CN215538613U

CN215538613U - Fixing device of chromatographic column

Info

Publication number: CN215538613U
Application number: CN202122058998.9U
Authority: CN
Inventors: 魏文涛
Original assignee: Sure Biotech (hangzhou) Ltd
Current assignee: Sure Biotech (hangzhou) Ltd
Priority date: 2021-08-30
Filing date: 2021-08-30
Publication date: 2022-01-18
Anticipated expiration: 2031-08-30

Abstract

The utility model discloses a chromatographic column fixing device, which belongs to the technical field of chromatographic columns and comprises a placing box, wherein a box door is installed at the opening end of the placing box, a plurality of supporting plates are fixedly installed on the inner walls of two sides of the placing box, a sliding frame is clamped on the supporting plates in a sliding manner, a plurality of connectors are attached to the sliding frame in a sliding manner, the bottoms of the connectors penetrate through the sliding frame and are connected with a sealing cover in a threaded manner, and the bottom of the upper sealing cover is connected with a chromatographic column in a threaded manner. The carriage slides along the backup pad and pulls out, then cup joints chromatography post screw thread in last closing cap bottom, with the bottom of last closing cap laminating carriage, again with connector threaded connection upper cover, and connector laminating carriage upper surface, realize a plurality of chromatography posts hoist and mount on the carriage, realize the quick fixed of a plurality of chromatography posts, then push into the carriage and place the incasement to it can to close the chamber door.

Description

Fixing device of chromatographic column

Technical Field

The utility model relates to the technical field of chromatographic columns, in particular to a fixing device for a chromatographic column.

Background

The chromatographic separation and purification is a process technology widely used in the separation and purification processes such as protein separation and purification, plant extract separation and purification, biological medicine purification and the like in recent years, a traditional chromatographic column fixing device achieves the fixing effect by matching an iron support, a clamp and double-jackscrews, and the external clamp is adopted for installation, so that the device not only occupies space, but also has poor fixing stability, is bulky, is inconvenient to use, can only fix one chromatographic column at one time and cannot fix the chromatographic columns in batches.

SUMMERY OF THE UTILITY MODEL

In view of the above technical shortcomings, the present invention provides a fixing device for a chromatography column.

In order to solve the technical problems, the utility model adopts the following technical scheme: the utility model provides a fixing device for a chromatographic column, which comprises a placing box, wherein a box door is installed at the opening end of the placing box, a plurality of supporting plates are fixedly installed on the inner walls of the two sides of the placing box, a sliding frame is slidably clamped on the supporting plates, a plurality of connectors are slidably attached to the sliding frame, the bottoms of the connectors penetrate through the sliding frame and are connected with an upper sealing cover in a threaded mode, and the bottom of the upper sealing cover is connected with the chromatographic column in a threaded mode.

Preferably, a transparent glass window is fixedly installed on the box door, and the length of the inner cavity of the placing box is equal to that of the sliding frame.

Preferably, the carriage includes fixed frame, fixed frame slip laminating backup pad, a plurality of bracing pieces of fixed welding between the inner wall of fixed frame, a plurality of joint bars of fixed welding in top of bracing piece, adjacent two form the stretching into groove between the joint bar, the top surface of the joint bar of closely laminating of connector.

Preferably, the width that stretches into the groove is less than the diameter of connector, the equal fixed welding in both ends top of fixed frame has the handle.

Preferably, the upper sealing cover comprises a cover body, the inner wall of the cover body is sleeved with the chromatographic column through a threaded structure, the top of the cover body is fixedly connected with the connecting pipe, the inner wall of the connecting pipe is provided with an internal thread, the connecting head is connected with the internal thread, and the connecting pipe is close to the outer wall of one end of the cover body and is fixedly provided with an elastic boss.

Preferably, the outer wall of one end of the connecting pipe, which is far away from the cover body, is provided with an arc-shaped groove, and the elastic boss is of an elastic rubber annular structure.

Preferably, the connector includes upper cover plate and lower apron, filler core between upper cover plate and lower apron, through viscose fixed bonding between upper cover plate and lower apron, the fastening ring is cup jointed to the circumference outer wall of upper cover plate and lower apron is fixed, fixed cover is gone up to the upper cover plate and is connect the breather pipe, the breather pipe is down cup jointed to the bottom of apron is fixed down, the outer wall bottom of breather pipe is equipped with the external screw thread down, the breather pipe slides and runs through the connecting pipe down, external screw thread threaded connection internal thread, the outer wall top fixed mounting sealing washer of breather pipe down.

Preferably, the filter core is multilayer fiber cloth, the sealing washer includes the clamp ring, the fixed top that cup joints at breather pipe down of clamp ring, the bottom integrated into one piece of clamp ring is equipped with the gradual change ring, the bottom integrated into one piece of gradual change ring is equipped with the path ring.

Preferably, the outer diameter of the compression ring is equal to the inner diameter of the connecting pipe, and the gradual change ring is of a round table structure with a large upper part and a small lower part.

The utility model has the beneficial effects that:

1. the chromatography column is in threaded sleeve connection with the bottom of the cover body, the connecting pipe penetrates through the extending groove, then the lower vent pipe is inserted into the connecting pipe, the external thread is in threaded connection with the internal thread, the connecting head and the upper sealing cover are fixed, at the moment, the fastening ring is pressed on the clamping rod, the chromatography column is hoisted and fixed, the operation is simple and convenient, a plurality of chromatography columns can be fixed, and the space is saved;

2. in the process of connecting the external thread and the internal thread, the small-diameter ring is firstly inserted into the connecting pipe, the gradual-change ring is gradually attached to the inner wall of the connecting pipe, finally, when the thread is screwed down, the compression ring is tightly pressed on the inner wall of the connecting pipe to realize sealing, and the elastic boss is attached to the clamping rod to achieve vibration buffering;

3. the outside air circulates through the upper breather pipe and the lower breather pipe, so that normal pressure is kept in the chromatographic column, chromatography is facilitated, and the air is filtered through the filter element, so that the substances in the chromatographic column are prevented from being polluted.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the drawings without creative efforts.

Fig. 1 is a schematic structural diagram of a fixing device for a chromatography column according to an embodiment of the present invention.

Fig. 2 is a schematic view of the sliding frame structure of the present invention.

FIG. 3 is a schematic view of the structure of the upper cover of the present invention.

Fig. 4 is a schematic diagram of the structure of the connecting head of the present invention.

Description of reference numerals: 1. placing a box; 2. a support plate; 3. a carriage; 31. a fixing frame; 32. a support bar; 33. a clamping and connecting rod; 34. extending into the groove; 35. a handle; 4. a chromatography column; 5. an upper sealing cover; 51. a cover body; 52. an elastic boss; 53. a connecting pipe; 54. an internal thread; 6. a connector; 61. an upper cover plate; 62. a lower cover plate; 63. a filter element; 64. a fastening ring; 65. an upper vent pipe; 66. a lower vent pipe; 67. an external thread; 68. a seal ring; 681. a small diameter ring; 682. a gradual change ring; 683. a compression ring; 7. a box door; 8. a transparent glass window.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Example (b): as shown in fig. 1-4, the present invention provides a fixing device for a chromatography column, which comprises a placing box 1, a box door 7 installed at the opening end of the placing box 1, a plurality of supporting plates 2 fixedly installed on the inner walls of the two sides of the placing box 1, a sliding clamping sliding frame 3 sliding on the supporting plates 2, a plurality of connectors 6 sliding on the sliding frame 3, a sealing cover 5 screwed on the bottom of the connectors 6 penetrating through the sliding frame 3, and a chromatography column 4 screwed on the bottom of the sealing cover 5. Carriage 3 slides along backup pad 2 and pulls out, then cup joints 4 screw threads of chromatography post in last closing cap 5 bottom, with the bottom of 5 laminating carriage 3 of last closing cap, again with 6 threaded connection upper cover 5 of connector, and the 3 upper surfaces of 6 laminating carriages of connector, realize a plurality of chromatography posts 4 hoist and mount on carriage 3, realize a plurality of chromatography posts 4's quick fixity, then push into carriage 3 and place in the case 1 to it can to close chamber door 7.

Furthermore, a transparent glass window is fixedly arranged on the box door 7, and the length of the inner cavity of the placing box 1 is equal to that of the sliding frame 3.

Further, carriage 3 includes fixed frame 31, fixed frame 31 slides laminating backup pad 2, a plurality of bracing pieces of fixed welding 32 between the inner wall of fixed frame 31, a plurality of joint bars 33 of the fixed welding in top of bracing piece 32, form between two adjacent joint bars 33 and stretch into groove 34, the top surface of the joint bar 33 of 6 inseparable laminatings of connector, the width that stretches into groove 34 is less than the diameter of connector 6, the equal fixed welding in both ends top of fixed frame 31 has handle 35, then go up closing cap 5 and connector 6 and run through and stretch into groove 34 and threaded connection, make connector 6 press on joint bar 33, realize chromatography column 4's fixed.

Further, go up closing cap 5 and include lid 51, chromatographic column 4 is cup jointed through helicitic texture to the lid 51 inner wall, lid 51's top fixed connection connecting pipe 53, and connecting pipe 53's inner wall is equipped with internal thread 54, and internal thread 54 connects connector 6, and connecting pipe 53 is close to the outer wall fixed mounting elasticity boss 52 of lid 51's one end, and connecting pipe 53 keeps away from lid 51's one end outer wall and opens and has the arc recess, and elasticity boss 52 is elastic rubber ring shape structure.

The connector 6 comprises an upper cover plate 61 and a lower cover plate 62, a filter element 63 is filled between the upper cover plate 61 and the lower cover plate 62, the upper cover plate 61 and the lower cover plate 62 are fixedly bonded through viscose glue, a fastening ring 64 is fixedly sleeved on the circumferential outer walls of the upper cover plate 61 and the lower cover plate 62, an upper vent pipe 65 is fixedly sleeved on the upper cover plate 61, a lower vent pipe 66 is fixedly sleeved at the bottom of the lower cover plate 62, an external thread 67 is arranged at the bottom of the outer wall of the lower vent pipe 66, the lower vent pipe 66 penetrates through the connecting pipe 53 in a sliding manner, the external thread 67 is in threaded connection with the internal thread 54, a sealing ring 68 is fixedly installed at the top of the outer wall of the lower vent pipe 66, the filter element 63 is made of multilayer fiber cloth, the sealing ring 68 comprises a pressing ring 683, the pressing ring 683 is fixedly sleeved at the top of the lower vent pipe 66, a gradual change ring 682 is integrally formed at the bottom of the pressing ring 683, a small diameter ring 681 is integrally formed at the bottom of the gradual change ring 682, and the outer diameter of the pressing ring 683 is equal to the inner diameter of the connecting pipe 53, the gradual change ring 682 has a circular truncated cone structure with a large top and a small bottom.

Connecting pipe 53 runs through stretching into groove 34, then lower breather pipe 66 inserts in connecting pipe 53, and make external screw thread 67 threaded connection internal thread 54, realize the fixed of connector 6 and upper seal 5, and among the threaded connection process, path ring 681 inserts in connecting pipe 53 earlier, gradual change ring 682 laminates the connecting pipe 53 inner wall gradually, when final screw is screwed up, clamp ring 683 closely presses on connecting pipe 53 inner wall, realize sealedly, clamp ring 64 presses on joint pole 33 this moment, realize the hoist and mount of chromatography column 4 fixed, outside air circulates through last breather pipe 65 and lower breather pipe 66, be convenient for keep normal pressure in the chromatography column 4, be convenient for the chromatography, and the air filters through filter element 63, avoid polluting the interior material of chromatography column 4.

When the device is used, the sliding frame 3 is pulled out along the support plate 2 in a sliding manner, the chromatographic column 4 is in threaded sleeve connection with the bottom of the cover body 51, the connecting pipe 53 penetrates through the extending groove 34, the lower vent pipe 66 is inserted into the connecting pipe 53, the external thread 67 is in threaded connection with the internal thread 54, the fixing of the connecting head 6 and the upper sealing cover 5 is realized, in the threaded connection process, the small-diameter ring 681 is firstly inserted into the connecting pipe 53, the gradual-changing ring 682 is gradually attached to the inner wall of the connecting pipe 53, finally, when the threads are screwed down, the pressing ring 683 is tightly pressed on the inner wall of the connecting pipe 53 to realize sealing, the fastening ring 64 is pressed on the clamping rod 33 to realize the hoisting and fixing of the chromatographic column 4, the operation is simple and convenient, a plurality of chromatographic columns can be fixed, the space is saved, the external air flows through the upper vent pipe 65 and the lower vent pipe 66, the normal pressure is convenient to maintain in the chromatographic column 4, the chromatography is convenient, and the air is filtered by the filter element 63, avoiding contamination of the contents of the chromatographic column 4.

It will be apparent to those skilled in the art that various changes and modifications may be made in the present invention without departing from the spirit and scope of the utility model. Thus, if such modifications and variations of the present invention fall within the scope of the claims of the present invention and their equivalents, the present invention is also intended to include such modifications and variations.

Claims

1. A fixing device of chromatographic column, is including placing case (1), its characterized in that: place open end installation chamber door (7) of case (1), place a plurality of backup pads of the equal fixed mounting of both sides inner wall (2) of case (1), slide clamping carriage (3) on backup pad (2), a plurality of connectors of sliding fit (6) on carriage (3), carriage (3) and threaded connection upper seal cover (5) are run through to the bottom of connector (6), go up bottom threaded connection chromatography post (4) of upper seal cover (5).

2. A chromatographic column fixing device as set forth in claim 1, wherein: a transparent glass window (8) is fixedly arranged on the box door (7), and the length of the inner cavity of the placing box (1) is equal to that of the sliding frame (3).

3. A chromatographic column fixing device as set forth in claim 1, wherein: carriage (3) are including fixed frame (31), fixed frame (31) slide laminating backup pad (2), a plurality of bracing pieces of fixed welding (32) between the inner wall of fixed frame (31), a plurality of joint bars of fixed welding (33) in top of bracing piece (32), adjacent two form between joint bar (33) and stretch into groove (34), the top surface of joint bar (33) is closely laminated in connector (6).

4. A chromatographic column fixing device as set forth in claim 3, wherein: the width that stretches into groove (34) is less than the diameter of connector (6), the equal fixed welding in both ends top of fixed frame (31) has handle (35).

5. A chromatographic column fixing device as set forth in claim 1, wherein: go up closing cap (5) including lid (51), lid (51) inner wall cup joints chromatography column (4) through helicitic texture, top fixed connection connecting pipe (53) of lid (51), the inner wall of connecting pipe (53) is equipped with internal thread (54), connector (6) is connected in internal thread (54), outer wall fixed mounting elasticity boss (52) that connecting pipe (53) are close to the one end of lid (51).

6. A chromatographic column fixing device as set forth in claim 5, wherein: the outer wall of one end, far away from the cover body (51), of the connecting pipe (53) is provided with an arc-shaped groove, and the elastic boss (52) is of an elastic rubber annular structure.

7. A chromatographic column fixing device as set forth in claim 1, wherein: connector (6) include upper cover plate (61) and lower cover plate (62), fill filter core (63) between upper cover plate (61) and lower cover plate (62), through viscose fixed bonding between upper cover plate (61) and lower cover plate (62), the fixed tighrening ring (64) that cup joints of circumference outer wall of upper cover plate (61) and lower cover plate (62), fixed cover is gone up in upper cover plate (61) and is connect breather pipe (65), breather pipe (66) down is cup jointed to the bottom of lower cover plate (62) is fixed, the outer wall bottom of breather pipe (66) is equipped with external screw thread (67) down, breather pipe (66) slide and run through connecting pipe (53) down, external screw thread (67) threaded connection internal thread (54), outer wall top fixed mounting sealing washer (68) of breather pipe (66) down.

8. A chromatographic column fixing device as set forth in claim 7, wherein: the filter core (63) is multilayer fiber cloth, sealing washer (68) include clamp ring (683), fixed the cup jointing in the top of breather pipe (66) down of clamp ring (683), the bottom integrated into one piece of clamp ring (683) is equipped with gradually becoming ring (682), the bottom integrated into one piece of gradually becoming ring (682) is equipped with path ring (681).

9. A chromatographic column fixing device as set forth in claim 8, wherein: the outer diameter of the compression ring (683) is equal to the inner diameter of the connecting pipe (53), and the gradual-change ring (682) is of a round table structure with a large upper part and a small lower part.