CN216294354U - Support for osteoarthritis patients with different bone conditions - Google Patents
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- CN216294354U CN216294354U CN202122605591.3U CN202122605591U CN216294354U CN 216294354 U CN216294354 U CN 216294354U CN 202122605591 U CN202122605591 U CN 202122605591U CN 216294354 U CN216294354 U CN 216294354U
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Abstract
The utility model discloses a bracket for osteoarthritis patients with different bone conditions, which comprises: the bottom layer bracket, the middle layer bracket and the porous polymer material layer; the top surface of the bottom layer bracket is fixedly connected with the bottom surface of the middle layer bracket, and the top surface of the middle layer bracket is fixedly connected with the bottom surface of the porous polymer material layer; the bottom layer support is of a multilayer structure and is formed by overlapping a plurality of TC4 plates, a pore group is formed on the top surface of the TC4 plate, the pore groups of the TC4 plates are vertically communicated, and the middle layer support is a titanium alloy 3D printing plate; the titanium alloy 3D printing plate top surface set up with a plurality of intercommunication punch combination of pore group looks adaptation, intercommunication punch combination bottom opening with a plurality of the TC4 board the pore group intercommunication, titanium alloy 3D printing plate top surface and porous macromolecular material layer bottom surface rigid coupling, just porous macromolecular material layer bottom will intercommunication punch combination top opening seals.
Description
Technical Field
The utility model relates to the field of medical instruments, in particular to a bracket for osteoarthritis patients with different bone conditions.
Background
Osteoarthritis is a common and frequent disease of middle-aged and elderly people, and has become the first cause of disability of the old people, and the life quality is seriously affected. At present, some clinical treatment methods cannot provide a good repairing effect on large-area cartilage defects formed in the middle and later stages of osteoarthritis, and the large-area cartilage defects can be only treated through joint replacement surgery. For middle-aged and elderly patients, the mechanical properties of bones and cartilages are very different due to factors such as height, weight and heredity, and the elderly are often accompanied by osteoporosis. Tissue engineering is a concept of planting cells on scaffolds. This whole is cultured in a bioreactor where appropriate stimuli (chemical, biological, mechanical and electrical) are applied to form new tissue in a relatively short time. This new tissue is then implanted in the body to help the patient restore function. Scaffolds are three-dimensional templates that provide a framework for cell growth. In the initial stage, cells are evenly plated on the scaffold to achieve the desired clinical results. It was found that scaffolds designed with high permeability, porosity and specific surface area can achieve very high cell seeding efficiency. The truncated octahedron has three times of specific surface area than the cubic structure under the same macroscopic structure size (same length, width and height) and the same porosity, not only shows better cell seeding efficiency, but also the cells are well distributed in the bracket.
SUMMERY OF THE UTILITY MODEL
The utility model aims to provide a bracket for osteoarthritis patients with different bone conditions, so as to solve the problems in the prior art.
In order to achieve the purpose, the utility model provides the following scheme: the utility model provides a bracket for osteoarthritis patients with different bone conditions, which comprises: the bottom layer bracket, the middle layer bracket and the porous polymer material layer; the top surface of the bottom layer bracket is fixedly connected with the bottom surface of the middle layer bracket, and the top surface of the middle layer bracket is fixedly connected with the bottom surface of the porous polymer material layer;
the bottom layer support is of a multilayer structure and is formed by overlapping a plurality of TC4 plates, a pore group is formed on the top surface of the TC4 plate, the pore groups of the TC4 plates are vertically communicated, and the middle layer support is a titanium alloy 3D printing plate; the titanium alloy 3D printing plate top surface set up with a plurality of intercommunication punch combination of pore group looks adaptation, intercommunication punch combination bottom opening with a plurality of the TC4 board the pore group intercommunication, titanium alloy 3D printing plate top surface and porous macromolecular material layer bottom surface rigid coupling, just porous macromolecular material layer bottom will intercommunication punch combination top opening seals.
Preferably, a plurality of through holes which are mutually interwoven and communicated are formed in the porous polymer material layer, and the aperture size of each through hole is gradually reduced from outside to inside.
Preferably, the porous polymer material layer is internally distributed with traditional Chinese medicine powder.
Preferably, the pore group includes a first pore group, a second pore group, and a third pore group; the first pore group is arranged in the center of the top surface of the TC4 plate, a plurality of second pore groups are arranged on the outer side of the first pore group, a plurality of second pore groups surround the top surface of the TC4 plate to form a first rectangular structure, the first pore group is arranged in the center of the first rectangular structure, a plurality of third pore groups are arranged on the outer side of the second pore group, a plurality of third pore groups surround the top surface of the TC4 plate to form a second rectangular structure, and the first rectangular structure is arranged in the center of the second rectangular structure; the first pore group, the second pore group and the third pore group are all provided with a plurality of pores, the occupied areas of the first pore group, the second pore group and the third pore group are the same, the pore numbers of the first pore group, the second pore group and the third pore group are gradually reduced, the pore diameters are gradually increased, and the pore ratio of the TC4 plate is 60-80%.
Preferably, with the pore group looks adaptation intercommunication punch combination sets up the top surface edge of titanium alloy 3D printing plate, intercommunication punch combination includes a plurality of first through-holes, and a plurality of first through-hole respectively with a plurality of the pore position that the third pore was divided into groups corresponds.
Preferably, the pore group comprises a first rectangular pore group and a second rectangular pore group which are arranged on the top surface of the TC4 plate, the center of the first rectangular pore group is arranged in a closed mode, the second rectangular pore group is sleeved outside the first rectangular pore group, the pore diameter of the first rectangular pore group is smaller than that of the second rectangular pore group, and the porosity of the TC4 plate is 70-85%.
Preferably, the communicating hole group matched with the pore group is arranged at the edge of the top surface of the titanium alloy 3D printing plate, the communicating hole group comprises a plurality of second through holes, and the second through holes correspond to the second rectangular pore grouping pore positions respectively.
Preferably, the pore group is composed of a plurality of pore spheres, the center of the top surface of the TC4 plate is open, the pore spheres are communicated with each other and arranged in the TC4 plate, each pore sphere is composed of a quadrilateral plate and a hexagonal plate, the quadrilateral plate and the hexagonal plate are respectively provided with polygonal pores matched with the number of the edges of the quadrilateral plate and the hexagonal plate, and the porosity of the TC4 plate is 85-95%.
Preferably, the communicating hole group matched with the pore group is arranged on the top surface of the titanium alloy 3D printing plate and comprises a plurality of third through holes, and the third through holes correspond to the pore ball bodies respectively in position.
The utility model discloses the following technical effects: the bottom support, the middle level support and the porous polymer material layer that set up mutually support and form a bionic structure, and according to the needs that bone and cartilage grow and design, the bottom support corresponds the bone, and the porous polymer material layer that sets up corresponds the cartilage layer, and the middle level support that sets up corresponds the cortex bone and realizes separation and being connected between bottom support and the porous polymer material layer. Physiologically, the synovial fluid is separated from the blood, and the synovial fluid is prevented from having negative influence on the proliferation and differentiation of the mesenchymal stem cells in the blood. In a bionic angle, the physical and mechanical properties of the subchondral bone plate are simulated, the intercommunication of synovial fluid and blood is blocked, and the cartilage layer and cancellous bone layer structures of the bracket are connected, so that the supporting function is achieved in mechanics.
Realize separation blood and synovial fluid and reinforcing joint strength, consequently have more excellent characteristic, this device is used for the damaged department of patient's cartilage, place this device in wherein to transplant the cell, make the cell proliferate the differentiation wherein, realize the regeneration of cartilage, the pore group who sets up is fit for catching cell and cell growth, makes inside the cell gets into the support, avoids it only externally to grow of cell, and can flow into the support through outside high porosity, proliferate the differentiation and stay inside, reinforcing repair effect. The TC4 plate can help the regeneration of the spongy bone and the cartilage in the whole tissue engineering repair process and prevent the transmission of excessive stress to the spongy bone. The porous polymer material layer is polylactic acid-glycolic acid copolymer (PLGA), and traditional Chinese medicine powder is added in the PLGA, so that the cartilage growth and differentiation efficiency is greatly improved.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings needed in the embodiments will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art to obtain other drawings without creative efforts.
FIG. 1 is a schematic view of a structure of a lower holder according to example 1 of the present invention;
FIG. 2 is a schematic structural view of a middle layer scaffold in example 1 of the present invention;
FIG. 3 is a schematic structural diagram of a porous polymer material layer in example 1 of the present invention;
FIG. 4 is a schematic view of the structure of a lower holder in example 2 of the present invention;
FIG. 5 is a schematic view showing the structure of a middle layer stent in example 2 of the present invention;
FIG. 6 is a schematic view showing the structure of a lower holder in example 3 of the present invention;
FIG. 7 is a schematic view showing the structure of a middle layer stent in example 3 of the present invention;
FIG. 8 is a schematic view of the structure of a 14-sided body in example 3 of the present invention;
FIG. 9 is a schematic structural view of a reinforcing column in example 4 of the present invention;
FIG. 10 is a schematic view showing the structure of a reinforcing pipe in example 5 of the present invention;
wherein, 1, a porous polymer material layer; 2. TC4 board; 3. 3D printing plate of titanium alloy; 4. a first pore grouping; 5. a second pore grouping; 6. a third aperture group; 7. a first through hole; 8. a first rectangular aperture grouping; 9. a second rectangular aperture grouping; 10. a second through hole; 11. a quadrilateral plate; 12. a hexagonal plate; 13. a third through hole; 14. a reinforcement column; 15. a first penetration hole; 16. a reinforcement tube; 17. and a second penetration hole.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
In order to make the aforementioned objects, features and advantages of the present invention comprehensible, embodiments accompanied with figures are described in further detail below.
Example 1
Referring to fig. 1-3, the present embodiment provides a scaffold for osteoarthritis patients of different bone conditions for elderly patients with young, middle-aged and stronger bone, comprising: a bottom layer bracket, a middle layer bracket and a porous polymer material layer 1; the top surface of the bottom layer bracket is fixedly connected with the bottom surface of the middle layer bracket, and the top surface of the middle layer bracket is fixedly connected with the bottom surface of the porous polymer material layer 1;
the bottom layer support is of a multilayer structure and is formed by overlapping a plurality of TC4 plates 2, the top surface of the TC4 plate 2 is provided with a pore group, the pore groups of the TC4 plates 2 are vertically communicated, and the middle layer support is a titanium alloy 3D printing plate 3; the top surface of the titanium alloy 3D printing plate 3 is provided with a plurality of communicating hole groups matched with the hole groups, the bottom openings of the communicating hole groups are communicated with the hole groups of the TC4 plates 2, the top surface of the titanium alloy 3D printing plate 3 is fixedly connected with the bottom surface of the porous polymer material layer 1, and the top openings of the communicating hole groups are sealed at the bottom of the porous polymer material layer 1.
The bottom layer support is integrally formed in an additive manufacturing (3D printing) mode, and then is subjected to heat treatment, namely, stress relief annealing at the temperature of 400-800 ℃, and heat preservation is carried out for 3 hours to obtain the bottom layer support.
The bottom support that sets up, middle level support and porous macromolecular material layer 1 mutually support and form a bionic structure, design according to bone and cartilage growth's needs, the bottom support corresponds the bone, the porous macromolecular material layer 1 that sets up corresponds the cartilage layer, the middle level support that sets up corresponds the cortex bone and realizes separation and connection between bottom support and the porous macromolecular material layer 1, realize separation blood and synovial fluid and reinforcing joint strength, consequently, have better characteristic, this device is used for the damaged department of patient's cartilage, place this device in wherein, and transplant the cell, make the cell proliferate the differentiation wherein, realize the regeneration of cartilage, the pore group of setting is fit for catching cell and cell growth, make the cell get into inside the support, avoid it to only stop on the surface, reinforcing repair effect. The TC4 plate 2 can support cartilage during the repair of the whole tissue engineering and prevent excessive stress from being transmitted to the cancellous bone. The porous polymer material layer 1 is polylactic acid-glycolic acid copolymer (PLGA), and traditional Chinese medicine powder is added in the PLGA, so that the cartilage growth and differentiation efficiency is greatly improved.
The middle layer bracket can also be made of polylactic acid (PLA) + graphene 5-15% or traditional Chinese medicine powder, polyether ether ketone (PEEK) or PEEK + graphene 5-15% or traditional Chinese medicine powder, and Polyimide (PI) or polyimide + graphene 5-15%.
According to the further optimization scheme, a plurality of through holes which are mutually interwoven and communicated are formed in the porous polymer material layer 1, and the aperture size of each through hole is gradually reduced from outside to inside.
The arranged through holes are mutually interwoven and communicated, so that the cartilage cells can be fully proliferated in the porous polymer material layer 1 and can be completely filled.
Further optimizing the scheme, traditional Chinese medicine powder is distributed in the porous polymer material layer 1.
The traditional Chinese medicine powder can promote the proliferation of chondrocytes.
In a further refinement, the pore groups include a first pore group 4, a second pore group 5 and a third pore group 6; the first pore group 4 is arranged at the center of the top surface of the TC4 plate 2, a plurality of second pore groups 5 are arranged on the outer side of the first pore group 4, a plurality of second pore groups 5 surround a first rectangular structure on the top surface of the TC4 plate 2, the first pore group 4 is positioned at the center of the first rectangular structure, a plurality of third pore groups 6 are arranged on the outer side of the second pore group 5, a plurality of third pore groups 6 surround a second rectangular structure on the top surface of the TC4 plate 2, and the first rectangular structure is positioned at the center of the second rectangular structure; the first pore group 4, the second pore group 5 and the third pore group 6 are all provided with a plurality of pores, the areas occupied by the first pore group 4, the second pore group 5 and the third pore group 6 are the same, the number of pores of the first pore group 4, the second pore group 5 and the third pore group 6 is gradually reduced, the pore diameter is gradually increased, and the porosity of the TC4 plate 2 is 60-80%.
A setting of 60-80% porosity may be an optimal porosity to accommodate recovery in young, middle-aged and elderly patients with better bone strength.
Further optimize the scheme, the top surface edge at titanium alloy 3D printing plate 3 is seted up with the intercommunication punch combination of pore group looks adaptation, and the intercommunication punch combination includes a plurality of first through-holes 7, and a plurality of first through-holes 7 correspond with the pore position of a plurality of third pore group 6 respectively.
The top of the set communicating hole group is blocked by the porous polymer material layer 1, so that the adverse effect caused by the fusion of blood and synovial fluid due to the communication is avoided.
Example 2
Referring to fig. 4-5, for a patient with general bone strength of the middle-aged and elderly people, the pore group in this embodiment includes a first rectangular pore group 8 and a second rectangular pore group 9 which are provided on the top surface of the TC4 plate 2, the center of the first rectangular pore group 8 is a closed setting, the second rectangular pore group 9 is sleeved outside the first rectangular pore group 8, the pore diameter of the first rectangular pore group 8 is smaller than that of the second rectangular pore group 9, and the porosity of the TC4 plate 2 is 70-85%.
A setting of 70-85% porosity may be an optimal porosity to accommodate recovery by patients with average bone strength in the middle and old aged.
The communicating hole group matched with the hole group is arranged at the edge of the top surface of the titanium alloy 3D printing plate 3 and comprises a plurality of second through holes 10, and the second through holes 10 correspond to the hole positions of the second rectangular hole groups 9 respectively.
Example 3
Referring to fig. 6-8, for the elderly osteoporosis patients, the pore group in this embodiment is composed of a plurality of pore spheres, the center of the top surface of the TC4 plate 2 is open, the pore spheres are mutually communicated and arranged in the TC4 plate 2, the pore spheres are a sphere composed of a quadrilateral plate 11 and a hexagonal plate 12, polygonal pores matched with the number of the sides of the quadrilateral plate 11 and the hexagonal plate 12 are respectively formed, and the porosity of the TC4 plate 2 is 85-95%.
The pore spheres are formed by connecting tetrakaidecahedrons (14 faces: 6 quadrangles and 8 hexagons), wherein the height, the length and the width of each tetrakaidecahedron are 1 mm. The outer TC4 panel 2 was 0.1mm thick.
A setting of 85-95% porosity may be the optimal porosity to accommodate recovery by patients with senile osteoporosis.
The communicating hole group matched with the pore group is arranged on the top surface of the titanium alloy 3D printing plate 3 and comprises a plurality of third through holes 13, and the third through holes 13 correspond to the pore ball bodies respectively.
Example 4
Referring to fig. 9, the bottom layer support is provided with a plurality of reinforcing columns 14 for reinforcing connection, the plurality of reinforcing columns 14 are arranged in the bottom layer support at equal intervals in the circumferential direction, the reinforcing columns 14 penetrate through the plurality of TC4 plates 2, the plurality of TC4 plates 2 are arranged at intervals, communicating cavities are formed in the reinforcing columns 14, a plurality of first penetrating holes 15 are formed in the outer walls of the reinforcing columns 14, the first penetrating holes 15 are communicated with the communicating cavities, and the TC4 plates 2 are fixedly connected with the reinforcing columns 14.
The reinforcing column 14 can not only reinforce the connection strength between the bottom layer supports, but also can enable a gap to be reserved between the adjacent TC4 plates 2, so that the connection between implanted cells and cells at the damaged part of cartilage is stronger, the implanted cells and the cells at the damaged part of cartilage are integrated, and the proliferation among the cells can be realized by the arrangement of the first penetration holes 15.
Example 5
Referring to fig. 10, the top surface and the bottom surface of the titanium alloy 3D printing plate 3 are fixedly connected with a plurality of reinforcing pipes 16, the reinforcing pipes 16 are respectively inserted into the bottom layer support and the porous polymer material layer 1, the pipe wall of each reinforcing pipe 16 is provided with a second penetration hole 17, and the reinforcing pipes 16 can enhance the connection strength between the titanium alloy 3D printing plate 3 and the bottom layer support and the porous polymer material layer 1.
Example 6
The bottom layer support in this embodiment is formed by the stack of a plurality of TC4 boards 2, and the TC4 board 2 outside is formed by the crisscross design of the cylinder of 1mm diameter, and 2 mid portions are solid trompil structures in the TC4 board, and the aperture is from outside to interior notch cuttype degressive. The middle aperture is small, and the peripheral aperture is large.
Example 7
The bottom layer support in this embodiment is formed by stacking a plurality of TC4 plates 2, and the outside of the TC4 plates 2 is designed by intersecting cylinders with a diameter of 0.5mm, so as to form a pore structure of 1.5mm by 1.5 mm. In the internal 1.5mm by 1.5mm pore structure, 0.5mm diameter cylinders were added in the middle of each cylinder at 0.75mm, and the TC4 plate 2 was a full solid structure. The aperture decreases gradually from outside to inside in a step-type manner.
In the description of the present invention, it is to be understood that the terms "longitudinal", "lateral", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", and the like, indicate orientations or positional relationships based on those shown in the drawings, are merely for convenience of description of the present invention, and do not indicate or imply that the referenced devices or elements must have a particular orientation, be constructed and operated in a particular orientation, and thus, are not to be construed as limiting the present invention.
The above-described embodiments are merely illustrative of the preferred embodiments of the present invention, and do not limit the scope of the present invention, and various modifications and improvements of the technical solutions of the present invention can be made by those skilled in the art without departing from the spirit of the present invention, and the technical solutions of the present invention are within the scope of the present invention defined by the claims.
Claims (9)
1. A scaffold for osteoarthritis patients of different bone conditions comprising: the bottom layer bracket, the middle layer bracket and the porous polymer material layer (1); the top surface of the bottom layer bracket is fixedly connected with the bottom surface of the middle layer bracket, and the top surface of the middle layer bracket is fixedly connected with the bottom surface of the porous polymer material layer (1);
the bottom layer support is of a multilayer structure and is formed by overlapping a plurality of TC4 plates (2), a pore group is formed on the top surface of each TC4 plate (2), the pore groups of the TC4 plates (2) are vertically communicated, and the middle layer support is a titanium alloy 3D printing plate (3); titanium alloy 3D prints board (3) top surface seted up with a plurality of intercommunication punch combination of pore group looks adaptation, intercommunication punch combination bottom opening with a plurality of TC4 board (2) the pore group intercommunication, titanium alloy 3D prints board (3) top surface with porous macromolecular material layer (1) bottom surface rigid coupling, just porous macromolecular material layer (1) bottom will intercommunication punch combination top opening seals.
2. The scaffold for osteoarthritis patients of different bone conditions of claim 1, wherein: a plurality of through holes which are mutually interwoven and communicated are formed in the porous polymer material layer (1).
3. The scaffold for osteoarthritis patients of different bone conditions of claim 1, wherein: the porous polymer material layer (1) is internally distributed with traditional Chinese medicine powder.
4. The scaffold for osteoarthritis patients of different bone conditions of claim 1, wherein: the pore group comprises a first pore group (4), a second pore group (5) and a third pore group (6); the first pore group (4) is arranged in the center of the top surface of the TC4 plate (2), a plurality of second pore groups (5) are arranged on the outer side of the first pore group (4), a plurality of second pore groups (5) form a first rectangular structure on the top surface of the TC4 plate (2), the first pore group (4) is positioned in the center of the first rectangular structure, a plurality of third pore groups (6) are arranged on the outer side of the second pore group (5), a plurality of third pore groups (6) form a second rectangular structure on the top surface of the TC4 plate (2), and the first rectangular structure is positioned in the center of the second rectangular structure; the first pore group (4), the second pore group (5) and the third pore group (6) are all provided with a plurality of pores, the areas occupied by the first pore group (4), the second pore group (5) and the third pore group (6) are the same, the number of pores of the first pore group (4), the second pore group (5) and the third pore group (6) is gradually reduced, the pore diameter is gradually increased, and the porosity of the TC4 plate (2) is 60-80%.
5. The scaffold for osteoarthritis patients in different bone conditions of claim 4, wherein: with pore group looks adaptation intercommunication punch combination sets up the top surface edge of titanium alloy 3D printing plate (3), intercommunication punch combination includes a plurality of first through-holes (7), and a plurality of first through-hole (7) respectively with a plurality of the pore position of third pore group (6) corresponds.
6. The scaffold for osteoarthritis patients of different bone conditions of claim 1, wherein: the aperture group comprises a first rectangular aperture group (8) and a second rectangular aperture group (9) which are arranged on the top surface of a TC4 plate (2), the center of the first rectangular aperture group (8) is arranged in a closed mode, the second rectangular aperture group (9) is sleeved outside the first rectangular aperture group (8), the aperture diameter of the first rectangular aperture group (8) is smaller than that of the second rectangular aperture group (9), and the aperture ratio of the TC4 plate (2) is 70-85%.
7. The scaffold for osteoarthritis patients in different bone conditions of claim 6, wherein: with the pore group looks adaptation the intercommunication punch combination sets up the top surface edge of titanium alloy 3D printing plate (3), the intercommunication punch combination includes a plurality of second through-holes (10), and is a plurality of second through-holes (10) respectively with a plurality of second rectangle pore group (9) pore position corresponds.
8. The scaffold for osteoarthritis patients of different bone conditions of claim 1, wherein: the pore group is composed of a plurality of pore spheres, the center of the top surface of the TC4 plate (2) is open, the pore spheres are communicated with one another and are arranged in the TC4 plate (2), the pore spheres are formed into a sphere by a quadrilateral plate (11) and a hexagonal plate (12), polygonal pores matched with the number of the edges of the quadrilateral plate (11) and the hexagonal plate (12) are respectively formed in the quadrilateral plate (11) and the hexagonal plate (12), and the porosity of the TC4 plate (2) is 85-95%.
9. The scaffold for osteoarthritis patients in different bone conditions of claim 8, wherein: with the pore group looks adaptation the intercommunication punch combination sets up the top surface of titanium alloy 3D printing plate (3), the intercommunication punch combination includes a plurality of third through-holes (13), and a plurality of third through-holes (13) respectively with a plurality of the pore spheroid position corresponds.
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| CN202122605591.3U CN216294354U (en) | 2021-10-28 | 2021-10-28 | Support for osteoarthritis patients with different bone conditions |
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