CN215996235U

CN215996235U - A purification equipment for exenatide production

Info

Publication number: CN215996235U
Application number: CN202023268572.8U
Authority: CN
Inventors: 钱海; 邱倩倩
Original assignee: Nanjing Novin Haitai Biomedical Co ltd
Current assignee: Nanjing Novin Haitai Biomedical Co ltd
Priority date: 2020-12-30
Filing date: 2020-12-30
Publication date: 2022-03-11
Anticipated expiration: 2030-12-30

Abstract

The utility model discloses a purification device for exenatide production, which comprises an upper tank and a lower tank, wherein a first channel is connected between the upper tank and the lower tank, a filter material is installed in the first channel, a detachable installation door is arranged on the side wall of the first channel, and a first valve is arranged on the first channel. The utility model integrates stirring re-dissolving, filtering and purifying and solution storing, reduces the quantity of the existing equipment and reduces the occupied area; a conveying pump is not needed when the solution is filtered and stored, so that the production cost is reduced; the filter media is dismantled and is changed comparatively simple and conveniently, and the work load is low, has avoided the filter media consume, influences the purification filtration quality of compound solution during unable normal filtration, can effectively get rid of the impurity in the compound solution of exenatide crude product, suspended particles etc., improve the purity of the compound solution of exenatide crude product, prevent impurity, suspended particles etc. from causing the influence to follow-up reversed-phase chromatographic column, block up the reversed-phase chromatographic column, influence the efficiency of direction chromatographic column, thereby guarantee the quality and the pure degree of the exenatide product of production.

Description

A purification equipment for exenatide production

Technical Field

The utility model relates to the technical field of purification equipment, in particular to purification equipment for exenatide production.

Background

Diabetes is a metabolic disorder characterized by chronic hyperglycemia due to various causes, and hyperglycemia is mainly caused by defects in insulin secretion or action. Diabetes can be divided into insulin-dependent diabetes (type I diabetes) and non-insulin-dependent diabetes (type II diabetes), with type II diabetes accounting for over 90%.

Exenatide (AC 2993) is a GLP-1 receptor agonist, is an artificial synthetic product of Exendin-4, is a novel medicament for treating type II diabetes, and has extremely high application value. The exenatide crude product obtained primarily in the production process of exenatide needs to be purified by a reversed phase chromatographic column to obtain the exenatide with higher purity. When the crude exenatide product in the prior art is redissolved and then purified by a reverse phase chromatographic column, sometimes impurities, suspended particles or the crude exenatide product which is not completely dissolved in the redissolved solution exist in the crude exenatide product, and the impurities, suspended particles or the crude exenatide product which is not completely dissolved can block micropores of a filler in the reverse phase chromatographic column without being processed and purified by the column, so that the blockage of the reverse phase chromatographic column is caused, the purification performance of the chromatographic column is influenced, and even the impurities and the like are washed by eluent to enter the purified exenatide product, so that the purity of the exenatide is influenced. The common treatment method at present is that the crude exenatide is redissolved in a stirring tank, then conveyed to a filter by a conveying pump, filtered, conveyed and stored in a storage tank, and impurities in the redissolved solution are purified by a reverse chromatographic column. The treatment method mainly has two problems: firstly, the number of used equipment is large, the occupied area of a factory is large, meanwhile, the equipment needs more energy, and the production cost of the exenatide is high; secondly, the filter media of the filter are consumable, the filter media of the existing filter equipment are often inconvenient to disassemble, the workload is large, and even professional personnel are needed to disassemble the filter equipment, so that the filter equipment is inconvenient.

Disclosure of Invention

In order to solve the problems, the utility model discloses an integrated purification and filtration device with conveniently-detachable filter material for the production of exenatide.

In order to achieve the purpose, the utility model adopts the following technical scheme: the utility model provides a purification equipment for exenatide production, includes jar and lower jar, go up the jar with be connected with first passageway down between the jar, install the filter media in the first passageway, be equipped with detachable installation door on the lateral wall of first passageway, be equipped with first valve on the first passageway.

Preferably, the upper tank is provided with a feeding port, a water inlet and a stirring assembly, the feeding port and the water inlet are respectively arranged at the top of the upper tank, and the stirring assembly comprises a motor, a stirring rod and stirring blades.

Preferably, the motor is fixed at the center of the top of the upper tank, an output shaft of the motor penetrates through the top of the upper tank and fixes the stirring rod, the lower end of the stirring rod is close to the bottom of the upper tank, and the stirring blade is fixed on the stirring rod.

Preferably, the bottom of the upper tank is a conical shell, the upper end of the first channel is connected to the bottom of the conical shell, the lower end of the first channel is connected to the top of the lower tank, a liquid conveying pipe is arranged at the bottom of the lower tank, and a second valve is arranged on the liquid conveying pipe.

Preferably, the first channel is a round pipe, the inner side wall horizontal fixing hole plate of the first channel is provided with a first notch on the side wall of the middle part of the first channel, the left side and the right side of the first notch of the first channel are respectively fixed with a first fastening lug, the installation door is a semicircular arc clamping plate, the installation door corresponds to the first notch, the left side and the right side of the installation door are respectively corresponding to a second fastening lug, the first fastening lug and the second fastening lug are provided with corresponding through holes, the first fastening lug and the second fastening lug are fixed by bolts, and a handle is fixed on the outer side wall of the installation door.

Preferably, the number of the perforated plates is at least two, and the filter material is placed between the perforated plates.

Preferably, a gasket is fixed on the surface of the installation door, which is in contact with the side wall of the first notch.

Preferably, the first valve is disposed between the upper tank and the installation door.

Compared with the prior art, the utility model has the beneficial effects that: (1) the upper tank is connected with the lower tank through a first channel, filter materials are installed in the first channel, a feeding port and a water inlet are formed in the top of the upper tank, a stirring assembly is further arranged, after crude exenatide is stirred and redissolved, after a first valve is opened, a redissolution flows through the first channel under the action of gravity and is filtered by the filter materials to flow into the lower tank, the device integrates stirring and redissolving, filtering and purifying and solution storage, the number of devices is greatly reduced, the occupied area of a factory is reduced, meanwhile, a conveying pump is not needed when the solution is filtered and stored, the use amount of energy is reduced, and the production cost of exenatide is reduced to a certain extent; (2) use the installation door of this semicircle cardboard of bolt detachable installation on the first passageway, be equipped with the utensil orifice plate in the first passageway, placed the filter media on the utensil orifice plate, the filter media that takes out the consume behind the convenient to detach installation door is changed new filter media, conveniently changes the filter media, prevents that the filter media from taking place the purification filtration quality that the compound solution of great consume influence when using for a long time, is equipped with the handle on the installation door, draws when being convenient for to install the door and draws when dismantling and demolish, and the dismantlement of installation door is more simple, convenient.

Drawings

FIG. 1 is a schematic structural view of the present invention;

FIG. 2 is a schematic perspective view of the first channel of the present invention at the location of the door;

fig. 3 is an exploded view of the first channel of the present invention with the door installed.

In the figure: 100 upper tank, 110 material inlet, 120 water inlet, 130 stirring component, 131 motor, 132 stirring rod, 133 stirring blade, 200 lower tank, 210 transfusion tube, 211 second valve, 300 first channel, 310 installation door, 311 second fastening ear, 312 handle, 313 sealing gasket, 320 first valve, 330 orifice plate, 340 first gap, 350 first fastening ear, 400 filtering material.

Detailed Description

The present invention will be further described with reference to fig. 1 to 3, but the scope of the present invention should not be limited thereto, and for convenience of explanation and understanding of the technical solutions of the present invention, the following description is based on the drawings. It should be noted that the terms "front," "back," "left," "right," "upper" and "lower" used in the following description refer to directions in the drawings, and the terms "inner" and "outer" refer to directions toward and away from, respectively, the geometric center of a particular component.

The utility model provides a purification device for exenatide production, which is shown in a combined figure 1-3 and comprises an upper tank 100 and a lower tank 200, wherein a first channel 300 is connected between the upper tank 100 and the lower tank 200, a filter material 400 is arranged in the first channel 300, the filter material 400 can be a filter element or the like, and the filter pore size of the filter element can be 20-50 mu m. A detachable installation door 310 is arranged on the side wall of the first channel 300, and a first valve 320 is arranged on the first channel 300. The upper tank 100 is provided with a material inlet 110, a water inlet 120 and a stirring assembly 130, the material inlet 110 and the water inlet 120 are respectively arranged at the top of the upper tank 100, and the stirring assembly 130 comprises a motor 131, a stirring rod 132 and stirring blades 133. The motor 131 is fixed at the center of the top of the upper tank 100, the output shaft of the motor 131 penetrates through the top of the upper tank 100 and fixes the stirring rod 132, the lower end of the stirring rod 132 is close to the bottom of the upper tank 100, and the stirring blade 133 is fixed on the stirring rod 132. The motor can drive the puddler 132 rotatory when opening, stirs the liquid in the jar, promotes that the exenatide crude dissolves. The bottom of the upper tank 100 is a conical shell, the upper end of the first channel 300 is connected to the bottom of the conical shell, the lower end of the first channel 300 is connected to the top of the lower tank 200, the bottom of the lower tank 200 is provided with a liquid conveying pipe 210, and the liquid conveying pipe 210 is provided with a second valve 211. The first channel 300 is a circular tube, the hole plate 330 is horizontally fixed on the inner side wall of the first channel 300, a first notch 340 is formed in the side wall of the middle of the first channel 300, the first notch is semicircular, first fastening lugs 350 are fixed on the left side and the right side of the first notch 340 of the first channel respectively, the installation door 310 is a semicircular arc clamping plate, the installation door 310 corresponds to the first notch 340, the left side and the right side of the installation door 310 correspond to second fastening lugs 311 respectively, corresponding through holes are formed in the first fastening lugs 350 and the second fastening lugs 311, the first fastening lugs 320 and the second fastening lugs 311 are fixed through bolts, and a handle 312 is fixed on the outer side wall of the installation door 310. The number of the perforated plates 330 is at least two, the filter material 400 is placed between the perforated plates 330, and the perforated plates 330 are fixed in the range of the upper and lower heights of the first notch 340, so that the filter material 400 placed on the perforated plates can be conveniently extracted. The surface of the installation door 310 contacting with the side wall of the first gap 340 is fixed with a sealing gasket 313 for sealing the first gap of the first channel. The sealing pad 313 may be a silicone pad or a rubber pad, and the surface of the mounting door contacting the sidewall of the first notch includes the upper and lower side surfaces and the sidewalls of the left and right sides of the mounting door. The first valve 320 is disposed between the upper tank 100 and the installation door 310.

The technical means disclosed in the present invention is not limited to the technical means disclosed in the above embodiments, and includes technical means formed by any combination of the above technical features. It will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the utility model as defined by the appended claims.

Claims

1. A purification equipment for exenatide production, comprising an upper tank and a lower tank, characterized in that: the filter is characterized in that a first channel is connected between the upper tank and the lower tank, filter materials are installed in the first channel, a detachable installation door is arranged on the side wall of the first channel, and a first valve is arranged on the first channel.

2. The purification apparatus for exenatide production as claimed in claim 1, wherein: the upper tank is provided with a feeding port, a water inlet and a stirring assembly, the feeding port and the water inlet are respectively arranged at the top of the upper tank, and the stirring assembly comprises a motor, a stirring rod and stirring blades.

3. The purification apparatus for exenatide production according to claim 2, wherein: the motor is fixed in the center of the top of the upper tank, an output shaft of the motor penetrates through the top of the upper tank and fixes the stirring rod, the lower end of the stirring rod is close to the bottom of the upper tank, and the stirring blade is fixed on the stirring rod.

4. The purification apparatus for exenatide production as claimed in claim 1, wherein: the bottom of going up the jar is the toper casing, the upper end of first passageway is connected the bottom of toper casing, the lower extreme of first passageway is connected the top of jar down, the bottom of jar is equipped with the transfer line down, be equipped with the second valve on the transfer line.

5. The purification apparatus for exenatide production as claimed in claim 1, wherein: the utility model discloses a door, including first passageway, first breach, installation door, first passageway, first breach has on the lateral wall at the middle part of first passageway, the left and right sides of the first breach of first passageway is fixed with first fastening ear respectively, the installation door is the semicircle cardboard, the installation door with first breach is corresponding, the left and right sides of installation door corresponds fixed second fastening ear respectively, first fastening ear with the through-hole that corresponds has on the second fastening ear, use the bolt fastening between first fastening ear and the second fastening ear, be fixed with the handle on the lateral wall of installation door.

6. The purification apparatus for exenatide production as claimed in claim 5, wherein: the porous plates are at least two, and the filter material is placed between the porous plates.

7. The purification apparatus for exenatide production as claimed in claim 5, wherein: and a sealing gasket is fixed on the surface of the mounting door, which is in contact with the side wall of the first notch.

8. The purification apparatus for exenatide production according to claim 4, wherein: the first valve is disposed between the upper tank and the installation door.