CN216294911U

CN216294911U - Portable active inhalation drug delivery device based on MEMS

Info

Publication number: CN216294911U
Application number: CN202122588360.6U
Authority: CN
Inventors: 王敏锐
Original assignee: Meiman Xinsheng Hangzhou Microelectronics Co ltd
Current assignee: Meiman Xinsheng Hangzhou Microelectronics Co ltd
Priority date: 2021-10-25
Filing date: 2021-10-25
Publication date: 2022-04-15
Anticipated expiration: 2031-10-25

Abstract

The utility model discloses a portable active inhalation drug delivery device based on MEMS, comprising: the liquid medicine box, lead the oil board, porous oil guide, atomizing chip, a pedestal, PCB board and suction nozzle, liquid medicine box bottom is provided with the liquid medicine guide mouth, be provided with symmetrical arrangement's air inlet through-hole on the relative lateral wall of liquid medicine box, be provided with the recess that admits air on leading the oil board, two air inlet through-hole symmetrical arrangement are at air inlet groove both ends, porous oil guide fixed mounting is at leading the oil board back, atomizing chip fixed mounting is on the mount pad of base, PCB board fixed mounting is at the base back, be provided with first aerosol passageway in the mount pad, be provided with the metal electrode on the mount pad, suction nozzle fixed mounting is on the base, be provided with the second aerosol passageway in the suction nozzle. Compared with the prior art, the utility model has the advantages that the liquid medicine is uniformly atomized, the occupation ratio of liquid medicine particles with target diameters is high, and the active inhalation type administration can effectively control the administration amount and prevent choking cough.

Description

Portable active inhalation drug delivery device based on MEMS

Technical Field

The utility model belongs to the technical field of MEMS medical treatment, and particularly relates to a portable active inhalation drug delivery device based on MEMS.

Background

Currently, with the diversification of life and the aggravation of environmental pollution, respiratory diseases have become common diseases today, such as asthma, chronic obstructive pulmonary disease, etc., and the number of patients is increasing continuously. In general, chronic respiratory diseases need long-term treatment, and the selection of treatment modes is very important. It has been shown that inhalation is the most simple and effective way to treat asthma, chronic pulmonary obstruction and other respiratory diseases.

Inhalation therapy is a method in which a liquid medicine is atomized to form an aerosol, and the aerosol is inhaled by a patient to complete treatment. The medicinal aerosol reaches the respiratory tract and then the lung from the oral cavity by inhalation, and is diffused in the lung to reach the diseased region. The inhalation therapy method can directly act the liquid medicine on the pathological change part and has the characteristics of direct effect, quick response, high safety and small side effect. The absorption of the liquid medicine in the respiratory tract and the lung is different according to the diameter of the liquid medicine particles. For adults, particles with the diameter of 0.5-1.0 um can be effectively deposited on respiratory bronchi and alveoli, most of the particles with the diameter of 1.0-5.0um are absorbed in 10-17 grades of bronchi, most of the liquid medicine is deposited on throats and respiratory tracts. The more the medicine liquid particles with the particle size of 1.0-3.0 um are generated by the inhalation administration device, the larger the proportion is, and the better the curative effect is.

The existing portable inhalation administration device has poor atomization effect on liquid medicine, and the proportion of generated liquid medicine particles with the diameter of 1.0-3.0 um is limited, so that the effective absorption of the medicine is influenced, and the treatment period is longer. Meanwhile, the existing portable inhalation administration device mostly adopts a passive form, forms high-pressure airflow by pushing and pressing and the like to eject liquid medicine, easily causes the patient to choke cough, and is inconvenient to use.

SUMMERY OF THE UTILITY MODEL

The utility model aims to: the portable active inhalation drug delivery device based on MEMS has uniform drug liquid atomization, high occupation ratio of target diameter drug liquid particles, active inhalation drug delivery, effective control of drug delivery amount, and prevention of cough.

In order to achieve the purpose, the utility model adopts the following technical scheme: a MEMS-based portable active inhalation drug delivery device comprising: the bottom of the liquid medicine box is provided with a liquid medicine guide opening, the oil guide plate is clamped in a clamping groove on the side wall of the liquid medicine box through a buckle, air inlet through holes are symmetrically arranged on one opposite side wall of the liquid medicine box, liquid medicine through holes corresponding to the liquid medicine guide opening in position are arranged on the oil guide plate, air inlet grooves are arranged on the oil guide plate, the two air inlet through holes are symmetrically arranged at two ends of the air inlet grooves, the porous oil guide member is fixedly arranged on the back surface of the oil guide plate, the position of the porous oil guide member is correspondingly arranged below the liquid medicine through holes, the atomizing chip is fixedly arranged on a mounting seat of the base, the PCB is fixedly arranged on the back surface of the base, a battery is arranged below the PCB, a first aerosol channel is arranged in the mounting seat, a metal electrode is arranged on the mounting seat, and a top contact point of the metal electrode is in electric contact with a resistance wire of the atomizing chip, and the bottom of the metal electrode is electrically connected with a connecting column of the PCB, the suction nozzle is fixedly arranged on the base, a second aerosol channel is arranged in the suction nozzle, and the second aerosol channel is communicated with the first aerosol channel.

As a further description of the above technical solution:

the bottom of the liquid medicine box is provided with two guide parts which are symmetrically arranged, and a liquid medicine guide port is arranged at the bottom of the guide parts.

As a further description of the above technical solution:

two porous oil guiding pieces are arranged below the oil guiding plate and are symmetrically arranged on two sides of the air inlet groove.

As a further description of the above technical solution:

the porous oil guide piece is fixedly arranged in a second groove formed in the back face of the oil guide plate.

As a further description of the above technical solution:

the surface of the oil guide plate is provided with a first groove extending along the circumferential direction of the liquid medicine through hole, and a first sealing ring is arranged in the first groove.

As a further description of the above technical solution:

the porous oil guide piece is made of porous cotton or porous ceramic.

As a further description of the above technical solution:

the atomization chip further comprises a silicon-based substrate, atomization through holes arranged in an array mode are formed in the silicon-based substrate, the porous oil guide piece abuts against the surface of the silicon-based substrate, the resistance wire is manufactured on the back of the silicon-based substrate, and a top contact of the metal electrode is in electric contact with a contact electrode at the end portion of the resistance wire.

In summary, due to the adoption of the technical scheme, the utility model has the beneficial effects that:

1. in the utility model, the atomization chip based on the MEMS technology is adopted, the size and the depth of the atomization through holes on the silicon-based substrate in the atomization chip are easy to process, and the structures of the atomization through holes are uniform, so that the liquid medicine is atomized uniformly, and the occupation ratio of liquid medicine particles with target diameters is high.

2. In the utility model, the MEMS atomization chip is thermally driven, and the liquid medicine can be actively aerosolized by controlling the chip resistance wire, so that the bad experience brought by a passive inhalation drug delivery device is improved. And the heating resistance wire prepared by the semiconductor process on the silicon-based substrate can provide enough heat energy under smaller power (such as dozens of milliwatts) to excite the liquid medicine into aerosol.

3. In the utility model, the porous oil guide part realizes the storage and the latching of the liquid medicine before the liquid medicine reaches the atomizing chip and assists the liquid medicine to be primarily dispersed. Meanwhile, the porous oil guide piece has liquid storage and liquid locking functions, the MEMS atomization chip structure can simplify liquid storage and liquid locking design, and liquid medicine only needs to be finely dispersed and atomized. The MEMS atomization chip structure is further simplified, the structural complexity is reduced, the manufacturing difficulty is reduced, and the manufacturing cost is reduced.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings needed to be used in the embodiments will be briefly described below, it should be understood that the following drawings only illustrate some embodiments of the present invention and therefore should not be considered as limiting the scope, and for those skilled in the art, other related drawings can be obtained according to the drawings without inventive efforts.

Fig. 1 is a schematic structural diagram of a portable active inhalation drug delivery device based on MEMS.

Fig. 2 is a schematic, broken away view of a portable active MEMS-based inhalation device.

Figure 3 is a cross-sectional view of a portable active MEMS-based inhalation delivery device.

Fig. 4 is a schematic structural diagram of a liquid medicine box in a portable active inhalation drug delivery device based on MEMS.

Fig. 5 is a schematic structural diagram of an oil guide plate in a portable active inhalation drug delivery device based on MEMS.

Fig. 6 is a schematic structural diagram of an atomizing chip in a portable active inhalation drug delivery device based on MEMS.

Illustration of the drawings:

1. a liquid medicine box; 11. a card slot; 12. an air inlet through hole; 13. a guide section; 2. an oil guide plate; 21. buckling; 22. a liquid medicine through hole; 23. an air inlet groove; 24. a first seal ring; 25. a second groove; 3. a porous oil guide; 4. atomizing the chip; 41. a resistance wire; 411. a contact electrode; 42. a silicon-based substrate; 421. an atomizing through-hole; 5. a base; 51. a mounting seat; 511. a first aerosol channel; 52. a metal electrode; 6. a PCB board; 61. a battery; 62. connecting columns; 7. a suction nozzle; 71. a second aerosol passage.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Referring to fig. 1-6, the present invention provides a technical solution: a MEMS-based portable active inhalation drug delivery device comprising: the device comprises a liquid medicine box 1, an oil guide plate 2, a porous oil guide part 3, an atomizing chip 4, a base 5, a PCB 6 and a suction nozzle 7, wherein the bottom of the liquid medicine box 1 is provided with a liquid medicine guide opening, the oil guide plate 2 is clamped in a clamping groove 11 on the side wall of the liquid medicine box 1 through a clamping buckle 21, one opposite side wall of the liquid medicine box 1 is provided with air inlet through holes 12 which are symmetrically arranged, the oil guide plate 2 is provided with liquid medicine through holes 22 which correspond to the liquid medicine guide opening in position, the oil guide plate 2 is provided with air inlet grooves 23, the two air inlet through holes 12 are symmetrically arranged at two ends of the air inlet grooves 23, the porous oil guide part 3 is fixedly arranged on the back surface of the oil guide plate 2, the porous oil guide part 3 is correspondingly arranged below the liquid medicine through holes 22, the atomizing chip 4 is fixedly arranged on a mounting seat 51 of the base 5, the PCB 6 is fixedly arranged on the back surface of the base 5, a battery 61 is arranged below the PCB 6, a first aerosol channel 511 is arranged in the mounting seat 51, the mounting seat 51 is provided with a metal electrode 52, a top contact of the metal electrode 52 is electrically contacted with the resistance wire 41 of the atomization chip 4, the bottom of the metal electrode 52 is electrically connected with the connecting column 62 of the PCB 6, the suction nozzle 7 is fixedly mounted on the base 5, a second aerosol channel 71 is arranged in the suction nozzle 7, and the second aerosol channel 71 is communicated with the first aerosol channel 511.

Two guide portions 13 of symmetrical arrangement are provided with to liquid medicine box 1 bottom, and liquid medicine guide port sets up in guide portion 13 bottom, and guide portion 13 is wide-end-up's toper structure, and better guide liquid medicine gets into oil guide plate 2.

Lead 2 belows in the oiled-plate to be provided with two porous oily pieces 3 of leading, two porous oily pieces 3 symmetrical arrangement of leading are in air inlet groove 23 both sides for the liquid medicine can be better with the air mixture formation aerosol that flows in through air inlet groove 23, improve atomization effect.

Porous oil guide member 3 fixed mounting is in setting up the second recess 25 at the back of leading oiled-plate 2 for porous oil guide member 3 installation is firm, and non-deformable guarantees stock solution, lock liquid effect.

Lead the first recess that oil board 2 surface was provided with along liquid medicine through-hole 22 circumference extension, be provided with first sealing ring 24 in the first recess, first sealing ring 24 specifically can adopt sealing materials such as rubber, glue, improves sealed effect, avoids the weeping.

The porous oil guide piece 3 is made of porous cotton or porous ceramic, and has good liquid storage and locking effects.

The atomizing chip 4 further comprises a silicon-based substrate 42, atomizing through holes 421 arranged in an array are formed in the silicon-based substrate 42, the porous oil guide member 3 abuts against the surface of the silicon-based substrate 42, the resistance wire 41 is manufactured on the back of the silicon-based substrate 42, a top contact of the metal electrode 52 is in electrical contact with a contact electrode 411 at the end of the resistance wire 41, and the PCB 6 supplies energy to the resistance wire 41 through a battery 61 arranged on the back.

The working principle is as follows: when the administration device works, liquid medicine is stored in the liquid medicine box 1 and flows into the oil guide plate 2 through the liquid medicine guide port, and the liquid medicine is separated from aerosol due to the arrangement of the oil guide plate 2; the liquid medicine flows into the porous oil guide piece 3 through the oil guide plate 2, and the porous oil guide piece 3 absorbs the liquid medicine to complete liquid storage and liquid locking of the liquid medicine and assist in primary dispersion of the liquid medicine; the porous oil guide piece 3 can avoid direct contact between the atomizing chip 4 and the liquid medicine guide opening of the liquid medicine box 1, and liquid leakage is avoided. The porous oil guide member 3 contacts with both ends of the atomizing chip 4 to guide the liquid medicine to the surface of the atomizing chip 4. When the atomizing chip 4 atomizes the drug solution, the drug solution is mixed with the air flowing into the drug delivery device through the air inlet 12 on the drug solution box 1, and the aerosol is formed by atomization and flows out of the drug delivery device from the first aerosol passage 511 and the second aerosol passage 71 in sequence.

The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and equivalent alternatives or modifications according to the technical solution of the present invention and the inventive concept thereof should be covered by the scope of the present invention.

Claims

1. A portable active MEMS-based inhalation delivery device comprising: the medicine liquid box comprises a medicine liquid box (1), an oil guide plate (2), a porous oil guide piece (3), an atomization chip (4), a base (5), a PCB (6) and a suction nozzle (7), wherein a medicine liquid guide opening is formed in the bottom of the medicine liquid box (1), the oil guide plate (2) is connected with a clamping groove (11) in the side wall of the medicine liquid box (1) in a clamping mode through a buckle (21), symmetrically-arranged air inlet through holes (12) are formed in one opposite side wall of the medicine liquid box (1), a medicine liquid through hole (22) corresponding to the medicine liquid guide opening in position is formed in the oil guide plate (2), air inlet grooves (23) are formed in the oil guide plate (2), the air inlet through holes (12) are symmetrically arranged at two ends of the air inlet grooves (23), the porous oil guide piece (3) is fixedly installed on the back of the oil guide plate (2), and the position of the porous oil guide piece (3) is correspondingly arranged below the medicine liquid through hole (22), atomizing chip (4) fixed mounting be in on mount pad (51) of base (5), PCB board (6) fixed mounting be in base (5) back, PCB board (6) below is provided with battery (61), be provided with first aerosol passageway (511) in mount pad (51), be provided with metal electrode (52) on mount pad (51), the top contact of metal electrode (52) with resistance wire (41) electrical contact of atomizing chip (4), just the bottom of metal electrode (52) with spliced pole (62) electricity of PCB board (6) are connected, suction nozzle (7) fixed mounting be in on base (5), be provided with second aerosol passageway (71) in suction nozzle (7), second aerosol passageway (71) intercommunication first aerosol passageway (511).

2. The portable active inhalation MEMS-based drug delivery device according to claim 1, wherein the bottom of the drug solution box (1) is provided with two guide portions (13) symmetrically arranged, and the drug solution guide port is arranged at the bottom of the guide portions (13).

3. The portable active MEMS-based inhalation drug delivery device according to claim 2, wherein two porous oil guide members (3) are disposed below the oil guide plate (2), and the two porous oil guide members (3) are symmetrically disposed at two sides of the air inlet groove (23).

4. A portable MEMS-based active inhalation delivery device according to claim 3, wherein the porous oil guide (3) is fixedly mounted in a second recess (25) provided in the back of the oil guide plate (2).

5. The portable active MEMS-based inhalation drug delivery device according to claim 1 or 4, wherein the surface of the oil guide plate (2) is provided with a first groove extending along the circumferential direction of the liquid medicine through hole (22), and a first sealing ring (24) is arranged in the first groove.

6. A portable active MEMS-based inhalation delivery device according to claim 1, wherein the porous oil guide (3) is porous cotton or porous ceramic.

7. The MEMS-based portable active inhalation drug delivery device according to claim 1, wherein the atomization chip (4) further comprises a silicon-based substrate (42), the silicon-based substrate (42) is provided with atomization through holes (421) arranged in an array, the porous oil guide member (3) abuts against the surface of the silicon-based substrate (42), the resistance wire (41) is manufactured on the back surface of the silicon-based substrate (42), and the top contact of the metal electrode (52) is electrically contacted with the contact electrode (411) at the end of the resistance wire (41).