CN216301834U

CN216301834U - Kit for detecting hyperglycemia drug metabolism related gene polymorphism

Info

Publication number: CN216301834U
Application number: CN202121941096.3U
Authority: CN
Inventors: 徐晓飞; 李振
Original assignee: Nanjing Dingde Biotechnology Co ltd
Current assignee: Suzhou Dingde Biotechnology Co.,Ltd.
Priority date: 2021-08-18
Filing date: 2021-08-18
Publication date: 2022-04-15
Anticipated expiration: 2031-08-18

Abstract

The utility model relates to the technical field of kits, and discloses a kit for detecting hyperglycemia drug metabolism related gene polymorphism, which solves the problem of detection liquid splashing caused by the vibration of the kit and comprises a detection box, wherein a top cover is installed at the top end of the detection box; according to the utility model, in the work, after the top cover is closed, the test tube and the tube plug are clamped to form a whole, the upper end and the lower end of the whole are provided with the springs, when the detection box is vibrated, the test tube and the tube plug vibrate up and down along with the springs, and the amplitude of the tube plug is the same as that of the test tube in the vibration process, so that the tube plug and the test tube are in consistent clamping state to form sealing, and the detection liquid is prevented from splashing.

Description

Kit for detecting hyperglycemia drug metabolism related gene polymorphism

Technical Field

The utility model belongs to the technical field of kits, and particularly relates to a kit for detecting hyperglycemia drug metabolism related gene polymorphism.

Background

Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia, which is caused by defects in insulin secretion or impaired biological action, or both. Hyperglycemia existing in diabetes for a long time leads to chronic damage and dysfunction of various tissues, particularly eyes, kidneys, hearts, blood vessels and nerves, and when hyperglycemia drug metabolism is detected, a detection sample needs to be placed in a kit for detecting gene polymorphism related to hyperglycemia drug metabolism.

Because the in-process of taking probably causes the vibrations collision of kit, probably makes the test tube in detect liquid spill at the vibrations in-process, then causes the testing result inaccurate.

SUMMERY OF THE UTILITY MODEL

Aiming at the situation, in order to overcome the defects of the prior art, the utility model provides the kit for detecting the polymorphism of the gene related to the metabolism of the hyperglycemia drug, and the problem of detection liquid splashing caused by vibration of the kit is effectively solved.

In order to achieve the purpose, the utility model provides the following technical scheme: detect relevant gene polymorphism kit of hyperglycemia medicine metabolism, including detecting the box, the top cap is installed on the top of detecting the box, detects the inside top of box and installs the cardboard, and the card hole has been seted up to the top equidistance of cardboard, and the internally mounted in card hole has the test tube, and the internally mounted of detecting the box has fixed subassembly, and the internally mounted of detecting the box has sealed damper.

Preferably, the fixed subassembly includes that the equidistance is seted up in the mounting groove of the inside bottom of detection box, and the movable groove has been seted up to the bottom of mounting groove, and the internally mounted of movable groove has the piston rod, and the intercommunication groove has been seted up to angles such as the outside of mounting groove, and the one end and the activity tank bottom end in intercommunication groove are linked together, and the other end in intercommunication groove is linked together with the mounting groove, and the kicking block is installed to the one end that the intercommunication groove is located the mounting groove.

Preferably, the top end of the piston rod is provided with an arc-shaped tray, and the radian of the top end of the arc-shaped tray is identical to that of the bottom end of the test tube.

Preferably, the communicating groove is E-shaped, and the two transverse grooves at the top end of the communicating groove are arranged in the mounting groove.

Preferably, sealed shock attenuation subassembly is including installing in the bottom spring of piston rod bottom, and the spacing ring is installed to the bottom equidistance of top cap, and the internally mounted of spacing ring has the stopcock, and the top spring is installed to the bottom of stopcock, and the draw-in groove has all been seted up to the both sides in card hole, and the inside fixed mounting of draw-in groove has damping spring, and splint are installed to damping spring's one end.

Preferably, the top end of the clamping plate close to one side of the test tube is provided with an arc groove, and the arc groove is matched with the bottom end of the test tube.

Preferably, the bottom of stopcock is provided with the radian, and the stopcock bottom adopts rubber to make, and the spacing groove has been seted up on the stopcock top, and the stopcock cup joints with the spacing ring activity.

Compared with the prior art, the utility model has the beneficial effects that:

1) in the work, after the top cover is closed, the test tube and the tube plug are connected in a clamped mode to form a whole, springs are arranged at the upper end and the lower end of the whole, after the detection box is vibrated, the test tube and the tube plug vibrate up and down along with the springs, the tube plug is the same as the amplitude of the test tube in the vibration process, the tube plug and the test tube are enabled to be in the clamped state in a consistent mode to form sealing, and therefore detection liquid is prevented from splashing;

2) the utility model discloses a test tube, including the test tube, the test tube is fixed on the piston rod top, in operation, receive test tube pressure back downstream back through the piston rod top that sets up to make the kicking block outwards ejecting, thereby block the test tube bottom, thereby fix, simultaneously under the centre gripping of splint, carry out elastic fixation to the test tube, thereby improve the fixed to the test tube.

Drawings

The accompanying drawings, which are included to provide a further understanding of the utility model and are incorporated in and constitute a part of this specification, illustrate embodiments of the utility model and together with the description serve to explain the principles of the utility model and not to limit the utility model.

In the drawings:

FIG. 1 is a schematic structural view of the present invention;

FIG. 2 is a schematic view of the internal structure of the cartridge of the present invention;

fig. 3 is a schematic view of the structure of the top cover of the present invention.

In the figure: 1. a detection cartridge; 2. a top cover; 3. clamping a plate; 4. a clamping hole; 5. a test tube; 6. a fixing assembly; 601. mounting grooves; 602. a movable groove; 603. a piston rod; 604. a communicating groove; 605. a top block; 7. sealing the shock absorbing assembly; 701. a bottom spring; 702. a limiting ring; 703. a pipe plug; 704. a top spring; 705. a card slot; 706. a damping spring; 707. and (4) clamping the plate.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments; all other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

In the first embodiment, as shown in fig. 1-3, the present invention includes a detection box 1, a top cover 2 is installed on the top end of the detection box 1, a clamping plate 3 is installed on the top end inside the detection box 1, clamping holes 4 are equidistantly formed on the top end of the clamping plate 3, test tubes 5 are installed inside the clamping holes 4, a fixing component 6 is installed inside the detection box 1, and a sealing and shock-absorbing component 7 is installed inside the detection box 1.

Second embodiment, on the basis of the first embodiment, the fixing assembly 6 includes a mounting groove 601 equidistantly disposed at the bottom end of the interior of the detecting box 1, a movable groove 602 is disposed at the bottom end of the mounting groove 601, a piston rod 603 is disposed in the movable groove 602, a communicating groove 604 is disposed at an equal angle outside the mounting groove 601, one end of the communicating groove 604 is communicated with the bottom end of the movable groove 602, the other end of the communicating groove 604 is communicated with the mounting groove 601, a top block 605 is disposed at one end of the communicating groove 604 located in the mounting groove 601, an arc-shaped tray is disposed at the top end of the piston rod 603, the radian of the top end of the arc-shaped tray is the same as that of the bottom end of the test tube 5, the communicating groove 604 is E-shaped, two transverse grooves at the top end of the communicating groove 604 are disposed in the mounting groove 601, after the test tube is filled with the detecting liquid, the test tube is inserted from the clamping plates 707 at both sides of the card hole 4, at this time, the clamping plates 707 move to both sides under the pressure of the test tube 5 to compress the damping spring 706, inside test tube 5 constantly moves down mounting groove 601, after test tube 5 bottom and piston rod 603 top contact, loosen test tube 5, test tube 5 is under self action of gravity, extrude piston rod 603 downwards, make piston rod 603 move down and compress bottom spring 701 under test tube 5's action of gravity, after piston rod 603 moves down, this moment because both ends of intercommunication groove 604 are all sealed, make piston rod 603 move the back, promote the gaseous removal of intercommunication groove 604, thereby release the kicking block 605 of the other end and test tube 5's outer wall contact, thereby press from both sides test tube 5's outer wall and press from both sides, test tube 5 installs the back, close top cap 2, the stopcock 703 and the 5 top joint of test tube of top cap 2 bottom this moment, thereby seal test tube 5.

Third embodiment, on the basis of the second embodiment, the sealing shock-absorbing assembly 7 includes a bottom spring 701 installed at the bottom end of the piston rod 603, a limiting ring 702 is installed at the bottom end of the top cover 2 at an equal distance, a tube plug 703 is installed inside the limiting ring 702, a top spring 704 is installed at the bottom end of the tube plug 703, two sides of the clamping hole 4 are both provided with clamping grooves 705, a shock-absorbing spring 706 is fixedly installed inside the clamping groove 705, one end of the shock-absorbing spring 706 is provided with a clamping plate 707, the top end of the clamping plate 707 near the side of the test tube 5 is provided with an arc groove, the arc groove is matched with the bottom end of the test tube 5, the bottom end of the tube plug 703 is provided with an arc, the bottom end of the tube plug 703 is made of rubber, the top end of the tube plug 703 is provided with a limiting groove, the tube plug 703 is movably sleeved with the limiting ring 702, when the test box 1 is vibrated, because the top end of the tube plug 703 is installed with the top spring 704, and the bottom end of the test tube 5 is installed with the bottom spring 701, the springs at the two ends can keep the clamping connection between the bottom end of the pipe plug 703 and the top end of the test tube 5 under the action of elastic force, so that the tightness of the test tube 5 is guaranteed, and meanwhile, the shock absorption is carried out under the action of the springs at the two ends and the shock absorption springs 706 at the two sides of the clamping plate 707.

The working principle is as follows: when the test tube clamping device works, firstly, after test tubes are filled with detection liquid, the test tubes are inserted from the clamping plates 707 at two sides of the clamping hole 4, at the moment, the clamping plates 707 move towards two sides under the pressure action of the test tubes 5 to compress the damping springs 706, the test tubes 5 continuously move downwards to the inside of the mounting groove 601, after the bottom ends of the test tubes 5 are contacted with the top ends of the piston rods 603, the test tubes 5 are loosened, the test tubes 5 downwards press the piston rods 603 under the self gravity action of the test tubes 5, so that the piston rods 603 move downwards and compress the bottom springs 701 under the gravity action of the test tubes 5, after the piston rods 603 move downwards, because both ends of the communicating grooves 604 are sealed, the piston rods 603 move, the communicating grooves 604 are pushed to move in an air mode, so that the top blocks 605 at the other ends are pushed out to be contacted with the outer walls of the test tubes 5, after the test tubes 5 are mounted, the top cover 2 is closed, at the moment, the tube plugs 703 at the bottom ends of the top cover 2 are clamped with the top ends of the test tubes 5, thereby sealing the test tube 5;

when detecting box 1 receives vibrations, this moment because top spring 704 is installed on stopcock 703 top, and bottom spring 701 is installed to the bottom of test tube 5 for when test tube 5 received vibrations, the spring at both ends can be under the spring action, makes the bottom of stopcock 703 and the top of test tube 5 keep the joint, thereby guarantees test tube 5's leakproofness, carries out the shock attenuation simultaneously under the damping spring 706 effect of both ends spring and splint 707 both sides.

It is noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the utility model, the scope of which is defined in the appended claims and their equivalents.

Claims

1. Detect hyperglycemia medicine metabolism associated gene polymorphism kit, including detection kit (1), its characterized in that: top cap (2) are installed on the top that detects box (1), and cardboard (3) are installed on the inside top of detecting box (1), and card hole (4) have been seted up to the top equidistance of cardboard (3), and the internally mounted of card hole (4) has test tube (5), and the internally mounted that detects box (1) has fixed subassembly (6), and the internally mounted that detects box (1) has sealed damper (7).

2. The kit for detecting polymorphism of gene associated with metabolism of hyperglycemia-producing drugs according to claim 1, wherein: fixed subassembly (6) are seted up mounting groove (601) in the inside bottom of detection box (1) including the equidistance, movable groove (602) have been seted up to the bottom of mounting groove (601), the internally mounted of movable groove (602) has piston rod (603), intercommunication groove (604) have been seted up to the angle such as the outside of mounting groove (601), the one end and the movable groove (602) bottom of intercommunication groove (604) are linked together, the other end and mounting groove (601) of intercommunication groove (604) are linked together, kicking block (605) are installed to the one end that intercommunication groove (604) are located mounting groove (601).

3. The kit for detecting polymorphism of gene associated with metabolism of hyperglycemia drug according to claim 2, wherein: the top end of the piston rod (603) is provided with an arc-shaped tray, and the radian of the top end of the arc-shaped tray is the same as that of the bottom end of the test tube (5).

4. The kit for detecting polymorphism of gene associated with metabolism of hyperglycemia drug according to claim 2, wherein: the communicating groove (604) is E-shaped, and two transverse grooves at the top end of the communicating groove (604) are arranged in the mounting groove (601).

5. The kit for detecting polymorphism of gene associated with metabolism of hyperglycemia-producing drugs according to claim 1, wherein: sealed damper assembly (7) are including installing bottom spring (701) in piston rod (603) bottom, and spacing ring (702) are installed to the bottom equidistance of top cap (2), and the internally mounted of spacing ring (702) has stopcock (703), and top spring (704) are installed to the bottom of stopcock (703), and draw-in groove (705) have all been seted up to the both sides of card hole (4), and the inside fixed mounting of draw-in groove (705) has damping spring (706), and splint (707) are installed to the one end of damping spring (706).

6. The kit for detecting polymorphism of gene associated with metabolism of hyperglycemia drug according to claim 5, wherein: the top end of the clamping plate (707) close to one side of the test tube (5) is provided with an arc groove, and the arc groove is matched with the bottom end of the test tube (5).

7. The kit for detecting polymorphism of gene associated with metabolism of hyperglycemia drug according to claim 5, wherein: the bottom end of the pipe plug (703) is provided with a radian, the bottom end of the pipe plug (703) is made of rubber, the top end of the pipe plug (703) is provided with a limiting groove, and the pipe plug (703) is movably sleeved with a limiting ring (702).