CN215713421U

CN215713421U - Deuterium gas, deuterated hydrogen and semi-heavy water mixed gas-liquid respirator and imaging system

Info

Publication number: CN215713421U
Application number: CN202120095633.0U
Authority: CN
Inventors: 杨晓军; 阮英恒
Original assignee: Shenzhen Dingbang Biotechnology Co ltd
Current assignee: Shenzhen Dingbang Biotechnology Co ltd
Priority date: 2021-01-13
Filing date: 2021-01-13
Publication date: 2022-02-01
Anticipated expiration: 2031-01-13

Abstract

The utility model discloses a deuterium gas, deuterium hydride and semi-heavy water mixed gas-liquid respirator and an imaging system, wherein the deuterium gas, deuterium hydride and semi-heavy water mixed gas-liquid respirator comprises: a frame; the electrolytic cell is arranged on the frame and is used for containing heavy water; an electrode assembly located within the electrolytic cell to electrolyze heavy water within the electrolytic cell to produce deuterium gas and/or deuterated hydrogen; the gas-liquid separator is positioned above the electrolytic bath and is communicated with the electrolytic bath; the first end of the vent pipe is communicated with the top of the separator; wherein the deuterium gas and/or deuterium oxide separated in the gas-liquid separator flows from the first end of the vent pipe to the second end of the vent pipe. Because the heavy water is electrolyzed to generate deuterium gas and/or deuterium hydride, the deuterium gas and/or deuterium hydride is separated by the gas-liquid separator, and the separated deuterium gas and/or deuterium hydride enters the vent pipe, the separated deuterium gas and/or deuterium hydride can be directly used.

Description

Deuterium gas, deuterated hydrogen and semi-heavy water mixed gas-liquid respirator and imaging system

Technical Field

The utility model relates to the technical field of medical instruments or medical detection, in particular to a deuterium gas, deuterium hydride and semi-heavy water mixed gas-liquid respirator and an imaging system.

Background

The increasing use of hydrogen and its isotopes in the pharmaceutical industry, for example, research in magnetic resonance molecular imaging has resulted in two promising methods of imaging isotopes of glucose metabolism: hyperpolarization (HP)¹³C Magnetic Resonance Imaging (MRI) and deuterometabolic imaging (DMI). Although it is used for¹³There are multiple possible pathways for C hyperpolarization, but HP¹³C MRI most often relies on¹³Dynamic nuclear polarization pre-polarization of the C-labeled substrate, followed by rapid dissolution, produces a large, albeit transient, signal enhancement four to five orders of magnitude higher than Boltzmann polarization at clinically viable MRI field strengths, enabling targeted metabolic studies by spectroscopic imaging.¹³C has a short magnetization lifetime and requires compact studies and fast, carefully calibrated MRI scans. In contrast, a DMI that is not hyperpolarized takes advantage of the relatively large magnetic moment provided by Boltzmann polarization.

For another example, Positron Emission Tomography (PET), the most advanced medical imaging technology at present, can realize high-resolution imaging of cell metabolism and function, and can perform molecular-level imaging of human physiologyAnd the biochemical process is subjected to noninvasive, three-dimensional and dynamic research. Positron drugs currently used in PET examinations include fluorine-18 (F-18), i.e., positron radionuclides, which are susceptible to secondary damage for multiple examinations of patients, and have a half-life period that is significantly increased (109.8min) compared to other imaging labeled nuclides such as oxygen-15 (O-15), nitrogen-13 (N-13), and carbon-11 (C-11), but still cannot be tracked for the entire metabolic process. By making use of¹The universality and the easy implementation advantage of H proton magnetic resonance spectrum detection and the excellent spectral resolution can track the metabolites transferred by the deuterated compounds, the detection resolution and the sensitivity are higher, the dynamic exchange of single metabolites can be detected, and the measurement is realized¹The change of the H proton magnetic resonance spectrum can be detected under high spectral resolution²Metabolites which cannot be detected by the H proton magnetic resonance spectrum are obtained, so that the rate of in vivo metabolic cycle is obtained, steady state information and metabolic rate of a plurality of metabolites can be provided by one-time acquisition, and meanwhile, the deuterated contrast agent used in the utility model can be taken, so that the deuterium contrast agent cannot cause harm to a human body after being detected for many times; for the¹The detection of H proton magnetic resonance spectrum can also use standard nuclear magnetic resonance instrument, does not need special equipment, has lower cost, and uses standard nuclear magnetic resonance instrument¹The conversion of deuterium marks can be directly monitored by H proton magnetic resonance spectrum acquisition hardware and signal processing, and the method is simple and practical, has high precision and reliable result, and can quantitatively position and analyze the metabolic condition.

The current main deuterium gas preparation technologies are: liquid hydrogen rectification technology, electrolytic heavy water technology, metal hydride technology, laser technology, gas chromatography technology and the like. In the prior art, the preparation device of deuterium gas is large, and the prepared deuterium gas cannot be used immediately.

Accordingly, the prior art is yet to be improved and developed.

SUMMERY OF THE UTILITY MODEL

The present invention provides a deuterium, deuterated hydrogen, and semi-heavy water mixed gas-liquid ventilator and an imaging system, aiming at solving the problem that the deuterium prepared by the deuterium preparation device in the prior art cannot be used immediately.

The technical scheme adopted by the utility model for solving the technical problem is as follows:

a deuterium, deuterated hydrogen and semi-heavy water mixed gas-liquid respirator, which comprises:

a frame;

the electrolytic tank is arranged on the frame and is used for containing heavy water;

an electrode assembly located within the electrolytic cell to electrolyze the heavy water within the electrolytic cell to produce deuterium gas and/or deuterated hydrogen;

the gas-liquid separator is positioned above the electrolytic bath and communicated with the electrolytic bath;

a vent pipe, a first end of which is communicated with the top of the separator;

wherein the deuterium gas and/or deuterium oxide separated in the gas-liquid separator flows from the first end of the vent pipe to the second end of the vent pipe.

The deuterium gas, deuterated hydrogen and semi-heavy water mixed gas-liquid respirator comprises the following components:

a flow meter disposed within the vent pipe, the flow meter configured to detect a flow rate of gas flowing from a first end of the vent pipe to a second end of the vent pipe.

a deuterium gas concentration detector disposed within the gas-liquid separator.

the display is arranged on the rack, connected with the flowmeter and the deuterium concentration detector and used for displaying the flow detected by the flowmeter and the deuterium concentration and/or deuterium hydride concentration detected by the deuterium concentration detector.

The deuterium gas, deuterated hydrogen and semi-heavy water mixed gas-liquid respirator is characterized in that,

the display comprises a touch screen;

the touch screen is electrically connected with the electrode assembly to control the electrode assembly to carry out electrolysis.

a diaphragm is arranged in the electrolytic cell.

the second end of the breather pipe is detachably provided with an air suction mask; and/or the presence of a gas in the gas,

the deuterium gas, deuterated hydrogen and semi-heavy water mixed gas-liquid respirator also comprises: the shell is a diamagnetic shell, and the electrolytic cell and the gas-liquid separator are both positioned in the diamagnetic shell.

and pulleys are arranged at the bottom of the frame.

An imaging system, comprising:

a deuterium, deuterated hydrogen and semi-heavy water mixed gas-liquid respirator as described in any one of the above;

an imaging device for imaging deuterium gas and/or deuterium hydride.

The imaging system of, wherein the imaging device includes: a nuclear magnetic imaging apparatus.

Has the advantages that: because the heavy water is electrolyzed to generate deuterium gas and/or deuterium hydride, the deuterium gas and/or deuterium hydride is separated by the gas-liquid separator, and the separated deuterium gas and/or deuterium hydride enters the vent pipe, the separated deuterium gas and/or deuterium hydride can be directly used.

Drawings

Fig. 1 is a perspective view of a deuterium/hydrogen hydride/semi-heavy water mixed gas/liquid respirator of the present invention.

FIG. 2 is a schematic view showing the structure of an electrolytic cell and a gas-liquid separator in the present invention.

Fig. 3 is a schematic diagram of the power supply and controller of the present invention.

Fig. 4 is a schematic diagram of the structure of the imaging system of the present invention.

Description of reference numerals:

1. a deuterium gas, deuterium hydride and semi-heavy water mixed gas-liquid respirator; 10. a frame; 11. a vertical plate; 20. An electrolytic cell; 21. a first conduit; 22. a second conduit; 23. a liquid level meter; 30. a gas-liquid separator; 31. a deuterium gas concentration detector; 40. an electrode assembly; 41. a positive electrode; 42. a negative electrode; 43. a diaphragm; 50. a breather pipe; 51. a flow meter; 52. an inhalation mask; 60. a display; 70. a pulley; 80. A power source; 90. a controller; 2. an image forming apparatus.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention clearer and clearer, the present invention is further described in detail below with reference to the accompanying drawings and examples. It should be understood that the specific embodiments described herein are merely illustrative of the utility model and are not intended to limit the utility model.

In the description of the present invention, it is to be understood that the terms "central," "longitudinal," "lateral," "length," "width," "thickness," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," "clockwise," "counterclockwise," "axial," "radial," "circumferential," and the like are used in the orientations and positional relationships indicated in the drawings for convenience in describing the utility model and to simplify the description, and are not intended to indicate or imply that the referenced devices or elements must have a particular orientation, be constructed and operated in a particular orientation, and are therefore not to be considered limiting of the utility model.

Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one such feature. In the description of the present invention, "a plurality" means at least two, e.g., two, three, etc., unless specifically limited otherwise.

In the present invention, unless otherwise expressly stated or limited, the terms "mounted," "connected," "secured," and the like are to be construed broadly and can, for example, be fixedly connected, detachably connected, or integrally formed; may be mechanically coupled, may be electrically coupled or may be in communication with each other; they may be directly connected or indirectly connected through intervening media, or they may be connected internally or in any other suitable relationship, unless expressly stated otherwise. The specific meanings of the above terms in the present invention can be understood by those skilled in the art according to specific situations.

In the present invention, unless otherwise expressly stated or limited, the first feature "on" or "under" the second feature may be directly contacting the first and second features or indirectly contacting the first and second features through an intermediate. Also, a first feature "on," "over," and "above" a second feature may be directly or diagonally above the second feature, or may simply indicate that the first feature is at a higher level than the second feature. A first feature being "under," "below," and "beneath" a second feature may be directly under or obliquely under the first feature, or may simply mean that the first feature is at a lesser elevation than the second feature.

Referring to fig. 1-4, the present invention provides some embodiments of a deuterium/hydrogen hydride/semi-heavy water mixture ventilator.

Nuclear Magnetic Resonance Imaging (NMRI), also called spin Imaging, also called Magnetic Resonance Imaging (MRI), uses the principle of Nuclear Magnetic Resonance (NMR) to detect the emitted electromagnetic waves by the applied gradient Magnetic field according to the different attenuation of the released energy in different structural environments inside the material, so as to obtain the position and type of the nuclei constituting the object, and accordingly, the structural image inside the object can be drawn.

In the prior art, when performing nuclear magnetic imaging on gas, special gas such as¹²⁹Xe and³he, and the gas needs to be hyperpolarized to generate a resonance signal in the nmr system. The utility model discloses the people finds that deuterium gas and/or deuterium hydride can produce strong resonance signal in the magnetic resonance system under the prerequisite of not carrying out gaseous hyperpolarization processing. However, the existing deuterium gas preparation device has a complex structure and a large volume, and cannot be used immediately.

The deuterium gas, deuterated hydrogen and semi-heavy water mixed gas-liquid respirator adopts the electrolytic bath to load heavy water, the heavy water is electrolyzed by the electrode assembly to generate deuterium gas and/or deuterated hydrogen, the deuterium gas and/or deuterated hydrogen is separated by the gas-liquid separator, and the separated deuterium gas and/or deuterated hydrogen enters the vent pipe, so that the separated deuterium gas and/or deuterated hydrogen can be directly used.

In an application scenario of the utility model, the deuterium gas and/or deuterium hydride in the ventilation tube of the deuterium gas, deuterium hydride and semi-heavy water mixed gas-liquid ventilator can be directly delivered to the lung without hyperpolarization treatment, and the deuterium gas and/or deuterium hydride in the lung is imaged, so that the internal structure of the lung can be known through images.

As shown in fig. 1-2, a deuterium, deuterated hydrogen and semi-heavy water mixed gas-liquid respirator 1 of the present invention comprises:

a frame 10;

an electrolytic cell 20, wherein the electrolytic cell 20 is arranged on the frame 10, and the electrolytic cell 20 is used for containing heavy water;

an electrode assembly 40, said electrode assembly 40 being positioned within said electrolytic cell 20 to electrolyze said heavy water within said electrolytic cell 20 to produce deuterium gas and/or deuterated hydrogen;

a gas-liquid separator 30, the gas-liquid separator 30 being located above the electrolytic bath 20 and communicating with the electrolytic bath 20;

a breather pipe 50, a first end of the breather pipe 50 being in communication with the top of the separator;

wherein the deuterium gas and/or deuterium oxide separated in the gas-liquid separator 30 flows from the first end of the breather pipe 50 to the second end of the breather pipe 50.

It should be noted that, in the deuterium gas (D-D), deuterated hydrogen (H-D) and semi-heavy water (H-O-D) mixed gas-liquid ventilator 1 of the present invention, heavy water is loaded in the electrolytic bath 20, the heavy water is electrolyzed by the electrode assembly 40 to generate deuterium gas and/or deuterated hydrogen, the deuterium gas and/or deuterated hydrogen is separated by the gas-liquid separator 30, and the separated deuterium gas and/or deuterated hydrogen enters the vent pipe 50, so that the separated deuterium gas and/or deuterated hydrogen can be directly used. When the deuterium and/or deuterated hydrogen is required to be used, the deuterium and/or deuterated hydrogen can be generated through electrolysis by the electrode assembly 40 and can be directly used after being separated, so that the effect of immediate use of the deuterium and/or deuterated hydrogen is realized. It should be noted that the gases formed by electrolysis may be contaminated with semi-heavy water or heavy water vapor, but of course, semi-heavy water or heavy water vapor may also be used for imaging, i.e., as long as the electrolyzed deuterium-containing gas or vapor is used for imaging.

Specifically, the stand 10 is provided with a vertical plate 11, the electrolytic tank 20 is arranged on a first side of the vertical plate 11, the electrolytic tank 20 is a cubic electrolytic tank 20, a liquid level meter 23 can be arranged in the electrolytic tank 20, and the amount of heavy water in the electrolytic tank 20 is determined by the liquid level meter 23.

The electrode assembly 40 includes a cathode 42 and an anode 41, the cathode 42 and the anode 41 are spaced apart from each other, heavy water is oxidized and reduced on the anode 41 and the cathode 42 to form deuterium gas and/or deuterated hydrogen and oxygen, and it should be noted that the gas in the vent pipe 50 may include air in addition to deuterium gas and/or deuterated hydrogen. Of course the gas in the ventilation duct 50 may also comprise oxygen from the electrolysis of heavy water.

In order to increase the concentration of deuterium gas and/or deuterium hydride in the gas in the vent pipe 50, a diaphragm 43 is arranged between the negative electrode 42 and the positive electrode 41, and the electrolyzed oxygen gas and deuterium gas (or deuterium hydride) are separated, namely, the diaphragm 43 divides the electrode groove into a first groove body and a second groove body, and the negative electrode 42 is positioned in the first groove body and can precipitate deuterium gas and/or deuterium hydride; the positive electrode 41 is located in the second tank and can precipitate oxygen.

Since the electrolyzed deuterium gas (or deuterated hydrogen) and oxygen carry heavy water molecules or semi-heavy water molecules, the heavy water molecules can be condensed to form liquid heavy water, and in order to separate the liquid heavy water from the deuterium gas (or deuterated hydrogen) and oxygen, a gas-liquid separator 30 is arranged for separation. The gas-liquid separator 30 is disposed above the electrolytic bath 20, the gas-liquid separator 30 is connected to the electrolytic bath 20 through the first pipe 21, and since the gas-liquid separator 30 is disposed above the electrode bath, the heavy water separated by the gas-liquid separator 30 can directly fall back into the electrolytic bath 20 through the first pipe 21, and the electrolysis can be continued. Of course, after separation by the gas-liquid separator 30, there may be a small amount of heavy or semi-heavy water vapor.

When the diaphragm 43 is disposed in the electrolytic cell 20, the gas-liquid separator 30 may be connected to the first tank body to separate heavy water and deuterium (or deuterated hydrogen) so as to transfer the separated deuterium and/or deuterated hydrogen to the vent pipe 50. Of course, if the electrolyzed oxygen gas in the second tank body is not required, the electrolyzed oxygen gas can be discharged. If the electrolyzed oxygen gas in the second tank is desired, a second conduit 22 may be provided connecting the second tank and the gas-liquid separator 30 to mix the electrolyzed oxygen gas with the electrolyzed deuterium gas and/or deuterated hydrogen.

In a preferred implementation manner of the embodiment of the present invention, as shown in fig. 1-2, the deuterium/hydrogen and semi-heavy water mixed gas-liquid ventilator 1 further includes: a flow meter 51, wherein the flow meter 51 is disposed in the vent pipe 50, and the flow meter 51 is used for detecting the flow rate of the gas flowing from the first end of the vent pipe 50 to the second end of the vent pipe 50.

Specifically, by providing the flow meter 51 in the breather pipe 50, the flow rate of the gas flowing in the breather pipe 50 can be determined. Since the imaging is different for different amounts of deuterium and/or deuterium hydride, when deuterium and/or deuterium hydride is used, the amount of deuterium and/or deuterium hydride needs to be determined, the flow rate of the gas in the ventilation pipe 50 can be determined by the flow meter 51, and the amount of deuterium and/or deuterium hydride can be obtained by combining the concentration of deuterium and/or deuterium hydride and the flow rate of the gas.

In a preferred implementation of the embodiment of the present invention, as shown in fig. 1-2, the second end of the ventilation tube 50 is detachably provided with an inhalation mask 52.

Specifically, in order to facilitate the absorption of deuterium gas and/or deuterium hydride in the deuterium gas, deuterium hydride, and semi-heavy water mixed gas-liquid ventilator 1, an inhalation mask 52 is provided at the second end of the ventilation tube 50, and the shape of the inhalation mask 52 may match the shape of the mouth or the nose. Of course, the inhalation mask 52 may cover both the mouth and nose. Inhalation mask 52 is removably attached to the second end of snorkel 50 to allow for replacement of inhalation mask 52.

In a preferred implementation of the embodiment of the present invention, as shown in fig. 1 and 4, the bottom of the frame 10 is provided with a pulley 70.

Specifically, in order to facilitate the movement of the deuterium, deuterated hydrogen and semi-heavy water mixed gas-liquid ventilator 1, a pulley 70 is provided at the bottom of the frame 10, so that the frame 10 can be conveniently pushed to move the deuterium, deuterated hydrogen and semi-heavy water mixed gas-liquid ventilator 1.

In a preferred implementation manner of the embodiment of the present invention, the deuterium, deuterated hydrogen, and semi-heavy water mixed gas-liquid ventilator further includes: the shell is a diamagnetic shell, and the electrolytic cell and the gas-liquid separator are both positioned in the diamagnetic shell.

Specifically, in order to avoid that the magnetic field outside the respirator affects the components inside the respirator, a diamagnetic shell is arranged outside the respirator, wherein the diamagnetic shell is made of diamagnetic materials, and diamagnetic substances have no unpaired electrons outside the core and hardly affect the external magnetic field. For example, the case is made of diamagnetic alloy, and the diamagnetic material includes: gold, silver, silicon, selenium and bismuth, and a diamagnetic alloy is formed by adding diamagnetic substances into metal, so that the diamagnetic shell is manufactured. After the diamagnetic shell is arranged, the respirator is not influenced by a magnetic field generated by the nuclear magnetic imaging device even when the respirator is used near the nuclear magnetic imaging device.

In a preferred implementation manner of the embodiment of the present invention, as shown in fig. 1-2, the deuterium/hydrogen and semi-heavy water mixed gas-liquid ventilator 1 further includes: a deuterium gas concentration detector 31, wherein the deuterium gas concentration detector 31 is disposed in the gas-liquid separator 30.

Specifically, the presence or absence of deuterium gas and/or deuterated hydrogen in the gas-liquid separator 30 can be detected by the deuterium gas concentration detector 31, thereby determining whether or not the electrode assembly 40 is subjected to electrolysis. Of course, the deuterium concentration detector 31 may detect the concentration of deuterium gas and/or deuterium hydride in the gas-liquid separator 30, and when the concentration of deuterium gas and/or deuterium hydride reaches a predetermined concentration, the ventilator 1 may use the mixture of deuterium gas, deuterium hydride, and semi-heavy water.

In a preferred implementation manner of the embodiment of the present invention, as shown in fig. 1-2, the deuterium/hydrogen and semi-heavy water mixed gas-liquid ventilator 1 further includes: and a display 60, wherein the display 60 is disposed on the housing 10, the display 60 is connected to the flow meter 51 and the deuterium concentration detector 31, and the display 60 is configured to display the flow rate detected by the flow meter 51 and the deuterium concentration or deuterium-hydride concentration detected by the deuterium concentration detector 31.

Specifically, a display screen is provided on the frame 10 of the deuterium/semi-heavy water mixture gas-liquid ventilator 1, and the flow rate detected by the flow meter 51 and the deuterium and/or deuterium/hydrogen concentration detected by the deuterium concentration detector 31 are displayed on the display screen. In order to obtain the amount of deuterium gas and/or deuterium hydride flowing through the vent pipe 50, the flow meter 51 may be disposed at the first end of the vent pipe 50, and the deuterium gas concentration detector 31 may be disposed at the edge of the junction of the vent pipe 50 and the gas-liquid separator 30, so that the flow meter 51 and the deuterium gas concentration detector 31 are closely spaced, the flow rate and the concentration at the same location can be obtained, and the accuracy of the amount of deuterium gas and/or deuterium hydride is higher.

In a preferred implementation of the embodiment of the present invention, as shown in fig. 1-4, the display 60 includes a touch screen; the touch screen is electrically connected to the electrode assembly 40 to control the electrode assembly 40 to perform electrolysis.

Specifically, the electrode assembly 40 may be turned on or off through the touch screen, thereby controlling the electrode assembly 40 to electrolyze the heavy water in the electrolytic bath 20. A power supply 80 and a controller 90 are disposed on the second side of the standing plate 11, the touch screen is connected to the electrode assembly 40 through the controller 90, the power supply 80 is respectively connected to the controller 90 and the electrode assembly 40, and the power supply 80 supplies electrolytic power to the electrode assembly 40. It should be noted that the electrolytic bath 20 and other components are disposed on the first side of the upright plate 11, and in order not to affect the electrolysis, the electrolytic bath 20 is disposed on the upper portion of the first side of the upright plate 11, and the power source 80 is disposed on the lower portion of the second side of the upright plate 11.

In summary, the present invention discloses a deuterium, deuterated hydrogen and semi-heavy water mixed gas-liquid ventilator, which comprises: a frame; the electrolytic tank is arranged on the frame and is used for containing heavy water; an electrode assembly located within the electrolytic cell to electrolyze the heavy water within the electrolytic cell to produce deuterium gas and/or deuterated hydrogen; the gas-liquid separator is positioned above the electrolytic bath and communicated with the electrolytic bath; a vent pipe, a first end of which is communicated with the top of the separator; wherein the deuterium gas and/or deuterium oxide separated in the gas-liquid separator flows from the first end of the vent pipe to the second end of the vent pipe. Because the heavy water is electrolyzed to generate deuterium gas and/or deuterium hydride, the deuterium gas and/or deuterium hydride is separated by the gas-liquid separator, and the separated deuterium gas and/or deuterium hydride enters the vent pipe, the separated deuterium gas and/or deuterium hydride can be directly used.

As shown in fig. 4, based on the deuterium-deuterium, deuterated hydrogen and semi-heavy water mixed gas-liquid ventilator 1 according to any one of the above embodiments, the present invention further provides an imaging system, comprising:

the deuterium/hydrogen hydride/semi-heavy water mixed gas-liquid ventilator 1 according to any one of the above embodiments; an imaging device 80, said imaging device 80 for imaging deuterium gas and/or deuterium hydride.

Since the deuterium gas, deuterated hydrogen and semi-heavy water mixed gas-liquid respirator 1 can be used immediately, the imaging device 80 and the deuterium gas, deuterated hydrogen and semi-heavy water mixed gas-liquid respirator 1 can form an imaging system, and the deuterium gas and/or deuterated hydrogen is provided by the deuterium gas, deuterated hydrogen and semi-heavy water mixed gas-liquid respirator 1 during imaging, so that the imaging device 80 can image the deuterium gas and/or deuterated hydrogen.

For example, the ventilator 1 is turned on to provide deuterium and/or deuterated hydrogen to the imaging target, and after the deuterium and/or deuterated hydrogen enters the imaging target, the imaging device 80 can image the deuterium and/or deuterated hydrogen in the imaging target.

The imaging device 80 refers to a device that images deuterium gas and/or deuterium hydride, and the imaging device 80 includes: the nuclear magnetic imaging device comprises a lung nuclear magnetic imaging device and/or a cardiovascular nuclear magnetic imaging device. A pulmonary mri apparatus refers to an apparatus for nuclear magnetic imaging of the lungs, including the lung organs, and of course, the lungs also include blood vessels between the lung organs and other tissues and/or organs. Cardiovascular includes heart organs, and certainly also includes blood vessels between heart organs and other tissues and/or organs. Blood vessels include veins and arteries and associated capillaries, and heart organs include the left atrium, right atrium, left ventricle, right ventricle, myocardium, aorta and aortic arch, coronary arteries, subclavian arteries and carotid arteries.

Specifically, deuterium gas and/or deuterium hydride can generate a strong resonance signal in a magnetic resonance system without performing gas hyperpolarization treatment. The application of deuterium gas and/or deuterium hydride to nuclear magnetic imaging realizes the visualization of deuterium gas and/or deuterium hydride diffusible organs and the unique capability of quantifying the functions of deuterium gas and/or deuterium hydride diffusible organs. Compared with the prior art, the deuterium gas and/or the deuterium hydride is applied to nuclear magnetic resonance imaging, the deuterium gas and/or the deuterium hydride is harmless to human bodies and higher in safety, meanwhile, gas hyperpolarization treatment is avoided, the cost is greatly saved, the popularization and the application are convenient, and furthermore, compared with the prior art, the deuterium gas and/or the deuterium hydride is applied to nuclear magnetic resonance imaging, and continuous nuclear magnetic imaging and dynamic monitoring can be achieved.

The imaging target includes: pulmonary, cardiovascular or luminal organs, e.g., intestinal wall, placenta, blood brain barrier. Specifically, deuterium gas (A), (B), (C) and C)²H) As imaging agents, applied to MRI systems, enable visual ventilation (ability of air to reach the alveoli) and gas exchange (ability of oxygen to diffuse through the alveolar membrane to the pulmonary vessels), local reduction to the smallest airways of the lung, tissue barriers between the lung and the blood stream and in the pulmonary vessels; and microvascular hemodynamics now within the lung.

When imaged by a nuclear magnetic imaging device, deuterium gas and/or deuterium hydride will resonate at different frequencies, for example, (i) in the bronchioles and alveoli of the lungs; (ii) in the barrier tissue of the lung; (iii) when dissolved in arterial blood in the pulmonary vessels, thereby providing information about ventilation (the ability of air to reach the alveoli) and gas exchange (the ability of air to diffuse through the alveolar membrane to the pulmonary vessels).

For convenience of explanation of the imaging system, an imaging method of the imaging system of any one of the above embodiments is explained:

the imaging method provided by the embodiment of the utility model comprises the following steps:

step S100, turning on the deuterium, deuterated hydrogen and semi-heavy water mixed gas-liquid ventilator 1 to provide deuterium and/or deuterated hydrogen for the imaging target.

Specifically, the deuterium, deuterated hydrogen and semi-heavy water mixed gas-liquid respirator 1 is started to provide deuterium and/or deuterated hydrogen for the imaging target, and the imaging target can inhale deuterium and/or deuterated hydrogen generated by the deuterium, deuterated hydrogen and semi-heavy water mixed gas-liquid respirator 1.

Step S200, after the deuterium gas and/or deuterated hydrogen enters the imaging target, imaging the deuterium gas and/or deuterated hydrogen in the imaging target through the imaging device 80.

Specifically, after the deuterium gas and/or the deuterium hydride enters the imaging target, the imaging device 80 is turned on to image the deuterium gas and/or the deuterium hydride in the imaging target, the position of the deuterium gas and/or the deuterium hydride in the imaging target is displayed through an image, and the deuterium gas and/or the deuterium hydride in the imaging target is visualized, so that the structure in the imaging target can be known. For example, deuterium and/or deuterated hydrogen may not reach the lesion of the imaging target when the lesion is present in the imaging target, and thus imaging the imaging target may determine the size and location of the lesion.

It should be noted that the imaging target is a lung, the imaging target is imaged to obtain a target image, and based on the target image, the lung blood perfusion and ejection fraction are determined.

In one implementation manner of the embodiment of the present invention, in step S200, after the deuterium and/or deuterated hydrogen enters the imaging target, the imaging of the deuterium and/or deuterated hydrogen in the imaging target by the imaging device 80 includes:

step S210, when the deuterium and/or deuterated hydrogen enters the imaging target and meets a preset time, imaging the deuterium and/or deuterated hydrogen in the imaging target through the imaging device 80.

Specifically, in order to facilitate sufficient entry of deuterium gas and/or deuterated hydrogen into the imaging target, imaging may be performed by the imaging device 80 after the deuterium gas and/or deuterated hydrogen enters the imaging target for a predetermined time. The preset time may be determined as needed, for example, by the time when deuterium and/or deuterated hydrogen enters the lungs when the lungs are used as an imaging target. As another example, when cardiovascular is used as the imaging target, the preset time is determined by the time when deuterium gas and/or deuterium hydride enters the lung and the total time when deuterium gas and/or deuterium hydride sequentially passes through the alveolar membrane and enters the blood.

step S220, after the deuterium gas and/or deuterated hydrogen enters the imaging target, continuously imaging the deuterium gas and/or deuterated hydrogen in the imaging target through the imaging device 80.

Specifically, the imaging target is continuously imaged by the imaging device 80, and a time constant, which is the total time for the deuterium gas and/or deuterated hydrogen to sequentially pass through the alveolar membrane and enter the blood, can be obtained through the continuous imaging; obtaining a diffusion thickness of the deuterium gas and/or deuterated hydrogen based on the time constant.

In certain embodiments, the spectral peaks may be quantified by normalizing the spectral data. The term "normalization" refers to the use of a predetermined adjustment or scaling factor, relational or mathematical equation, to a selected signal variable (e.g., intensity, dose, concentration/mixture in dose, etc.). The adjustment may include obtaining a mathematical ratio of the values of certain peaks associated with selected known biological substances (RBCs, plasma, etc.) to certain peaks associated with tissue, blood or gas signals within the response spectrum to quantify the deuterium and/or deuterated hydrogen signals in the region. Benefits. The adjustment may include calculating a value for the signal strength by multiplying it by the resonance level (and/or amount) of deuterium and/or deuterated hydrogen administered, which may be measured at delivery time to obtain a baseline or reference spectrum to quantify the amplitude signal. Normalization can be done using the resonance intensity of the deuterium and/or deuteron as delivered to the patient, and the signal values obtained can also be adjusted for the amount of deuterium and/or deuteron applied (the% mixture of deuterium and/or deuteron) to account for the percentage of deuterium and/or deuteron and/or the resonance level of deuterium and/or deuteron that is applied by the intensity change caused by deuterium and/or deuteron.

A region-specific NMR coil can be placed over the target region and transmit a selected RF pulse sequence. The coil receives the FID signal. A localization gradient may also be applied around the region of interest to localize the resonance region. For example, local gradients may be applied in order to excite a desired region of interest. In any event, a Fourier transform of the acquired data is then computed. The transformed signal data may be further processed, which may include, but is not limited to, one or more of the following: subtracting background noise, filtering unwanted signal data (e.g., those portions of the signal or spectrum attributable to carrier fluid or non-deposits-target tissue or blood, etc.), determining the frequency shift of any number of peaks in the spectrum within a predetermined range, and normalizing the data, e.g., finding a spectrum of the ratio of the size and/or area of the different spectral peaks in the response or taking into account the level of resonance and the amount of deuterium and/or deuterated hydrogen delivered to the subject. For further discussion of exemplary background subtraction or adjustment methods and cardiac gating methods, see co-pending U.S. application serial nos. 09/271,476 and 09/271,476, incorporated by reference above.

The utility model is useful in preclinical animal research, veterinary and medical applications. The present invention can image an imaging target for diagnostic assessment and/or monitoring of the imaging target, particularly a human subject, because it is minimally invasive and more than other methods known in the art (e.g., radioactive methods). In general, the methods of the present invention may be more readily accepted because they avoid the level of radioactivity or toxicity of chemicals or other agents. The imaging target according to the present invention may be any animal imaging target, and is preferably a mammalian imaging target (e.g. human, canine, feline, bovine, caprine, ovine, equine, rodent, porcine and/or lagomorph), more preferably a human.

It is to be understood that the utility model is not limited to the examples described above, but that modifications and variations may be effected thereto by those of ordinary skill in the art in light of the foregoing description, and that all such modifications and variations are intended to be within the scope of the utility model as defined by the appended claims.

Claims

1. A deuterium gas, deuterium hydride and semi-heavy water mixed gas-liquid respirator is characterized by comprising:

a frame;

2. The deuterium, deuterated hydrogen and semi-heavy water mixed gas-liquid ventilator according to claim 1, further comprising:

3. The deuterium, deuterated hydrogen and semi-heavy water mixed gas-liquid ventilator according to claim 2, further comprising:

4. The deuterium, deuterated hydrogen and semi-heavy water mixed gas-liquid ventilator according to claim 3, further comprising:

5. The deuterium, deuterated hydrogen and semi-heavy water mixed gas-liquid ventilator as recited in claim 4,

the display comprises a touch screen;

6. The deuterium, deuterated hydrogen and semi-heavy water mixed gas-liquid ventilator as recited in claim 1,

a diaphragm is arranged in the electrolytic cell.

7. The deuterium, deuterated hydrogen and semi-heavy water mixed gas-liquid ventilator according to any one of claims 1 to 6,

8. The deuterium, deuterated hydrogen and semi-heavy water mixed gas-liquid ventilator according to any one of claims 1 to 6, wherein a pulley is arranged at the bottom of the frame.

9. An imaging system, comprising:

the deuterium, deuterated hydrogen and semi-heavy water mixed gas-liquid ventilator of any one of claims 1 to 8;

an imaging device for imaging deuterium gas and/or deuterium hydride.

10. The imaging system of claim 9, wherein the imaging device comprises: a nuclear magnetic imaging apparatus.