CN215916207U - Reversible thermochromic microneedle acupoint patch - Google Patents
Reversible thermochromic microneedle acupoint patch Download PDFInfo
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- CN215916207U CN215916207U CN202120532795.6U CN202120532795U CN215916207U CN 215916207 U CN215916207 U CN 215916207U CN 202120532795 U CN202120532795 U CN 202120532795U CN 215916207 U CN215916207 U CN 215916207U
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Abstract
The utility model provides a reversible thermochromic microneedle acupoint plaster, which comprises a reversible thermochromic microneedle acupoint plaster module, a first adhesive patch and a first reversible thermochromic nanocapsule, wherein the reversible thermochromic microneedle acupoint plaster module comprises a soluble microneedle, the first adhesive patch and the first reversible thermochromic nanocapsule which are sequentially arranged from bottom to top; the soluble microneedle is used for carrying active ingredients and penetrating the stratum corneum of the skin to conduct the active ingredients to the position below the skin to be dissolved in subcutaneous water, the first adhesive patch is used for fixing the soluble microneedle and the first reversible thermochromic nanocapsules and is pasted to the skin to enable the active ingredients to act below the skin, and the first reversible thermochromic nanocapsules change color when being in contact with the skin to display the contact degree of the microneedle acupuncture point paste and the skin. The utility model combines a structure with reversible thermochromism function and a soluble microneedle which can be used as a biological indication mark sensing system, when the soluble microneedle is stuck to the acupuncture point of the skin, the temperature of the skin activates the reversible thermochromism function and is used as a biological indication mark for judging whether the acupuncture point of the microneedle completely acts on the skin.
Description
Technical Field
The utility model relates to the technical field of medicinal preparations characterized by special physical shapes, in particular to a reversible thermochromic microneedle acupoint plaster.
Background
The microneedle transdermal drug delivery is a novel transdermal drug delivery mode, integrates the advantages of a subcutaneous injection drug delivery mode and a transdermal patch drug delivery mode, is painless and minimally invasive, has high drug absorption efficiency, and is rapidly developed in the research of the medical field.
The acupuncture point paste is a traditional Chinese medical health care product, can be used for acupuncture points of a human body to carry out targeted physical therapy on all parts, thereby achieving treatment and health care effects, but the prior soluble microneedle array type microneedle patch is not specially applied to the traditional Chinese medical acupuncture point physical therapy, and the prior microneedle patch cannot confirm whether the existing microneedle patch is fully contacted with the skin or not so as to enable the medicine to completely permeate the skin to act due to no indication mark when acting on the skin.
Disclosure of Invention
The utility model provides a reversible thermochromic microneedle acupoint plaster, which aims to solve the problem that a microneedle plaster cannot show whether the microneedle plaster completely acts on the skin or not.
The utility model provides a reversible thermochromic microneedle acupoint plaster, which comprises a reversible thermochromic microneedle acupoint plaster module;
the reversible thermochromic microneedle acupoint plaster module comprises a soluble microneedle, a first adhesive patch and a first reversible thermochromic nanocapsule which are sequentially arranged from bottom to top;
the soluble microneedle is used for carrying active ingredients and penetrating the stratum corneum of the skin to conduct the active ingredients to the position below the skin to be dissolved in subcutaneous water, the first adhesive patch is used for fixing the soluble microneedle and the first reversible thermochromic nanocapsules and is pasted to the skin to enable the active ingredients to act below the skin, and the first reversible thermochromic nanocapsules change color when being in contact with the skin to display the contact degree of the microneedle acupuncture point paste and the skin.
The reversible thermochromic microneedle acupoint plaster disclosed by the utility model further comprises a reversible thermochromic module which is arranged adjacent to the reversible thermochromic microneedle acupoint plaster module as an optimal mode, wherein the reversible thermochromic module comprises a second adhesive patch and a second reversible thermochromic nanocapsule which are sequentially arranged from bottom to top;
the second adhesive patch is used for fixing the second reversible thermochromic nanocapsule, and the second reversible thermochromic nanocapsule is used for changing color when contacting the skin so as to display the contact degree of the microneedle acupuncture point patch and the skin.
As an optimal mode, the reversible thermochromic microneedle acupoint plaster comprises a first adhesive patch and a second adhesive patch which are connected to form an adhesive patch layer.
As an optimal mode, the reversible thermochromic microneedle acupoint plaster is characterized in that a first reversible thermochromic nanocapsule and a second reversible thermochromic nanocapsule are connected to form a reversible thermochromic nanocapsule layer.
As a preferred mode, the reversible thermochromic nano microcapsule layer comprises a plurality of reversible thermochromic nano microcapsule belts which are intersected transversely and longitudinally;
the micro-needle acupoint plaster also comprises an adhesive patch module arranged in a gap between the reversible thermochromic nanometer microcapsule belts, and the adhesive patch module is connected with the first adhesive patch and the second adhesive patch to form an adhesive patch layer.
As a preferred mode, the reversible thermochromic nano microcapsule layer comprises a plurality of reversible thermochromic nano microcapsule belts which are vertically crossed in a transverse direction and a longitudinal direction.
As an optimal mode, the reversible thermochromic microneedle acupoint plaster has the length of 10-1000 microns and the diameter of 10-1000 microns.
As an optimal mode, the reversible thermochromic microneedle acupoint plaster comprises a plurality of first reversible thermochromic nanocapsules and a plurality of second reversible thermochromic nanocapsules.
The reversible thermochromic microneedle acupoint plaster is preferably provided with microcapsules with the particle size of 0.1-100 microns.
As a preferred mode, the reversible thermochromic microneedle acupoint plaster comprises active ingredients including functional active substances, traditional Chinese medicines or plant extracts.
The reversible thermochromic intelligent heat sensing system is a phenomenon that the color of a heat sensing system is changed into another color when heated and heated, and the original color is recovered after the initial temperature is recovered.
The reversible thermochromic microcapsule is prepared by encapsulating a leuco agent, a color developing agent and a solvent by an in-situ polymerization method, a condensation method or an interface polymerization method to form a microcapsule structure, and attaching and fixing the microcapsule to a sticky patch by using a binder, and the preparation method of the reversible thermochromic microcapsule comprises the following steps: taking crystal violet lactone and thermosensitive rose bengal as a leuco agent, taking bisphenol A alcohol as a color developing agent, and compounding tetradecanol, hexadecanol or a tetradecanol-hexadecanol binary eutectic as a solvent, wherein the mixture ratio of the crystal violet lactone to the thermosensitive rose bengal can be 1: 2-8: 10-100, the color-changing temperature range of the mixture is 15-60 ℃ through color difference analysis, and the particle size of the microcapsule is observed to be 0.1-100 mu m through a biological microscope.
The adhesive patch can be made of non-woven fabric patch, hydrogel patch or composite material patch, and is used for fixing the microcapsule and the soluble microneedle, and can be applied to skin and acupuncture points.
The soluble microneedle transdermal drug delivery technology is characterized in that biodegradable high-molecular soluble materials are used for carrying drugs or active ingredients, and the soluble microneedle can penetrate through the stratum corneum of a skin barrier and conduct the drugs to the subcutaneous part to be dissolved in subcutaneous water. The preparation method can be a mold method or a stretching method, and the macromolecule viscous solution is solidified with the drug or other effective components to be made into a soluble microneedle shape and fixed on the viscous patch. The biodegradable polymer soluble material can be polyester, PHA, PHBV, PHP, PHH, PHA-PEG, poly-4-hydroxy acid, poly-alpha-hydroxy acid, poly-beta-hydroxy acid, poly-4-hydroxybutyrate, poly-4-hydroxyvalerate, poly-4-hydroxyhexanoate, polyesteramide, polycaprolactone, polylactide, polyglycolide, PLGA, polydioxanone, polyorthoester, polyetherester, polyanhydride, glycolic acid-trimethylene carbonate copolymer, polyphosphate urethane, polyamino acid, polycyanoacrylate, polytrimethylene carbonate, polyiminocarbonate, polytyrosine carbonate, polycarbonate, poly-aryl-tyrosine, polyalkylene oxalate, creatine polyphosphate, chitosan, dextran, cellulose, heparin, hyaluronic acid (hyaluronic acid), Alginic acid, inulin, starch or glycogen, one or more of the above materials mixed; the carried medicine or effective component can be traditional Chinese medicine effective component or plant extract. Microneedles may range from 10 μm to 1000 μm in length and from 10 μm to 1000 μm in diameter.
The reversible thermochromic nanometer microcapsule biological identification type soluble microneedle acupoint plaster has the action principle that the normal temperature range of a human body is 36.1-37 ℃, the average temperature of skin is 33.8 ℃, the reversible thermochromic microcapsule is controlled to change color at 32-40 ℃, when the acupoint plaster acts on the skin, the acupoint plaster is pressed to contact the skin to trigger a biological identification heat sensing system, the part of the acupoint plaster fully contacting the skin generates a color change reaction, otherwise, the part which does not penetrate into the skin or does not fully penetrate into the skin does not change color or does not fully change color, and the unchanged color part is continuously pressed until all biological identification heat sensing systems fully change color, so that the acupoint plaster is completely pasted on the skin acupoint.
The utility model has the following advantages:
(1) the micro-needle acupoint plaster is different from the traditional acupoint plaster only used for massaging or stimulating the acupoints, can conduct the medicines acting on the acupoints into the skin while acting on the human acupoints, and achieves the effect of transdermal administration while stimulating the acupoints.
(2) Reversible thermochromic nanometer microcapsule in this micropin acupuncture point subsides is reversible thermochromic microcapsule biological identification heat sensing system, the function of thermochromism when contacting skin through the microcapsule, play the indicating action, the problem of whether unable soluble micropin paster acts on skin and acupuncture point completely has been solved effectively, make soluble micropin paster can fully act on skin and acupuncture point, avoid leading to the unable problem that gets into the skin of medicine because the micropin can not pierce through the skin stratum corneum, can ensure that the medicine of carrying on can fully see through the skin in the soluble micropin, contact with subcutaneous moisture and dissolve in the hypodermis.
Drawings
FIG. 1 is a schematic structural view of a reversible thermochromic microneedle acupoint plaster module;
FIG. 2 is a schematic structural view of a reversible thermochromic microneedle acupoint-attached reversible thermochromic module;
FIG. 3 is an exploded view of the reversible thermochromic microneedle acupuncture point patch of example 2-4;
FIG. 4 is a schematic structural view of embodiments 2-4 of a reversible thermochromic microneedle acupuncture point patch;
FIG. 5 is a top view of an embodiment 3 of a reversible thermochromic microneedle acupuncture point patch;
fig. 6 is a top view of an embodiment 4 of a reversible thermochromic microneedle acupuncture patch.
Reference numerals:
1. a reversible thermochromic microneedle acupoint plaster module; 11. a soluble microneedle; 12. a first adhesive patch; 13. a first reversible thermochromic nanocapsule; 2. a reversible thermochromic module; 21. a second adhesive patch; 22. a second reversible thermochromic nanocapsule; 3. an adhesive patch module.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments.
Example 1
As shown in fig. 1, a reversible thermochromic microneedle acupoint plaster comprises a reversible thermochromic microneedle acupoint plaster module 1;
the reversible thermochromic microneedle acupoint plaster module 1 comprises a soluble microneedle 11, a first adhesive patch 12 and a first reversible thermochromic nano microcapsule 13 which are sequentially arranged from bottom to top;
the soluble micro-needle 11 is used for carrying active ingredients and penetrating the stratum corneum of the skin to conduct the active ingredients to the position below the skin to be dissolved in subcutaneous water, the first adhesive patch 12 is used for fixing the soluble micro-needle 11 and the first reversible thermochromic nano-microcapsule 13 and is pasted to the skin to enable the active ingredients to act below the skin, and the first reversible thermochromic nano-microcapsule 13 is used for changing color when contacting the skin to display the contact degree of the micro-needle acupoint paste and the skin.
Example 2
As shown in fig. 1 to 4, a reversible thermochromic microneedle acupoint plaster comprises a reversible thermochromic microneedle acupoint plaster module 1 and a reversible thermochromic module 2 arranged adjacent to the reversible thermochromic microneedle acupoint plaster module 1;
the reversible thermochromic microneedle acupoint plaster module 1 comprises a soluble microneedle 11, a first adhesive patch 12 and a first reversible thermochromic nano microcapsule 13 which are sequentially arranged from bottom to top;
the soluble micro-needle 11 is used for carrying active ingredients and penetrating the stratum corneum of the skin to conduct the active ingredients to the position below the skin to be dissolved in subcutaneous water, the first adhesive patch 12 is used for fixing the soluble micro-needle 11 and the first reversible thermochromic nano-microcapsule 13 and is pasted to the skin to enable the active ingredients to act below the skin, and the first reversible thermochromic nano-microcapsule 13 is used for changing color when contacting the skin to display the contact degree of the micro-needle acupoint paste and the skin;
the reversible thermochromic module 2 comprises a second adhesive patch 21 and a second reversible thermochromic nanocapsule 22 which are sequentially arranged from bottom to top;
the second adhesive patch 21 is used for fixing the second reversible thermochromic nanocapsule 22, and the second reversible thermochromic nanocapsule 22 is used for changing color when contacting the skin;
the first adhesive patch 12 and the second adhesive patch 21 are connected to form an adhesive patch layer;
the first reversible thermochromic nanocapsule 13 and the second reversible thermochromic nanocapsule 22 are connected to form a reversible thermochromic nanocapsule layer.
Example 3
As shown in fig. 1 to 5, a reversible thermochromic microneedle acupoint plaster comprises a reversible thermochromic microneedle acupoint plaster module 1 and a reversible thermochromic module 2 disposed adjacent to the reversible thermochromic microneedle acupoint plaster module 1;
the reversible thermochromic microneedle acupoint plaster module 1 comprises a soluble microneedle 11, a first adhesive patch 12 and a first reversible thermochromic nano microcapsule 13 which are sequentially arranged from bottom to top;
the soluble micro-needle 11 is used for carrying active ingredients and penetrating the stratum corneum of the skin to conduct the active ingredients to the position below the skin to be dissolved in subcutaneous water, the first adhesive patch 12 is used for fixing the soluble micro-needle 11 and the first reversible thermochromic nano-microcapsule 13 and is pasted to the skin to enable the active ingredients to act below the skin, and the first reversible thermochromic nano-microcapsule 13 is used for changing color when contacting the skin to display the contact degree of the micro-needle acupoint paste and the skin;
the reversible thermochromic module 2 comprises a second adhesive patch 21 and a second reversible thermochromic nanocapsule 22 which are sequentially arranged from bottom to top;
the second adhesive patch 21 is used for fixing the second reversible thermochromic nanocapsule 22, and the second reversible thermochromic nanocapsule 22 is used for changing color when contacting the skin so as to display the contact degree of the microneedle acupuncture point patch with the skin;
the first adhesive patch 12 and the second adhesive patch 21 are connected to form an adhesive patch layer;
the first reversible thermochromic nanocapsule 13 and the second reversible thermochromic nanocapsule 22 are connected to form a reversible thermochromic nanocapsule layer;
the reversible thermochromic nanometer microcapsule layer comprises reversible thermochromic nanometer microcapsule belts which are uniformly distributed;
the micro-needle acupoint plaster also comprises an adhesive patch module arranged in a gap between the reversible thermochromic nanometer microcapsule belts, and the adhesive patch module is connected with the first adhesive patch 12 and the second adhesive patch 21 to form an adhesive patch layer.
Example 4
As shown in fig. 1-4 and 6, a reversible thermochromic microneedle acupoint plaster comprises a reversible thermochromic microneedle acupoint plaster module 1 and a reversible thermochromic module 2 arranged adjacent to the reversible thermochromic microneedle acupoint plaster module 1;
the reversible thermochromic microneedle acupoint plaster module 1 comprises a soluble microneedle 11, a first adhesive patch 12 and a first reversible thermochromic nano microcapsule 13 which are sequentially arranged from bottom to top;
the soluble micro-needle 11 is used for carrying active ingredients and penetrating the stratum corneum of the skin to conduct the active ingredients to the position below the skin to be dissolved in subcutaneous water, the first adhesive patch 12 is used for fixing the soluble micro-needle 11 and the first reversible thermochromic nano-microcapsule 13 and is pasted to the skin to enable the active ingredients to act below the skin, and the first reversible thermochromic nano-microcapsule 13 is used for changing color when contacting the skin to display the contact degree of the micro-needle acupoint paste and the skin;
the reversible thermochromic module 2 comprises a second adhesive patch 21 and a second reversible thermochromic nanocapsule 22 which are sequentially arranged from bottom to top;
the second adhesive patch 21 is used for fixing the second reversible thermochromic nanocapsule 22, and the second reversible thermochromic nanocapsule 22 is used for changing color when contacting the skin so as to display the contact degree of the microneedle acupuncture point patch with the skin;
the first adhesive patch 12 and the second adhesive patch 21 are connected to form an adhesive patch layer;
the first reversible thermochromic nanocapsule 13 and the second reversible thermochromic nanocapsule 22 are connected to form a reversible thermochromic nanocapsule layer;
the reversible thermochromic nanometer microcapsule layer comprises a plurality of reversible thermochromic nanometer microcapsule belts which are intersected transversely and longitudinally;
the micro-needle acupoint plaster also comprises an adhesive patch module 3 arranged in a gap between the reversible thermochromic nano-microcapsule belts, and the adhesive patch module 3 is connected with the first adhesive patch 12 and the second adhesive patch 21 to form an adhesive patch layer;
the reversible thermochromic nanometer microcapsule layer comprises a plurality of reversible thermochromic nanometer microcapsule belts which are vertically crossed in the transverse direction and the longitudinal direction;
the length of the soluble microneedle 11 is 10-1000 μm, and the diameter of the soluble microneedle 11 is 10-1000 μm;
the first reversible thermochromic nanocapsule 13 and the second reversible thermochromic nanocapsule 22 comprise a plurality of microcapsules; the grain diameter of the microcapsule is 0.1-100 μm;
the effective components include functional active substances, Chinese medicinal materials or plant extracts.
The working principle of the embodiment 1-4 is that the normal temperature range of the human body is 36.1-37 ℃, the average temperature of the skin is 33.8 ℃, the reversible thermochromism microcapsules are controlled to change color at 32-40 ℃, when the acupoint plaster acts on the skin, the acupoint plaster is pressed to contact the skin to trigger the biological identification heat sensing system, the part of the acupoint plaster fully contacting the skin generates color change reaction, otherwise, the part which does not penetrate into the skin or the part which does not completely penetrate into the skin does not change color or does not completely change color, and the non-color change part is continuously pressed until all the biological identification heat sensing systems fully change color, so that the acupoint plaster is ensured to be completely pasted on the acupoint of the skin.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and equivalent alternatives or modifications according to the technical solution of the present invention and the inventive concept thereof should be covered by the scope of the present invention.
Claims (9)
1. A reversible thermochromic microneedle acupoint plaster is characterized in that: comprises a reversible thermochromic microneedle acupuncture point patch module (1);
the reversible thermochromic microneedle acupoint plaster module (1) comprises a soluble microneedle (11), a first adhesive patch (12) and a first reversible thermochromic nanocapsule (13) which are sequentially arranged from bottom to top;
the soluble microneedle (11) is used for carrying an effective component and penetrating the stratum corneum of the skin to conduct the effective component to the part below the skin to be dissolved in subcutaneous moisture, the first adhesive patch (12) is used for fixing the soluble microneedle (11) and the first reversible thermochromic nanocapsule (13) and is pasted to the skin to enable the effective component to act below the skin, and the first reversible thermochromic nanocapsule (13) is used for changing color when contacting the skin to display the contact degree of the microneedle acupuncture point paste and the skin.
2. The reversible thermochromic microneedle acupoint patch according to claim 1, wherein: the micro-needle acupoint plaster also comprises a reversible thermochromic module (2) which is arranged adjacent to the reversible thermochromic micro-needle acupoint plaster module (1), wherein the reversible thermochromic module (2) comprises a second adhesive patch (21) and a second reversible thermochromic nano microcapsule (22) which are sequentially arranged from bottom to top;
the second adhesive patch (21) is used for fixing the second reversible thermochromic nanocapsule (22), and the second reversible thermochromic nanocapsule (22) is used for changing color when contacting the skin so as to display the contact degree of the microneedle acupuncture point patch and the skin.
3. The reversible thermochromic microneedle acupoint patch according to claim 2, wherein: the first adhesive patch (12) and the second adhesive patch (21) are connected to form an adhesive patch layer.
4. The reversible thermochromic microneedle acupoint patch according to claim 3, wherein: the first reversible thermochromic nanocapsule (13) and the second reversible thermochromic nanocapsule (22) are connected to form a reversible thermochromic nanocapsule layer.
5. The reversible thermochromic microneedle acupoint patch according to claim 4, wherein: the reversible thermochromic nanometer microcapsule layer comprises a plurality of reversible thermochromic nanometer microcapsule belts which are intersected in the transverse direction and the longitudinal direction;
the micro-needle acupoint plaster further comprises an adhesive patch module (3) arranged in a gap between the reversible thermochromic nano-microcapsule belts, and the adhesive patch module (3) is connected with the first adhesive patch (12) and the second adhesive patch (21) to form an adhesive patch layer.
6. The reversible thermochromic microneedle acupoint patch according to claim 5, wherein: the reversible thermochromic nanometer microcapsule layer comprises a plurality of reversible thermochromic nanometer microcapsule belts which are vertically crossed in the transverse direction and the longitudinal direction.
7. The reversible thermochromic microneedle acupoint patch according to claim 1, wherein: the length of the soluble microneedle (11) is 10-1000 μm, and the diameter of the soluble microneedle (11) is 10-1000 μm.
8. The reversible thermochromic microneedle acupoint patch according to claim 2, wherein: the first reversible thermochromic nanocapsule (13) and the second reversible thermochromic nanocapsule (22) comprise a number of microcapsules.
9. The reversible thermochromic microneedle acupoint patch according to claim 8, wherein: the grain diameter of the microcapsule is 0.1-100 μm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202120532795.6U CN215916207U (en) | 2021-03-15 | 2021-03-15 | Reversible thermochromic microneedle acupoint patch |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202120532795.6U CN215916207U (en) | 2021-03-15 | 2021-03-15 | Reversible thermochromic microneedle acupoint patch |
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| Publication Number | Publication Date |
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| CN215916207U true CN215916207U (en) | 2022-03-01 |
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| CN202120532795.6U Active CN215916207U (en) | 2021-03-15 | 2021-03-15 | Reversible thermochromic microneedle acupoint patch |
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- 2021-03-15 CN CN202120532795.6U patent/CN215916207U/en active Active
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