CN216266444U - Three-dimensional tissue slice device and three-dimensional tissue slice equipment - Google Patents
Three-dimensional tissue slice device and three-dimensional tissue slice equipment Download PDFInfo
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- CN216266444U CN216266444U CN202120710749.0U CN202120710749U CN216266444U CN 216266444 U CN216266444 U CN 216266444U CN 202120710749 U CN202120710749 U CN 202120710749U CN 216266444 U CN216266444 U CN 216266444U
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Abstract
The utility model provides a three-dimensional tissue slicing device and three-dimensional tissue slicing equipment, wherein the three-dimensional tissue slicing device comprises an installation platform, an object carrying disc, a horizontal cutter seat and a vertical cutter seat, the object carrying disc is arranged on the installation platform, the horizontal cutter seat is arranged on the installation platform and can be relatively close to or far away from the object carrying disc, a plurality of horizontal blades are arranged on the horizontal cutter seat side by side and are relatively parallel to the object carrying disc, the vertical cutter seat is arranged on the installation platform and can be relatively close to or far away from the object carrying disc, the vertical cutter seat can rotate relatively around the object carrying disc, a plurality of vertical blades are arranged on the vertical cutter seat side by side and are relatively perpendicular to the object carrying disc. By providing a plurality of horizontal blades and a plurality of vertical blades, the three-dimensional tissue slice apparatus is capable of rapidly slicing a tissue sample into a plurality of tissue pieces.
Description
Technical Field
The utility model relates to the field of medical instrument research, in particular to a three-dimensional tissue slicing device and three-dimensional tissue slicing equipment.
Background
Tissue sectioning is a technique often used in biomedical experiments, and a biological tissue sample needs to be cut into thin tissues for subsequent tissue staining, drug sensitivity detection and the like. For example, tumor tissue is clinically sliced, and the cut tissue is used for tissue culture in vivo and drug sensitivity test. There are two major types of tissue microtomes currently on the market, one based on paraffin-embedded tissue microtomes and one frozen tissue section. Either paraffin or frozen microtomes can only slice fixed biological samples and the cut tissue cannot be used for subsequent tissue culture. At present, the section for tissue culture can only be manually operated, the speed is low, the thickness of the cut tissue is not controllable, the thickness difference between tissue blocks is large, and the section has great influence on subsequent research. Therefore, there is a need for a device capable of cutting biological tissue rapidly and precisely to solve the above problems.
SUMMERY OF THE UTILITY MODEL
The present invention is directed to solving at least one of the problems of the prior art. Therefore, the utility model provides a three-dimensional tissue slice device and three-dimensional tissue slice equipment, wherein the three-dimensional tissue slice device can rapidly slice a tissue sample.
The three-dimensional tissue slice device provided by the utility model comprises an installation platform, a carrying disc, a horizontal cutter seat and a vertical cutter seat, the object carrying disc is arranged on the mounting table, the horizontal cutter seat is arranged on the mounting table, the horizontal cutter seat can be relatively close to or far away from the carrying disc, a plurality of horizontal blades are arranged on the horizontal cutter seat side by side, the horizontal blade is arranged relatively parallel to the carrying tray and is used for cutting the tissue sample along the horizontal direction, the vertical cutter seat is arranged on the mounting table and can be relatively close to or far away from the object carrying disc, the vertical cutter seat can rotate relatively around the loading disc, a plurality of vertical blades are arranged on the vertical cutter seat side by side, the vertical blade is arranged relatively perpendicular to the carrier plate and is used for cutting the tissue sample along the vertical direction.
The three-dimensional tissue slice device provided by the utility model at least has the following technical effects: by providing a plurality of horizontal blades and a plurality of vertical blades, the three-dimensional tissue slice apparatus is capable of rapidly slicing a tissue sample into a plurality of tissue pieces.
According to some embodiments of the utility model, the carrier plate is rotatably disposed on the mounting table.
According to some embodiments of the utility model, a steering handle for steering is provided on the carrier tray.
According to some embodiments of the utility model, the mounting table is provided with an angle scale.
According to some embodiments of the utility model, the vertical cutter seat is located above the carrier tray.
According to some embodiments of the utility model, the mounting table is provided with a vertical guide structure, the vertical guide structure is matched with the vertical cutter seat, and the vertical cutter seat can be close to or far away from the carrying disc along the vertical guide structure.
According to some embodiments of the utility model, the mounting table is provided with a horizontal guiding structure, the horizontal guiding structure is matched with the horizontal cutter seat, and the horizontal cutter seat can be close to or far away from the carrying tray along the horizontal guiding structure.
According to some embodiments of the utility model, the three-dimensional tissue slice apparatus comprises two of the horizontal cutter seats, wherein one of the horizontal cutter seats is disposed on one side of the carrier plate and the other horizontal cutter seat is disposed on the other side of the carrier plate.
According to some embodiments of the utility model, the horizontal blades are detachably arranged on the horizontal cutter base, the vertical blades are detachably arranged on the vertical cutter base, the spacing between the horizontal blades is adjustable, and the spacing between the vertical blades is adjustable.
According to the three-dimensional tissue slice device provided by the utility model, the three-dimensional tissue slice device further comprises a driving element and a control element, wherein the control element is used for controlling the driving element, and the driving element is used for driving the three-dimensional tissue slice device to cut a tissue sample.
According to the three-dimensional tissue slice equipment provided by the utility model, at least the following technical effects are achieved: by using the three-dimensional tissue slice device provided by the utility model, the three-dimensional tissue slice equipment can rapidly slice the tissue sample.
Drawings
The above and/or additional aspects and advantages of the present invention will become apparent and readily appreciated from the following description of the embodiments, taken in conjunction with the accompanying drawings of which:
FIG. 1 is an isometric view of a three-dimensional tissue slice apparatus provided in accordance with the present invention;
fig. 2 is an isometric view of a three-dimensional tissue slice apparatus provided in accordance with the present invention.
Reference numerals:
the cutting machine comprises a base 1, a loading disc 2, a steering handle 3, a sliding table 4, a horizontal cutter seat 5, a vertical cutter seat 6, a horizontal blade 7, a vertical blade 8 and a support 9.
Detailed Description
Reference will now be made in detail to embodiments of the present invention, examples of which are illustrated in the accompanying drawings, wherein like or similar reference numerals refer to the same or similar elements or elements having the same or similar function throughout. The embodiments described below with reference to the accompanying drawings are illustrative only for the purpose of explaining the present invention, and are not to be construed as limiting the present invention.
In the description of the present invention, it should be understood that the orientation or positional relationship referred to in the description of the orientation, such as the upper, lower, front, rear, left, right, etc., is based on the orientation or positional relationship shown in the drawings, and is only for convenience of description and simplification of description, and does not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus, should not be construed as limiting the present invention.
In the description of the present invention, the meaning of a plurality of means is one or more, the meaning of a plurality of means is two or more, and larger, smaller, larger, etc. are understood as excluding the number, and larger, smaller, inner, etc. are understood as including the number. If the first and second are described for the purpose of distinguishing technical features, they are not to be understood as indicating or implying relative importance or implicitly indicating the number of technical features indicated or implicitly indicating the precedence of the technical features indicated.
In the description of the present invention, unless otherwise explicitly limited, terms such as arrangement, installation, connection and the like should be understood in a broad sense, and those skilled in the art can reasonably determine the specific meanings of the above terms in the present invention in combination with the specific contents of the technical solutions.
The three-dimensional tissue slicing device comprises an installation platform, an object carrying disc 2, a horizontal cutter seat 5 and a vertical cutter seat 6, wherein the object carrying disc 2 is arranged on the installation platform, the horizontal cutter seat 5 can be relatively close to or far away from the object carrying disc 2, a plurality of horizontal blades 7 are arranged on the horizontal cutter seat 5 side by side, the horizontal blades 7 are arranged relatively parallel to the object carrying disc 2, the horizontal blades 7 are used for cutting a tissue sample along the horizontal direction, the vertical cutter seat 6 is arranged on the installation platform, the vertical cutter seat 6 can be relatively close to or far away from the object carrying disc 2, the vertical cutter seat 6 can rotate relatively around the object carrying disc 2, a plurality of vertical blades 8 are arranged on the vertical cutter seat 6 side by side, the vertical blades 8 are arranged relatively vertical to the object carrying disc 2, and the vertical blades 8 are used for cutting the tissue sample along the vertical direction.
During the use, horizontal blade 7 is responsible for carrying out a cutting in the horizontal direction, and perpendicular blade 8 is responsible for carrying out a cutting respectively in two perpendicular directions, and perpendicular blade 8 rotates certain angle for carrying thing dish 2 after accomplishing a cutting, carries out the cutting for the second time afterwards. The three cuts act together to slice the tissue sample into tissue pieces.
According to the three-dimensional tissue slice device provided by the utility model, the plurality of horizontal blades 7 and the plurality of vertical blades 8 are arranged, so that the three-dimensional tissue slice device can rapidly cut a tissue sample into a plurality of tissue blocks.
It will be appreciated that both the relatively parallel and the relatively perpendicular are referenced to the carrier plane of the carrier plate 2.
Furthermore, the relative movement between the horizontal cutter holder 5 and the carrier plate 2 and the relative movement between the vertical cutter holder 6 and the carrier plate 2 can take a number of forms. For example, the horizontal cutting may be performed by the carrier tray 2 being stationary and the horizontal cutter holder 5 being moved, or the horizontal cutting may be performed by the horizontal cutter holder 5 being stationary and the carrier tray 2 being moved. The cutting angle of the vertical cutting can be changed by rotating the carrier plate 2 and the vertical cutter holder 6, or by rotating the carrier plate 2 and the vertical cutter holder 6. Of course the above are only examples of alternatives and other similar arrangements may be used to achieve relative movement.
The three-dimensional tissue slice device provided by the utility model can be used for cutting tumor tissue samples and can also be used for cutting tissue samples in other biomedical fields.
In some embodiments, the carrier 2 is rotatably mounted on the mounting table.
In some embodiments, a steering handle 3 for steering is provided on the carrier plate 2. The steering handle 3 can be convenient for control and carry thing dish 2 to rotate, makes three-dimensional tissue slice device convenient operation. It will be appreciated that the steering handle 3 may be replaced with other structures such as a snap groove structure to facilitate dialing, a surface texture to increase contact friction, etc. in an equivalent manner.
In some embodiments, an angle scale is provided on the mounting table. The angle scale is used for marking the angle change of the object carrying disc 2, so that the angle adjustment of the object carrying disc 2 is more accurate. The angle scales can be attached to the surface of the mounting table in a printing mode, a spraying mode and the like, the angle scales can also be directly formed on the surface of the mounting table, and the angle scales can also be used for positioning the object carrying disc 2. For example, in the embodiment shown in fig. 2, two angle scale grooves are formed on the mounting table, the included angle between the two angle scale grooves is 90 °, a positioning structure adapted to the shape of the angle scale groove is provided on the steering handle 3, for example, the positioning structure adopts a ball plunger, a movable positioning bead is provided on the head of the ball plunger, and when the position of the ball plunger coincides with the angle scale groove, the positioning bead is clamped into the angle scale groove, so as to position the object carrying tray 2. Of course, other similar configurations may be used for the positioning structure.
According to some embodiments of the utility model, the vertical cutter seat 6 is located above the carrier plate 2. The vertical cutter holder 6 cuts the tissue sample on the carrier tray 2 by moving up and down. In some embodiments, the mounting table is provided with a vertical guide structure, which is adapted to the vertical cutter holder 6, along which the vertical cutter holder 6 can be moved towards or away from the carrier plate 2. For example, in the embodiment shown in fig. 1, a vertical guide rail is arranged on the mounting table, the guide rail is in a dovetail shape, a dovetail groove adapted to the guide rail is formed in the vertical cutter holder 6, and the vertical cutter holder 6 is mounted on the guide rail through the dovetail groove. The vertical guide structure enables the vertical cutter seat 6 to move more accurately and not to deflect easily, and ensures that the vertical cutter 8 cuts a tissue sample accurately and stably. Of course, the dovetail rail may be replaced with other guide structures of the same or similar function, such as guide posts, guide slots, etc.
It will be appreciated that the vertical blade 8 cuts into the tissue sample from the top, is only an alternative arrangement, and that the vertical blade 8 may also cut into the tissue sample from the side, for example the vertical blade holder 6 is arranged on the front side of the carrier plate 2 in a similar manner to the horizontal blade holder 5, and the vertical blade holder 6 cuts the tissue sample by moving it back and forth.
According to some embodiments of the utility model, the mounting table is provided with a horizontal guiding structure, which is adapted to the horizontal cutter holder 5, along which the horizontal cutter holder 5 can be moved towards or away from the carrier plate 2. For example, in the embodiment shown in fig. 1, a horizontal guide rail is provided on the mounting table, the guide rail is in a dovetail shape, a dovetail groove adapted to the guide rail is formed on the horizontal cutter holder 5, and the horizontal cutter holder 5 is mounted on the guide rail through the dovetail groove. The horizontal guide structure enables the horizontal cutter seat 5 to move more accurately and not to deflect easily, and ensures that the horizontal blade 7 cuts a tissue sample accurately and stably.
In some embodiments, the three-dimensional tissue sectioning device comprises two horizontal cutter seats 5, wherein one horizontal cutter seat 5 is arranged on one side of the carrier plate 2 and the other horizontal cutter seat 5 is arranged on the other side of the carrier plate 2. During cutting, the two horizontal cutter seats 5 respectively provide support for each other, so that the horizontal blade 7 can smoothly cut into the tissue sample. In some embodiments, the horizontal cutters 7 on the two horizontal cutter seats 5 are staggered with respect to each other.
It will be appreciated that other means of providing support for the horizontal blade 7 may be used, for example, a three-dimensional tissue sectioning device comprising a horizontal knife holder 5, the horizontal knife holder 5 being disposed on one side of the carrier plate 2, and a support plate disposed on the other side of the carrier plate 2, the support plate being adapted to bear against the tissue sample from the opposite side when the horizontal blade 7 is cutting, thereby allowing the horizontal blade 7 to smoothly cut into the tissue sample.
According to some embodiments of the present invention, the horizontal blades 7 are detachably provided on the horizontal cutter base 5, the vertical blades 8 are detachably provided on the vertical cutter base 6, the pitch of the horizontal blades 7 is adjustable, and the pitch of the vertical blades 8 is adjustable. Tissue blocks with different sizes can be cut out by adjusting the distance, so that the tissue slicing device is suitable for different research needs, and the applicability of the three-dimensional tissue slicing device is provided.
The three-dimensional tissue slice equipment provided by the utility model comprises the three-dimensional tissue slice device provided by the utility model.
According to the three-dimensional tissue slice device provided by the utility model, the tissue sample can be rapidly sliced by using the three-dimensional tissue slice device provided by the utility model.
The three-dimensional tissue slice apparatus further comprises drive and control elements to enable automated tissue sample dissection.
The three-dimensional tissue slice apparatus provided according to the present invention is described in detail in a specific embodiment with reference to fig. 1 and 2. It is to be understood that the following description is illustrative only and is not intended as a specific limitation on the utility model.
The embodiment comprises a mounting table, a carrier plate 2, a horizontal cutter holder 5 and a vertical cutter holder 6.
The mount table includes base 1, slip table 4 and pillar 9, and four pillars 9 set up base 1's four corners, pillar 9 hold base 1, and slip table 4 sets up in one side of base 1.
The carrying plate 2 is rotatably arranged on the base 1, the bottom of the carrying plate 2 is connected with a steering handle 3, a ball plunger for positioning is arranged on the steering handle 3, and the head of the ball plunger faces the base 1. The bottom surface shaping of base 1 has two angle scale recesses, and the contained angle between two angle scale recesses is 90, and the shape and the bulb plunger looks adaptation of angle scale recess.
The three-dimensional tissue slice device comprises two horizontal cutter seats 5, wherein the horizontal cutter seats 5 are arranged on the base 1, one horizontal cutter seat 5 is arranged on one side of the object carrying disc 2, and the other horizontal cutter seat 5 is arranged on the other side of the object carrying disc 2. Be provided with the horizontally guide rail on the base 1, the guide rail adopts the forked tail shape, offer the dovetail with the guide rail adaptation on the horizontal cutter seat 5, horizontal cutter seat 5 passes through the dovetail and installs on the guide rail, horizontal cutter seat 5 can be followed the guide rail and be close to relatively or keep away from year thing dish 2, be provided with a plurality of horizontal blades 7 on the horizontal cutter seat 5 side by side, horizontal blade 7 is on a relatively parallel with carries thing dish 2 setting, horizontal blade 7 is used for following the horizontal direction cutting tissue sample. The horizontal cutters 7 on the two horizontal cutter seats 5 are staggered with each other.
The horizontal blade 7 and the vertical blade 8 adopt double-sided 316 stainless steel blades, and the length, the width and the thickness of the blades are 15mm, 15mm and 0.25mm respectively. The material of the three-dimensional tissue slice device is selected from the materials meeting the medical standard, and is suitable for alcohol disinfection and high-temperature disinfection.
Tissue sample dicing may be performed using the present embodiment according to the following method:
1. sterilizing the three-dimensional tissue slice device for later use;
2. the pretreatment of the clinically provided biological tissue sample: removing fat, fiber and blood stains;
3. placing the pretreated biological tissue sample on a carrying disc 2, adjusting the blade distance according to the requirement, enabling a horizontal blade 7 to be close to cut the tissue once in the horizontal direction without penetrating through the tissue;
4. the horizontal blade 7 is separated by a distance, and the vertical blade 8 does not penetrate through the cutting part downwards;
5. the vertical blade 8 is pulled upwards for a distance, the object carrying disc 2 rotates for 90 degrees, the vertical blade 8 cuts downwards, and the cutting can penetrate through the whole tissue;
6. cutting the tissue sample into tissue blocks with required sizes through the three times of cutting;
7. after tissue cutting is complete, the device is sterilized with alcohol or at high temperature.
According to the three-dimensional tissue slice device provided by the embodiment of the utility model, at least some functions can be realized by adopting the design: by providing a plurality of horizontal blades 7 and a plurality of vertical blades 8, the three-dimensional tissue slice apparatus is capable of rapidly cutting a tissue sample into a plurality of tissue pieces.
The cutting size of the three-dimensional tissue slicing device is controlled by the distance between the horizontal blades 7 and the distance between the vertical blades 8, the cutting size precision is high, the cutting angle of the three-dimensional tissue slicing device is controlled by the angle scale groove, and the cutting shape precision is high. The three-dimensional tissue slice device meets medical standards, is suitable for alcohol disinfection and high-temperature disinfection, and is not easy to cause cross contamination of tissue samples.
In the description herein, references to the description of the term "one embodiment," "some embodiments," "an illustrative embodiment," "an example," "a specific example," or "some examples" or the like mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the utility model. In this specification, the schematic representations of the terms used above do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
While embodiments of the utility model have been shown and described, it will be understood by those of ordinary skill in the art that: various changes, modifications, substitutions and alterations can be made to the embodiments without departing from the principles and spirit of the utility model, the scope of which is defined by the claims and their equivalents.
Claims (10)
1. A three-dimensional tissue slice apparatus, comprising:
an installation table;
the carrying plate (2), the carrying plate (2) is arranged on the mounting table;
the horizontal cutter seat (5), the horizontal cutter seat (5) is arranged on the mounting table, the horizontal cutter seat (5) can be relatively close to or far away from the object carrying disc (2), a plurality of horizontal blades (7) are arranged on the horizontal cutter seat (5) side by side, the horizontal blades (7) are arranged relatively parallel to the object carrying disc (2), and the horizontal blades (7) are used for cutting a tissue sample along the horizontal direction;
perpendicular cutter seat (6), perpendicular cutter seat (6) set up on the mount table, perpendicular cutter seat (6) can be close to relatively or keep away from carry thing dish (2), perpendicular cutter seat (6) can wind carry thing dish (2) relative rotation, be provided with a plurality of perpendicular blades (8) side by side on perpendicular cutter seat (6), perpendicular blade (8) perpendicular to relatively carry thing dish (2) to set up, perpendicular blade (8) are used for along the vertical direction cutting tissue sample.
2. The three-dimensional tissue slice apparatus of claim 1, wherein: the carrying plate (2) is rotatably arranged on the mounting table.
3. The three-dimensional tissue slice apparatus of claim 2, wherein: the carrying plate (2) is provided with a steering handle (3) for steering.
4. The three-dimensional tissue slice apparatus of claim 2 or 3, wherein: the mounting table is provided with angle scales.
5. The three-dimensional tissue slice apparatus of claim 1 or 2, wherein: the vertical cutter seat (6) is positioned above the object carrying disc (2).
6. The three-dimensional tissue slice apparatus of claim 5, wherein: the mounting table is provided with a vertical guide structure, the vertical guide structure is matched with the vertical cutter seat (6), and the vertical cutter seat (6) can be close to or far away from the object carrying disc (2) along the vertical guide structure.
7. The three-dimensional tissue slice apparatus of claim 1, wherein: the mounting table is provided with a horizontal guide structure, the horizontal guide structure is matched with the horizontal cutter seat (5), and the horizontal cutter seat (5) can be close to or far away from the object carrying disc (2) along the horizontal guide structure.
8. The three-dimensional tissue slice apparatus of claim 1 or 7, wherein: the three-dimensional tissue slicing device comprises two horizontal cutter seats (5), wherein one horizontal cutter seat (5) is arranged on one side of the object carrying disc (2), and the other horizontal cutter seat (5) is arranged on the other side of the object carrying disc (2).
9. The three-dimensional tissue slice apparatus of claim 1, wherein: the horizontal blades (7) are detachably arranged on the horizontal cutter seat (5), the vertical blades (8) are detachably arranged on the vertical cutter seat (6), the distance between the horizontal blades (7) is adjustable, and the distance between the vertical blades (8) is adjustable.
10. A three-dimensional tissue slice apparatus comprising the three-dimensional tissue slice device of any one of claims 1 to 9, the three-dimensional tissue slice apparatus further comprising a drive element and a control element, the control element for controlling the drive element, the drive element for driving the three-dimensional tissue slice device to cut a tissue sample.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202120710749.0U CN216266444U (en) | 2021-04-08 | 2021-04-08 | Three-dimensional tissue slice device and three-dimensional tissue slice equipment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202120710749.0U CN216266444U (en) | 2021-04-08 | 2021-04-08 | Three-dimensional tissue slice device and three-dimensional tissue slice equipment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN216266444U true CN216266444U (en) | 2022-04-12 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202120710749.0U Active CN216266444U (en) | 2021-04-08 | 2021-04-08 | Three-dimensional tissue slice device and three-dimensional tissue slice equipment |
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| CN (1) | CN216266444U (en) |
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2021
- 2021-04-08 CN CN202120710749.0U patent/CN216266444U/en active Active
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