CN215916998U

CN215916998U - Dialysis device

Info

Publication number: CN215916998U
Application number: CN202122440383.2U
Authority: CN
Inventors: 戴伶俐; 赵世华; 王娜; 张帆; 白帆; 宋越; 张月梅; 陈伟; 刘威; 达来宝力格; 杨斌; 钱琳娜
Original assignee: Inner Mongolia Academy of Agricultural and Animal Husbandry Sciences
Current assignee: Inner Mongolia Academy of Agricultural and Animal Husbandry Sciences
Priority date: 2021-10-11
Filing date: 2021-10-11
Publication date: 2022-03-01
Anticipated expiration: 2031-10-11

Abstract

The utility model relates to the technical field of separation, and discloses a dialysis device, which comprises: the dialysis device comprises a sample tube, a dialysis membrane and a fixing ring, wherein one end of the sample tube is provided with an opening, the open end of the sample tube is an open end, and the sample tube is provided with a tube cavity for containing a sample; the dialysis membrane is used for completely covering the opening end and closing the opening, the fixing ring can be detachably arranged on the sample tube, and the annular wall surface of the fixing ring and the annular wall surface of the sample tube can clamp the dialysis membrane to fix the position of the dialysis membrane. The dialysis device provided by the utility model is convenient for sampling operation, has good tightness and is not easy to leak samples.

Description

Dialysis device

Technical Field

The utility model relates to the technical field of separation, in particular to a dialysis device.

Background

The dialysis technology is one of the separation and purification technologies commonly used in biomedical experiments at present; the dialysis device commonly used at present is a dialysis bag, the dialysis bag is folded into a pocket shape by a special semipermeable membrane, one end of the dialysis bag is tied by a rubber band or a thread rope or is clamped by a special dialysis bag clamp, a sample mixed with micromolecules and macromolecules is filled in the other end of the dialysis bag, the dialysis bag is sunk into a large amount of water or buffer solution when in use, the micromolecules in the bag continuously enter an external solvent through the membrane until the balance is reached, and if the dialysis is carried out on the running water or the solvent is continuously changed, the mixture in the bag hardly contains the micromolecules.

The problem that the biological sample leaks because the ligature is not tight easily appears in the in-process of ligature in the dialysis bag, perhaps in the sample process, often go to untie the dialysis bag, the not tight condition of ligature easily leads to the biological sample to leak, the sampling operation of being not convenient for.

SUMMERY OF THE UTILITY MODEL

The utility model aims to provide a dialysis device, which solves the problems in the prior art, is convenient for sampling operation, has good tightness and is not easy to leak samples.

In order to achieve the purpose, the utility model provides the following scheme:

the present invention provides a dialysis device comprising: the device comprises a sample tube, a sample tube and a liquid storage tank, wherein one end of the sample tube is provided with an opening, the open end of the sample tube is an open end, and the sample tube is provided with a tube cavity for containing a sample; a dialysis membrane for completely covering the open end and closing the opening; and the fixing ring can be detachably arranged on the sample tube, and the annular wall surface of the fixing ring and the annular wall surface of the sample tube can clamp the dialysis membrane to fix the position of the dialysis membrane.

Preferably, the fixing ring is sleeved outside the opening end, and the inner side wall of the fixing ring and the outer wall of the sample tube clamp the part of the dialysis membrane covering the outer side wall of the sample tube.

Preferably, an annular bulge is arranged in the fixing ring, and the annular bulge divides the fixing ring into a connecting section and a protruding section along the axial direction; when the fixing ring is sleeved on the opening end, the inner wall of the connecting section and the outer wall of the sample tube tightly clamp the dialysis membrane, the opening end faces the side face of the connecting section in an annular protruding mode, and the protruding section and the annular protruding portion can be tightly pressed on the end face of the opening end.

Preferably, when the open end abuts against the annular protrusion, the edge of the annular protrusion does not protrude beyond the inner wall of the sample tube.

Preferably, the dialysis membrane fixing device further comprises a furling ring, the furling ring is used for being sleeved on the outer wall of the sample tube and located on one side, away from the opening end, of the fixing ring, and the inner wall of the furling ring is used for clamping the dialysis membrane with the outer wall of the sample tube.

Preferably, the fixing ring is sleeved in the opening end, and the inner wall of the sample tube and the outer wall of the fixing ring clamp the part of the dialysis membrane covered on the inner side wall of the sample tube.

Preferably, one end of the sample tube is the open end, and the other end of the sample tube is the closed end without an opening; an annular piston is arranged in the tube cavity and is in close contact with the inner wall of the sample tube; the tube cavity between the open end and the annular piston is a sample cavity for containing samples, and the tube cavity between the annular piston and the closed end is an air cavity.

Preferably, the annular piston is movable within the lumen to adjust the volume of the sample chamber.

Preferably, both ends of the sample tube are provided as the open ends, each open end is covered with the dialysis membrane, and each dialysis membrane at the open end is fixed by one of the fixing rings.

Preferably, the sample tube is made of PET plastic.

Compared with the prior art, the utility model has the following technical effects:

according to the dialysis device provided by the utility model, after the sample liquid is filled in the tube cavity of the sample tube, the open end of the dialysis membrane is completely covered by the dialysis membrane, and the dialysis membrane can be detachably arranged on the sample tube through the fixing ring, so that the dialysis membrane is clamped by the annular wall surface of the fixing ring and the annular wall surface of the sample tube, the dialysis membrane is fixed, the sealing is realized without binding a rope, the operation is simple, the tightness is good, the sample liquid is subjected to molecular exchange with external liquid through the dialysis membrane at the open end, and the annular wall of the fixing ring can not shield the dialysis membrane, so that the liquid molecular exchange is avoided being influenced; during the sample, only need to follow the sample cell with solid fixed ring and pull down, take a sample can, need not to untie the ligature rope, the sample is convenient, is difficult for appearing the sample and leaks.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings needed in the embodiments will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art to obtain other drawings without creative efforts.

FIG. 1 is a schematic structural diagram of a dialysis apparatus according to a first embodiment;

FIG. 2 is a schematic longitudinal sectional view taken at an enlarged scale A in FIG. 1;

FIG. 3 is a schematic structural diagram of a sample tube according to the first embodiment;

FIG. 4 is a schematic view of a retaining ring according to an embodiment;

fig. 5 is a schematic structural view of a furling ring according to an embodiment.

Icon: 1-a dialysis device; 10-sample tube; 110-open end; 120-a lumen; 121-a sample chamber; 122-an air cavity; 130-a closed end; 140-an annular piston; 20-dialysis membrane; 30-a fixed ring; 310-an annular projection; 320-a connecting segment; 330-a protruding section; 40-gathering the ring.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

In order to make the aforementioned objects, features and advantages of the present invention comprehensible, embodiments accompanied with figures are described in further detail below.

Example one

The present embodiment provides a dialysis apparatus, please refer to fig. 1, which includes a sample tube 10, a dialysis membrane 20 and a fixing ring 30; at least one end of the sample tube 10 is provided as an open end 110, and the sample tube 10 is provided with a tube cavity 120 for containing a sample; the dialysis membrane 20 is used to completely cover the open end 110 and close the opening, the fixing ring 30 is detachably disposed on the sample tube 10, and the annular wall surface of the fixing ring 30 and the annular wall surface of the sample tube 10 can clamp the dialysis membrane 20 to fix the position of the dialysis membrane 20.

After the sample liquid is filled in the tube cavity 120 of the sample tube 10, the dialysis membrane 20 completely covers the open end 110, and is detachably arranged on the sample tube 10 through the fixing ring 30, so that the dialysis membrane 20 is clamped by the annular wall surface of the fixing ring 30 and the annular wall surface of the sample tube 10, the dialysis membrane 20 is fixed, a binding rope is not needed for sealing, the operation is simple, the tightness is good, the sample liquid is subjected to molecular exchange with the external liquid through the dialysis membrane 20 at the open end 110, and the annular wall of the fixing ring 30 does not shield the dialysis membrane 20, so that the liquid molecular exchange is avoided being influenced; during sampling, only the fixing ring 30 needs to be detached from the sample tube 10, sampling can be carried out without unfastening the binding rope, sampling is convenient, and sample leakage is not easy to occur.

In the alternative of this embodiment, please refer to fig. 1, preferably, the fixing ring 30 is sleeved on the opening end 110, so as to fix the dialysis membrane 20 at the opening end 110 directly, and further improve the tightness; the inner side wall of the fixing ring 30 and the outer side wall of the sample tube 10 clamp the part of the dialysis membrane 20 covering the outer side wall of the sample tube 10, and the area of the dialysis membrane 20 is usually required to be larger than the area of the open end 110, so that the part of the dialysis membrane 20 exceeding the open end 110 needs to cover the outer side wall of the sample tube 10, and the position of the dialysis membrane 20 is convenient to fix; specifically, the inner diameter of the fixing ring 30 should be slightly larger than the outer diameter of the sample tube 10, so that the fixing ring 30 can be sleeved on the outer wall of the sample tube 10 and can clamp the dialysis membrane 20 with the sample tube 10, thereby ensuring tightness and preventing damage to the dialysis membrane 20.

In an alternative of this embodiment, please refer to fig. 2 and fig. 4, preferably, an annular protrusion 310 is disposed in the fixing ring 30, and the annular protrusion 310 divides the fixing ring 30 into a connecting section 320 and a protruding section 330 in the axial direction; when the fixing ring 30 is sleeved on the opening end 110, the inner wall of the connecting section 320 and the outer wall of the sample tube 10 clamp the dialysis membrane 20, the opening end 110 abuts against the side surface of the annular protrusion 310 facing the connecting section 320, and the protruding section 330 can be pressed against the end surface of the opening end 110; so, annular protrusion 310 and protruding section 330 can further compress tightly dialysis membrane 20 with fixed its position, and protruding section 330 can protect dialysis membrane 30 not to a certain extent to receive damage such as colliding with.

Further, a plurality of tooth gaps can be arranged on the protruding section 330 along the circumferential direction, so that the buffer liquid in the space surrounded by the protruding section 330 can conveniently circulate.

In an alternative of this embodiment, referring to fig. 2, preferably, when the open end 110 abuts against the annular protrusion 310, the edge of the annular protrusion 310 does not protrude beyond the inner wall of the sample tube 10, so as to prevent the annular protrusion 310 from affecting the dialysis area of the dialysis membrane 20.

In an alternative of this embodiment, please refer to fig. 1 and fig. 2, it is preferable that the dialysis device further includes a drawing ring 40, the drawing ring 40 is sleeved on the outer wall of the sample tube 10, the drawing ring 40 is located on a side of the fixing ring 30 away from the opening end 110, and an inner wall of the drawing ring 40 is used for clamping the dialysis membrane 20 with the outer wall of the sample tube 10; when the dialysis device 1 is sealed, after the dialysis membrane 20 covers the open end 110, the dialysis membrane 20 can be sleeved on the sample tube 10 through the folding ring 40, the edge of the dialysis membrane 20 can be folded and fixed, and then the dialysis membrane is further fixed by being sleeved on the open end 110 through the fixing ring 30.

In the alternative of this embodiment, preferably, referring to fig. 1, one end of the sample tube 10 is an open end 110, and the other end is a closed end 130 without an opening; an annular piston 140 is arranged in the lumen 120, and the annular piston 140 is in close contact with the inner wall of the sample tube 10; the lumen 120 between the open end 110 and the annular piston 140 is a sample chamber 121 for holding a sample, and the lumen 120 between the annular piston 140 and the closed end 130 is an air chamber 122; so set up, can make the focus of dialysis unit 1 be located sample chamber 121, make sample chamber 121 can immerse the buffer solution completely in, need not to adjust sample height that floats through setting up parts such as extra steel ball to and need not to set up the cursory of other part control dialysis unit 1.

In the alternative of this embodiment, it is preferable that the annular piston 140 is movable within the lumen 120 to adjust the volume of the sample chamber 121; specifically, the position of the annular piston 140 can be adjusted by extending a finger or some rod into the lumen 120 to adjust the volume of the sample chamber 121 from small to large.

Further, the size and volume of the sample tube 10 in this embodiment can be set to several hundred microliters or several milliliters, etc. according to the requirement, so as to realize micro-dialysis, and can also be set to have a larger volume according to the actual requirement; correspondingly, the other mating parts are arranged according to the size of the sample tube 10.

In an alternative of this embodiment, the sample tube 10 is preferably made of PET plastic.

EXAMPLE two (not shown)

The present embodiment provides a dialysis apparatus 1, which is different from the first embodiment in the way that the fixing ring 30 is engaged with the open end 110 of the sample tube 10: the fixing ring 30 is sleeved in the opening end 110, that is, the fixing ring 30 is embedded in the opening end 110, the inner wall of the sample tube 10 and the outer wall of the fixing ring 30 clamp the part of the dialysis membrane 20 covering the inner side wall of the sample tube 10, the outer diameter of the fixing ring 30 is slightly smaller than the inner diameter of the sample tube 10, and the dialysis membrane 20 is prevented from being damaged while the dialysis membrane 20 is clamped; when the embodiment is used, the fixing ring 30 can be inserted into the sample tube 10, and further the closing ring 40 is sleeved on the sample tube 10 to close the edge of the dialysis membrane 20.

EXAMPLE three (not shown)

The present embodiment provides a dialysis apparatus 1, which is different from the first embodiment in that: the two ends of the sample tube 10 are both provided with open ends 110, each open end 110 is covered with a dialysis membrane 20, the dialysis membrane 20 at each open end 110 is fixed by a fixing ring 30, and a furling ring 40 can be further provided to furl the dialysis membrane 20, and the specific arrangement mode can be described with reference to the first embodiment; so set up and to make the both ends of sample cell 10 all dialyse for efficiency.

Further, the fixing ring 40 can be engaged with the opening end 110 in the manner described in the second embodiment.

The principle and the implementation mode of the utility model are explained by applying a specific example, and the description of the embodiment is only used for helping to understand the method and the core idea of the utility model; meanwhile, for a person skilled in the art, according to the idea of the present invention, the specific embodiments and the application range may be changed. In view of the above, the present disclosure should not be construed as limiting the utility model.

Claims

1. A dialysis device, characterized by: the method comprises the following steps:

the sample tube (10), at least one end of the sample tube (10) is arranged to be open, the open end of the sample tube (10) is an open end (110), and the sample tube (10) is provided with a tube cavity (120) for containing a sample;

a dialysis membrane (20) for completely covering the open end (110) and closing the opening; and

a fixing ring (30), wherein the fixing ring (30) is detachably arranged on the sample tube (10), and the annular wall surface of the fixing ring (30) and the annular wall surface of the sample tube (10) can clamp the dialysis membrane (20) to fix the position of the dialysis membrane (20).

2. The dialysis device of claim 1, wherein: the fixing ring (30) is sleeved outside the opening end (110), and the inner side wall of the fixing ring (30) and the outer side wall of the sample tube (10) clamp the part of the dialysis membrane (20) covering the outer side wall of the sample tube (10).

3. The dialysis device of claim 2, wherein: an annular bulge (310) is arranged in the fixing ring (30), and the annular bulge (310) divides the fixing ring (30) into a connecting section (320) and a protruding section (330) along the axial direction; when the fixing ring (30) is sleeved on the opening end (110), the inner wall of the connecting section (320) and the outer wall of the sample tube (10) clamp the dialysis membrane (20), the opening end (110) and the side face, facing the connecting section (320), of the annular bulge (310) are abutted, and the protruding section (330) and the annular bulge (310) can be pressed on the end face of the opening end (110).

4. The dialysis device of claim 3, wherein: when the open end (110) is abutted against the annular bulge (310), the edge of the annular bulge (310) does not exceed the inner wall of the sample tube (10).

5. The dialysis device of claim 2, wherein: the dialysis membrane dialysis device is characterized by further comprising a furling ring (40), wherein the furling ring (40) is sleeved on the outer wall of the sample tube (10), the furling ring (40) is located on one side, away from the opening end (110), of the fixing ring (30), and the inner wall of the furling ring (40) is used for clamping the dialysis membrane (20) with the outer wall of the sample tube (10).

6. The dialysis apparatus of claim 1, wherein: the fixing ring (30) is sleeved in the opening end (110), and the inner wall of the sample tube (10) and the outer wall of the fixing ring (30) clamp the part of the dialysis membrane (20) covered on the inner side wall of the sample tube (10).

7. Dialysis device according to any one of claims 2 to 5, wherein: one end of the sample tube (10) is the open end (110), and the other end is a closed end (130) without an opening; an annular piston (140) is arranged in the tube cavity (120), and the annular piston (140) is tightly contacted with the inner wall of the sample tube (10); the lumen (120) between the open end (110) and the annular piston (140) is a sample chamber (121) for holding a sample, and the lumen (120) between the annular piston (140) and the closed end (130) is an air chamber (122).

8. The dialysis device of claim 7, wherein: the annular piston (140) is movable within the lumen (120) to adjust the volume of the sample chamber (121).

9. Dialysis device according to any one of claims 2 to 5, wherein: the two ends of the sample tube (10) are respectively provided with the opening end (110), the dialysis membrane (20) is covered at each opening end (110), and the dialysis membrane (20) at each opening end (110) is fixed through the fixing ring (30).

10. The dialysis device of claim 1, wherein: the sample tube (10) is made of PET plastic.