CN215651149U - Elevated plus maze for detecting anxiety behavior of tree shrews - Google Patents

Elevated plus maze for detecting anxiety behavior of tree shrews Download PDF

Info

Publication number
CN215651149U
CN215651149U CN202122039152.0U CN202122039152U CN215651149U CN 215651149 U CN215651149 U CN 215651149U CN 202122039152 U CN202122039152 U CN 202122039152U CN 215651149 U CN215651149 U CN 215651149U
Authority
CN
China
Prior art keywords
plates
elevated plus
plus maze
connecting plate
arm
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN202122039152.0U
Other languages
Chinese (zh)
Inventor
赵洪庆
王宇红
杨冬梅
孟盼
柳卓
韩远山
李春艳
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hunan University of Chinese Medicine
Original Assignee
Hunan University of Chinese Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hunan University of Chinese Medicine filed Critical Hunan University of Chinese Medicine
Priority to CN202122039152.0U priority Critical patent/CN215651149U/en
Application granted granted Critical
Publication of CN215651149U publication Critical patent/CN215651149U/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Landscapes

  • Management, Administration, Business Operations System, And Electronic Commerce (AREA)

Abstract

The utility model provides an elevated crisscross maze for detecting anxiety behaviors of tree shrews, which comprises a connecting plate, wherein closed arm plates are arranged on the front side and the rear side of the connecting plate, open arm plates are arranged on the left side and the right side of the connecting plate, first side plates vertically arranged along the length direction of the closed arm plates, second side plates vertically arranged far away from the closed arm plates and cover plates arranged in parallel with the closed arm plates are arranged on the closed arm plates, the two first side plates, the second side plates and the cover plates are enclosed to form closed arm spaces, fences are arranged on the open arm plates, the open arm plates and the fences are enclosed to form open arm spaces, a throwing door is arranged above the connecting plate in parallel, and the throwing door and the connecting plate are communicated with the two closed arm spaces and the two open arm spaces; the elevated cross maze for detecting the anxiety behavior of the tree shrews provided by the utility model has the advantages of simple structure, practicability and convenience, and ensures the normal operation of an experiment.

Description

Elevated plus maze for detecting anxiety behavior of tree shrews
Technical Field
The utility model belongs to the technical field of experimental instruments, and particularly relates to an elevated plus maze for detecting anxiety behaviors of tree shrews.
Background
The tree shrews are small mammals mainly distributed in southwest areas of China, and genome research shows that the genetic relationship of the tree shrews is closest to that of primates (about 93.4 percent), and compared with the primates, the tree shrews have the characteristics of small body size, short reproduction period, easiness in experimental operation, low feeding cost and the like, and have unique application advantages in the research of animal models of human diseases. The tree shrew has high brain mass ratio, a developed nervous system and a stress system similar to human beings, so the tree shrew is widely applied to the study of neuropsychiatric diseases.
Anxiety, depression, and depression are common affective disorders of the nervous system, and both are frequently associated. At present, the anxiety/depression phenotype of model animals is mainly evaluated by different behavioral testing methods to simulate different symptoms under human disease states through behavioral means, for example, a sugar water preference test for depression is a core symptom simulating anhedonia of patients, and an open field test is used for simulating the spontaneous activity and exploration capacity of human beings. The elevated plus maze simulates the anxiety state of human beings by the contradiction psychology formed between the exploration characteristics of animals in a new environment and the fear characteristics of animals in a highly suspended open environment, and is the most classical instrument for detecting the anxiety behaviors of animals. However, the tree shrew is good in climbing and jumping, agile in movement, small in gallbladder and easy to fright, the traditional elevated plus maze is not suitable for being used, and compared with the mode that the depression behavior of the tree shrew can be evaluated by a sweet water preference experiment and an improved open field experiment, an instrument for evaluating the anxiety behavior is not available, and the tree shrew is very inconvenient to use for researching the diseases such as anxiety, anxiety depression and the like.
SUMMERY OF THE UTILITY MODEL
The utility model aims to provide an elevated cross maze for detecting anxiety behaviors of tree shrews, which has a simple structure, is practical and convenient, and ensures normal experiment.
In order to achieve the purpose, the utility model adopts the technical scheme that the elevated crisscross maze for detecting the anxiety behavior of the tree shrews comprises a connecting plate, wherein closed arm plates are arranged on the front side and the rear side of the connecting plate, open arm plates are arranged on the left side and the right side of the connecting plate, first side plates vertically arranged along the length direction of the closed arm plates, second side plates vertically arranged far away from the closed arm plates and cover plates parallel to the closed arm plates are arranged on the closed arm plates, the two first side plates, the second side plates and the cover plates are enclosed to form closed arm spaces, fences are arranged on the open arm plates, the open arm plates and the fences are enclosed to form open arm spaces, a throwing door is arranged above the connecting plate in parallel, and the throwing door and the connecting plate are communicated with the two closed arm spaces and the two open arm spaces.
Preferably, one end of the cover plate close to the throwing door is provided with an observation window made of transparent materials or a fence plate.
Preferably, the projection door is made of transparent materials or a gate.
Preferably, a sliding door parallel to the second side plate is arranged between the two first side plates, and a first handle is arranged on the sliding door.
Preferably, the first side plate is provided with a sliding groove matched with the sliding door.
Preferably, the second side plate is hinged to one first side plate and is connected with the other first side plate through a lock catch.
Preferably, the bottom surfaces of the connecting plate, the two closed arm plates and the two open arm plates are provided with supporting columns with adjustable heights, and the bottom ends of the supporting columns are provided with bases.
Preferably, the bottom surface of the base is provided with an anti-skid pad.
Preferably, the system further comprises a video monitor arranged above the throwing door.
Preferably, a second handle is arranged on the throwing door.
The utility model has the beneficial effects that when in use, the throwing door 4 is opened to put the tree shrews into the elevated cross maze, the closed arm space formed by enclosing the closed arm plate 2, the two first side plates 21, the second side plate 22 and the cover plate 23 and the open arm space formed by enclosing the open arm plate 3 and the fence 31 can prevent the tree shrews from jumping out of the elevated cross maze, the structure is simple, the practicability and the convenience are realized, and the normal operation of the experiment is ensured.
Drawings
FIG. 1 is a schematic structural diagram of an embodiment of the present invention;
FIG. 2 is a schematic structural view of a connecting plate;
FIG. 3 is a schematic view of the drop door of FIG. 1;
FIG. 4 is a schematic view of the second side plate shown in FIG. 1;
fig. 5 is a schematic structural view of the chute.
In the figure, 1, a connecting plate; 2. closing the arm plate; 21. a first side plate; 211. a chute; 22. a second side plate; 221. locking; 23. a cover plate; 231. an observation window; 3. opening the arm plate; 31. a fence; 4. a drop door; 41. a second handle; 5. a sliding door; 51. a first handle; 6. a support pillar; 61. a base.
Detailed Description
The technical scheme of the utility model is further described in detail by combining the drawings and the specific embodiments:
referring to fig. 1-5 together, the elevated cross maze for detecting anxiety behaviors of tree shrews provided by the present embodiment includes a connecting plate 1, closed arm plates 2 are disposed on the front and back sides of the connecting plate 1, open arm plates 3 are disposed on the left and right sides of the connecting plate 1, a first side plate 21 vertically disposed along the length direction of the closed arm plates 2, a second side plate 22 vertically disposed away from the closed arm plates 2, and a cover plate 23 parallel to the closed arm plates 2 are disposed on the closed arm plates 2, the two first side plates 21, the second side plate 22, and the cover plate 23 enclose to form a closed arm space, a fence 31 is disposed on the open arm plates 3, the open arm plates 3 and the fence 31 enclose to form an open arm space, a drop door 4 is disposed above the connecting plate 1 in parallel, and the drop door 4 and the connecting plate 1 communicate the two closed arm spaces and the two open arm spaces.
During the use, open and throw door 4 and put into the overhead cross maze with the tree shrew, close arm plate 2, two first curb plate 21, second curb plate 22 and apron 23 and enclose to close the closed arm space that forms and open arm plate 3 and fence 31 and enclose to close and form the open arm space and can prevent the tree shrew from jumping out of the overhead cross maze, simple structure, practical convenient, guarantee that the experiment normally goes on.
More specifically, in this embodiment, the closing arm plate 2, the two first side plates 21, the second side plate 22 and the cover plate 23 are all black baffle plates, an observation window 231 is disposed at one end of the cover plate 23 close to the projection door 4, the observation window 231 is made of transparent material, so as to facilitate observation and recording of the times of the tree shrew passing through the closing arm and calculation of the total times of arm passing, and the observation window 231 can also be a fence plate, which facilitates observation and prevents the tree shrew from jumping out of the elevated plus maze.
As a variation of the above scheme, the projection door 4 may be made of a transparent material, which is convenient for observing and recording the times of arm penetration of the tree shrew and the residence time in the arm opening space; the throwing door 4 can also be a grid door, which is convenient for observation and can prevent the tree shrews from jumping out of the elevated plus maze.
More specifically, a sliding door 5 parallel to the second side plate 22 is arranged between the two first side plates 21, a first handle 51 is arranged on the sliding door 5, and when the sliding door is used, the sliding door 5 can be quickly inserted into the arm closing space by holding the first handle 51, so that the movement of the tree shrew is limited.
More specifically, the first side plate 21 is provided with a sliding groove 211 adapted to the sliding door 5, so that the sliding door 5 can slide stably, and tree shrews can be prevented from colliding with the sliding door 5.
More specifically, the second side plate 22 is hinged to one first side plate 21 and connected to the other first side plate 21 through a lock catch 221; the second side plate 22 can be pulled open by opening the lock catch 221, and the second side plate 22 at least one end can be pulled open, so that the animal can be conveniently grabbed after the measurement is finished; after the experiment is finished, the tree shrews tend to stay in the arm closing space, the sliding door 5 corresponding to the arm closing space is put down, the tree shrews can be grabbed by opening the second side plate 22, and the time for the tree shrews to be hidden in the elevated plus maze is avoided; after use, the closed arm space can be cleaned by opening the second side plate 22.
More specifically, connecting plate 1, two close armplate 2, all be provided with height-adjustable's support column 6 on two bottom surfaces of opening armplate 3, 6 bottoms of support column are equipped with base 61, the stand of blind hole is seted up including the top to support column 6, be equipped with in the blind hole and follow the gliding slide bar of vertical direction, be equipped with the screw that is used for locking the slide bar on the stand, the top and the connecting plate 1 of slide bar, close armplate 2 or open armplate 3's bottom surface and be connected, the bottom and the base 61 of stand are connected, the terrain clearance of the cross maze of going up can be changed through the position of adjusting the slide bar, moreover, the steam generator is simple in structure, can satisfy the not experimental requirement of co-altitude.
More specifically, the anti-slip mat is arranged on the bottom surface of the base 61, so that the base 61 is firmly fixed on the ground, and a good support is provided for the elevated plus maze.
More specifically, still including locating the video watch-dog that throws above door 4, the video watch-dog is hung in throwing above door 4 through the support frame, replaces artifical tally, and the number of times of wearing the arm of the automatic recording tree shrew, calculation dwell time in the space of opening the arm, and data are accurate, can reduce working strength by a wide margin, reduce artificial tally error.
More specifically, the drop door 4 is provided with a second handle 41, which facilitates opening and locking the drop door 4.
The above examples are only for illustrating the technical solutions of the present invention, and not for limiting the same; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions of the embodiments of the present invention.

Claims (10)

1. An elevated plus maze for detecting anxiety behavior of tree shrews, characterized in that: including connecting plate (1), both sides are equipped with closed armplate (2) around connecting plate (1), and the left and right sides of connecting plate (1) is equipped with out armplate (3), be equipped with first curb plate (21), second curb plate (22) and apron (23) on closed armplate (2), close armplate (2), two first curb plates (21), second curb plate (22) and apron (23) and enclose to close and form closed arm space, be equipped with fence (31) on out armplate (3), it forms open arm space to open armplate (3) and fence (31) to enclose to close, the top parallel of connecting plate (1) is equipped with throws door (4), throw door (4), connecting plate (1) and communicate two closed arm spaces and two open arm spaces.
2. The elevated plus maze for detecting anxiety behavior of tree shrews according to claim 1, wherein: one end of the cover plate (23) close to the throwing door (4) is provided with an observation window (231), and the observation window (231) is made of transparent materials or is provided with a fence plate.
3. The elevated plus maze for detecting anxiety behavior of tree shrews according to claim 1, wherein: the throwing door (4) is made of transparent materials or a gate.
4. The elevated plus maze for detecting anxiety behavior of tree shrews according to any one of claims 1-3, wherein: a sliding door (5) parallel to the second side plate (22) is arranged between the two first side plates (21), and a first handle (51) is arranged on the sliding door (5).
5. The elevated plus maze for detecting anxiety behavior of tree shrews according to claim 4, wherein: the first side plate (21) is provided with a sliding groove (211) matched with the sliding door (5).
6. The elevated plus maze for detecting anxiety in tree shrew according to claim 1, 2, 3 or 5, wherein: the second side plate (22) is hinged with one first side plate (21) and is connected with the other first side plate (21) through a lock catch (221).
7. The elevated plus maze for detecting anxiety behavior of tree shrews according to claim 6, wherein: the bottom surfaces of the connecting plate (1), the two closed arm plates (2) and the two open arm plates (3) are provided with supporting columns (6) with adjustable heights, and the bottom ends of the supporting columns (6) are provided with bases (61).
8. The elevated plus maze for detecting anxiety behavior of tree shrews according to claim 7, wherein: and the bottom surface of the base (61) is provided with an anti-skid pad.
9. The elevated plus maze for detecting anxiety in tree shrews of claim 1, 2, 3, 5, 7, or 8, wherein: the device also comprises a video monitor arranged above the throwing door (4).
10. The elevated plus maze for detecting anxiety behavior of tree shrews according to claim 9, wherein: and a second handle (41) is arranged on the throwing door (4).
CN202122039152.0U 2021-08-26 2021-08-26 Elevated plus maze for detecting anxiety behavior of tree shrews Active CN215651149U (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202122039152.0U CN215651149U (en) 2021-08-26 2021-08-26 Elevated plus maze for detecting anxiety behavior of tree shrews

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202122039152.0U CN215651149U (en) 2021-08-26 2021-08-26 Elevated plus maze for detecting anxiety behavior of tree shrews

Publications (1)

Publication Number Publication Date
CN215651149U true CN215651149U (en) 2022-01-28

Family

ID=79956593

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202122039152.0U Active CN215651149U (en) 2021-08-26 2021-08-26 Elevated plus maze for detecting anxiety behavior of tree shrews

Country Status (1)

Country Link
CN (1) CN215651149U (en)

Similar Documents

Publication Publication Date Title
Salegio et al. A unilateral cervical spinal cord contusion injury model in non-human primates (Macaca mulatta)
Prusky et al. Characterization of mouse cortical spatial vision
Geyer et al. Animal models of psychiatric disorders
Whishaw et al. Long–Evans and Sprague–Dawley rats have similar skilled reaching success and limb representations in motor cortex but different movements: some cautionary insights into the selection of rat strains for neurobiological motor research
Walsh et al. Eight weeks of non-nightly use of zolpidem for primary insomnia
Simons et al. Responses of barrel cortex neurons in awake rats and effects of urethane anesthesia
MacDonald et al. Early nutritional stress impairs development of a song-control brain region in both male and female juvenile song sparrows (Melospiza melodia) at the onset of song learning
Golden et al. Rat strain and age differences in kainic acid induced seizures
Stiles et al. Miniature endplate current rise times< 100 μ s from improved dual recordings can be modeled with passive acetylcholine diffusion from a synaptic vesicle
García-Alías et al. Functional and electrophysiological characterization of photochemical graded spinal cord injury in the rat
Yang et al. Chronic administration of methylphenidate produces neurophysiological and behavioral sensitization
Becker et al. An automated task for the training and assessment of distal forelimb function in a mouse model of ischemic stroke
Klöcker et al. Morphological and functional analysis of an incomplete CNS fiber tract lesion: graded crush of the rat optic nerve
CN215651149U (en) Elevated plus maze for detecting anxiety behavior of tree shrews
Lavond et al. Lesions of the cerebellar interpositus nucleus abolish both nictitating membrane and eyelid EMG conditioned responses
Cowan et al. The new-object and new-place reactions of Rattus rattus L.
Nygren et al. Heterogeneity of action potential durations in isolated mouse left and right atria recorded using voltage-sensitive dye mapping
Vistamehr et al. Light deprivation suppresses the light response of inner retina in both young and adult mouse
Moldovan et al. Persistent abnormalities of membrane excitability in regenerated mature motor axons in cat
Marighetto et al. Septal α-noradrenergic antagonism in vivo blocks the testing-induced activation of septo-hippocampal cholinergic neurones and produces a concomitant deficit in working memory performance of mice
Horn et al. Discharge of inferior olive cells during reaching errors and perturbations
Anderson et al. A novel naïve Bayes approach to identifying grooming behaviors in the force-plate actometric platform
Manning et al. What’s wrong with MHC mate choice experiments?
Havton et al. Partial peripheral motor nerve lesions induce changes in the conduction properties of remaining intact motoneurons
Moisset Genetic analysis of the behavioral response to d-amphetamine in mice

Legal Events

Date Code Title Description
GR01 Patent grant
GR01 Patent grant