Disclosure of Invention
The utility model aims to provide a shock wave generating device for cardiovascular stenosis, and provides a novel structure for controlling the energy release of an electrode pair by detecting the voltage and the resistance between the electrode pair.
In order to achieve the purpose, the utility model adopts the technical scheme that:
a shock wave generating device for cardiovascular stenosis comprises a balloon catheter and an energy supply unit, wherein the balloon catheter comprises a catheter main body, a balloon connected to the catheter main body and an electrode pair, the electrode pair comprises a first electrode and a second electrode, the electrode pair is arranged in the balloon and is electrically connected with the energy supply unit, the energy supply unit is provided with a release state detection circuit, the release state detection circuit is used for detecting an energy release state between the first electrode and the second electrode, the release state detection circuit comprises at least one of a pulse voltage detection circuit and a resistance detection circuit, and the pulse voltage detection circuit is used for detecting a voltage between the first electrode and the second electrode at the moment of discharge; the resistance detection circuit is used for detecting the resistance between the first electrode and the second electrode at the moment of discharging, the first end of the electrode pair is connected with the pulse power supply, the second end of the electrode pair is connected with the first end of the switch, the second end of the switch is grounded, and when the pulse voltage detection circuit is arranged, the pulse voltage detection circuit is connected to the first end of the electrode pair and the second end of the switch; when the resistance detection circuit is arranged, the resistance detection circuit is connected to the second end of the electrode pair and the second end of the switch.
Preferably, the pulse voltage detection circuit comprises a voltage division module, an operational amplifier and an on-off controller, wherein the voltage division module is provided with an input end, an output end and a grounding end, the operational amplifier is provided with a positive input end, a negative input end and an output end, the input end of the voltage division module is connected with the first end of the electrode pair, the grounding end is grounded, the output end is connected with the positive input end of the operational amplifier, and the negative input end of the operational amplifier is grounded and the output end is connected with the on-off controller.
Preferably, the pulse voltage detection circuit comprises a voltage division module, a comparator, a turn-off circuit and an on-off controller, wherein the voltage division module is provided with an input end, an output end and a grounding end, the comparator is provided with a positive input end, a negative input end and an output end, the input end of the voltage division module is connected with the first end of the electrode pair, the grounding end is grounded, the output end is connected with the positive input end of the comparator, the negative input end of the comparator is connected with a Vref power supply, the output end is connected with the on-off controller, the first end of the turn-off circuit is connected with the output end of the comparator, and the second end of the turn-off circuit is connected with the contact of the switch.
Further preferably, the release state detection circuit further includes a first resistor and/or a second resistor, a first end of the first resistor is connected to the output end of the comparator, and a second end of the first resistor is connected to the negative input end of the comparator; the first end of the second resistor is grounded, and the second end of the second resistor is connected with the negative input end of the comparator.
Further preferably, the pulse voltage detection circuit further includes a capacitor, a first end of the capacitor is connected to the output end of the voltage division module, and a second end of the capacitor is grounded.
Preferably, the resistance detection circuit includes a voltage signal source, a voltage dividing module, an operational amplifier, a capacitor and an on-off controller, the voltage dividing module has an input end, an output end and a ground end, the operational amplifier has a positive input end, a negative input end and an output end, the first end of the voltage signal source is connected with the first end of the electrode pair, the second end of the voltage signal source is connected with the first end of the switch, the first end of the capacitor is connected with the second end of the electrode pair, the second end of the capacitor is connected with the input end of the voltage dividing module, the ground end and the output end of the voltage dividing module are connected with the positive input end of the operational amplifier, and the negative input end of the operational amplifier is connected with the ground end and the output end of the operational amplifier is connected with the on-off controller.
Further preferably, the voltage dividing module includes a voltage sensor, an input end of the voltage sensor is an input end of the voltage dividing module, an output end of the voltage sensor is an output end of the voltage dividing module, and a ground end of the voltage sensor is a ground end of the voltage dividing module.
Further preferably, the voltage dividing module includes a third resistor and a fourth resistor connected in series, a first end of the third resistor is an input end of the voltage dividing module, a second end of the third resistor is connected with a first end of the fourth resistor, a second end of the third resistor is an output end of the voltage dividing module, and a second end of the fourth resistor is a ground end of the voltage dividing module.
Further preferably, the release state detection circuit further includes a diode, and an anode of the diode is grounded and a cathode of the diode is connected to the output terminal of the voltage division module.
Still more preferably, the diode is a schottky diode.
Further preferably, the release state detection circuit further includes a first resistor and/or a second resistor, a first end of the first resistor is connected to the output end of the operational amplifier, and a second end of the first resistor is connected to the negative input end of the operational amplifier; the first end of the second resistor is grounded, and the second end of the second resistor is connected with the negative input end of the operational amplifier.
Preferably, the release state detection circuit further includes a fifth resistor, a first end of the fifth resistor is connected to the second end of the electrode pair, and a second end of the fifth resistor is connected to the first end of the switch.
Due to the application of the technical scheme, compared with the prior art, the utility model has the following advantages:
the utility model switches on the pulse power supply for the electrode pair, sets the switch to control the duration of the pulse circuit provided for the electrode pair, adds the pulse voltage detection circuit on the electrode pair and the switch, and the resistance detection circuit detects the sudden change of the voltage and the resistance between the electrode pair after the energy is released, controls the on-off of the switch, and saves unnecessary energy waste.
The voltage detection circuit and the resistance detection circuit have simple circuit structures and high detection stability, can select any one of the voltage detection circuit and the resistance detection circuit to carry out detection and judgment, and ensure that when a certain detection circuit fails, the completion of the whole detection process can be ensured through another detection circuit.
Detailed Description
The technical solutions of the present invention will be described clearly and completely with reference to the accompanying drawings, and it should be understood that the described embodiments are some, but not all embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc., indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and simplicity of description, but do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be construed as limiting the present invention. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.
In the description of the present invention, it should be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.
As shown in fig. 2-7, a shock wave generating device for cardiovascular stenosis comprises a balloon catheter and an energy supply unit, wherein the balloon catheter comprises a catheter main body, a balloon connected to the catheter main body, and an electrode pair 1, the electrode pair 1 is disposed in the balloon and electrically connected to the energy supply unit, and the energy supply unit can emit and control ultrasound with specific frequency in the balloon filled with a liquid medium so that the electrode pair 1 forms cavitation bubbles to generate shock waves. The energy supply unit provides a pulse power supply 31 with the voltage of 300V-20000V, the pulse width is adjustable, the adjusting range is 10 ns-100 ms, the switch 2 is connected to the electrode pair 1, the switch 2 is a controllable switch for high voltage and comprises an IGBT, an MOS tube, a thyristor, a relay and the like, the energy supply unit is also provided with an on-off controller 41, and the on-off controller 41 can control the on-off of the switch 2. The electrode pair 1 comprises a first electrode and a second electrode, the electrode pair 1 is connected with a pulse power supply 31, an electric arc can be formed between the first electrode and the second electrode, the electric arc forms cavitation bubbles to further form shock waves, the electrode pair 1 can accumulate and release energy when the switch 2 is connected, the energy accumulation has a highest value, the switch 2 is controlled to be switched off, delay time is provided, the electrode pair 1 can be stopped from applying high voltage when the energy reaches a peak value by sending a switching-off instruction in advance, the electrodes can be protected, and the service life of the electrodes can be prolonged.
The energy supply unit is also provided with a release state detection circuit, the release state detection circuit is used for detecting the energy release state between the first electrode and the second electrode, the release state detection circuit comprises at least one of a pulse voltage detection circuit and a resistance detection circuit, and the pulse voltage detection circuit is used for detecting the voltage between the first electrode and the second electrode at the moment of discharging; the resistance detection circuit is used for detecting the resistance between the first electrode and the second electrode at the moment of discharge, the first end of the electrode pair 1 is connected with the pulse power supply 31, the second end of the electrode pair is connected with the first end of the switch 2, the second end of the switch 2 is grounded, and the pulse voltage detection circuit is connected with the first end of the electrode pair 1 and the second end of the switch 2; the resistance detection circuit is connected to the second end of the electrode pair 1 and the second end of the switch 2.
As shown in fig. 1, which is a schematic diagram of a waveform of voltage (a) changing with time when a conduit electrode discharges, a high-voltage pulse is loaded on an electrode pair 1, after 10ns-10ms, a conductive liquid is broken down by discharge, current rapidly reaches hundreds of amperes after nanosecond level, voltage between a first electrode and a second electrode drops steeply, and resistance between the first electrode and the second electrode drops steeply. The method can be used for controlling the pulse width of the discharge pulse by a release state detection circuit by detecting the discharge voltage and the resistance steep drop value, and finally realizes the control of the release energy. The pulse voltage detection circuit can detect the released voltage by adopting a voltage transformer or a voltage division sampling resistor and other modes, the voltage drops suddenly at the moment of electrode discharging, the pulse width is controlled according to the voltage drop, and finally the control of the released energy is realized. The resistance detection circuit increases a high-frequency voltage signal and divides the voltage through the divider resistor to analyze again, and the resistance between the electrodes can drop suddenly at the moment of electrode discharge, controls pulse width according to the resistance drop, and finally realizes the control of energy release. The following describes the pulse voltage detection circuit and the resistance detection circuit in detail.
The first embodiment is as follows:
the first form of the pulse voltage detection circuit:
as shown in fig. 2 and 3, the first-type circuit includes a voltage dividing module, an operational amplifier 81 and an on-off controller 41, the voltage dividing module has an input end, an output end and a ground end, the operational amplifier 81 has a positive input end, a negative input end and an output end, the input end of the voltage dividing module is connected to the first end of the electrode pair 1, the ground end is connected to the ground end, the output end is connected to the positive input end of the operational amplifier 81, the negative input end of the operational amplifier 81 is connected to the ground end, and the output end is connected to the on-off controller 41, the first-type circuit divides voltage by setting the voltage dividing module between the pulse power supplies 31, then adjusts the voltage by the operational amplifier 81, and finally inputs the voltage value to the on-off controller 41 for analysis and makes on-off or not.
The second form of the pulse voltage detection circuit:
as shown in fig. 4 and 5, the second type circuit includes a voltage dividing module, a comparator 82, a turn-off circuit 42 and an on-off controller 41, the voltage dividing module has an input end, an output end and a ground end, the comparator 82 has a positive input end, a negative input end and an output end, the input end of the voltage dividing module is connected with the first end of the electrode pair 1, the ground end is grounded, the output end is connected with the positive input end of the comparator 82, the negative input end of the comparator 82 is connected with the Vref power source 32, the output end is connected with the on-off controller 41, the first end of the turn-off circuit 42 is connected with the output end of the comparator 82, and the second end is connected with the contact of the switch 2. The second type of circuit also provides a voltage dividing block and a comparator 82 and a Vref source 32, the Vref source 32 can provide a reference voltage whose voltage is independent of load, power supply, temperature drift, time, etc., and can be kept constant all the time, the divided voltage value of the voltage dividing block is compared with the set value of the Vref source 32 by the comparator 82, and then the switch 2 is directly turned off by the off-circuit 42.
As shown in fig. 2-5, the pulse voltage detection circuit further includes a diode 7, an anode of the diode 7 is grounded, a cathode of the diode 7 is connected to an output terminal of the voltage division module, when the divided voltage of the voltage division module is too large, the diode 7 plays a role of protection, and prevents overvoltage from damaging circuits such as a following operational amplifier 81 or a comparator 82, and the diode 7 is a schottky diode. The pulse voltage detection circuit further comprises a capacitor 6, wherein the first end of the capacitor 6 is connected with the output end of the voltage division module, and the second end of the capacitor is grounded.
The pulse voltage detection circuit further comprises a first resistor 91 and/or a second resistor 92, and in the first form circuit, a first end of the first resistor 91 is connected with the output end of the operational amplifier 81, and a second end is connected with the negative input end of the operational amplifier 81; the second resistor 92 has a first end connected to ground and a second end connected to the negative input terminal of the operational amplifier 81, as shown in fig. 2 and 3. In the second type of circuit, the first end of the first resistor 91 is connected to the output end of the comparator 82, and the second end is connected to the negative input end of the comparator 82; the second resistor 92 has a first terminal connected to ground and a second terminal connected to the negative input terminal of the comparator 82, as shown in fig. 4 and 5.
The voltage dividing module in the two types of circuits may adopt a voltage sensor 5 or one of a third resistor 93 and a fourth resistor 94 connected in series, when the voltage sensor 5 is adopted, the input end of the voltage sensor 5 is the input end of the voltage dividing module, the output end of the voltage sensor 5 is the output end of the voltage dividing module, and the grounding end of the voltage sensor 5 is the grounding end of the voltage dividing module, as shown in fig. 2 and 4. When the third resistor 93 and the fourth resistor 94 are connected in series, a first end of the third resistor 93 is an input end of the voltage dividing module, a second end of the third resistor 93 is connected to a first end of the fourth resistor 94, a second end of the third resistor 93 is an output end of the voltage dividing module, and a second end of the fourth resistor 94 is a ground end of the voltage dividing module, as shown in fig. 3 and 5.
As shown in fig. 2 to 5, the pulse voltage detection circuit further includes a fifth resistor 95, wherein a first terminal of the fifth resistor 95 is connected to the second terminal of the electrode pair 1, and a second terminal thereof is connected to the first terminal of the switch 2.
As shown in fig. 8, the operation principle of the pulse voltage detection circuit is as follows: the electrode pair 1 is connected with the switch 2 in series, the electrode discharge is controlled through the switch 2, the voltage is divided through the voltage dividing module, the divided voltage is adjusted through the operational amplifier 81 and then sent to the on-off controller 41, the on-off controller 41 turns off the pulse after detecting that the voltage drops steeply and delaying for a certain time, so that the frequency and the duty ratio of pulse release are controlled, the control of energy release is finally realized, when the voltage value is reduced by more than 100V magnitude, the switch 2 is turned off by delaying for 50ns magnitude, so that the frequency and the duty ratio of pulse release are controlled, and the control of energy release is finally realized; the divided voltage value after voltage division and the set value of the Vref power supply 32 can be compared through the comparator 82, when the voltage value is reduced by more than 100V, the switch 2 is turned off by delaying the magnitude of 50ns, the high-voltage switch 2 is directly turned off through the hardware circuit of the turn-off circuit 42, and the turn-off reaction can be more sensitive.
Example two:
as shown in fig. 6 and 7, the resistance detection circuit includes a voltage signal source 33, a voltage dividing module, an operational amplifier 81, a capacitor 6 and an on-off controller 41, the voltage dividing module has an input end, an output end and a ground end, the operational amplifier 81 has a positive input end, a negative input end and an output end, a first end of the voltage signal source 33 is connected to a first end of the electrode pair 1, a second end is connected to a first end of the switch 2, a first end of the capacitor 6 is connected to a second end of the electrode pair 1, the second end is connected to the input end of the voltage dividing module, the ground end of the voltage dividing module is grounded, the output end is connected to the positive input end of the operational amplifier 81, the negative input end of the operational amplifier 81 is grounded, and the output end is connected to the on-off controller 41. The voltage signal source 33 provides a high-frequency voltage signal, the frequency range of the high-frequency voltage signal is 10 Hz-1 MHz, and the voltage amplitude is 1V-1000V.
The resistance detection circuit further comprises a diode 7, the anode of the diode 7 is grounded, the cathode of the diode 7 is connected with the output end of the voltage division module, the diode 7 plays a role in protection when the divided voltage of the voltage division module is overlarge, the overvoltage is prevented from damaging circuits such as the following operational amplifier 81 or the comparator 82, and the diode 7 is a Schottky diode.
The resistance detection circuit further comprises a first resistor 91 and/or a second resistor 92, wherein a first end of the first resistor 91 is connected with the output end of the operational amplifier 81, and a second end of the first resistor 91 is connected with the negative input end of the operational amplifier 81; a first terminal of the second resistor 92 is grounded, and a second terminal of the second resistor 92 is connected to the negative input terminal of the operational amplifier 81.
The voltage dividing module in the resistance detection circuit may adopt a voltage sensor 5 or one of a third resistor 93 and a fourth resistor 94 connected in series, when the voltage sensor 5 is adopted, an input end of the voltage sensor 5 is an input end of the voltage dividing module, an output end of the voltage sensor 5 is an output end of the voltage dividing module, and a grounding end of the voltage sensor 5 is a grounding end of the voltage dividing module, as shown in fig. 6. When the third resistor 93 and the fourth resistor 94 are connected in series, a first end of the third resistor 93 is an input end of the voltage dividing module, a second end of the third resistor 93 is connected to a first end of the fourth resistor 94, a second end of the third resistor 93 is an output end of the voltage dividing module, and a second end of the fourth resistor 94 is a ground end of the voltage dividing module, as shown in fig. 7.
As shown in fig. 6 and 7, the resistance detection circuit further includes a fifth resistor 95, wherein a first end of the fifth resistor 95 is connected to the second end of the electrode pair 1, and a second end is connected to the first end of the switch 2. A fifth resistor 95 in the resistor detection circuit is a divider resistor with a resistance range of 0.001m omega-10K omega, and after the switch 2 is switched on, when the electrode pair 1 is not broken down, the resistance range of the electrode is 1K-100K omega; when the electrode pair 1 is breakdown-discharged, the resistance value ranges from 10 to 500 Ω.
As shown in fig. 9, the operating principle of the resistance detection circuit is as follows: the electrode pair 1 and the fifth resistor 95 are connected in series with the switch 2, the electrode discharge is controlled by the switch 2, a high-frequency voltage signal given by the voltage signal source 33 is superposed on a high-voltage pulse of the pulse power supply 31 and is loaded on the electrode pair 1 and the fifth resistor 95, the high-frequency voltage signal is detected by the capacitor 6 and then is sent to the on-off controller 41 after being regulated by the operational amplifier 81, the resistance values of two ends of the electrode pair 1 are measured, the resistance value is above 1K omega before discharge breakdown and below 100 omega after breakdown, the pulse is turned off after a certain time delay by detecting that the resistance value is suddenly reduced, and the switch 2 is turned off by delaying the magnitude of 50ns when the resistance value is reduced by more than 10 omega magnitude, so that the frequency and the duty ratio of pulse release are controlled, and finally the control of energy release is realized.
Example three:
when the pulse voltage detection circuit and the resistance detection circuit exist at the same time, the pulse voltage detection circuit is connected to the first end of the electrode pair 1 and the second end of the switch 2; the resistance detection circuit is connected to the second end of the electrode pair 1 and the second end of the switch 2, and the shock wave detection is performed by selecting any one of the detection circuits. When one circuit fails, detection can still be realized through the other detection circuit, and normal control of the shock wave is ensured.
The above embodiments are merely illustrative of the technical ideas and features of the present invention, and the purpose thereof is to enable those skilled in the art to understand the contents of the present invention and implement the present invention, and not to limit the protection scope of the present invention. All equivalent changes and modifications made according to the spirit of the present invention should be covered within the protection scope of the present invention.