed by only using one oral swab, so that the consumption of the oral swab can be reduced, and the detection cost is saved.

Drawings

Fig. 1 is a schematic structural view of a novel buccal swab provided in accordance with an embodiment of the present invention;

fig. 2 is a schematic structural view of a novel buccal swab provided in the second embodiment of the present invention;

fig. 3 is a schematic structural view of a novel buccal swab provided in the third embodiment of the present invention;

fig. 4 is a schematic structural view of a novel buccal swab provided in the fourth embodiment of the present invention;

fig. 5 is an enlarged schematic structural view of a protective plate in the second and fourth embodiments of the present invention.

Wherein: 1. a swab body; 11. a sampling plate; 111. a first side; 112. a second face; 1131. a groove; 1132. a protrusion; 12. a connecting rod; 121. folding the groove; 13. a handle; 131. a first side surface; 132. a second side surface; 133. an operation slot; 2. a protection plate; 21. a plate body; 22. mounting holes; 23. a clamping groove.

Detailed Description

The present invention is described in detail below with reference to the accompanying drawings and examples:

as shown in fig. 1 to 4, the embodiment of the present invention provides a novel oral swab, which comprises a swab body 1, wherein the swab body 1 comprises a sampling plate 11 and a connecting rod 12, wherein the sampling plate 11 comprises a first surface 111 and a second surface 112, and the first surface 111 and the second surface 112 are provided with the same scraping part for scraping oral epithelial mucosal cells; the connecting rod 12 comprises a first end and a second end along the length direction of the connecting rod, the first end of the connecting rod 12 is provided with a sampling plate 11, and the length direction of the connecting rod 12 is arranged along the length direction of the sampling plate 11.

Wherein, sampling board 11 can adopt inside to be the square plate structure of plastics, surface cladding flocking material, can conveniently squeeze out the residual cell when extracting DNA, and is preferred, and sampling board 11 width is 0.8cm, and length is 2 cm. Compared with the sampling head in the prior art, the surface area of the first surface 111 or the second surface 112 of the sampling plate 11 of the novel oral swab is larger, the sampling plate has a larger contact area with the oral epithelial mucosa, and the scraping part on the sampling plate 11 can improve the scraping amount of the oral epithelial mucosa cells, thereby being beneficial to improving the yield and the integrity of DNA and meeting higher downstream experiment requirements; the first surface 111 can be used for collecting epithelial mucosal cells on one side of the oral cavity, and the second surface 112 can be used for collecting epithelial mucosal cells on the other side of the oral cavity, so that the collection of the epithelial mucosal cells on two sides of the oral cavity can be completed by only using one oral swab, the consumption of the oral swabs can be reduced, and the detection cost can be saved.

Further, sampling board 11, recess 1131 or protruding 1132 adjacent surface transition position all adopt circular arc transition structure, make its no edges and corners burr, sampling board 11 brings unnecessary wearing and tearing to oral cavity epithelium mucosa tissue in the reducible use, improves the comfort level of using.

Further, the link rod 12 is provided with a folding groove 121, the folding groove 121 is provided on the first end side, and preferably, the distance from the folding groove 121 to the distal end of the sampling plate is 1 cm. After collection, the sampling plate 11 can be placed into a collection tube filled with a DNA preservation solution, and the folding groove 121 is placed at the tube opening of the collection tube, so that the connecting rod 12 can be broken by force, and the sampling plate 11 falls into the collection tube.

The first embodiment is as follows: as shown in fig. 1, the embodiment of the present invention provides a novel oral swab, the oral swab includes a swab body 1, the swab body 1 includes a sampling plate 11 and a connecting rod 12, wherein the sampling plate 11 includes a first surface 111 and a second surface 112, the first surface 111 and the second surface 112 are provided with the same scraping part, the scraping part is used for scraping oral epithelial mucosal cells, the scraping part includes a plurality of parallel grooves 1131, the grooves 1131 are arranged along the length direction of the sampling plate 11, or along the width direction of the sampling plate 11, or inclined to the length direction of the sampling plate 11; the connecting rod 12 comprises a first end and a second end along the length direction of the connecting rod, the first end of the connecting rod 12 is provided with a sampling plate 11, and the first end side of the connecting rod 12 is provided with a folding groove 121. The connecting rod 12 is arranged along the length direction of the sampling plate 11.

The groove 1131 can adopt a square groove structure, and scraped epithelial mucosa cells can be retained in the groove 1131 and are not easy to lose. The shape of the groove 1131 is not limited by the present invention, and for example, the groove 1131 may be a linear groove, a curved groove or a polygonal groove. Preferably, the grooves 1131 are uniformly spaced and distributed on the first surface 111 or the second surface 112 of the sampling plate 11 in parallel, which is beneficial to uniformly collect the oral epithelial mucosal cells.

Example two: as shown in fig. 2 and 5, the embodiment of the present invention provides a novel oral swab, which differs from the first embodiment in that the swab body 1 further includes a handle 13, the handle 13 is disposed at the second end of the connecting rod 12, the handle 13 includes a first side surface 131 and a second side surface 132 that are disposed opposite to each other, the first side surface 131 and the second side surface 132 are provided with the same operation groove 133, the operation groove 133 of the first side surface 131 and the operation groove 133 of the second side surface 132 are disposed opposite to each other, the operation groove 133 is used for accommodating a finger, so that a user can push and pull and rotate the handle 13 conveniently, and the handle 13 can be controlled flexibly during operation, thereby shortening the sampling time.

Further, the mouth swab further comprises a protection plate 2 arranged at the second end side of the connecting rod 12, and the axis of the connecting rod 12 is collinear with the axis of the protection plate 2. Preferably, the diameter of the protection plate 2 is larger than the diameter of the mouth of a patient, so that the risk of the infection of the oral cavity by hands in the sampling process can be reduced, and the safety of the sampling process is improved.

Further, the protection plate 2 includes the plate body 21, and the plate body 21 is equipped with along the plate body 21 diametric (al) and its width match in the mounting hole 22 of connecting rod 12 diameter, and the one end of the length direction of mounting hole 22 is located the plate body 21 middle part, and the other end of the length direction of mounting hole 22 is open end, and a plate body 21 side is equipped with along its diametric draw-in groove 23, and draw-in groove 23 adopts logical groove structure, and draw-in groove 23 width and handle 13 thickness phase-match. The connecting rod 12 can be installed into the protection plate 2 through the installation hole 22, and then one end of the handle 13 is engaged with the slot 23, so that the installation plate is fixed on the swab body 1. The protection plate 2 is detachably provided on the swab body 1, and whether the protection plate 2 is mounted or not can be selected according to the use requirement.

The remaining technical measures of this embodiment are the same as those of the first embodiment, so that all the above beneficial effects are achieved, and are not described herein again.

Example three: as shown in fig. 3, the embodiment of the present invention provides a novel oral swab, the oral swab includes a swab body 1, the swab body 1 includes a sampling plate 11 and a connecting rod 12, wherein the sampling plate 11 includes a first surface 111 and a second surface 112, the first surface 111 and the second surface 112 are provided with the same scraping part, the scraping part is used for scraping oral epithelial mucosal cells, the scraping part includes a plurality of parallel protrusions 1132, the protrusions 1132 are arranged along the length direction of the sampling plate 11, or along the width direction of the sampling plate 11, or inclined to the length direction of the sampling plate 11; the connecting rod 12 comprises a first end and a second end along the length direction of the connecting rod, the first end of the connecting rod 12 is provided with a sampling plate 11, and the first end side of the connecting rod 12 is provided with a folding groove 121. The connecting rod 12 is arranged along the length direction of the sampling plate 11.

The scraped epithelial mucosal cells can be retained on both sides of the protrusion 1132, and the cell amount is not easily lost. The shape of the protrusion 1132 is not limited in the present invention, and for example, the protrusion 1132 may have a linear groove, a curved groove, or a polygonal groove. Preferably, the plurality of protrusions 1132 are uniformly spaced and distributed on the first surface 111 or the second surface 112 of the sampling plate 11 in parallel, which is favorable for uniform collection of oral epithelial mucosal cells.

Example four: as shown in fig. 4 and 5, the embodiment of the present invention provides a novel oral swab, which is different from the third embodiment in that the swab body 1 further includes a handle 13, the handle 13 is disposed at the second end of the connecting rod 12, the handle 13 includes a first side surface 131 and a second side surface 132 that are disposed opposite to each other, the first side surface 131 and the second side surface 132 are provided with the same operation groove 133, the operation groove 133 of the first side surface 131 and the operation groove 133 of the second side surface 132 are disposed opposite to each other, the operation groove 133 is used for accommodating a finger, so that a user can push and pull and rotate the handle 13 conveniently, and the handle 13 can be controlled flexibly during operation, thereby shortening the sampling time.

Further, the mouth swab further comprises a protection plate 2 arranged at the second end side of the connecting rod 12, and the axis of the connecting rod 12 is collinear with the axis of the protection plate 2. Preferably, the diameter of the protection plate 2 is larger than that of the mouth, so that the risk of the oral cavity being infected by hands in the sampling process can be reduced, and the safety of the sampling process is improved.

The other technical measures of this embodiment are the same as those of this embodiment, so that all the above beneficial effects are achieved, and are not described herein again.

Compared with the sampling head in the prior art, in the novel oral swab provided by the embodiment of the utility model, the first surface 111 or the second surface 112 of the sampling plate 11 has a larger contact area with the oral epithelial mucosa, and the scraping part on the sampling plate 11 can adopt a groove 1131 or a protrusion 1132 structure, so that the scraping amount of the oral epithelial mucosal cells can be increased, the yield and the integrity of DNA can be improved, and the requirements of higher downstream experiments can be met. The first surface 111 and the second surface 112 of the sampling plate 11 can be respectively used for collecting epithelial mucosal cells on two sides of the oral cavity, and the collection of the epithelial mucosal cells on the two sides of the oral cavity can be completed by only using one oral swab, so that the consumption of the oral swab can be reduced, and the detection cost can be saved. The connecting rod second end can be equipped with handle 13, can be used to control the 11 motion of sampling board, and the second end side detachable installation protection shield 2 of connecting rod can reduce the risk that the oral cavity is infected by the hand among the sampling process.

The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the utility model, and any modifications, equivalents and improvements made within the spirit and principle of the present invention are intended to be included within the scope of the present invention.

Claims

1. A novel oral swab, comprising a swab body, wherein the swab body comprises: the sampling plate comprises a first surface and a second surface, wherein the first surface and the second surface are provided with the same scraping parts which are used for scraping oral epithelial mucosal cells; the connecting rod, including following its length direction first end and second end, the first end of connecting rod is equipped with the sampling board, connecting rod length direction follows the setting of sampling board length direction.

2. A novel buccal swab as claimed in claim 1, wherein the scraping means comprises a plurality of parallel grooves, which are arranged in the longitudinal direction of the sampling plate, in the width direction of the sampling plate or obliquely to the longitudinal direction of the sampling plate.

3. A novel buccal swab as recited in claim 1, wherein the scraping means comprises a plurality of parallel projections, said projections being arranged along the length of the sampling plate, or along the width of the sampling plate, or inclined to the length of the sampling plate.

4. The novel buccal swab of claim 1 wherein the connecting rod is provided with a fold in the first end.

5. The novel oral swab of claim 1 wherein the swab body further comprises a handle disposed at the second end of the connecting rod, wherein the handle comprises a first side and a second side opposite to each other, wherein the first side and the second side are provided with the same operation slot, the operation slot of the first side and the operation slot of the second side are opposite to each other, and the operation slot is used for accommodating a finger.

6. The novel buccal swab of claim 5 further comprising a shield plate disposed on the second end side of the connecting rod, wherein the connecting rod axis is collinear with the shield plate axis.

7. The novel oral swab as recited in claim 6, wherein the protection plate comprises a plate body, the plate body is provided with a mounting hole having a width corresponding to the diameter of the connecting rod along the diameter of the plate body, one end of the mounting hole along the length direction is located in the middle of the plate body, the other end of the mounting hole along the length direction is an open end, a side surface of the plate body is provided with a slot along the diameter direction, the slot has a through slot structure, and the width of the slot is matched with the thickness of the handle.