CN215741895U - Crystallization reaction kettle for pharmacy - Google Patents

Abstract

The utility model discloses a crystallization reaction kettle for pharmacy, which comprises a kettle body, wherein a motor is arranged at the upper end of the kettle body and is connected with a stirring paddle through a stirring rod, a feeding pipe is arranged at the upper end of the kettle body, a cooling box and a funnel are arranged below the kettle body, a filter plate is movably arranged at the upper part of the funnel, a liquid collecting barrel is arranged below the funnel, a heating sleeve is arranged at the lower part of the outer wall of the kettle body, and one side of the kettle body is connected with a vacuum pump through a vacuum pumping pipe. Let in high temperature steam in the heating jacket and carry out heat-conduction to heat the supersaturated solution in the cauldron body, the motor drives the stirring rake and stirs the supersaturated solution in the cauldron body, promote the flow of solution, it is even to make solution be heated, the vacuum pump carries out the evacuation through the evacuation pipe to the cauldron body, reduce the boiling point of moisture in the internal pressure of cauldron and the supersaturated solution, thereby accelerated the evaporation rate of moisture in the solution, shorten crystallization time, improve the economic benefits of crystallization rate and enterprise.

Description

Crystallization reaction kettle for pharmacy

Technical Field

The utility model belongs to the technical field of pharmacy, and particularly relates to a crystallization reaction kettle for pharmacy.

Background

Crystallization refers to a process of automatically precipitating solute from a supersaturated solution to form a new phase, and a pharmaceutical semi-finished product is obtained in a crystallization mode in the pharmaceutical process. The existing crystallization mode is mainly cooling crystallization, the crystallization speed is low, the crystallization efficiency is low, the production requirements of enterprises cannot be met, and the economic benefits of the enterprises are reduced.

SUMMERY OF THE UTILITY MODEL

In order to solve the problems, the utility model provides a crystallization reaction kettle for pharmacy.

The utility model is realized by the following steps: a crystallization reaction kettle for pharmacy comprises a kettle body, wherein a motor is fixedly arranged at the middle position of the upper end of the kettle body and used for providing power for rotation of a stirring rod and a stirring paddle, the stirring rod is vertically arranged in the kettle body, the upper end of the stirring rod penetrates through the kettle body and is connected with a transmission shaft of the motor, a shaft seal is arranged at the joint of the stirring rod and the kettle body and used for ensuring the connection tightness of the stirring rod and the kettle body, the stirring paddle is fixedly arranged at the lower end of the stirring rod and used for starting the motor, the stirring rod drives the stirring paddle to stir supersaturated solution in the kettle body and promote the flow of the solution, so that the solution is heated uniformly, the evaporation rate of water in the solution is accelerated, the crystallization time is shortened, an inlet pipe and a first exhaust pipe are arranged at the upper end of the kettle body, the supersaturated solution is poured into the kettle body along the inlet pipe, and high-temperature steam generated after the kettle body is cleaned and vapor generated in the heating process of the supersaturated solution are discharged along the first exhaust pipe, the bottom of the kettle body is provided with a first discharging pipe, the first discharging pipe is provided with a first discharging valve, the first discharging valve is opened, supersaturated solution precipitated in the kettle body is discharged along the first discharging pipe, a cooling tank is arranged below the first discharging pipe, the supersaturated solution in a high-temperature state is cooled, the precipitation rate of crystals is accelerated, the working time is reduced, the bottom of the cooling tank is provided with a second discharging pipe, the second discharging pipe is provided with a second discharging valve, the second discharging valve is opened, the crystals and the low-temperature saturated solution in the cooling tank are discharged along the second discharging pipe, a funnel is arranged below the second discharging pipe, an opening of the funnel is upward, mixed liquid containing the crystals is collected, a filter plate is movably arranged at the upper part of the funnel, the crystals in the solution are filtered and separated, and sieve meshes are uniformly and densely distributed on the filter plate, a liquid collecting barrel is arranged under the funnel, supersaturated solution flows into the liquid collecting barrel along the sieve holes and the funnel to be collected and then is continuously poured into the kettle body along the feeding pipe to carry out crystallization process, a heating sleeve is fixedly arranged at the lower part of the outer wall of the kettle body, high-temperature steam is introduced into the heating sleeve to carry out heat conduction, so that the supersaturated solution in the kettle body is heated, the evaporation rate of water in the solution is accelerated, the crystallization time is shortened, the lower part of one side of the heating sleeve is communicated with an air inlet main pipe, a first stop valve is arranged on the air inlet main pipe and is opened, the high-temperature steam enters the heating sleeve along the air inlet main pipe, the upper part of one side of the heating sleeve, which is deviated from the air inlet main pipe, is communicated with a first exhaust pipe through a second exhaust pipe, the heated steam is discharged along the second exhaust pipe, and an exhaust valve and a condenser are sequentially arranged on the first exhaust pipe, which is positioned at the communication part of the first exhaust pipe and the second exhaust pipe and is deviated from one side of the kettle body, the opening and closing of the first exhaust pipe are reasonably controlled through the exhaust valve, steam is condensed into liquid drops through the condenser and then is recycled, resource waste is avoided, a cleaning pipe is arranged on the upper portion of the side wall of the kettle body, a second stop valve is arranged on the cleaning pipe, the second stop valve is opened, hot water is used for cleaning the kettle body through the cleaning pipe, cleanness of the kettle body is guaranteed, the air inlet main pipe is communicated with the cleaning pipe through an air inlet branch pipe, a third stop valve is arranged on the air inlet branch pipe and is opened, high-temperature steam enters the kettle body along the cleaning pipe to sterilize and disinfect the kettle body, pollution to supersaturated solution and crystal particles in the kettle body is avoided, one side of the kettle body is connected with the vacuum pump through a vacuum pumping pipe, a fourth stop valve is arranged on the vacuum pumping pipe and is opened, and the vacuum pump is used for vacuumizing the kettle body through the vacuum pumping pipe, the pressure in the kettle body and the boiling point of the water in the supersaturated solution are reduced, the evaporation rate of the water is accelerated, and the crystallization time is shortened.

Preferably, cauldron body upper end is provided with thermometer and manometer, and the thermometer monitors the internal temperature of cauldron, guarantees the suitable of the internal temperature of cauldron, and the manometer monitors the internal pressure value of cauldron, guarantees the stability of the internal pressure of cauldron.

Preferably, the outer fringe of the upper end of filter is fixed and is provided with the ring cover, the ring cover is located the funnel and is followed, and easy dismounting is swift, both is convenient for the reliable connection of filter and funnel, is convenient for take off the filter again and carries out the processing of crystallization.

Preferably, the outside of heating jacket is provided with the heat preservation, adopts the polyurethane foaming to separate the temperature with the external world, guarantees the heat preservation effect.

Preferably, a speed reducer is arranged on the stirring rod between the motor and the shaft seal, so that the rotating speed of the stirring rod and the stirring paddle is reduced, and the phenomenon that the stirring paddle rotates too fast to cause crystallization is avoided.

Preferably, the kettle body is provided with an observation window for observing the crystallization condition of the supersaturated solution in the kettle body.

The utility model has the beneficial effects that: the heating kettle is reasonable in structural design, high-temperature steam is introduced into the heating sleeve for heat conduction, so that supersaturated solution in the kettle body is heated, the motor drives the stirring paddle to stir the supersaturated solution in the kettle body, the flow of the solution is promoted, the solution is heated uniformly, the vacuum pump vacuumizes the kettle body through the vacuum pumping pipe, the pressure in the kettle body and the boiling point of water in the supersaturated solution are reduced, the evaporation rate of the water in the solution is accelerated, the crystallization time is shortened, and the crystallization rate and the economic benefits of enterprises are improved.

Drawings

FIG. 1 is a schematic structural view of the present invention;

in the figure: 1. a kettle body; 2. a motor; 3. a stirring rod; 4. shaft sealing; 5. a stirring paddle; 6. a feed pipe; 7. a first exhaust pipe; 8. a first discharging pipe; 9. a first discharge valve; 10. a cooling tank; 11. a second discharge pipe; 12. a second discharge valve; 13. a funnel; 14. a filter plate; 15. screening holes; 16. a liquid collecting barrel; 17. heating a jacket; 18. a main air inlet pipe; 19. a first shut-off valve; 20. a second exhaust pipe; 21. an exhaust valve; 22. a condenser; 23. cleaning the tube; 24. a second stop valve; 25. an intake branch pipe; 26. a third stop valve; 27. vacuumizing a tube; 28. a vacuum pump; 29. a fourth stop valve; 30. a thermometer; 31. a pressure gauge; 32. sleeving a ring; 33. a heat-insulating layer; 34. a speed reducer; 35. and (4) an observation window.

Detailed Description

In order to clearly understand the technical scheme of the utility model, the utility model is further explained with reference to the attached drawings.

As shown in fig. 1, a crystallization reaction kettle for pharmacy comprises a kettle body 1, a motor 2 is fixedly arranged at the middle position of the upper end of the kettle body 1, and provides power for the rotation of a stirring rod 3 and a stirring paddle 5, the stirring rod 3 is vertically arranged in the kettle body 1, the upper end of the stirring rod 3 passes through the kettle body 1 and is connected with a transmission shaft of the motor 2, a shaft seal 4 is arranged at the joint of the stirring rod 3 and the kettle body 1 to ensure the connection tightness between the stirring rod 3 and the kettle body 1, the stirring paddle 5 is fixedly arranged at the lower end of the stirring rod 3, the motor 2 is started, the stirring rod 3 drives the stirring paddle 5 to stir supersaturated solution in the kettle body 1, so as to promote the flow of the solution, so that the solution is heated uniformly, thereby accelerating the evaporation rate of water in the solution and shortening crystallization time, a speed reducer 34 is arranged on the stirring rod 3 between the motor 2 and the shaft seal 4, the rotating speed of the stirring rod 3 and the stirring paddle 5 is reduced, the stirring paddle 5 is prevented from rotating too fast to cause crystallization breakage, the observation window 35 is arranged on the kettle body 1 to observe the crystallization condition of supersaturated solution in the kettle body 1, the thermometer 30 and the pressure gauge 31 are arranged at the upper end of the kettle body 1, the thermometer 30 monitors the temperature in the kettle body 1 to ensure the suitability of the temperature in the kettle body 1, the pressure gauge 31 monitors the pressure value in the kettle body 1 to ensure the stability of the pressure in the kettle body 1, the upper end of the kettle body 1 is provided with the feeding pipe 6 and the first exhaust pipe 7, the supersaturated solution is poured into the kettle body 1 along the feeding pipe 6, high-temperature steam after the kettle body 1 is cleaned and vapor generated in the heating process of the supersaturated solution are discharged along the first exhaust pipe 7, the bottom of the kettle body 1 is provided with the first discharge pipe 8, the first discharge pipe 8 is provided with the first discharge valve 9, opening a first discharge valve 9, discharging supersaturated solution precipitated crystals in the kettle body 1 along a first discharge pipe 8, arranging a cooling box 10 below the first discharge pipe 8, cooling the supersaturated solution in a high-temperature state, accelerating the precipitation rate of the crystals and reducing the working time, arranging a second discharge pipe 11 at the bottom of the cooling box 10, arranging a second discharge valve 12 on the second discharge pipe 11, opening the second discharge valve 12, discharging the crystals and low-temperature saturated solution in the cooling box 10 along the second discharge pipe 11, arranging a funnel 13 below the second discharge pipe 11, collecting mixed liquid containing the crystals with an upward opening of the funnel 13, movably arranging a filter plate 14 at the upper part of the funnel 13, filtering and separating the crystals in the solution, uniformly and densely arranging sieve pores 15 on the filter plate 14, and arranging a liquid collecting barrel 16 under the funnel 13, supersaturated solution flows into a liquid collecting barrel 16 along a sieve hole 15 and a funnel 13 to be collected and then is continuously poured into a kettle body 1 along a feeding pipe 6 for crystallization process, a ring sleeve 32 is fixedly arranged at the outer edge of the upper end of a filter plate 14, the ring sleeve 32 is sleeved at the upper edge of the funnel 13, the assembly and disassembly are convenient and rapid, the filter plate 14 is conveniently and reliably connected with the funnel 13, the filter plate 14 is conveniently taken down for crystallization treatment, a heating sleeve 17 is fixedly arranged at the lower part of the outer wall of the kettle body 1, high-temperature steam is introduced into the heating sleeve 17 for heat conduction, so that the supersaturated solution in the kettle body 1 is heated, the evaporation rate of water in the solution is accelerated, the crystallization time is shortened, a heat insulation layer 33 is arranged outside the heating sleeve 17, polyurethane foaming is adopted to insulate from the outside, the heat insulation effect is ensured, and the lower part of one side of the heating sleeve 17 is communicated with an air inlet main pipe 18, the main gas inlet pipe 18 is provided with a first stop valve 19, the first stop valve 19 is opened, high-temperature steam enters the heating jacket 17 along the main gas inlet pipe 18, the upper part of one side of the heating jacket 17, which is far away from the main gas inlet pipe 18, is communicated with the first exhaust pipe 7 through a second exhaust pipe 20, the heated steam is discharged along the second exhaust pipe 20, the first exhaust pipe 7, which is positioned at the communication part of the first exhaust pipe 7 and the second exhaust pipe 20 and is far away from one side of the kettle body 1, is sequentially provided with an exhaust valve 21 and a condenser 22, the opening and closing of the first exhaust pipe 7 are reasonably controlled through the exhaust valve 21, the steam is condensed into liquid drops through the condenser 22 and then is recycled, the waste of resources is avoided, the upper part of the side wall of the kettle body 1 is provided with a cleaning pipe 23, the cleaning pipe 23 is provided with a second stop valve 24, the second stop valve 24 is opened, and hot water cleans the kettle body 1 through the cleaning pipe 23, guarantee the cleanness in the cauldron body 1, the person in charge 18 that admits air is linked together through inlet branch 25 and scavenge pipe 23, be provided with third stop valve 26 on the inlet branch 25, open third stop valve 26, high temperature steam disinfects the disinfection to cauldron body 1 in getting into cauldron body 1 along scavenge pipe 23, avoids causing the pollution to supersaturated solution and crystalline particle in the cauldron body 1, one side of cauldron body 1 is connected with vacuum pump 28 through evacuation pipe 27, be provided with fourth stop valve 29 on the evacuation pipe 27, open fourth stop valve 29, vacuum pump 28 carries out the evacuation through evacuation pipe 27 to cauldron body 1, reduces the boiling point of the pressure in the cauldron body 1 and moisture in the supersaturated solution for the evaporation rate of moisture shortens the crystallization time.

Cauldron body 1 is before the use, pour hot water into cauldron body 1 along scavenge pipe 23 and wash in, the washing liquid is discharged along first row of material pipe 8, let in the disinfection of disinfecting in cauldron body 1 along air intake branch 25 and scavenge pipe 23 with high-temperature steam, high-temperature steam discharges along first exhaust pipe 7, pour supersaturated solution into cauldron body 1 along inlet pipe 6, high-temperature steam carries out heat-conduction along the main pipe 18 that admits air and gets into in heating jacket 17, starter motor 2 and vacuum pump 28 simultaneously, stir supersaturated solution in the evacuation, the mixed liquid that contains the crystallization falls into cooling tank 10 along the first row of material pipe 8 after cooling down in along second row of material pipe 11 and falls into funnel 13, carry out filtering separation through the crystallization of filter 14 in to the solution.

The above description is only a preferred embodiment of the present invention, and all equivalent changes or modifications of the structure, characteristics and principles described in the present invention are included in the scope of the present invention.

Claims (6)

1. A crystallization reaction kettle for pharmacy comprises a kettle body and is characterized in that a motor is fixedly arranged at the middle position of the upper end of the kettle body, a stirring rod is vertically arranged in the kettle body, the upper end of the stirring rod penetrates through the kettle body to be connected with a transmission shaft of the motor, a shaft seal is arranged at the joint of the stirring rod and the kettle body, a stirring paddle is fixedly arranged at the lower end of the stirring rod, a feeding pipe and a first exhaust pipe are arranged at the upper end of the kettle body, a first discharge pipe is arranged at the bottom of the kettle body, a first discharge valve is arranged on the first discharge pipe, a cooling box is arranged below the first discharge pipe, a second discharge pipe is arranged at the bottom of the cooling box, a second discharge valve is arranged on the second discharge pipe, a funnel is arranged below the second discharge pipe, the opening of the funnel is upward, and a filter plate is movably arranged at the upper part of the funnel, sieve pores are uniformly and densely distributed on the filter plate, a liquid collecting barrel is arranged right below the funnel, a heating sleeve is fixedly arranged at the lower part of the outer wall of the kettle body, the lower part of one side of the heating jacket is communicated with an air inlet main pipe, a first stop valve is arranged on the air inlet main pipe, the upper part of one side of the heating jacket, which is far away from the main gas inlet pipe, is communicated with the first exhaust pipe through a second exhaust pipe, the first exhaust pipe, which is positioned at the communication part of the first exhaust pipe and the second exhaust pipe and is far away from the kettle body, is sequentially provided with an exhaust valve and a condenser, a cleaning pipe is arranged at the upper part of the side wall of the kettle body, a second stop valve is arranged on the cleaning pipe, the main air inlet pipe is communicated with the cleaning pipe through an air inlet branch pipe, a third stop valve is arranged on the air inlet branch pipe, one side of the kettle body is connected with a vacuum pump through a vacuumizing pipe, and a fourth stop valve is arranged on the vacuumizing pipe.

2. A crystallization reaction kettle for pharmacy according to claim 1, wherein a temperature gauge and a pressure gauge are arranged at the upper end of the kettle body.

3. A pharmaceutical crystallization reactor according to claim 1, wherein the filter plate is provided with a ring sleeve fixed to the upper edge of the filter plate, and the ring sleeve is disposed on the upper edge of the funnel.

4. A crystallization reactor as claimed in claim 1, wherein the heating jacket is provided with an insulating layer on the outside.

5. The crystallization reactor according to claim 1, wherein a speed reducer is disposed on the stirring rod between the motor and the shaft seal.

6. A crystallization reaction kettle for pharmacy according to claim 1, wherein the kettle body is provided with an observation window.

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