CN216192262U - Centrifugal separation case for immune cells - Google Patents
Centrifugal separation case for immune cells Download PDFInfo
- Publication number
- CN216192262U CN216192262U CN202122680122.8U CN202122680122U CN216192262U CN 216192262 U CN216192262 U CN 216192262U CN 202122680122 U CN202122680122 U CN 202122680122U CN 216192262 U CN216192262 U CN 216192262U
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- China
- Prior art keywords
- groove
- test tube
- fixedly connected
- centrifugal separation
- immune cells
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000926 separation method Methods 0.000 title claims abstract description 38
- 210000002865 immune cell Anatomy 0.000 title claims abstract description 27
- 238000012360 testing method Methods 0.000 claims abstract description 46
- 230000007246 mechanism Effects 0.000 claims abstract description 21
- 230000000087 stabilizing effect Effects 0.000 claims description 5
- 229920000742 Cotton Polymers 0.000 claims description 4
- 239000004677 Nylon Substances 0.000 claims description 4
- 229920001778 nylon Polymers 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 3
- 210000003719 b-lymphocyte Anatomy 0.000 abstract description 16
- 210000001744 T-lymphocyte Anatomy 0.000 abstract description 9
- 230000007306 turnover Effects 0.000 abstract description 8
- 238000001179 sorption measurement Methods 0.000 abstract description 5
- 238000000034 method Methods 0.000 abstract description 3
- 230000008569 process Effects 0.000 abstract description 3
- 238000007789 sealing Methods 0.000 description 7
- 238000007790 scraping Methods 0.000 description 4
- 210000004698 lymphocyte Anatomy 0.000 description 3
- 230000008878 coupling Effects 0.000 description 2
- 238000010168 coupling process Methods 0.000 description 2
- 238000005859 coupling reaction Methods 0.000 description 2
- 230000028993 immune response Effects 0.000 description 2
- 230000009471 action Effects 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 210000004443 dendritic cell Anatomy 0.000 description 1
- 210000003714 granulocyte Anatomy 0.000 description 1
- 210000003630 histaminocyte Anatomy 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000001616 monocyte Anatomy 0.000 description 1
- 210000001539 phagocyte Anatomy 0.000 description 1
- 238000012805 post-processing Methods 0.000 description 1
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- Centrifugal Separators (AREA)
Abstract
The utility model discloses a centrifugal separation box for immune cells, which comprises a treatment box, wherein a rectangular groove is formed in the middle of the front side of the treatment box, a motor is fixedly connected to the inner wall of the bottom side of the rectangular groove, a rotating shaft is fixedly connected to the output end of the motor, a circular groove is formed in the middle of the upper surface of the treatment box, a separation mechanism is arranged on the inner wall of the lower side of the circular groove, a turnover cover is rotatably connected to the right side of the upper surface of the treatment box through a rotating rod, and a connection mechanism is arranged on the left side of the turnover cover. According to the utility model, through the adsorption layer on the test tube, when the test tube rotates, B cells in the solution are adsorbed on the inner wall of the test tube, the centrifugal treatment time is not too long, T cells and B cells are not damaged, the separation efficiency is increased, and the stable plate is in sliding connection with the sliding groove, so that the rotation process of the test tube is more stable, and the stability of the separation box is increased.
Description
Technical Field
The utility model relates to the field of immune cell separation, in particular to a centrifugal separation box for immune cells.
Background
Immune cells refer to cells involved in or associated with an immune response. Including lymphocytes, dendritic cells, monocytes/macrophages, granulocytes, mast cells, and the like. Immune cells can be classified into various types, and various immune cells play an important role in the human body. Immune cells are commonly called leukocytes and include innate lymphocytes, various phagocytic cells and the like, and lymphocytes which recognize antigens and produce specific immune responses.
When the staff is separating T cell and B cell, need use centrifugal separation case to assist staff's work, centrifugal separation case is when using at present, and the time of separation consumption is longer, can damage some immunocytes, makes the testing result inaccurate.
SUMMERY OF THE UTILITY MODEL
The utility model aims to solve the defects in the prior art and provides a centrifugal separation box for immune cells.
In order to achieve the purpose, the utility model adopts the following technical scheme: a centrifugal separation box for immune cells comprises a treatment box, wherein a rectangular groove is formed in the middle of the front side of the treatment box, a motor is fixedly connected to the inner wall of the bottom side of the rectangular groove, a rotating shaft is fixedly connected to the output end of the motor, a circular groove is formed in the middle of the upper surface of the treatment box, a separation mechanism is arranged on the inner wall of the lower side of the circular groove, a turnover cover is rotatably connected to the right side of the upper surface of the treatment box through a rotating rod, and a connection mechanism is arranged on the left side of the turnover cover;
separating mechanism comprises placing piece, firm board, spread groove, standing groove and test tube, place a fixed connection in the upper end of pivot, firm board fixed connection is at the surface of placing the piece, the upper surface of placing the piece is seted up to the standing groove, the spread groove is seted up at the upper surface of placing the piece and is located the outside of standing groove, the test tube sets up the inside at the standing groove.
As a further description of the above technical solution:
coupling mechanism comprises connecting rod, closing cap, go-between, telescopic link and scraper blade, the connecting rod rotates to be connected in flip's left side, closing cap fixed connection is at the left end of connecting rod, telescopic link fixed connection is in the left side of closing cap, scraper blade fixed connection is at the left end of telescopic link, connecting ring fixed connection just is located the outside of telescopic link in the left side of closing cap.
As a further description of the above technical solution:
the inner wall of the circular groove is provided with a sliding groove, and one end, far away from the outer surface of the placing block, of the stabilizing plate is connected with the inner wall of the sliding groove in a sliding mode.
As a further description of the above technical solution:
the inside of test tube is provided with the adsorbed layer, just the adsorbed layer is made for the cotton material of nylon.
As a further description of the above technical solution:
the connecting ring and the connecting groove are mutually matched.
As a further description of the above technical solution:
the middle part of the front side of the treatment box is fixedly connected with a transparent frame.
As a further description of the above technical solution:
the left end fixedly connected with control panel around handling the case.
As a further description of the above technical solution:
the diameter of the scraper is equal to that of the test tube.
The utility model has the following beneficial effects:
1. compared with the prior art, this centrifugal separation case for immune cell, through the adsorbed layer on the test tube, when making the test tube rotate, B cell adsorbs on the inner wall of test tube in the solution, and centrifugal treatment's time need not too long, can not damage and take T cell and B cell, increases the efficiency of separation, and firm board and sliding tray sliding connection, makes the rotation process of test tube more stable, increases the stability of separator case.
2. Compared with the prior art, this centrifugal separation case for immune cell, through the telescopic link among the coupling mechanism, make the B cell that adsorbs on the test tube inner wall scraped and take the test tube bottom, the staff of being convenient for collects the B cell, reduces staff's post processing's work load, increases separation efficiency, and go-between and the mutual adaptation of spread groove, makes the test tube when rotating, outside inside solution can not spatter the test tube, increases the precision of separation.
Drawings
FIG. 1 is an overall perspective view of a centrifugal separation chamber for immune cells according to the present invention;
FIG. 2 is a front view of a centrifugal separation chamber for immune cells according to the present invention;
FIG. 3 is an enlarged view taken at A in FIG. 1;
FIG. 4 is a top view of a centrifugal separation chamber for immune cells according to the present invention;
FIG. 5 is a perspective view of a tube of a centrifugal separation chamber for immune cells according to the present invention.
Illustration of the drawings:
1. a treatment tank; 2. a rectangular groove; 3. a motor; 4. a rotating shaft; 5. a transparent frame; 6. a circular groove; 7. a sliding groove; 8. a separating mechanism; 801. placing the blocks; 802. a stabilizing plate; 803. connecting grooves; 804. a placement groove; 805. a test tube; 806. an adsorption layer; 9. a cover is turned; 10. a rotating rod; 11. a connecting mechanism; 1101. a connecting rod; 1102. sealing the cover; 1103. a connecting ring; 1104. a telescopic rod; 1105. a squeegee; 12. and a control panel.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc., indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and simplicity of description, but do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be construed as limiting the present invention; the terms "first," "second," and "third" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance, and furthermore, unless otherwise explicitly stated or limited, the terms "mounted," "connected," and "connected" are to be construed broadly and may be, for example, fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.
Referring to fig. 1-5, one embodiment of the present invention is provided: a centrifugal separation box for immune cells comprises a treatment box 1, wherein a rectangular groove 2 is formed in the middle of the front side of the treatment box 1, a motor 3 is fixedly connected to the inner wall of the bottom side of the rectangular groove 2, a rotating shaft 4 is fixedly connected to the output end of the motor 3, a circular groove 6 is formed in the middle of the upper surface of the treatment box 1, a separation mechanism 8 is arranged on the inner wall of the lower side of the circular groove 6, a turning cover 9 is rotatably connected to the right side of the upper surface of the treatment box 1 through a rotating rod 10, a connecting mechanism 11 is arranged on the left side of the turning cover 9, a control panel 12 is fixedly connected to the left ends of the front side and the rear side of the treatment box 1, a worker firstly adds a proper amount of solution to be separated into a test tube 805, then can separate T cells from B cells through the separation mechanism 8, then can scrape off the B cells adsorbed on an adsorption layer 806 through the connecting mechanism 11, and reduce the workload of the worker;
the separating mechanism 8 is composed of a placing block 801, a fixing plate 802, a connecting groove 803, a placing groove 804 and a test tube 805, the placing block 801 is fixedly connected to the upper end of the rotating shaft 4, the fixing plate 802 is fixedly connected to the outer surface of the placing block 801, the placing groove 804 is provided with the upper surface of the placing block 801, the connecting groove 803 is provided on the upper surface of the placing block 801 and located on the outer side of the placing groove 804, the test tube 805 is arranged inside the placing groove 804, a worker firstly adds a proper amount of solution into the test tube 805, then the turning cover 9 is closed, the motor 3 is started to drive the rotating shaft 4 to rotate, the rotating shaft 4 drives the placing block 801 to rotate, the placing block 801 drives the test tube 805 to rotate, and a part of the solution in the test tube 805 is adsorbed on an adsorbing layer 806 inside the test tube 805 under the action of centrifugal force, and the other part of the solution is suspended inside the test tube 805, so that the separating function of T cells and B cells is realized.
The connecting mechanism 11 is composed of a connecting rod 1101, a sealing cover 1102, a connecting ring 1103, a telescopic rod 1104 and a scraping plate 1105, the connecting rod 1101 is rotatably connected to the left side of the turnover cover 9, the sealing cover 1102 is fixedly connected to the left end of the connecting rod 1101, the telescopic rod 1104 is fixedly connected to the left side of the sealing cover 1102, the scraping plate 1105 is fixedly connected to the left end of the telescopic rod 1104, the connecting ring 1103 is fixedly connected to the left side of the sealing cover 1102 and located outside the telescopic rod 1104, when a worker adds a proper amount of solution into the test tube 805, the turnover cover 9 is rotated to enable the turnover cover 9 to drive the connecting mechanism 11 to approach the separating mechanism 8, during the rotation of the turnover cover 9, the connecting ring 1103 and the connecting groove 803 are connected with each other, the scraping plate 1105 extends into the test tube 805, so that the internal solution does not splash out of the test tube 805 during the rotation of the test tube 805, after the separation, the worker pours out the T cell solution in the test tube 805, and then the worker controls the telescopic rod 1104 to stretch out, the telescopic link 1104 drives the scraper 1105 to move inside the test tube 805, so that the B cells adsorbed inside the test tube 805 are scraped off, the workers can collect the B cells conveniently, and the workload of the workers is reduced.
The inner wall of circular slot 6 has seted up sliding tray 7, and the one end that the stabilizing plate 802 kept away from the surface of placing piece 801 and the inner wall sliding connection of sliding tray 7, stabilizing plate 802 can increase and place the rotatory stability of piece 801.
The inside of test tube 805 is provided with adsorbed layer 806, and adsorbed layer 806 is the cotton material of nylon and makes, and the cotton B cell that can adsorb of nylon, T cell do not adsorb, are convenient for separate T cell and B cell.
The connection ring 1103 and the connection groove 803 are fitted to each other.
The middle part fixedly connected with transparent frame 5 of handling case 1 front side is convenient for the staff to observe the behavior of motor 3, avoids taking place emergency.
The diameter of the wiper 1105 is equal to the diameter of the test tube 805.
The working principle is as follows: when the device is used, a worker firstly adds a solution to be separated into the test tube 805, places the test tube 805 in the placement groove 804, then rotates the turning cover 9 to enable the sealing cover 1102 to be in contact with the placement block 801, in the process that the sealing cover 1102 is in contact with the placement block 801, the connecting ring 1103 is connected with the connecting groove 803, so that the solution in the test tube 805 does not spill out during separation, then the motor 3 is started, the motor 3 drives the placement block 801 to rotate, the placement block 801 drives the test tube 805 to rotate, so that B cells in the solution are adsorbed on the adsorption layer 806 on the inner wall of the test tube 805, after separation is finished, the worker pours out the T cell solution in the test tube 805, then closes the turning cover 9, and controls the telescopic rod 1104 to drive the scraping plate 1105 to stretch out and draw back inside the test tube 805, so that the B cells adsorbed on the adsorption layer 806 are scraped off, and the separation function of immune cells is realized.
Finally, it should be noted that: although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that modifications may be made to the embodiments or portions thereof without departing from the spirit and scope of the utility model.
Claims (8)
1. A centrifugal separation case for immune cell, includes processing case (1), its characterized in that: the middle part of the front side of the treatment box (1) is provided with a rectangular groove (2), the inner wall of the bottom side of the rectangular groove (2) is fixedly connected with a motor (3), the output end of the motor (3) is fixedly connected with a rotating shaft (4), the middle part of the upper surface of the treatment box (1) is provided with a circular groove (6), the inner wall of the lower side of the circular groove (6) is provided with a separating mechanism (8), the right side of the upper surface of the treatment box (1) is rotatably connected with a flip (9) through a rotating rod (10), and the left side of the flip (9) is provided with a connecting mechanism (11);
separating mechanism (8) comprises placing piece (801), firm board (802), connecting groove (803), standing groove (804) and test tube (805), place piece (801) fixed connection in the upper end of pivot (4), firm board (802) fixed connection is in the surface of placing piece (801), the upper surface of placing piece (801) is seted up in standing groove (804), the outside at the upper surface of placing piece (801) and being located standing groove (804) is seted up in connecting groove (803), test tube (805) set up the inside at standing groove (804).
2. The centrifugal separation chamber for immune cells according to claim 1, wherein: the connecting mechanism (11) comprises a connecting rod (1101), a cover (1102), a connecting ring (1103), a telescopic rod (1104) and a scraper (1105), wherein the connecting rod (1101) is rotatably connected to the left side of the flip cover (9), the cover (1102) is fixedly connected to the left end of the connecting rod (1101), the telescopic rod (1104) is fixedly connected to the left side of the cover (1102), the scraper (1105) is fixedly connected to the left end of the telescopic rod (1104), and the connecting ring (1103) is fixedly connected to the left side of the cover (1102) and located outside of the telescopic rod (1104).
3. The centrifugal separation chamber for immune cells according to claim 1, wherein: the inner wall of the circular groove (6) is provided with a sliding groove (7), and one end, far away from the outer surface of the placing block (801), of the stabilizing plate (802) is connected with the inner wall of the sliding groove (7) in a sliding mode.
4. The centrifugal separation chamber for immune cells according to claim 1, wherein: the inside of test tube (805) is provided with adsorbed layer (806), and adsorbed layer (806) is for nylon cotton material to make.
5. The centrifugal separation chamber for immune cells according to claim 2, wherein: the connecting ring (1103) and the connecting groove (803) are mutually matched.
6. The centrifugal separation chamber for immune cells according to claim 1, wherein: the middle part of the front side of the treatment box (1) is fixedly connected with a transparent frame (5).
7. The centrifugal separation chamber for immune cells according to claim 1, wherein: the left ends of the front and the back of the treatment box (1) are fixedly connected with a control plate (12).
8. The centrifugal separation chamber for immune cells according to claim 2, wherein: the diameter of the scraper (1105) is equal to the diameter of the test tube (805).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202122680122.8U CN216192262U (en) | 2021-11-03 | 2021-11-03 | Centrifugal separation case for immune cells |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202122680122.8U CN216192262U (en) | 2021-11-03 | 2021-11-03 | Centrifugal separation case for immune cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN216192262U true CN216192262U (en) | 2022-04-05 |
Family
ID=80901301
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202122680122.8U Expired - Fee Related CN216192262U (en) | 2021-11-03 | 2021-11-03 | Centrifugal separation case for immune cells |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN216192262U (en) |
-
2021
- 2021-11-03 CN CN202122680122.8U patent/CN216192262U/en not_active Expired - Fee Related
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| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20220405 |