CN215809548U - Low-temperature storage device for immune cells - Google Patents
Low-temperature storage device for immune cells Download PDFInfo
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- CN215809548U CN215809548U CN202121262474.5U CN202121262474U CN215809548U CN 215809548 U CN215809548 U CN 215809548U CN 202121262474 U CN202121262474 U CN 202121262474U CN 215809548 U CN215809548 U CN 215809548U
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Abstract
The utility model provides a low-temperature storage device for immune cells. The cryogenic storage device for immune cells comprises: the device comprises a box body, a liquid nitrogen refrigerating assembly, an automatic lifting assembly, a containing box, four arc-shaped clamping plates, a plurality of first springs, four rubber pads, a limiting mechanism and an automatic illuminating mechanism; the liquid nitrogen refrigeration subassembly sets up in the box, the liquid nitrogen refrigeration subassembly includes: the cavity is arranged on the box body, and the hydraulic pump is fixedly arranged at the top of the box body. The low-temperature storage device for the immune cells, provided by the utility model, has the advantages of convenience in use, capability of automatically lifting the test tube, convenience in taking the test tube, disinfection mechanism arrangement and reinforced sealing effect.
Description
Technical Field
The utility model belongs to the field of immune cell storage, and particularly relates to a low-temperature storage device for immune cells.
Background
Immune cells refer to cells involved in or associated with an immune response. Including lymphocytes, dendritic cells, monocytes/macrophages, granulocytes, mast cells, and the like. Immune cells can be classified into various types, and various immune cells play an important role in the human body. Immune cells are commonly called as leucocytes and comprise congenital lymphocytes, various phagocytes and the like, lymphocytes capable of recognizing antigens and generating specific immune response and the like, and the immune cells need to be stored at low temperature in storage so as to ensure that the immune cells can be stored for a long time and can be effectively used after being used subsequently. In the correlation technique, a stem cell low temperature storage device for bio-pharmaceuticals is disclosed, comprising a base plate, square groove upside is provided with sealed lid, bottom plate downside fixedly connected with liquid nitrogen strorage device, liquid nitrogen strorage device inner wall overlap joint has the liquid nitrogen jar, liquid nitrogen pipe suction head rear side fixedly connected with liquid nitrogen conveyer pipe, hydraulic means right side fixedly connected with fixed plate. This a stem cell low temperature storage device for bio-pharmaceuticals, through setting up the inside liquid nitrogen container at liquid nitrogen strorage device, and through the liquid nitrogen conveyer pipe of setting on the liquid nitrogen container, and through setting up the liquid nitrogen injector head in liquid nitrogen conveyer pipe upper end and setting up the liquid nitrogen pipe suction head at liquid nitrogen conveyer pipe lower extreme, make the liquid nitrogen in the liquid nitrogen container enter into square inslot, the rethread sets up the sealed lid in square groove top, make sealed lid fix the top at square groove, thereby the effect of stem cell low temperature storage has been reached.
However, still have the weak point in the above-mentioned structure, the liquid nitrogen direct storage is square inslot, when opening sealed lid and getting the test tube, because of the liquid nitrogen temperature is low excessively, can cause harm to the human body, and does not set up disinfection mechanism, and the test tube easily receives the pollution.
Therefore, there is a need to provide a new low-temperature storage device for immune cells to solve the above technical problems.
SUMMERY OF THE UTILITY MODEL
The utility model solves the technical problem of providing the low-temperature storage device for the immune cells, which is convenient to use, can automatically lift the test tube, is convenient to take the test tube, is provided with a disinfection mechanism and has a reinforced sealing effect.
In order to solve the above technical problems, the present invention provides a low temperature storage device for immune cells, comprising: the device comprises a box body, a liquid nitrogen refrigerating assembly, an automatic lifting assembly, a containing box, four arc-shaped clamping plates, a plurality of first springs, four rubber pads, a limiting mechanism and an automatic illuminating mechanism;
the liquid nitrogen refrigeration assembly is arranged in the box body and comprises a cavity, a hydraulic pump, a liquid conveying pipe and a liquid level sensor, the cavity is formed in the box body, the hydraulic pump is fixedly installed at the top of the box body, the liquid conveying pipe is fixedly installed on a liquid conveying port of the hydraulic pump, one end, far away from the hydraulic pump, of the liquid conveying pipe extends into the cavity, and the liquid level sensor is fixedly installed on the inner wall of one side of the cavity;
automatic lifting unit sets up in the box, automatic lifting unit includes first motor, two threaded rods, belt and backup pad, first motor fixed mounting is at the top of box, two the threaded rod all rotates to be installed in the box, the top of the threaded rod that corresponds extend to the box the top and with the output shaft fixed connection of motor, two all fixed cover is equipped with the idler on the threaded rod, the belt cover is established on two idlers, the backup pad screw thread is installed on two threaded rods.
As a further scheme of the utility model, the storage box is fixedly mounted at the top of the support plate, two test tube boxes are arranged in the storage box, a fixed block is fixedly mounted on the inner wall of the bottom of each test tube box, a first groove is formed in the top of the fixed block, the four arc-shaped clamping plates are respectively arranged in the two test tube boxes, four first springs are respectively fixedly mounted on the inner walls of two sides of each test tube box, the ends, close to each other, of the four first springs are respectively fixedly connected with the outer walls of the two arc-shaped clamping plates, and a rubber pad is fixedly mounted on one side, far away from the first springs, of each arc-shaped clamping plate.
As a further scheme of the utility model, the limiting mechanism is arranged on the box body, the limiting mechanism comprises a top cover, a fixed rod, a second slider, a second spring and a limiting block, the top cover is hinged to the top of the box body, a second groove is formed in the top of the box body, the fixed rod is fixedly arranged in the second groove, the second slider is slidably arranged on the fixed rod, the top of the second slider extends to the upper side of the second groove, the second spring is slidably sleeved on the fixed rod, one end of the second spring is fixedly connected with the outer wall of one side of the second slider, the other end of the second spring is fixedly connected with the inner wall of one side of the second groove, a third groove is formed in the outer wall of one side of the top cover, the limiting block is fixedly arranged on the outer wall of one side of the second slider, and the limiting block is matched with the third groove.
As a further scheme of the present invention, the automatic lighting mechanism is disposed in the box, the automatic lighting mechanism includes a second motor, a fixing plate, a bulb, and a cylinder, the second motor is fixedly mounted on an inner wall of a top portion of the box, the fixing plate is fixedly mounted on an output shaft of the second motor, the bulb is hinged to a bottom of the fixing plate, the cylinder is hinged to a bottom of the fixing plate, and the output shaft of the cylinder is hinged to the bulb.
As a further scheme of the utility model, the inner walls of two sides of the box body are fixedly provided with ultraviolet lamps, the inner wall of one side of the box body is fixedly provided with a heat conducting fin, the inner wall of one side of the box body is fixedly provided with a temperature sensor, and the top of the box body is fixedly provided with a controller.
As a further scheme of the utility model, a first through hole is formed in the top of the box body, a second through hole is formed in the top of the containing box, and the hydraulic pump, the liquid level sensor, the first motor, the second motor, the ultraviolet lamp, the heat conducting fin and the temperature sensor are electrically connected with the controller in sequence.
Compared with the related art, the low-temperature storage device for the immune cells provided by the utility model has the following beneficial effects:
1. according to the utility model, the automatic lifting assembly is arranged, so that the test tube can be automatically lifted along with the supporting plate, and the test tube is convenient to take;
2. according to the utility model, the top cover is sealed by arranging the limiting mechanism, so that no gap is formed between the top cover and the box body;
3. according to the utility model, the automatic lighting mechanism is arranged, so that the box body is lighted, and the test tube is convenient to take.
Drawings
In order to facilitate understanding for those skilled in the art, the present invention will be further described with reference to the accompanying drawings.
FIG. 1 is a schematic front sectional view of a cryogenic storage device for immune cells according to the present invention;
FIG. 2 is an enlarged schematic view of portion A of FIG. 1;
fig. 3 is an enlarged schematic view of a portion B in fig. 1.
Fig. 4 is an enlarged schematic structural view of a portion C in fig. 1.
In the figure: 1. a box body; 2. a cavity; 3. a hydraulic pump; 4. a transfusion tube; 5. a liquid level sensor; 6. a first motor; 7. a threaded rod; 8. a belt; 9. a support plate; 10. a storage box; 11. an arc-shaped splint; 12. a first spring; 13. a rubber pad; 14. a top cover; 15. a fixed block; 16. a second slider; 17. a second spring; 18. a limiting block; 19. a second motor; 20. a fixing plate; 21. a bulb; 22. a cylinder; 23. an ultraviolet lamp; 24. a heat conductive sheet; 25. a temperature and humidity sensor; 26. and a controller.
Detailed Description
Please refer to fig. 1, fig. 2, fig. 3 and fig. 4 in combination, wherein fig. 1 is a schematic front sectional view illustrating a low-temperature storage device for immune cells according to the present invention; FIG. 2 is an enlarged schematic view of portion A of FIG. 1; FIG. 3 is an enlarged schematic view of portion B of FIG. 1;
fig. 4 is an enlarged schematic structural view of a portion C in fig. 1. A cryogenic storage device for immune cells comprising: the device comprises a box body 1, a liquid nitrogen refrigerating assembly, an automatic lifting assembly, a containing box 10, four arc-shaped clamping plates 11, a plurality of first springs 12, four rubber pads 13, a limiting mechanism and an automatic illuminating mechanism;
the liquid nitrogen refrigeration assembly is arranged in the box body 1 and comprises a cavity 2, a hydraulic pump 3, a liquid conveying pipe 4 and a liquid level sensor 5, the cavity 2 is arranged on the box body 1, the hydraulic pump 3 is fixedly arranged at the top of the box body 1, the liquid conveying pipe 4 is fixedly arranged on a liquid conveying port of the hydraulic pump 3, one end, far away from the hydraulic pump 3, of the liquid conveying pipe 4 extends into the cavity 2, and the liquid level sensor 5 is fixedly arranged on the inner wall of one side of the cavity 2.
Automatic lifting unit sets up in box 1, automatic lifting unit includes first motor 6, two threaded rods 7, belt 8 and backup pad 9, 6 fixed mounting of first motor is at the top of box 1, two threaded rod 7 all rotates to be installed in box 1, the top of corresponding threaded rod 7 extend to box 1 the top and with motor 6's output shaft fixed connection, two all fixed cover is equipped with the idler on threaded rod 7, 8 covers of belt establish on two idlers, backup pad 9 screw thread is installed on two threaded rods 7.
As shown in fig. 2, containing box fixed mounting is at the top of backup pad, be equipped with two test tube boxes in the containing box 10, the bottom inner wall fixed mounting of test tube box has the fixed block, first recess, four have been seted up at the top of fixed block arc splint 11 sets up respectively in two test tube boxes, the both sides inner wall of test tube box is fixed mounting four first springs 12 respectively, the one end that four first springs 12 are close to each other respectively with the outer wall fixed connection of two arc splint 11, one side fixed mounting that first spring 12 was kept away from to arc splint 11 has rubber pad 13.
Mutually support through first motor 6, threaded rod 7 and backup pad 9 for threaded rod 7 drives backup pad 9 and reciprocates, conveniently takes the test tube.
As shown in fig. 3, the limiting mechanism is arranged on the box body 1, the limiting mechanism comprises a top cover 14, a fixed rod 15, a second sliding block 16, a second spring 17 and a limiting block 18, the top cover 14 is hinged on the top of the box body 1, a second groove is arranged on the top of the box body 1, the fixed rod 15 is fixedly arranged in the second groove, the second sliding block 16 is slidably arranged on the fixed rod 15, the top of the second sliding block 16 extends to the upper part of the second groove, the second spring 17 is sleeved on the fixed rod 15 in a sliding way, one end of the second spring 17 is fixedly connected with the outer wall of one side of the second sliding block 16, the other end of the second spring 17 is fixedly connected with the inner wall of one side of the second groove, a third groove is formed in the outer wall of one side of the top cover 14, the limiting block 18 is fixedly mounted on the outer wall of one side of the second sliding block 16, and the limiting block 18 is matched with the third groove.
Through mutual cooperation of the second sliding block 16, the second spring 17 and the limiting block 18, no gap exists between the top cover 14 and the top of the box body 1, air cannot enter, and the sealing performance is high.
As shown in fig. 4, the automatic lighting mechanism is disposed in the box body 1, the automatic lighting mechanism includes a second motor 19, a fixing plate 20, a bulb 21 and a cylinder 22, the second motor 19 is fixedly mounted on the inner wall of the top of the box body 1, the fixing plate 20 is fixedly mounted on the output shaft of the second motor 19, the bulb 21 is hinged to the bottom of the fixing plate 20, the cylinder 22 is hinged to the bottom of the fixing plate 20, and the output shaft of the cylinder 22 is hinged to the bulb 21.
Through second motor 19, bulb 21 and cylinder 22 mutually support, can multi-angle illumination box 1, more conveniently take the test tube.
As shown in fig. 1, the inner walls of the two sides of the box body 1 are fixedly provided with ultraviolet lamps 23, the inner wall of one side of the box body 1 is fixedly provided with a heat conducting fin 24, the inner wall of one side of the box body 1 is fixedly provided with a temperature and humidity sensor 25, and the top of the box body 1 is fixedly provided with a controller 26.
As shown in fig. 1, a first through hole is opened at the top of the box body 1, a second through hole is opened at the top of the storage box 10, and the hydraulic pump 3, the liquid level sensor 5, the first motor 6, the second motor 19, the ultraviolet lamp 23, the heat-conducting fin 24, the temperature and humidity sensor 25 and the controller 26 are electrically connected.
The ultraviolet lamp 23, the heat conducting fins 24, the temperature and humidity sensor 25 and the controller 26 are matched with each other, so that the operation work can be effectively and automatically completed, and the inside of the box body 1 is disinfected.
The working principle of the low-temperature storage device for immune cells provided by the utility model is as follows:
the first step is as follows: when immunocytes need to be stored at low temperature, the hydraulic pump 3 is started, a liquid suction pipe is fixedly installed on a liquid suction port of the hydraulic pump 3 and is connected with a hydraulic tank, liquid nitrogen is extracted, the liquid nitrogen is conveyed into the cavity 2 through the liquid conveying pipe 4 to form a low-temperature storage environment, the temperature in the box body 1 can be monitored through the temperature and humidity sensor 25, the liquid level sensor 5 is arranged, if the liquid nitrogen is lower than the position of the liquid level sensor 5, the hydraulic pump 3 is started, the liquid nitrogen is conveyed into the cavity 2, when the liquid nitrogen reaches the highest position, the hydraulic pump 3 is closed, before a test tube is stored and taken, the ultraviolet lamp 23 is opened, the containing box 10 and the test tube are disinfected, when the test tube is stored and taken, the first motor 6 is started, the output shaft of the first motor 6 drives the threaded rods 7 to rotate, under the action of the idler and the belt 8, the two threaded rods 7 rotate, the two threaded rods 7 drive the supporting plate 9 to move, containing box 10 reciprocates along with backup pad 9, stimulate second slider 16, make second slider 16 come the extrusion second spring 17, make second slider 16 drive stopper 18 and break away from the third recess, thereby can open top cap 14, take out the test tube, loosen second slider 16 again, reset under the elastic action of second spring 17, make stopper 18 return to the third recess, carry out spacing fixed, after taking out the test tube, open ultraviolet lamp 23 again, disinfect containing box 10 and surplus test tube;
the second step is as follows: when the test tube is stored and taken, the bulb 21 is turned on, so that illumination observation is facilitated, if the angle is required to be adjusted for checking, the cylinder 22 is started, the inclination angle of the bulb 21 is adjusted, after the adjustment is finished, the second motor 19 is started again, the fixing plate 20 is driven to rotate, so that the bulb 21 is driven to rotate, and after the illumination is finished, the second motor 19 is turned off; by providing the temperature/humidity sensor 25, it can be known that the heat-conducting fins 24 start to be heated if the low temperature in the case 1 is lower than the predetermined value, and the heat-conducting fins 24 stop heating when the predetermined value is reached.
It should be noted that the device structure and the accompanying drawings of the present invention mainly describe the principle of the present invention, and in the technology of the design principle, the settings of the power mechanism, the power supply system, the control system, and the like of the device are not completely described and clear, and on the premise that the skilled person understands the principle of the utility model, the details of the power mechanism, the power supply system, and the control system can be clearly known, the control mode of the application document is automatically controlled by the controller, and the control circuit of the controller can be realized by simple programming of the skilled person in the art;
the standard parts used in the method can be purchased from the market, and can be customized according to the description of the specification and the accompanying drawings, the specific connection mode of each part adopts conventional means such as mature bolts, rivets, welding and the like in the prior art, the machines, parts and equipment adopt conventional models in the prior art, and the structure and the principle of the parts known by the skilled person can be known by technical manuals or conventional experimental methods.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments, or a direct or indirect use of these embodiments, without departing from the principles and spirit of the utility model, the scope of which is defined in the claims and their equivalents, which are to be included in the scope of the utility model as defined in the claims.
Claims (6)
1. A cryogenic storage device for immune cells, comprising: the device comprises a box body, a liquid nitrogen refrigerating assembly, an automatic lifting assembly, a containing box, four arc-shaped clamping plates, a plurality of first springs, four rubber pads, a limiting mechanism and an automatic illuminating mechanism;
the liquid nitrogen refrigeration assembly is arranged in the box body and comprises a cavity, a hydraulic pump, a liquid conveying pipe and a liquid level sensor, the cavity is formed in the box body, the hydraulic pump is fixedly installed at the top of the box body, the liquid conveying pipe is fixedly installed on a liquid conveying port of the hydraulic pump, one end, far away from the hydraulic pump, of the liquid conveying pipe extends into the cavity, and the liquid level sensor is fixedly installed on the inner wall of one side of the cavity;
automatic lifting unit sets up in the box, automatic lifting unit includes first motor, two threaded rods, belt and backup pad, first motor fixed mounting is at the top of box, two the threaded rod all rotates to be installed in the box, the top of the threaded rod that corresponds extend to the box the top and with the output shaft fixed connection of motor, two all fixed cover is equipped with the idler on the threaded rod, the belt cover is established on two idlers, the backup pad screw thread is installed on two threaded rods.
2. The cryogenic storage device for immune cells of claim 1, wherein: containing box fixed mounting is at the top of backup pad, be equipped with two test tube boxes in the containing box, the bottom inner wall fixed mounting of test tube box has the fixed block, first recess, four have been seted up at the top of fixed block the arc splint set up respectively in two test tube boxes, the both sides inner wall of test tube box is fixed mounting four first springs respectively, the one end that four first springs are close to each other respectively with the outer wall fixed connection of two arc splint, one side fixed mounting that first spring was kept away from to the arc splint has the rubber pad.
3. The cryogenic storage device for immune cells of claim 1, wherein: stop gear sets up on the box, stop gear includes top cap, dead lever, second slider, second spring and stopper, the top cap articulates at the top of box, the second recess has been seted up at the top of box, dead lever fixed mounting is in the second recess, second slider slidable mounting is on the dead lever, the top of second slider extends to the top of second recess, second spring sliding sleeve is established on the dead lever, one side outer wall fixed connection of one end of second spring and second slider, the other end of second spring and one side inner wall fixed connection of second recess, the third recess has been seted up to one side outer wall of top cap, stopper fixed mounting is on one side outer wall of second slider, stopper and third recess looks adaptation.
4. The cryogenic storage device for immune cells of claim 1, wherein: the automatic lighting mechanism is arranged in the box body and comprises a second motor, a fixing plate, a bulb and a cylinder, the second motor is fixedly installed on the inner wall of the top of the box body, the fixing plate is fixedly installed on an output shaft of the second motor, the bulb is hinged to the bottom of the fixing plate, the cylinder is hinged to the bottom of the fixing plate, and the output shaft of the cylinder is hinged to the bulb.
5. The cryogenic storage device for immune cells of claim 1, wherein: the ultraviolet lamp is fixedly mounted on the inner walls of the two sides of the box body, the heat conducting fins are fixedly mounted on the inner wall of one side of the box body, the temperature and humidity sensor is fixedly mounted on the inner wall of one side of the box body, and the controller is fixedly mounted at the top of the box body.
6. The cryogenic storage device for immune cells of claim 5, wherein: first opening has been seted up at the top of box, the second opening has been seted up at the top of containing box, hydraulic pump, level sensor, first motor, second motor, ultraviolet lamp, conducting strip, temperature and humidity sensor in proper order and controller electric connection.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202121262474.5U CN215809548U (en) | 2021-06-07 | 2021-06-07 | Low-temperature storage device for immune cells |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202121262474.5U CN215809548U (en) | 2021-06-07 | 2021-06-07 | Low-temperature storage device for immune cells |
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| Publication Number | Publication Date |
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| CN215809548U true CN215809548U (en) | 2022-02-11 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202121262474.5U Active CN215809548U (en) | 2021-06-07 | 2021-06-07 | Low-temperature storage device for immune cells |
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| CN (1) | CN215809548U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114903031A (en) * | 2022-06-22 | 2022-08-16 | 朗姿赛尔生物科技（广州）有限公司 | Stem cell extraction and storage device and method |
| CN115152744A (en) * | 2022-07-13 | 2022-10-11 | 吉林医药学院 | Temperature and humidity regulation storage device for storing umbilical cord stem cell activity |
-
2021
- 2021-06-07 CN CN202121262474.5U patent/CN215809548U/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114903031A (en) * | 2022-06-22 | 2022-08-16 | 朗姿赛尔生物科技（广州）有限公司 | Stem cell extraction and storage device and method |
| CN114903031B (en) * | 2022-06-22 | 2023-11-10 | 朗姿赛尔生物科技（广州）有限公司 | Stem cell extraction and storage device and method |
| CN115152744A (en) * | 2022-07-13 | 2022-10-11 | 吉林医药学院 | Temperature and humidity regulation storage device for storing umbilical cord stem cell activity |
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