CN216013153U

CN216013153U - Microfluidic chip, urine analysis device and toilet

Info

Publication number: CN216013153U
Application number: CN202120388921.5U
Authority: CN
Inventors: 林鹤全
Original assignee: Shanmu Shenzhen Biotechnology Co ltd
Current assignee: Shanmu Shenzhen Biotechnology Co ltd
Priority date: 2021-02-22
Filing date: 2021-02-22
Publication date: 2022-03-11
Anticipated expiration: 2031-02-22

Abstract

The embodiment of the utility model provides a micro-fluidic chip, a urine analysis device and a closestool, and relates to the technical field of detection. A microfluidic chip comprising: the chip comprises a chip main body, an optical detection module and a plurality of electromagnetic valves, wherein the optical detection module is fixed on the chip main body; the electromagnetic valve is used for controlling the reagent hole corresponding to the valve hole to be opened when the detection instruction is received, so that the detection reagent in the reagent bag arranged on the opened reagent hole flows into the reaction cavity through the corresponding reagent channel; the reaction cavity is used for reacting the urine flowing into the microfluidic chip through the urine channel with the detection reagent in the reagent bag; the optical detection module is used for carrying out optical detection on the mixed liquid obtained after the reaction of the urine in the reaction cavity and the detection reagent so as to obtain detection data. The microfluidic chip can perform at least one optical detection on the urine of the user, so that the urine of the user can be analyzed daily, the user can check the analysis data of the urine, and the self health condition can be known.

Description

Microfluidic chip, urine analysis device and toilet

Technical Field

The utility model relates to the technical field of detection, in particular to a micro-fluidic chip, a urine analysis device and a closestool.

Background

Urine test is a general test item for a patient in medical institutions, and the analysis of urine of a patient can obtain the concentration of chemical components in urine, for example, glucose, urine protein, PH, occult blood, nitrite, bilirubin, urobilinogen, red blood cells, white blood cells, and the like. The concentration of the chemical components in the human urine has a normal range, and after a patient suffers from pathological changes or the dietary habit is changed, the chemical components in the urine can be correspondingly changed, so that the health condition of the patient can be judged according to the concentration of the chemical components in the urine of the patient.

At present, the concentration change of chemical components in urine can reflect the health condition of a patient to a certain extent and change, and the urine monitoring device has very important significance if the health condition of the patient can be judged in advance by monitoring the urine of the patient before the patient perceives the body to be abnormal.

SUMMERY OF THE UTILITY MODEL

The utility model aims to provide a micro-fluidic chip, a urine analysis device and a closestool, wherein the micro-fluidic chip can perform at least one optical detection on the urine of a user, so that the urine of the user can be analyzed daily, and the user can check the analysis data of the urine and know the self health condition.

In order to achieve the above object, the present invention provides a microfluidic chip, comprising: the chip comprises a chip main body, an optical detection module and a plurality of electromagnetic valves, wherein the optical detection module is fixed on the chip main body; a reaction cavity and a plurality of reagent channels connected to the reaction cavity are formed in the chip main body, the plurality of reagent channels form a plurality of reagent holes on the chip main body, the reaction cavity is also connected with a urine channel, the urine channel forms a urine hole on the chip main body, each reagent hole is used for installing a reagent bag, valve holes corresponding to the reagent holes one by one are also formed on the chip main body, and each electromagnetic valve is respectively installed at each valve hole on the chip main body; the electromagnetic valve is used for controlling the reagent hole corresponding to the valve hole to be opened when the detection instruction is received, so that the detection reagent in the reagent capsule arranged on the opened reagent hole flows into the reaction cavity through the corresponding reagent channel; the reaction cavity is used for allowing urine flowing into the microfluidic chip through the urine channel to react with the detection reagent in the reagent bag; the optical detection module is used for carrying out optical detection on the mixed liquid obtained after the reaction of the urine in the reaction cavity and the detection reagent so as to obtain detection data.

The utility model also provides a urine detection method, which comprises the following steps: the microfluidic chip is applied, and the method comprises the following steps: when a detection instruction is received, the corresponding reagent hole is controlled to be opened through an electromagnetic valve in the microfluidic chip, a detection reagent in a reagent bag arranged on the opened reagent hole flows into the reaction cavity through the corresponding reagent channel, urine flows into the reaction cavity through the urine channel, and the reagent flowing into the reaction cavity reacts with the urine; and the optical detection module performs optical detection on the mixed liquid obtained after the reaction of the urine in the reaction cavity and the detection reagent to obtain detection data.

The utility model also provides a urine analysis device, which comprises the microfluidic chip, a plurality of reagent capsules and a processor, wherein the reagent capsules are respectively arranged on the reagent holes of the microfluidic chip, and the processor is connected with an optical detection module and an electromagnetic valve in the microfluidic chip; the processor is used for controlling the opening of the corresponding reagent hole through the electromagnetic valve in the microfluidic chip when urine flows, the detection reagent in the reagent bag arranged on the reagent hole flows into the reaction cavity through the corresponding reagent channel, and the urine is controlled to flow into the reaction cavity through the urine channel, and the detection reagent flowing into the reaction cavity reacts with the urine; the processor is also used for carrying out optical detection on the mixed liquid obtained after the reaction of the urine in the reaction cavity and the detection reagent by using the optical detection module to obtain detection data.

The utility model also provides a closestool comprising the urine analysis device.

Compared with the prior art, the utility model provides a microfluidic chip with an optical detection function, which comprises a chip main body, an optical detection module fixed on the chip main body and a plurality of electromagnetic valves, wherein a reaction cavity and a plurality of reagent channels connected to the reaction cavity are formed in the chip main body, a plurality of corresponding reagent holes are formed on the chip main body by the reagent channels, the reaction cavity is also connected with a urine channel, the urine channel forms a urine hole on the chip main body, and each reagent hole is used for installing a reagent capsule; the solenoid valve is when received detection instruction, control the reagent hole that the valve hole corresponds is opened, make and install open detect reagent in the reagent bag on the reagent hole flows into the reaction cavity through the reagent passageway that corresponds, after having urine to flow into the reaction cavity through the detect reagent in urine passageway and the reagent bag and carry out chemical reaction, optical detection module can carry out optical detection to the mixed liquid after urine and detect reagent react in the reaction cavity, obtain the testing data, this micro-fluidic chip can carry out at least one item optical detection to user's urine promptly, thereby can be at daily urine to user's analysis, so that the user looks over the analytical data of urine, know self health status.

In one embodiment, the chip body includes an upper plate and a lower plate fixed to each other, the reaction chamber, the urine channel, and the reagent channel are formed between the upper plate and the lower plate, the reagent hole and the urine hole are formed on an upper surface of the upper plate, and the valve hole is formed on a lower surface of the lower plate.

In one embodiment, the microfluidic chip further comprises: a control circuit board; the control circuit board is fixed with the lower plate; each of the solenoid valves includes: the magnetic circuit comprises an armature, an elastic device, a shell, an electromagnetic coil and a magnetic core; a closed shell is arranged at each valve hole of the lower plate, the elastic device and the armature are arranged in the shell, the armature is arranged on the elastic device, the shell is fixed on the control circuit board and is a hollow cylinder, the electromagnetic coil is fixed on the inner surface of the hollow cylinder, and the magnetic core is positioned in the hollow cylinder and fixed on the control circuit board; the housing is located in the electromagnetic coil and in contact with the magnetic core when the control circuit board is fixed to the lower plate; when the electromagnetic valve is in an open state, the armature moves towards the magnetic core, the elastic device is compressed by the armature, the electromagnetic valve is opened corresponding to a reagent hole, and a detection reagent in a reagent capsule arranged on the reagent hole flows into the reaction cavity through a corresponding reagent channel; when the electromagnetic valve is in a closed state, the elastic device is in an initial state, and the armature closes the reagent hole corresponding to the electromagnetic valve.

In one embodiment, the optical detection module comprises: a light source and a chromatographic sensor; the light source is fixed on the upper plate at a position corresponding to the reaction cavity, and the chromatographic sensor is fixed on the lower plate at a position corresponding to the reaction cavity; when the mixed liquid in the reaction cavity is subjected to optical detection, the light source emits test light towards the reaction cavity, and the test light irradiates the chromatographic sensor after passing through the mixed liquid in the reaction cavity.

In one embodiment, the reaction cavity is provided with a plurality of light-transmitting upper detection points on the upper plate, and the reaction cavity is provided with a plurality of light-transmitting lower detection points on the lower plate, wherein the upper detection points correspond to the lower detection points one by one; and the test light emitted by the light source towards the reaction cavity irradiates the chromatographic sensor through the upper detection point, the mixed liquid in the reaction cavity and the lower detection point.

In one embodiment, the chip body is further formed therein with a cleaning inlet channel and a cleaning outlet channel respectively connected to the reaction chamber, the cleaning inlet channel forming a cleaning inlet on the chip body, and the cleaning outlet channel forming a cleaning outlet on the chip body; the cleaning inlet channel is used for cleaning the reaction cavity by the cleaning liquid flowing in from the cleaning inlet; and the cleaning outlet channel is used for allowing the cleaning liquid in the reaction cavity to flow out from the cleaning outlet.

In one embodiment, the chip body is also provided with an air channel connected with the reaction cavity; the air channel is used for allowing air to enter the reaction cavity from the air inlet after the reaction cavity is cleaned so as to discharge liquid in the reaction cavity.

In one embodiment, a plurality of reagent wells share one of the reagent channels.

Drawings

FIG. 1 is a schematic view of a urine analysis device and a toilet bowl to which a microfluidic chip is applied according to a first embodiment of the present invention;

fig. 2 is a schematic structural view of a microfluidic chip according to a first embodiment of the present invention;

fig. 3 is a schematic structural view of an upper plate of a chip main body of a microfluidic chip according to a first embodiment of the present invention;

fig. 4 is a schematic structural view of a lower plate of a chip body of a microfluidic chip according to a first embodiment of the present invention;

fig. 5 and 6 are schematic structural views of a urine analysis device to which a microfluidic chip according to a first embodiment of the present invention is applied;

fig. 7 is a schematic structural view of a microfluidic chip according to a second embodiment of the present invention;

fig. 8 is a schematic structural view of an upper plate of a chip main body of a microfluidic chip according to a third embodiment of the present invention;

FIG. 9 is a detailed flowchart of a urine detection method according to a fourth embodiment of the present invention;

FIG. 10 is a schematic view of a toilet according to a fifth embodiment of the present invention;

FIG. 11 is a schematic view of a urine analysis device in a toilet bowl according to a fifth embodiment of the present invention.

Detailed Description

The embodiments of the present invention will be described in detail below with reference to the accompanying drawings in order to more clearly understand the objects, features and advantages of the present invention. It should be understood that the embodiments shown in the drawings are not intended to limit the scope of the present invention, but are merely intended to illustrate the spirit of the technical solution of the present invention.

In the following description, for the purposes of illustrating various disclosed embodiments, certain specific details are set forth in order to provide a thorough understanding of the various disclosed embodiments. One skilled in the relevant art will recognize, however, that the embodiments may be practiced without one or more of the specific details. In other instances, well-known devices, structures and techniques associated with this application may not be shown or described in detail to avoid unnecessarily obscuring the description of the embodiments.

Throughout the specification and claims, the word "comprise" and variations thereof, such as "comprises" and "comprising," are to be understood as an open, inclusive meaning, i.e., as being interpreted to mean "including, but not limited to," unless the context requires otherwise.

Reference throughout this specification to "one embodiment" or "an embodiment" means that a particular feature, structure, or characteristic described in connection with the embodiment is included in at least one embodiment. Thus, the appearances of the phrases "in one embodiment" or "in an embodiment" in various places throughout this specification are not necessarily all referring to the same embodiment. Furthermore, the particular features, structures, or characteristics may be combined in any suitable manner in one or more embodiments.

As used in this specification and the appended claims, the singular forms "a", "an", and "the" include plural referents unless the context clearly dictates otherwise. It should be noted that the term "or" is generally employed in its sense including "and/or" unless the context clearly dictates otherwise.

In the following description, for the purposes of clearly illustrating the structure and operation of the present invention, directional terms will be used, but terms such as "front", "rear", "left", "right", "outer", "inner", "outer", "inward", "upper", "lower", etc. should be construed as words of convenience and should not be construed as limiting terms.

The first embodiment of the present invention relates to a microfluidic chip for optically detecting urine, as shown in fig. 1, the microfluidic chip may be disposed in a urine analysis device 10, the urine analysis device 10 is assembled in a toilet bowl 20, for example, the urine analysis device 10 is fixed on the inner wall of the toilet bowl 20 by means of adhesion, an opening 11 is formed on a housing of the urine analysis device 10, so that the urine analysis device 10 can collect urine of a user through the opening 11 and input the urine into the microfluidic chip each time the user uses the toilet bowl, and the microfluidic chip optically detects the urine.

The micro-fluidic chip comprises a chip main body, an optical detection module and a plurality of electromagnetic valves, wherein the optical detection module is fixed on the chip main body.

The reaction cavity and the reagent channels are formed in the chip main body, the reagent channels are connected to the reaction cavity, a plurality of reagent holes are formed in the chip main body, the reaction cavity is further connected with a urine channel, the urine channel forms a urine hole in the chip main body, each reagent hole is used for installing a reagent bag, valve holes which correspond to the reagent holes in a one-to-one mode are further formed in the chip main body, and the electromagnetic valves are respectively installed at the valve holes in the chip main body.

The electromagnetic valve is used for controlling the reagent hole corresponding to the valve hole to be opened when the received detection instruction is received, so that the detection reagent in the reagent capsule arranged on the opened reagent hole flows into the reaction cavity through the corresponding reagent channel.

The reaction cavity is used for allowing urine flowing into the microfluidic chip through the urine channel to react with the detection reagent in the reagent bag; the optical detection module is used for carrying out optical detection on the mixed liquid obtained after the reaction of the urine in the reaction cavity and the detection reagent so as to obtain detection data.

The following is a detailed description of the microfluidic chip in fig. 2 to 4 and the urine analysis device in fig. 5 and 6.

The chip main body comprises an upper plate 101 and a lower plate 102 which are fixed with each other, a reaction cavity 103, a urine channel 104 and a reagent channel 105 are formed between the upper plate 101 and the lower plate 102, reagent holes 106 and urine holes 107 are formed on the upper surface of the upper plate 101, a reagent capsule 3 is installed in each reagent hole 106, a valve hole 121 forms the lower surface of the lower plate 102, each electromagnetic valve 4 of the microfluidic chip is respectively installed on each valve hole 121, and each electromagnetic valve 4 is used for controlling the opening or closing of the corresponding reagent hole 106; in addition, the lower surface of the lower plate 102 is provided with a valve hole 121 corresponding to the urine hole 107, and the valve hole 121 is also provided with an electromagnetic valve 4, and the electromagnetic valve 4 is used for controlling the opening or closing of the urine hole 107. Wherein, a channel fence 1012 is arranged between the upper plate 101 and the lower plate 102, and the channel fence 1012 forms a plurality of channels for liquid in the chip body; the urine channel 104 and the reagent channel 105 are partially routed within a common chip body.

The optical detection module includes: a light source 21 and a chromatographic sensor 22. The light source 21 is fixed to the upper plate 101 at a position corresponding to the reaction chamber 103, and the color spectrum sensor 22 is fixed to the lower plate 102 at a position corresponding to the reaction chamber 103. The light source 21 may be a laser, a light emitting diode, a halogen tungsten lamp, or the like. The chromatographic sensor 22 includes a photodetector and a wavelength selector, the photodetector being capable of converting an optical signal into an electrical signal, such as a photomultiplier tube, a photodiode, a CMOS sensor, or the like; the wavelength selector is used to select a set wavelength of the incident light, and the wavelength selector is, for example, a grating, a triangular prism, a filter, or the like.

When the mixed liquid in the reaction chamber 103 is optically detected, the light source 21 emits a test light toward the reaction chamber 103, and the test light irradiates the chromatographic sensor 22 after passing through the mixed liquid in the reaction chamber 103.

In one example, the reaction chamber 103 has a plurality of light-transmitting upper detection points 1031 formed on the upper plate 101, and the reaction chamber 103 has a plurality of light-transmitting lower detection points 1032 formed on the lower plate 102, wherein the upper detection points 1031 correspond to the lower detection points 1032 one by one. As shown in fig. 3 and 4, the number of the upper detection points 1031 and the lower detection points 1032 is three as an example. The test light emitted from the light source 21 toward the reaction chamber 103 passes through the upper detection point 1031, the mixed liquid in the reaction chamber 103 and the lower detection point 1032 to irradiate the chromatographic sensor 22.

In this embodiment, the microfluidic chip further includes a control circuit board 5, and the control circuit board 5 is fixed to the lower plate 102, which may be fixed by screws. Each solenoid valve 4 of the microfluidic chip is mounted on the control circuit board 5, the processor 6 of the urine analysis device is mounted on the main circuit board 6, and the control circuit board 5 is fixed and electrically connected with the main circuit board 7, so that the processor 6 can control the opening or closing of each solenoid valve 4. It should be noted that the control circuit board 5 and the main circuit board 7 in this embodiment further include a plurality of components such as peripheral circuits and interfaces, which are not described in detail herein. In addition, the urine analysis device further includes a housing including an upper housing 81 and a lower housing 82, and the opening 11 is formed on the upper housing 81.

When a user uses the toilet, when the urine of the user flows into the urine analysis device through the opening 11 on the upper shell 81 of the urine analysis device, the processor 6 inputs the urine into the microfluidic chip for multiple times based on items to be detected, and when each item of the urine is detected, the corresponding reagent hole 106 is opened by controlling the electromagnetic valve 4 to be opened, so that the detection reagent in the reagent bag 3 mounted on the opened reagent hole 106 flows into the reaction cavity 103 of the microfluidic chip, and the urine flowing into the reaction cavity 103 can chemically react with the detection reagent.

Specifically, when the user uses the toilet, urine flows in through the opening 11 of the urine analysis device, and the processor 6 in the urine molecular device is connected to the optical detection module of the microfluidic chip; the processor 6 can control urine to flow into the reaction cavity 103 of the microfluidic chip, and at the same time, the processor 6 can open the reagent hole 106 by controlling the electromagnetic valve 4 to control the detection reagent in the reagent bag 3 to flow into the reaction cavity 103 of the microfluidic chip, the urine flowing into the reaction cavity 103 of the microfluidic chip and the detection reagent are chemically reacted, the processor 6 sends a detection instruction to the optical detection module of the microfluidic chip, after the optical detection module receives the detection instruction, the light source 21 in the optical detection module sends a test light (generally, a diffused light) with a preset wavelength towards the reaction cavity 103, the test light is emitted into the reaction cavity 103 through each upper detection point and is reflected in the mixed liquid in the reaction cavity 103, and the light after reflection is emitted onto the spectrum sensor 22 through the lower detection point 1032, the wavelength selection in the spectrum sensor 22 firstly selects light with a set wavelength from incident light, and then converts the light with the set wavelength into an electrical signal, wherein the electrical signal is detection data, and the spectrum sensor 22 sends the detection data to the processor 6 after generating the detection data; in a urine analysis, need carry out the multinomial detection to the urine, be equipped with multiple detect reagent in the a plurality of reagent sacs 3 of installation on the micro-fluidic chip this moment, multiple detect reagent reacts with the urine in reaction chamber 103 respectively, and optical detection module also can carry out a plurality of optical detection respectively to the urine and obtain a plurality of detected data to processor 6 can be based on these a plurality of detected data generation urine analysis results and supply the user to look over.

Compared with the prior art, the embodiment provides a microfluidic chip with an optical detection function, the microfluidic chip comprises a chip main body, an optical detection module fixed on the chip main body, and a plurality of electromagnetic valves, wherein a reaction cavity and a plurality of reagent channels connected to the reaction cavity are formed in the chip main body, the plurality of reagent channels form a plurality of corresponding reagent holes on the chip main body, the reaction cavity is further connected with a urine channel, the urine channel forms a urine hole on the chip main body, and each reagent hole is used for installing a reagent capsule; the solenoid valve is when received detection instruction, control the reagent hole that the valve hole corresponds is opened, make and install open detect reagent in the reagent bag on the reagent hole flows into the reaction cavity through the reagent passageway that corresponds, after having urine to flow into the reaction cavity through the detect reagent in urine passageway and the reagent bag and carry out chemical reaction, optical detection module can carry out optical detection to the mixed liquid after urine and detect reagent react in the reaction cavity, obtain the testing data, this micro-fluidic chip can carry out at least one item optical detection to user's urine promptly, thereby can be at daily urine to user's analysis, so that the user looks over the analytical data of urine, know self health status.

The second embodiment of the present invention relates to a microfluidic chip, and compared with the first embodiment, the present embodiment mainly differs from the first embodiment in that: referring to fig. 7, each of the solenoid valves 4 includes: an armature 41, a resilient means 42, a housing 43, an electromagnetic coil 44 and a magnetic core 45. Wherein the elastic device 42 may be a spring or other elastic device.

A closed outer shell 122 is arranged at each valve hole 121 of the lower plate 102, the elastic device 42 and the armature 41 are both arranged in the outer shell 122, the armature 41 is arranged on the elastic device 42, the shell 43 is fixed on the control circuit board 5, the shell 43 is a hollow cylinder, the electromagnetic coil 44 is fixed on the inner surface of the hollow cylinder, and the magnetic core 45 is positioned inside the hollow cylinder and fixed on the control circuit board 5; when the control circuit board 5 is fixed to the lower plate 102, the housing 122 is located in the electromagnetic coil 44 and contacts the magnetic core 45.

When the electromagnetic valve 4 is in an open state, the armature 41 moves towards the magnetic core 45, the elastic device 42 is compressed by the armature 41, the electromagnetic valve 4 is opened corresponding to the reagent hole 106, and the detection reagent in the reagent capsule 3 mounted on the reagent hole 106 flows into the reaction cavity 103 through the corresponding reagent passage.

When the electromagnetic valve 4 is in a closed state, the elastic device 42 is in an initial state, and the armature 41 closes the reagent hole 106 corresponding to the electromagnetic valve 4.

When the processor 6 needs to control the flow of the test reagent in a certain reagent capsule 3 into the reaction chamber 103, the corresponding solenoid valve 4 may be energized, the coil in the solenoid valve 4 generates a magnetic field, the magnetic core 45 attracts the armature 41 to move towards the armature, the elastic device 42 is compressed by the armature 41 from the initial state, so that the reagent hole 106 closed by the armature 41 is opened, and the test reagent in the reagent capsule 3 installed in the reagent hole 106 flows into the reaction chamber 103. Subsequently, when the processor 6 controls the solenoid valve 4 to be de-energized, the magnetic core 45 no longer exerts an attractive force on the armature 41, and the elastic device 42 returns to the initial state, in which the armature 41 closes the corresponding reagent hole 106 under the elastic force of the elastic device 42. It should be noted that the opening and closing manner of the urine hole 107 is similar to that described above, and the description thereof is omitted.

A third embodiment of the present invention relates to a microfluidic chip, and compared with the first embodiment, the present embodiment mainly differs from the first embodiment in that: referring to FIG. 8, a cleaning inlet channel and a cleaning outlet channel connected to the reaction chamber 103 are formed in the chip body, respectively, the cleaning inlet channel forms a cleaning inlet 108 on the upper surface of the upper plate 101 of the chip body, and the cleaning outlet channel forms a cleaning outlet 109 on the upper surface of the upper plate 101 of the chip body.

The cleaning inlet channel is used for cleaning the reaction chamber 103 by the cleaning liquid flowing in from the cleaning inlet 108.

The cleaning outlet channel 109 is used for allowing the cleaning liquid in the reaction chamber 103 to flow out from the cleaning outlet 109.

In one example, an air passage connected to the reaction chamber is further formed in the chip body, and the air passage forms an air inlet 110 on the upper surface of the upper plate 101 of the chip body.

The air passage 112 is used for supplying air from the air inlet 110 into the reaction chamber 103 to discharge the liquid in the reaction chamber 103 after the reaction chamber 103 is cleaned.

In one example, the chip body of the microfluidic chip further has a cleaning solution connecting channel and a waste liquid channel formed therein, the cleaning solution connecting channel forms a cleaning solution interface 111 on the upper surface of the upper plate 101 of the chip body, and the waste liquid channel forms a waste liquid outlet 112 on the upper surface of the upper plate 101 of the chip body. In addition, the chip main body of the microfluidic chip is formed with a gas permeation channel, and the gas permeation channel 118 is formed with a gas permeation opening 113 on the upper surface of the upper plate 101 of the chip main body.

The urine analysis device applied to the microfluidic chip shown in fig. 5 and 6 will be described in detail below.

In this embodiment, the cleaning inlet 108 and the cleaning outlet are connected to a cleaning pump (e.g. a diaphragm pump) in the urine analyzer, the cleaning solution interface 111 is connected to a cleaning solution storage for storing cleaning solution in the urine analyzer, the waste liquid outlet 112 is connected to one end of a peristaltic pump in the urine analyzer, and the other end of the peristaltic pump is connected to a waste liquid storage in the urine analyzer.

The reagent hole 106, the urine hole 107, the waste liquid outlet 112, the cleaning liquid connection port 111, the cleaning inlet 108, the cleaning outlet 109, the air inlet 110 and the ventilation port 113 on the microfluidic chip are controlled to be opened or closed by corresponding electromagnetic valves 4, each electromagnetic valve 4 is respectively installed on each valve hole 121 on the lower plate 102, and the electromagnetic valves 4 are used for controlling the opening or closing of each opening or hole on the upper plate 101.

When no urine enters the urine analysis device, the electromagnetic valves 4 corresponding to the air vents 113 on the microfluidic chip are in an open state, and other electromagnetic valves 4 are in a closed state, when urine enters a urine storage device in the urine analysis device through the opening 11 on the shell, the processor 6 controls the electromagnetic valves 4 corresponding to the air vents 113 to be closed, controls the electromagnetic valves 4 corresponding to the urine holes 107 to be opened, controls the peristaltic pump to pump the urine with a first preset proportion from the urine storage device to the reaction cavity 103, then closes the electromagnetic valves 4 corresponding to the urine holes 107, controls the electromagnetic valves 4 corresponding to the reagent bags 3 of the current detection item to be opened, controls the peristaltic pump to pump the detection reagent with a second preset proportion from the reagent bags 3 to the reaction cavity 103, and then closes the electromagnetic valves 4 corresponding to the reagent bags 3; at the moment, the detection reagent reacts with urine in the reaction cavity 103, the processor 6 controls an optical detection module in the microfluidic chip to perform optical detection on the mixed liquid obtained after the urine in the reaction cavity 103 reacts with the detection reagent, the optical detection module sends detection data obtained by the optical detection to the processor 6, the processor 6 judges that the current detection item is finished, and controls a peristaltic pump to pump the mixed liquid obtained after the reaction out of the reaction cavity 103 to a waste liquid storage; then, the electromagnetic valve 4 of the cleaning liquid connecting port 111 and the cleaning inlet 108 is controlled to be opened, the cleaning pump is controlled to pump out the cleaning liquid from the cleaning liquid storage to clean the reaction cavity 103 of the microfluidic chip, and then the electromagnetic valve 4 of the cleaning liquid connecting port 111 and the cleaning inlet 108 is closed; then the electromagnetic valve 4 of the cleaning outlet 109 is opened to control the cleaning pump to pump out the cleaning liquid in the reaction chamber 103, then the electromagnetic valve 4 of the cleaning outlet 109 is closed, then the electromagnetic valve 4 corresponding to the air inlet 27 is opened, air is pumped by the cleaning pump to discharge and blow dry the liquid in the reaction chamber 103, and then the electromagnetic valve 4 corresponding to the air inlet 27 is closed. Then the processor 6 detects the next detection item, controls the electromagnetic valve 4 corresponding to the urine hole 107 to open, controls the peristaltic pump to pump the urine with the first preset proportion from the urine storage device to the reaction cavity 103, closes the electromagnetic valve 4 corresponding to the urine hole 107, then controlling the electromagnetic valve 4 corresponding to the reagent capsule 3 of the next detection item to open, controlling the peristaltic pump to pump the detection reagent with a second preset proportion from the reagent capsule 3 to the reaction cavity 103, then closing the electromagnetic valve 4 corresponding to the reagent capsule 3, repeating the above processes to complete the optical detection, after completing the detection item each time, the reaction cavity 103 is cleaned, and then the next detection item is detected until all detection items are completed, the detection data of a plurality of detection items in the current urine detection is summarized in the processor 6, and then the urine analysis data of the current urine detection is obtained based on the plurality of detection data.

In this embodiment, the types of the detection reagents in the reagent bags correspond to the second preset ratios one by one, that is, based on different detection items, the amounts of the detection reagents required each time are different, so that the processor 6 controls the peristaltic pumps to pump the reagents from different reagent bags 3 into the reaction cavity 103 in different ratios, so as to prevent the amounts of the detection reagents from affecting the detection data of the optical detection, and to ensure the accuracy of the urine analysis to a certain extent.

The fourth embodiment of the present invention relates to a urine detection method applied to the microfluidic chip described in any one of the first to third embodiments.

Please refer to fig. 9, which is a flowchart illustrating a urine detection method according to the present embodiment.

Step 101, when a detection instruction is received, controlling a corresponding reagent hole to be opened through an electromagnetic valve in a microfluidic chip, enabling a detection reagent in a reagent bag arranged on the opened reagent hole to flow into a reaction cavity through a corresponding reagent channel, enabling urine to flow into the reaction cavity through a urine channel, and enabling the reagent flowing into the reaction cavity to react with the urine.

And 102, carrying out optical detection on the mixed liquid obtained after the reaction of the urine in the reaction cavity and the detection reagent by using an optical detection module to obtain detection data.

Specifically, a light source in the optical detection module is used for emitting test light towards the reaction cavity, and the test light irradiates the chromatographic sensor after passing through the mixed liquid in the reaction cavity to obtain detection data.

Referring to fig. 1 to 6, when the user uses the toilet, urine flows in through the opening 11 of the urine analysis device, and the processor 6 in the urine molecular device is connected to the optical detection module of the microfluidic chip; the processor 6 can control urine to flow into the reaction cavity 103 of the microfluidic chip, at the same time, the processor 6 can open the reagent hole 106 by controlling the electromagnetic valve 4 to control the detection reagent in the reagent bag 3 to flow into the reaction cavity 103 of the microfluidic chip, the urine flowing into the reaction cavity 103 of the microfluidic chip and the detection reagent are chemically reacted, the processor 6 sends a detection instruction to the optical detection module of the microfluidic chip, after the optical detection module receives the detection instruction, the light source 21 in the optical detection module sends a test light (generally, a diffused light) with a preset wavelength towards the reaction cavity 103, the test light is emitted into the reaction cavity 103 through each upper detection point and is reflected in the mixed liquid in the reaction cavity 103, the light after being reflected is emitted onto the spectrum sensor 22 through the lower detection point 1032, the wavelength in the spectrum sensor 22 is selected to first select a light with a set wavelength from the incident light, then, the light with the set wavelength is converted into an electric signal, the electric signal is detection data, and the spectral sensor 22 sends the detection data to the processor 6 after generating the detection data; in a urine analysis, need carry out the multinomial detection to the urine, be equipped with multiple detect reagent in the a plurality of reagent sacs 3 of installation on the micro-fluidic chip this moment, multiple detect reagent reacts with the urine in reaction chamber 103 respectively, and optical detection module also can carry out a plurality of optical detection respectively to the urine and obtain a plurality of detected data to processor 6 can be based on these a plurality of detected data generation urine analysis results and supply the user to look over.

Compared with the prior art, the embodiment provides a urine detection method based on a microfluidic chip with an optical detection function, wherein an electromagnetic valve controls a reagent hole corresponding to a valve hole to be opened when receiving a detection instruction, allowing the detection reagent in the reagent capsule mounted on the opened reagent hole to flow into the reaction chamber through the corresponding reagent channel, after urine flows into the reaction cavity through the urine channel and the detection reagent in the reagent bag for chemical reaction, the optical detection module can perform optical detection on the mixed liquid obtained after the reaction of the urine in the reaction cavity and the detection reagent to obtain detection data, the microfluidic chip can perform at least one optical detection on the urine of the user, so that the urine of the user can be analyzed daily, the user can check the analysis data of the urine, and the health condition of the user can be known.

A fifth embodiment of the present invention relates to a urine analysis device for detecting urine of a user, and as shown in fig. 1, the urine analysis device 10 is assembled in a toilet bowl 20, for example, the urine analysis device 10 is fixed on the inner wall of the toilet bowl 20 by means of adhesion, so that the urine of the user can be collected and detected each time the user uses the toilet bowl.

Referring to fig. 5 and 6, the urine analysis device includes the microfluidic chip of the first embodiment or the second embodiment, a plurality of reagent capsules 3 and a processor 6. In addition, the urine analysis device further includes a housing including an upper housing 81 and a lower housing 82, and the opening 11 is formed on the upper housing 81.

The processor 6 is used for controlling the detection reagent in the reagent capsule 3 to flow into the reaction cavity 103 through the corresponding reagent channel when urine flows in, and controlling the urine to flow into the reaction cavity 103 through the urine channel, wherein the detection reagent flowing into the reaction cavity 103 reacts with the urine.

The processor 6 is further configured to perform optical detection on the mixed liquid obtained after the reaction between the urine in the reaction cavity 103 and the detection reagent by using an optical detection module, so as to obtain detection data.

The processor 6 is also used for receiving a plurality of detection data returned by the microfluidic chip to obtain urine analysis data.

In one example, a wireless communication module (not shown in the figure, the wireless communication module may be mounted on the circuit board 7), such as WIFI, 4G, 5G, etc., is further provided in the urine analysis device, so that the processor 6 can be wirelessly connected to the cloud server, and transmit the urine analysis data obtained by each urine detection to the cloud server, and the cloud server monitors the urine analysis data of the user for a long period, such as 7 days, 15 days, 30 days, etc. In addition, the user can also connect the electronic equipment such as a mobile phone and a computer with the urine analysis device, so that the processor 6 can also send the urine analysis data to the electronic equipment of the user, so that the user can check the urine analysis data of the user in real time, and check the physical condition of the user through the urine analysis data.

In this embodiment, the plurality of reagent bags 4 may contain different types of detection reagents, and the types of the detection reagents may be set according to the detection item types of urine, for example, the detection reagents used for urinary creatinine detection are creatinine color development solution and creatinine analysis buffer solution; the detection reagent adopted for detecting the urine protein is a sulfosalicylic acid solution; the detection reagent adopted for detecting the alkalinity of uric acid is bromothymol blue liquid; the detection reagent adopted for detecting the urine ketone body is ferric trichloride with the concentration of 10 percent; the detection reagents adopted for vitamin C detection are an acidic buffer solution, a phenanthroline color developing solution and a VC analysis buffer solution; the detection reagent adopted for detecting the nitrite in the urine is Grice solution; it should be noted that, only some of the test items and the required test reagents are listed above, and the test items may be added or reduced as required, such as increasing the detection of urine albumin and urine hemoglobin, etc.

It should be noted that the urine analysis device in this embodiment may further include a battery holder (not shown in the figure), the battery holder is connected to the circuit board 202, and when a battery is installed in the battery holder, the battery can supply power to the processor 6 in the urine analysis device, the optical detection module 204 in the microfluidic chip, the valve 201, and the like. In addition, the urine analysis device in this embodiment may further include remaining amount sensors for detecting the remaining amount of the detection reagent in each reagent capsule 4, and each remaining amount sensor is connected to the processor 6, so that the processor 6 can issue a prompt in time when the remaining amount of the detection reagent in any reagent capsule 4 is insufficient, and the prompt manner is, for example: and sending prompt information to the electronic equipment of the connected user through the cloud server or directly.

In one example, referring to fig. 10, the urine analysis device further includes: a power supply receiving module 901 and a power supply 902, wherein the power supply receiving module 901 is connected to the processor 6 and the microfluidic chip respectively.

The urine analysis device 10 is assembled on the inner wall of the toilet bowl 20, and the power supply receiving module 901 is fixed in a preset area inside the casing, that is, the power supply receiving module 901 is assembled in a preset area on the lower casing 31 of the casing, and the preset area is located in an area on the lower casing 82 of the casing close to the inner wall of the toilet bowl 20; the power receiving module 901 is mounted on an outer wall of the toilet bowl 20, and the power source 902 corresponds to a position of the power receiving module 901. Wherein the power supply 902 can be fixed to the toilet bowl 20 by adhesion.

The power supply 902 is used for supplying power to the power receiving module 901.

The power supply receiving module 901 is used for respectively supplying power to the processor 6 and the microfluidic chip by using the received electric energy.

Referring to fig. 11, in this embodiment, the power supply module 901 may use electromagnetic induction to perform wireless power supply, the power supply receiving module 901 includes a charging chip 9011 and a wireless receiving coil 9012, the charging chip 9011 is disposed on the circuit board 7, the wireless receiving coil 9012 is fixed on the housing 82 and is located inside the urine analysis device, the wireless receiving coil 9012 is connected to the circuit board 7 of the urine analysis device 10, the wireless receiving coil 9012 is connected to the charging chip 9011 through a wire on the circuit board 7, a wireless transmitting coil and a battery pack (not shown) are arranged in the power supply 102, the battery pack is connected to the wireless transmitting coil, the wireless transmitting coil converts the electric energy of the battery pack into a magnetic field, the wireless receiving coil 9012 induces an alternating current due to the existence of the alternating magnetic field, then, the wireless charging chip 9011 on the circuit board 7 converts the alternating current into direct current to respectively supply power to the processor 6 and the microfluidic chip.

It should be noted that fig. 11 only schematically illustrates the positions of the charging chip 9011 and the wireless receiving coil 9012, but is not limited to this, a power supply circuit board for fixing the charging chip 9011 may be additionally provided, the wireless receiving coil 9012 is fixed on the housing 82 and is located inside the urine analysis device, and the wire receiving coil 1012 is connected to the charging chip 9011 through the power supply circuit board.

In this embodiment, the power supply 902 utilizes the power receiving module 901 to perform wireless power supply for the urine analysis device 10, so that the user can keep the power supply of the urine analysis device 10 by charging the power supply 902, which is more convenient and faster and is convenient for the user to operate. The battery pack in the power supply 902 can be a rechargeable battery pack, a charging interface is arranged on the power supply 902 at the moment, the power supply 902 can be connected to an external power supply through a charging wire, and the rechargeable battery pack is charged by the external power supply.

In this embodiment, the types of the detection reagents in the plurality of reagent bags correspond to the plurality of second preset ratios one by one, that is, based on different detection items, the amounts of the detection reagents required each time are different, so that the processor 6 controls the peristaltic pumps to pump the reagents from different reagent bags into the reaction cavity in different ratios, so as to prevent the amounts of the detection reagents from affecting detection data of optical detection, and to ensure accuracy of urine analysis to a certain extent.

In one example, a temperature sensor (not shown) is further provided in the urine analysis device, the temperature sensor is provided at the opening 11 or in the housing near the opening 11 and is connected to the circuit board 7, so that the processor 6 is electrically connected to the temperature sensor through the circuit board 7, and when the toilet bowl 20 is not used by a user, the temperature detected by the temperature sensor is an indoor temperature and the indoor temperature value is transmitted to the processor 6; when a user uses the toilet 20, when urine flows into the urine analysis device from the opening 11, the temperature sensor detects a urine temperature value of the user, the detected urine temperature value is sent to the processor 6, the urine temperature value is larger than the indoor temperature, the processor 6 judges that the detected temperature value is increased, the difference value obtained by subtracting the indoor temperature value from the urine temperature value is larger than or equal to a preset first temperature threshold value, the judgment that the urine flows into the urine analysis device is detected, the processor 6 controls the urine analysis device to enter a detection state, and the microfluidic chip is awakened to perform urine detection. The first temperature threshold is, for example, 2 degrees, 5 degrees, 10 degrees, or the like.

In an example, the processor 6 is further configured to, after receiving a plurality of detection data returned by the microfluidic chip and obtaining urine analysis data, control the urine analysis device to enter a standby state if the temperature value sent by the temperature sensor is decreased and the temperature decrease value is greater than or equal to a preset second temperature threshold value. Specifically, when this urine detection is completed, if the user flushes water at this time, the temperature value of water detected by the temperature sensor is sent to the processor 6, the temperature value sent by the temperature sensor received by the processor 6 is smaller than the urine temperature value, it is determined that the temperature is reduced and the temperature reduction value is greater than or equal to the preset second temperature threshold value, it is indicated that the user has finished using the toilet, and the urine analysis device is controlled again to enter the standby state, so that the power consumption of the urine analysis device can be reduced. The second temperature threshold is, for example, 2 degrees, 5 degrees, 10 degrees, or the like.

In one example, the processor 6 is further configured to adjust the first temperature threshold and the second temperature threshold according to a currently detected temperature value when the received temperature value sent by the temperature sensor is kept unchanged for a preset time. Specifically, when the user does not use the toilet for a long time, the temperature detected by the temperature sensor is the indoor temperature at the moment, and since the indoor temperature changes along with seasons and the temperature of the urine of the human body is maintained to be constant, the first temperature threshold and the second temperature threshold can be adjusted in real time according to the indoor temperature value, for example, in summer, the indoor temperature is high, the temperature difference between the indoor temperature and the urine temperature is reduced, and the first temperature threshold and the second temperature threshold can be appropriately reduced; in winter, the indoor temperature is low, the temperature difference between the indoor temperature and the urine temperature is increased, and the first temperature threshold and the second temperature threshold can be properly increased.

The urine analysis device in this embodiment can obtain the correlation data of the metabolism condition of user and the daily behavior state of user based on the urine analysis data of user that continuous, long-term collection. For example, the behavior states of the eating habits (including meals, nutrition, vitamins, smoking and drinking, and the like), disease states, work and rest rules, exercise habits, sleep states, medicine taking conditions, and the like of the user can be displayed in the urine of the user, after some behavior states of the user are changed, the urine of the user is correspondingly influenced, the urine analysis device can also check the change of the urine, and then the urine analysis device can analyze and obtain the correlation between the metabolism condition of the user and the behavior state of the user based on long-term and continuous urine analysis data.

Since the first to fourth embodiments correspond to the present embodiment, the present embodiment can be implemented in cooperation with the first to fourth embodiments. The related technical details mentioned in the first to fourth embodiments are still valid in this embodiment, and the technical effects that can be achieved in the first to fourth embodiments can also be achieved in this embodiment, and are not described herein again in order to reduce repetition. Accordingly, the related-art details mentioned in the present embodiment can also be applied to the first to fourth embodiments.

A fifth embodiment of the present invention is directed to a toilet including the urine analysis device of the fourth embodiment. Referring to fig. 1, the urine analysis device 10 is assembled in a toilet bowl 20, for example, the urine analysis device 10 is fixed on the inner wall of the toilet bowl 20 by bonding, so that the urine of the user can be collected and detected each time the user uses the toilet bowl.

Since the first to fifth embodiments correspond to the present embodiment, the present embodiment can be implemented in cooperation with the first to fifth embodiments. The related technical details mentioned in the first to fifth embodiments are still valid in this embodiment, and the technical effects that can be achieved in the first to fifth embodiments can also be achieved in this embodiment, and are not described herein again in order to reduce repetition.

While the preferred embodiments of the present invention have been described in detail above, it should be understood that aspects of the embodiments can be modified, if necessary, to employ aspects, features and concepts of the various patents, applications and publications to provide yet further embodiments.

These and other changes can be made to the embodiments in light of the above detailed description. In general, in the claims, the terms used should not be construed to be limited to the specific embodiments disclosed in the specification and the claims, but should be construed to include all possible embodiments along with the full scope of equivalents to which such claims are entitled.

Claims

1. A microfluidic chip, comprising: the chip comprises a chip main body, an optical detection module and a plurality of electromagnetic valves, wherein the optical detection module is fixed on the chip main body;

a reaction cavity and a plurality of reagent channels connected to the reaction cavity are formed in the chip main body, the plurality of reagent channels form a plurality of reagent holes on the chip main body, the reaction cavity is also connected with a urine channel, the urine channel forms a urine hole on the chip main body, each reagent hole is used for installing a reagent bag, valve holes corresponding to the reagent holes one by one are also formed on the chip main body, and each electromagnetic valve is respectively installed at each valve hole on the chip main body;

the electromagnetic valve is used for controlling the reagent hole corresponding to the valve hole to be opened when the detection instruction is received, so that the detection reagent in the reagent capsule arranged on the opened reagent hole flows into the reaction cavity through the corresponding reagent channel;

the reaction cavity is used for allowing urine flowing into the microfluidic chip through the urine channel to react with the detection reagent in the reagent bag;

the optical detection module is used for carrying out optical detection on the mixed liquid obtained after the reaction of the urine in the reaction cavity and the detection reagent so as to obtain detection data.

2. The microfluidic chip according to claim 1, wherein the chip body comprises an upper plate and a lower plate fixed to each other, the reaction chamber, the urine channel, and the reagent channel are formed between the upper plate and the lower plate, the reagent well and the urine well are formed on an upper surface of the upper plate, and the valve well is formed on a lower surface of the lower plate.

3. The microfluidic chip according to claim 2, further comprising: a control circuit board; the control circuit board is fixed with the lower plate;

each of the solenoid valves includes: the magnetic circuit comprises an armature, an elastic device, a shell, an electromagnetic coil and a magnetic core;

a closed shell is arranged at each valve hole of the lower plate, the elastic device and the armature are arranged in the shell, the armature is arranged on the elastic device, the shell is fixed on the control circuit board and is a hollow cylinder, the electromagnetic coil is fixed on the inner surface of the hollow cylinder, and the magnetic core is positioned in the hollow cylinder and fixed on the control circuit board; the housing is located in the electromagnetic coil and in contact with the magnetic core when the control circuit board is fixed to the lower plate;

when the electromagnetic valve is in an open state, the armature moves towards the magnetic core, the elastic device is compressed by the armature, the electromagnetic valve is opened corresponding to a reagent hole, and a detection reagent in a reagent capsule arranged on the reagent hole flows into the reaction cavity through a corresponding reagent channel;

when the electromagnetic valve is in a closed state, the elastic device is in an initial state, and the armature closes the reagent hole corresponding to the electromagnetic valve.

4. The microfluidic chip according to claim 2, wherein the optical detection module comprises: a light source and a chromatographic sensor; the light source is fixed on the upper plate at a position corresponding to the reaction cavity, and the chromatographic sensor is fixed on the lower plate at a position corresponding to the reaction cavity;

when the mixed liquid in the reaction cavity is subjected to optical detection, the light source emits test light towards the reaction cavity, and the test light irradiates the chromatographic sensor after passing through the mixed liquid in the reaction cavity.

5. The microfluidic chip according to claim 4, wherein the reaction chamber has a plurality of light-transmissive upper detection points formed on the upper plate, and a plurality of light-transmissive lower detection points formed on the lower plate, the upper detection points corresponding to the lower detection points one-to-one;

and the test light emitted by the light source towards the reaction cavity irradiates the chromatographic sensor through the upper detection point, the mixed liquid in the reaction cavity and the lower detection point.

6. The microfluidic chip according to claim 1, wherein the chip body further has a cleaning inlet channel and a cleaning outlet channel formed therein, respectively, the cleaning inlet channel forming a cleaning inlet on the chip body and the cleaning outlet channel forming a cleaning outlet on the chip body;

the cleaning inlet channel is used for cleaning the reaction cavity by the cleaning liquid flowing in from the cleaning inlet;

and the cleaning outlet channel is used for allowing the cleaning liquid in the reaction cavity to flow out from the cleaning outlet.

7. The microfluidic chip according to claim 6, wherein the chip body further has an air channel formed therein and connected to the reaction chamber;

the air channel is used for allowing air to enter the reaction cavity from the air inlet after the reaction cavity is cleaned so as to discharge liquid in the reaction cavity.

8. The microfluidic chip according to claim 1, wherein the plurality of reagent wells share one of the reagent channels.

9. A urine analysis device, comprising the microfluidic chip according to any one of claims 1 to 8, a plurality of reagent capsules respectively mounted on the reagent wells of the microfluidic chip, and a processor connected to the optical detection module and the electromagnetic valve in the microfluidic chip;

the processor is used for controlling the opening of the corresponding reagent hole through the electromagnetic valve in the microfluidic chip when urine flows, the detection reagent in the reagent bag arranged on the reagent hole flows into the reaction cavity through the corresponding reagent channel, and the urine is controlled to flow into the reaction cavity through the urine channel, and the detection reagent flowing into the reaction cavity reacts with the urine;

the processor is also used for carrying out optical detection on the mixed liquid obtained after the reaction of the urine in the reaction cavity and the detection reagent by using the optical detection module to obtain detection data.

10. A toilet comprising the urine analysis device of claim 9 mounted on an interior wall of the toilet.