CN215855859U

CN215855859U - Automatic collection device for antibody purification effluent liquid

Info

Publication number: CN215855859U
Application number: CN202121872534.5U
Authority: CN
Inventors: 陈德君; 徐新东; 董成贺; 陈�峰; 王群行; 裔思远
Original assignee: Yangzhou Branch Technology Co ltd
Current assignee: Yangzhou Branch Technology Co ltd
Priority date: 2021-08-11
Filing date: 2021-08-11
Publication date: 2022-02-18
Anticipated expiration: 2031-08-11

Abstract

The utility model discloses an automatic collection device for antibody purification effluent liquid, which relates to the technical field of biological pharmaceutical equipment and comprises the following components: a stable bottom plate; the lifting rod is positioned at the top end of one side of the stable bottom plate and is used for lifting the purification bottle; and the lifting mechanism is positioned right above the stable bottom plate and is mutually sleeved with the lifting rod. The lifting mechanism is arranged, the mechanism can realize stable lifting of the purification bottle, the fixed block is driven to be separated from the inside of the fixed clamping groove of the sleeving sliding block by pulling the push-pull block, the sleeving sliding block is limited and fixed through the limiting sliding plate of the connecting rotating rod at the moment, then the first knob is rotated to enable the first gear to drive the connecting rotating rod to rotate, the sleeving sliding block is meshed with the first gear through the tooth block at the moment, when the purification bottle rises to a specified position, the push-pull block is pushed to enable the fixed block to be clamped into the fixed clamping groove at the moment, and the height of the purification bottle can be quickly adjusted through mutual matching of the plurality of parts.

Description

Automatic collection device for antibody purification effluent liquid

Technical Field

The utility model relates to the technical field of biological pharmaceutical equipment, in particular to an automatic collection device for antibody purification effluent liquid.

Background

The preparation of high-specificity and high-titer antibodies is the basis of experimental immunology technology, the quality of the antibodies directly influences the success or failure of the experiment, the antibodies prepared by different methods are often mixed with various hybrid proteins, and the purification of the antibodies is needed in order to obtain the antibodies with relatively single components or use the antibodies for specific purposes.

Current antibody purification effluent liquid automatic collection device is when using, and it is fixed that unable convenient highly carry out quick adjustment to the purification bottle, is being handled the body when placing the purification bottle fixed rare simultaneously for use is inconvenient, is unfavorable for installing fixedly to the body of variation in size.

SUMMERY OF THE UTILITY MODEL

The utility model aims to: in order to solve the problem that the purification bottle can not be stably clamped and lifted, the automatic collection device for the antibody purification effluent liquid is provided.

In order to achieve the purpose, the utility model provides the following technical scheme: an antibody-purification effluent automatic collection device comprising:

a stable bottom plate;

the lifting rod is positioned at the top end of one side of the stable bottom plate and is used for lifting the purification bottle;

the lifting mechanism is positioned right above the stable bottom plate, is mutually sleeved with the lifting rod and is used for stably lifting the height of the purification bottle;

and the clamping mechanism is positioned at the formal side of the stable bottom plate, is fixed at one end of the lifting mechanism and is used for stably clamping the purification bottle.

As a still further scheme of the utility model: the lifting mechanism comprises a first knob, a first gear, a connecting rotating rod, a push-pull block, a fixed block, a sleeve sliding block and a lifting plate, the sleeve sliding block is located right above the stable bottom plate and is sleeved with the lifting rod, the first gear is located on one side of the lifting rod and is sleeved with the sleeve sliding block, the first knob is located on one side of the sleeve sliding block and penetrates through the inside of the sleeve sliding block to be connected with the first gear in a rotating mode, the connecting rotating rod is located at the central position of one end, away from the first knob, of the first gear and penetrates through one side of the sleeve sliding block, the fixed block is located on one side, away from the first knob, of the sleeve sliding block and is sleeved with the connecting rotating rod, the push-pull block is fixed at the central position of one end, away from the first knob, of the lifting plate is fixed at one end, away from the first gear, of the sleeve sliding block.

As a still further scheme of the utility model: the clamping mechanism comprises a second gear, a telescopic fixture block, a spring, a telescopic rod, a bidirectional threaded rod, a movable sliding block, a first clamping frame, a second knob and a stabilizing plate, the stabilizing plate is fixed at the bottom end of one side, far away from the first gear, of the lifting plate, the second knob is located at the central position of one end of the lifting plate, the bidirectional threaded rod is fixed at the central position of one end of the second knob and located inside the lifting plate, the second gear is fixed at one end, far away from the second knob, of the bidirectional threaded rod, the telescopic fixture block is located on one side of the second gear, the telescopic rod is fixed at the central position of one end, far away from the second gear, of the telescopic fixture block, the spring is located on one side, far away from the telescopic fixture block, of the two movable sliding blocks are respectively located on the outer walls of two sides of the bidirectional threaded rod and are mutually sleeved with the bidirectional threaded rod, the first clamping frame is located on one side, far away from the first gear, of the lifting plate, and with a removal slider fixed connection, the second centre gripping frame is fixed in the one end of another removal slider, and cup joints each other with first centre gripping frame.

As a still further scheme of the utility model: the utility model discloses a telescopic sliding plate, including lifter, fixed block, first gear, fixed block, first gear and connecting bull stick, the lifter meets position department with first gear is provided with the tooth piece rather than outer wall intermeshing, it is provided with the fixed slot rather than outer wall assorted to cup joint slider, first gear and fixed block department of meeting position, the one end of connecting the bull stick and keeping away from first gear is provided with spacing slide, the fixed block is provided with the flexible spout rather than outer wall assorted with the position department of connecting the bull stick.

As a still further scheme of the utility model: the lifting plate is provided with a movable sliding groove matched with the outer wall of the lifting plate at the connecting position of the telescopic clamping block, the telescopic rod and the movable sliding block, a rotating groove matched with the outer wall of the lifting plate at the connecting position of the lifting plate and the second gear is provided, and a threaded groove matched with the outer wall of the movable sliding block at the connecting position of the movable sliding block and the bidirectional threaded rod is provided.

As a still further scheme of the utility model: the top of the stabilizing plate is provided with a stabilizing groove, the lifting plate is rotatably connected with the fixed block through a bearing, and a limiting sliding plate is arranged at the joint of the telescopic rod and the spring.

As a still further scheme of the utility model: the second gear is meshed with the telescopic clamping block and fixed through the tooth block, the second knob is rotatably connected with the bidirectional threaded rod through a rotating shaft, and rubber pads are arranged on the inner walls of the first clamping frame and the second clamping frame.

Compared with the prior art, the utility model has the beneficial effects that:

1. the mechanism can realize stable lifting of the purification bottle by arranging the lifting mechanism, the fixed block is driven to be separated from the inside of the fixed clamping groove of the sleeving sliding block by pulling the push-pull block, the sleeving sliding block is limited and fixed by the connecting rotating rod limiting sliding plate at the moment, then the first knob is rotated to drive the first gear to drive the connecting rotating rod to rotate, the sleeving sliding block is meshed with the first gear through the tooth block at the moment, when the purification bottle is lifted to a specified position, the push-pull block is pushed to clamp the fixed block into the fixed clamping groove at the moment, and the height of the purification bottle can be quickly adjusted by mutual matching of the plurality of parts;

2. through setting up fixture, this mechanism can realize the perpendicular centre gripping to the purification bottle, through passing first centre gripping frame with the purification bottle, the inside at firm groove is placed to the second centre gripping frame, then rotatory second knob, make two-way threaded rod pass through two removal sliders, drive first centre gripping frame, the second centre gripping frame is close to each other, the second gear passes through under the drive of two-way threaded rod simultaneously, it is rotatory in the inside of rotating the groove, and extrude flexible fixture block, flexible fixture block promotes the telescopic link through the extrusion this moment and extrudees the spring, then the spring makes flexible fixture block mesh fixedly to the second gear through the pressure bounce-back promotion telescopic link, can carry out the vertical fixation to the purification bottle through mutually supporting of above a plurality of parts.

Drawings

FIG. 1 is a schematic structural view of the present invention;

FIG. 2 is a schematic cross-sectional view of the lifting mechanism and clamping mechanism of the present invention;

FIG. 3 is a schematic partial cross-sectional view of the lift mechanism of the present invention;

fig. 4 is a partially enlarged view of the point a of the present invention.

In the figure: 1. a stable bottom plate; 2. a lifting mechanism; 201. a first knob; 202. a first gear; 203. connecting the rotating rod; 204. a push-pull block; 205. a fixed block; 206. sleeving a sliding block; 207. a lifting plate; 3. a clamping mechanism; 301. a second gear; 302. a telescopic clamping block; 303. a spring; 304. a telescopic rod; 305. a bidirectional threaded rod; 306. moving the slide block; 307. a first clamping frame; 308. a second clamping frame; 309. a second knob; 3010. a stabilizing plate; 4. a lifting rod.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc., indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and simplicity of description, but do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be construed as limiting the present invention. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance. In the description of the present invention, it should be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "disposed" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art. The following describes an embodiment of the present invention based on its overall structure.

Referring to fig. 1-4, in an embodiment of the present invention, an automatic collection device for antibody purification effluent includes:

a stable bottom plate 1;

the lifting rod 4 is positioned at the top end of one side of the stable bottom plate 1 and is used for lifting the purification bottle;

the lifting mechanism 2 is positioned right above the stable bottom plate 1, is mutually sleeved with the lifting rod 4 and is used for stably lifting the height of the purification bottle;

and the clamping mechanism 3 is positioned at the formal side of the stable bottom plate 1, is fixed at one end of the lifting mechanism 2 and is used for stably clamping the purification bottle.

Please refer to fig. 2-3, the lifting mechanism 2 includes a first knob 201, a first gear 202, a connecting rotating rod 203, a push-pull block 204, a fixed block 205, a sliding block 206 and a lifting plate 207, the sliding block 206 is located right above the stable bottom plate 1 and is sleeved with the lifting rod 4, the first gear 202 is located at one side of the lifting rod 4 and is sleeved with the sliding block 206, the first knob 201 is located at one side of the sliding block 206 and penetrates through the inside of the sliding block 206 to be connected with the first gear 202 in a rotating manner, the connecting rotating rod 203 is located at a central position of one end of the first gear 202 far away from the first knob 201 and penetrates through one side of the sliding block 206, the fixed block 205 is located at one side of the sliding block 206 far away from the first knob 201 and is sleeved with the connecting rotating rod 203, the push-pull block 204 is fixed at a central position of one end of the fixed block 205 far away from the first knob 201, the lifting plate 207 is fixed at one end of the sliding block 206 far away from the first gear 202, the first gear 202 drives the lifting plate 207 to vertically lift the purification bottle.

Referring to fig. 2 to 4, the clamping mechanism 3 includes a second gear 301, a retractable latch 302, a spring 303, a retractable rod 304, a two-way threaded rod 305, a movable slider 306, a first clamping frame 307, a second clamping frame 308, a second knob 309 and a stabilizing plate 3010, the stabilizing plate 3010 is fixed to the bottom end of the side of the lifting plate 207 away from the first gear 202, the second knob 309 is located at the center of one end of the lifting plate 207, the two-way threaded rod 305 is fixed to the center of one end of the second knob 309 and located inside the lifting plate 207, the second gear 301 is fixed to one end of the two-way threaded rod 305 away from the second knob 309, the retractable latch 302 is located on one side of the second gear 301, the retractable rod 304 is fixed to the center of one end of the retractable latch 302 away from the second gear 301, the spring 303 is located on one side of the retractable latch 304 away from the retractable latch 302, the two movable sliders 306 are respectively located on the outer walls of two sides of the two-way threaded rod 305, and cup joint each other with two-way threaded rod 305, first centre gripping frame 307 is located the one side that lifter plate 207 kept away from first gear 202, and with a removal slider 306 fixed connection, and second centre gripping frame 308 is fixed in the one end of another removal slider 306, and cup joint each other with first centre gripping frame 307, places purification bottle steadily through stabilizing board 3010.

Please refer to fig. 2 to 3, a tooth block engaged with the outer wall of the lifting rod 4 is disposed at the position where the lifting rod 4 is connected to the first gear 202, a fixed slot matched with the outer wall of the sleeve slider 206 is disposed at the position where the first gear 202 is connected to the fixed block 205, a limit sliding plate is disposed at the end of the connecting rotating rod 203 far away from the first gear 202, a telescopic slot matched with the outer wall of the fixed block 205 is disposed at the position where the fixed block 205 is connected to the connecting rotating rod 203, and the fixed block 205 can fix the first gear 202 quickly.

Please refer to fig. 2 to 4, the connection position of the lifting plate 207, the retractable block 302, the retractable rod 304, and the movable slider 306 is provided with a movable sliding slot matching with the outer wall thereof, the connection position of the lifting plate 207 and the second gear 301 is provided with a rotating slot matching with the outer wall thereof, the connection position of the movable slider 306 and the bidirectional threaded rod 305 is provided with a threaded slot matching with the outer wall thereof, and the bidirectional threaded rod 305 drives the movable slider 306 to approach or separate from each other through the threaded slot.

Please refer to fig. 2 to 4, the top end of the stabilizing plate 3010 is provided with a stabilizing groove, the lifting plate 207 is rotatably connected to the fixing block 205 through a bearing, a position of the telescopic rod 304 connected to the spring 303 is provided with a limiting sliding plate, and the telescopic rod 304 is enabled to slide in the lifting plate 207 in a limiting manner through the limiting sliding plate.

Please refer to fig. 2 to 4, the second gear 301 and the retractable latch 302 are engaged and fixed by a tooth block, the second knob 309 is rotatably connected with the bidirectional threaded rod 305 by a rotating shaft, and rubber pads are disposed on inner walls of the first clamping frame 307 and the second clamping frame 308, so that the retractable latch 302 can extend and fix the second gear 301 by engaging the tooth block.

The working principle of the utility model is as follows: when in use, a purification bottle passes through the first clamping frame 307 and the second clamping frame 308 and is placed inside the stable groove of the stable plate 3010, then the second knob 309 is rotated, so that the bidirectional threaded rod 305 drives the two movable sliding blocks 306 to approach each other through the threaded groove, and simultaneously the first clamping frame 307 and the second clamping frame 308 approach each other under the driving of the movable sliding blocks 306, so as to be convenient for rapidly clamping the purification bottle, and be beneficial for vertically fixing the purification bottle, meanwhile, the second gear 301 is rotated inside the rotating groove under the driving of the bidirectional threaded rod 305, and extrudes the retractable clamping block 302, at the moment, the retractable clamping block 302 pushes the retractable rod 304 to extrude the spring 303 through extrusion, then the spring 303 pushes the retractable rod 304 through compression and rebound to enable the retractable clamping block 302 to mesh and fix the second gear 301, so as to prevent the bidirectional threaded rod 305 from self-sliding, and then the push-pull block 204 is pulled to drive the fixing block 205 to be separated from the inside of the fixing slot of the fixed clamping block 206, cup joint slider 206 and carry out spacing fixed through connecting the spacing slide of bull stick 203 this moment, then rotatory first knob 201 makes first gear 202 drive and connects bull stick 203 and rotate, cup joint slider 206 this moment and mesh through tooth piece and first gear 202, it drives lifter plate 207 and makes the purification bottle carry out the vertical lift to be convenient for cup joint slider 206, when the purification bottle rises to assigned position department, promote to push away and draw piece 204 this moment and make fixed block 205 card go into fixed slot, be convenient for fix fast first gear 202, be favorable to preventing that the purification bottle from taking place to reset, then place the receiving flask under the purification bottle, be convenient for collect fast the liquid that produces after the purification.

The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the scope of the present invention, and the technical solutions and the utility model concepts of the present invention are equivalent to or changed within the scope of the present invention.

Claims

1. An antibody-purification effluent automatic collection device, comprising:

a stable base plate (1);

the lifting rod (4) is positioned at the top end of one side of the stable bottom plate (1) and is used for lifting the purification bottle;

the lifting mechanism (2) is positioned right above the stable bottom plate (1), is sleeved with the lifting rod (4) and is used for stably lifting the height of the purification bottle;

and the clamping mechanism (3) is positioned at the formal side of the stable bottom plate (1), is fixed at one end of the lifting mechanism (2), and is used for stably clamping the purification bottle.

2. The automatic collection device for antibody purification effluent liquid as claimed in claim 1, wherein the lifting mechanism (2) comprises a first knob (201), a first gear (202), a connecting rotating rod (203), a push-pull block (204), a fixed block (205), a sleeve sliding block (206) and a lifting plate (207), the sleeve sliding block (206) is located right above the stable bottom plate (1) and is sleeved with the lifting rod (4), the first gear (202) is located on one side of the lifting rod (4) and is sleeved with the sleeve sliding block (206), the first knob (201) is located on one side of the sleeve sliding block (206) and penetrates through the inner part of the sleeve sliding block (206) to be rotatably connected with the first gear (202), the connecting rotating rod (203) is located at a central position of one end of the first gear (202) far away from the first knob (201) and penetrates through one side of the sleeve sliding block (206), the fixed block (205) is located one side that first knob (201) were kept away from in the slider (206) that cup joints, and cup joints each other with connecting bull stick (203), push and pull piece (204) are fixed and are kept away from the one end central point department of first knob (201) in fixed block (205), lifter plate (207) are fixed and are kept away from the one end of first gear (202) in the slider (206) that cup joints.

3. The automatic collection device for antibody purification effluent liquid as claimed in claim 1, wherein the clamping mechanism (3) comprises a second gear (301), a telescopic fixture block (302), a spring (303), a telescopic rod (304), a bidirectional threaded rod (305), a moving slider (306), a first clamping frame (307), a second clamping frame (308), a second knob (309) and a stabilizing plate (3010), the stabilizing plate (3010) is fixed at the bottom end of one side of the lifting plate (207) far away from the first gear (202), the second knob (309) is located at the center position of one end of the lifting plate (207), the bidirectional threaded rod (305) is fixed at the center position of one end of the second knob (309) and located inside the lifting plate (207), the second gear (301) is fixed at one end of the bidirectional threaded rod (305) far away from the second knob (309), the telescopic clamping block (302) is located on one side of the second gear (301), the telescopic rod (304) is fixed at the position of the center of one end, far away from the second gear (301), of the telescopic clamping block (302), the spring (303) is located on one side, far away from the telescopic clamping block (302), of the telescopic rod (304), the two movable sliding blocks (306) are located on the outer walls of the two sides of the two-way threaded rod (305) respectively and are sleeved with the two-way threaded rod (305) mutually, the first clamping frame (307) is located on one side, far away from the first gear (202), of the lifting plate (207) and is fixedly connected with one movable sliding block (306), the second clamping frame (308) is fixed at one end of the other movable sliding block (306) and is sleeved with the first clamping frame (307) mutually.

4. The automatic collection device for antibody purification effluent liquid as claimed in claim 2, wherein a tooth block meshed with the outer wall of the lifting rod (4) is arranged at the joint of the lifting rod and the first gear (202), a fixed clamping groove matched with the outer wall of the fixed block (205) is arranged at the joint of the sleeve sliding block (206), the first gear (202) and the fixed block (205), a limit sliding plate is arranged at one end of the connecting rotating rod (203) far away from the first gear (202), and a telescopic sliding groove matched with the outer wall of the fixed block (205) is arranged at the joint of the connecting rotating rod (203).

5. The automatic collecting device for antibody purification effluent according to claim 3, wherein a moving sliding groove matched with the outer wall of the lifting plate (207) is arranged at the connecting position of the lifting plate (207) with the telescopic fixture block (302), the telescopic rod (304) and the moving sliding block (306), a rotating groove matched with the outer wall of the lifting plate (207) is arranged at the connecting position of the lifting plate (207) with the second gear (301), and a threaded groove matched with the outer wall of the moving sliding block (306) is arranged at the connecting position of the moving sliding block (306) with the bidirectional threaded rod (305).

6. The automatic collecting device for antibody purification effluent according to claim 3, wherein a stabilizing groove is arranged at the top end of the stabilizing plate (3010), the lifting plate (207) is rotatably connected with the fixing block (205) through a bearing, and a limiting sliding plate is arranged at the connecting position of the telescopic rod (304) and the spring (303).

7. The automatic antibody purification effluent collecting device according to claim 3, wherein the second gear (301) is fixed to the telescopic fixture block (302) by means of meshing of a toothed block, the second knob (309) is rotatably connected to the bidirectional threaded rod (305) by means of a rotating shaft, and rubber pads are disposed on inner walls of the first clamping frame (307) and the second clamping frame (308).