CN215538579U - Andrographolide production extraction element - Google Patents
Andrographolide production extraction element Download PDFInfo
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- CN215538579U CN215538579U CN202121669873.3U CN202121669873U CN215538579U CN 215538579 U CN215538579 U CN 215538579U CN 202121669873 U CN202121669873 U CN 202121669873U CN 215538579 U CN215538579 U CN 215538579U
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- water bath
- wall
- fixed mounting
- mixing
- casing
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- 238000000605 extraction Methods 0.000 title claims abstract description 36
- BOJKULTULYSRAS-OTESTREVSA-N Andrographolide Chemical compound C([C@H]1[C@]2(C)CC[C@@H](O)[C@]([C@H]2CCC1=C)(CO)C)\C=C1/[C@H](O)COC1=O BOJKULTULYSRAS-OTESTREVSA-N 0.000 title claims abstract description 19
- ASLUCFFROXVMFL-UHFFFAOYSA-N andrographolide Natural products CC1(CO)C(O)CCC2(C)C(CC=C3/C(O)OCC3=O)C(=C)CCC12 ASLUCFFROXVMFL-UHFFFAOYSA-N 0.000 title claims abstract description 19
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 12
- 238000002156 mixing Methods 0.000 claims abstract description 71
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 59
- 239000007788 liquid Substances 0.000 claims abstract description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 51
- 244000118350 Andrographis paniculata Species 0.000 claims description 19
- 239000000843 powder Substances 0.000 claims description 18
- 238000000967 suction filtration Methods 0.000 claims description 17
- 239000013049 sediment Substances 0.000 claims description 6
- 239000012141 concentrate Substances 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 230000005540 biological transmission Effects 0.000 claims description 2
- 238000010030 laminating Methods 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 9
- 238000002137 ultrasound extraction Methods 0.000 abstract description 7
- 238000007789 sealing Methods 0.000 abstract description 3
- 238000007599 discharging Methods 0.000 abstract 2
- 230000010354 integration Effects 0.000 abstract 1
- 238000003756 stirring Methods 0.000 description 6
- 239000002893 slag Substances 0.000 description 3
- 150000002596 lactones Chemical class 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000007790 scraping Methods 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 241000207965 Acanthaceae Species 0.000 description 1
- 241000746375 Andrographis Species 0.000 description 1
- 208000004429 Bacillary Dysentery Diseases 0.000 description 1
- 244000110343 Elephantopus scaber Species 0.000 description 1
- 208000004232 Enteritis Diseases 0.000 description 1
- 206010017553 Furuncle Diseases 0.000 description 1
- 206010017915 Gastroenteritis shigella Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 241001571736 Lysimachia foenum-graecum Species 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 241000124033 Salix Species 0.000 description 1
- 206010040943 Skin Ulcer Diseases 0.000 description 1
- 241001327268 Sorghastrum Species 0.000 description 1
- 241001123263 Zostera Species 0.000 description 1
- 206010001093 acute tonsillitis Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 238000009795 derivation Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 206010022000 influenza Diseases 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 201000005113 shigellosis Diseases 0.000 description 1
- 231100000019 skin ulcer Toxicity 0.000 description 1
- 238000009210 therapy by ultrasound Methods 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
- 208000019206 urinary tract infection Diseases 0.000 description 1
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Abstract
The utility model discloses an andrographolide production and extraction device, which comprises a base, wherein a shell is fixedly installed at the top of the base, a mixing box, an extraction water bath and a mixing water bath are sequentially and fixedly installed on the inner wall of the rear side of the shell from top to bottom, a vertical pipe is hermetically communicated with the inner wall of the bottom of the mixing box, a liquid discharging pipe is hermetically communicated with the top of the mixing water bath, one end, close to each other, of the liquid discharging pipe and one end, close to the vertical pipe, of the vertical pipe are hermetically communicated with the interior of the extraction water bath, two ultrasonic extractors are fixedly installed on the inner wall of the top of the extraction water bath, and filter screens are fixedly installed on the inner wall of the extraction water bath in a sealing manner. Compared with the conventional andrographolide production and extraction device, the integration level is high, secondary ultrasonic extraction can be performed on filter residues in the extraction water bath, the resource utilization rate is high, the filter residues after secondary ultrasonic extraction can be conveniently cleaned and collected, and the using effect is good.
Description
Technical Field
The utility model relates to a production and extraction device, in particular to an andrographolide production and extraction device.
Background
The herba Andrographitis is dry aerial part of herba Andrographitis (Burm.F.) Nees of Acanthaceae, and is harvested and sun-dried in early autumn when stem and leaf are flourishing. The common andrographis herb is also called Chunlian autumn willow, which is a Chinese character of happiness, elegans, elephantopus scaber, lysimachia foenum-graecum hance, golden earhook, indian grass, eel grass and the like. Has effects in clearing away heat and toxic materials, relieving inflammation, and relieving swelling and pain. It can be used for treating bacillary dysentery, urinary tract infection, acute tonsillitis, enteritis, pharyngolaryngitis, pneumonia, influenza, etc., and can be used for treating skin ulcer, furuncle, toxic swelling, and traumatic infection. Mainly produced in Guangdong provinces, Fujian provinces and other provinces, and also introduced in China, North China, northwest China and other places. The variety is collected in the 2010 pharmacopoeia of the people's republic of China.
The utility model document with the publication number of CN108239052A discloses andrographolide and an extraction method thereof, secondary ultrasonic extraction of filter residues is inconvenient in a coarse crystallization process, the utilization rate of resources is low, the filter residues after secondary ultrasonic treatment are inconvenient to clean and collect, and the using effect is influenced, so that an andrographolide production and extraction device is provided for solving the problems.
SUMMERY OF THE UTILITY MODEL
The utility model aims to solve the problems and provide the andrographolide production and extraction device which is convenient for carrying out secondary ultrasonic extraction on filter residues and cleaning and collecting the filter residues.
The utility model realizes the purpose through the following technical scheme:
the utility model provides an andrographis paniculata lactone production extraction element, includes the base, the top fixed mounting of base is by the casing, from last to in proper order fixed mounting has the mixing box, draws water bath and mixing water bath on the rear side inner wall of casing, sealed intercommunication has the standpipe on the bottom inner wall of mixing box, the sealed intercommunication in top of mixing water bath has the downcomer, and the one end that downcomer and standpipe are close to each other all with draw the inside sealed intercommunication of water bath, fixed mounting has the supersound extractor on the top inner wall of drawing water bath, and the supersound extractor is provided with two, sealed fixed mounting has the filter screen on the inner wall of drawing water bath, fixed mounting has same mounting panel on the left side inner wall of drawing water bath and the right side inner wall, and the bottom fixed mounting of mounting panel has the fixed block, logical groove has been seted up to the bottom of fixed block, it scrapes the sediment subassembly to be equipped with in the logical groove, and scrape the driven connection and have the scraper blade on the sediment subassembly, the bottom of scraper blade and the top of filter screen slide the laminating, sealed intercommunication has the ethanol to advance the pipe on the right side inner wall of drawing the water bath, and the right-hand member that the ethanol advanced the pipe extends to the right side of casing.
In order to facilitate the filter residue after drawing the secondary to clear up and collect, scrape the sediment subassembly and include slagging-off motor, screw rod and movable block, the right side of slagging-off motor and the left side fixed mounting of fixed block, the left end of screw rod and the right-hand member fixed mounting of slagging-off motor output shaft, screw rod and movable block threaded connection, the top of movable block and the top inner wall sliding connection who leads to the groove, the bottom fixed mounting who moves the block has the connecting rod, and the rear side of connecting rod and the front side fixed mounting of scraper blade, the inside mixed subassembly of mixing box.
In order to facilitate the improvement of the mixing rate of andrographis paniculata powder and ethanol, the mixing assembly comprises a mixing motor, a mixing shaft and a plurality of stirring rods, the right side of the mixing motor and the left side fixed mounting of the mixing box are fixedly mounted, the left end of the mixing shaft and the right end of an output shaft of the mixing motor are fixedly mounted, the mixing shaft is rotatably mounted in the mixing box, the plurality of stirring rods are fixedly mounted at the top and the bottom of the mixing shaft respectively, an ethanol adding pipe is communicated with the inner wall of the right side of the mixing box in a sealing manner, and the right end of the ethanol adding pipe extends to the right side of the shell.
For the convenience of deriving the filter residue, it has the filter residue passageway to draw sealed intercommunication on the bottom inner wall of water bath, and the filter residue passageway is provided with two, and two filter residue passageways are located the left end and the right-hand member of filter screen respectively, and the outside of two filter residue passageways all is provided with the solenoid valve, and the bottom of two filter residue passageways runs through the left side inner wall and the right side inner wall of casing respectively and is located same vertical line with the left side and the right side of casing respectively.
For the convenience of carrying out the suction filtration, the right side fixed mounting of casing has the suction filtration pump, and the sealed intercommunication of input of suction filtration pump has the chimney filter, and the left end of chimney filter and the inside seal of mixing the water bath are linked together, the sealed intercommunication of output of suction filtration pump has the concentrate tank, and the top fixed mounting of the bottom of concentrate tank and base.
In order to promote intelligent degree, the sealed intercommunication in top of mixing box has the andrographis paniculata powder to advance the pipe, and the outside that the andrographis paniculata powder advances the pipe is provided with the control valve, the top that the andrographis paniculata powder advances the pipe extends to the top of casing, fixed mounting has the PLC control panel on the left side inner wall of casing, PLC control panel and the equal electric connection of mixed water bath, suction filtration pump, slagging-off motor, control valve, supersound extractor, hybrid motor and control valve.
The utility model has the beneficial effects that:
the andrographis paniculata powder inlet pipe can be used for carrying out ultrasonic extraction in the extraction water bath, the models of the PLC control board, the extraction water bath and the mixed water bath can be selected according to actual requirements, the extracted extracting solution enters the mixed water bath, secondary ultrasonic extraction can be carried out on the filter residue in the extraction water bath, and the filter residue after secondary extraction can be collected to the outside of the shell under the action of the scraper;
in order to solve the problem that the mixing effect of the andrographis paniculata powder inlet pipe and the ethanol is poor, the mixing effect of the ethanol and the andrographis paniculata powder inlet pipe can be better through the arranged mixing motor, the mixing shaft and the plurality of stirring rods;
in order to solve the problem that the conventional ethanol countercurrent extraction effect is not good, the extraction effect of the extracting solution can be improved through two ultrasonic extractors arranged inside the extracting water bath.
Drawings
FIG. 1 is a perspective view of a part of the structure of an apparatus for producing and extracting andrographolide according to the present invention;
FIG. 2 is a schematic structural view of an apparatus set for producing and extracting andrographolide according to the present invention;
FIG. 3 is a perspective view of the mixing shaft structure of the apparatus for producing and extracting andrographolide according to the present invention;
fig. 4 is an enlarged schematic view of the structure of part a in fig. 2 of the andrographolide production and extraction device of the present invention.
In the figure: 1-base, 2-shell, 3-mixing box, 4-andrographis paniculata powder inlet pipe, 5-control valve, 6-mixing motor, 7-mixing shaft, 8-ethanol adding pipe, 9-vertical pipe, 10-extraction water bath kettle, 11-ultrasonic extractor, 12-filter screen, 13-fixed block, 14-through groove, 15-deslagging motor, 16-screw, 17-movable block, 18-connecting rod, 19-scraper, 20-filter residue channel, 21-liquid outlet pipe, 22-mixing water bath kettle, 23-suction filtration pump, 24-concentration box and 25-PLC control panel.
Detailed Description
The utility model will be further described with reference to the accompanying drawings in which:
as shown in fig. 1-4, the andrographolide production and extraction device of the utility model comprises a base 1, wherein the top of the base 1 is fixedly provided with a shell 2, a mixing box 3, an extraction water bath 10 and a mixing water bath 23 are sequentially and fixedly arranged on the inner wall of the rear side of the shell 2 from top to bottom, the inner wall of the bottom of the mixing box 3 is hermetically communicated with a vertical pipe 9, the top of the mixing water bath 23 is hermetically communicated with a lower liquid pipe 21, the close ends of the lower liquid pipe 21 and the vertical pipe 9 are hermetically communicated with the inside of the extraction water bath 10, the inner wall of the top of the extraction water bath 10 is fixedly provided with an ultrasonic extractor 11, the ultrasonic extractors 11 are provided with two parts, the inner wall of the extraction water bath 10 is fixedly provided with a filter screen 12 in a sealing manner, the same mounting plate is fixedly arranged on the inner wall of the left side and the inner wall of the extraction water bath 10, and the bottom of the mounting plate is fixedly provided with a fixing block 13, the bottom of the fixed block 13 is provided with a through groove 14, the through groove 14 is internally provided with a slag scraping component, the slag scraping component is connected with a scraper 19 in a transmission manner, the left end of the screw 16 and the right end of an output shaft of the slag removing motor 15 are fixedly arranged, the screw 16 is in threaded connection with the movable block 17, the top of the movable block 17 is in sliding connection with the inner wall of the top of the through groove 14, the bottom of the movable block 17 is fixedly provided with a connecting rod 18, the rear side of the connecting rod 18 and the front side of the scraper 19 are fixedly arranged, the internal mixing component of the mixing box 3 is arranged, the mixing component comprises a mixing motor 6, a mixing shaft 7 and a plurality of stirring rods, the right side of the mixing motor 6 and the left side of the mixing box 3 are fixedly arranged, the filter residues after secondary extraction are conveniently cleaned and collected, the left end of a mixing shaft 7 and the right end of an output shaft of a mixing motor 6 are fixedly installed, the mixing shaft 7 is rotatably installed inside a mixing box 3, a plurality of stirring rods are respectively and fixedly installed at the top and the bottom of the mixing shaft 7, the right inner wall of the mixing box 3 is hermetically communicated with an ethanol adding pipe 8, the right end of the ethanol adding pipe 8 extends to the right side of a shell 2, in order to facilitate the derivation of filter residues, two filter residue channels 20 are hermetically communicated with the inner wall of the bottom of a water extracting bath 10 and are respectively located at the left end and the right end of a filter screen 12, electromagnetic valves are respectively arranged at the outer sides of the two filter residue channels 20, the bottoms of the two filter residue channels 20 respectively penetrate through the inner wall of the left side and the inner wall of the right side of the shell 2 and are respectively located on the same vertical line with the left side and the right side of the shell 2, the bottom of a scraper 19 is in sliding fit with the top of the filter screen 12, the inner wall of the right inner wall of the water extracting bath 10 is hermetically communicated with an ethanol inlet pipe, and the right end of the ethanol inlet pipe extends to the right side of the shell 2, in order to facilitate the suction filtration, a suction filtration pump 23 is fixedly arranged on the right side of the shell 2, the input end of the suction pump 23 is hermetically communicated with a filter tube, the left end of the filter tube is hermetically communicated with the interior of the mixed water bath 22, the output end of the suction pump 23 is hermetically communicated with a concentration tank 24, the bottom of the concentration tank 24 is fixedly arranged with the top of the base 1, in order to improve the intelligent degree, the top of the mixing box 3 is hermetically communicated with an andrographis paniculata powder inlet pipe 4, and the outside that the andrographis paniculata powder advances pipe 4 is provided with control valve 5, and the top that the andrographis paniculata powder advances pipe 4 extends to the top of casing 2, and fixed mounting has PLC control panel 25 on the left side inner wall of casing 2, PLC control panel 25 and mixed water bath 22, suction filtration pump 23, slagging-off motor 15, control valve, supersound extractor 11, hybrid motor 6 and the equal electric connection of control valve 5.
Fig. 1 has still shown the toper end of locating on the inner wall of mixing box 3 bottoms, the purpose that sets up like this is in order to make the inside that the mixed liquid of ethanol and andrographis paniculata powder can all get into and draw water bath 10, improve the utilization ratio of resource, it is fourteen degrees centigrade to draw the temperature of drawing in water bath 10, the inside suction filtration temperature of mixing water bath 22 is seventy five degrees centigrade, add pipe 8 and ethanol and advance and all set up the measuring pump on managing at ethanol, two measuring pumps all with PLC control panel 25 electric connection, control ethanol quantity that like this can be accurate, promote mixed effect, the choke valve of locating the standpipe 9 outside has still been shown in fig. 2, choke valve and PLC control panel 25 electric connection.
As shown in FIGS. 1-4, when the andrographis paniculata lactone is to be extracted, the prepared andrographis paniculata powder is led into the interior of the mixing box 3 through the arranged andrographis paniculata powder inlet pipe 4 by acting the control valve 5 through the arranged PLC control board 25, then the ethanol is led into the interior of the mixing box 3 through the arranged ethanol adding pipe 8, the mixing motor 6 is started, the ethanol and the andrographis paniculata powder are mixed through the arranged mixing shaft 7 and the stirring rod, the mixture is kept still for fifteen seconds after mixing, the PLC control board 25 acts the throttle valve to lead the mixed mixture into the interior of the extraction water bath 10 through the arranged vertical pipe 9, the temperature in the extraction water bath 10 is controlled by the PLC control board 25 to be forty ℃ after the ultrasonic extractor is started 11, the ultrasonic extraction is carried out for forty minutes, the extracted extracting solution is led into the interior of the mixing water bath 22 through the arranged lower liquid pipe 21, and then the ethanol is led into the extraction water bath 10 through the arranged ethanol inlet pipe, continuing the supersound and extracting for forty minutes, the extract continues to be directed into in the mixed water bath 22, start two solenoid valves on slagging-off motor 15 and the slagging-off passageway 20, make screw rod 16 rotate, via the screw connection relation of screw rod 16 and movable block 17 that sets up, turn into the sideslip of movable block 17 and scraper blade 19 with the rotation of screw rod 16, clear up and collect the filter residue after the secondary extraction, the temperature control in the mixed water bath 22 is at seventy-five degrees centigrade, start suction filtration pump 23, liquid after the high temperature suction filtration gets into the inside of concentrator box 24 and crystallizes, the integrated level is high, can carry out secondary supersound to the filter residue in extracting water bath 10 and extract, the high-usage of resource, can also be convenient for clear up and collect the filter residue after the secondary supersound is extracted, excellent in use effect.
The whole control process is controlled by a PLC control panel 25, and the extraction solution is crystallized after suction filtration in the concentration box 24.
The above embodiments are only preferred embodiments of the present invention, and are not intended to limit the technical solutions of the present invention, so long as the technical solutions can be realized on the basis of the above embodiments without creative efforts, which should be considered to fall within the protection scope of the patent of the present invention.
Claims (6)
1. The utility model provides an andrographolide production extraction element, includes base (1), the top fixed mounting of base (1) has casing (2), its characterized in that: the utility model discloses a solar water heater, including casing (2), rear side inner wall, last from last to down in proper order fixed mounting have mixing box (3), draw water bath (10) and mix water bath (22), sealed intercommunication has standpipe (9) on the bottom inner wall of mixing box (3), the sealed intercommunication in top of mixing water bath (22) has down liquid pipe (21), and the one end that down liquid pipe (21) and standpipe (9) are close to each other all with draw the inside seal of water bath (10) and be linked together, fixed mounting has supersound extractor (11) on the top inner wall of drawing water bath (10), and supersound extractor (11) are provided with two, sealed fixed mounting has filter screen (12) on the inner wall of drawing water bath (10), fixed mounting has same mounting panel on the left side inner wall and the right side inner wall of drawing water bath (10), and the bottom fixed mounting of mounting panel has fixed block (13), logical groove (14) have been seted up to the bottom of fixed block (13), it scrapes the sediment subassembly to be equipped with in logical groove (14), and scrapes the transmission connection on the sediment subassembly and have scraper blade (19), the bottom of scraper blade (19) and the top of filter screen (12) slide the laminating, it has ethanol to advance to draw sealed intercommunication on the right side inner wall of water bath (10), and the right-hand member that ethanol advances the pipe extends to the right side of casing (2).
2. The apparatus for producing and extracting andrographolide according to claim 1, wherein: scrape the sediment subassembly and include slagging-off motor (15), screw rod (16) and move piece (17), the right side of slagging-off motor (15) and the left side fixed mounting of fixed block (13), the left end of screw rod (16) and the right-hand member fixed mounting of slagging-off motor (15) output shaft, screw rod (16) and move piece (17) threaded connection, the top of moving piece (17) and the top inner wall sliding connection who leads to groove (14), the bottom fixed mounting who moves piece (17) has connecting rod (18), and the rear side of connecting rod (18) and the front side fixed mounting of scraper blade (19), the inside mixed subassembly of mixing box (3).
3. The apparatus for producing and extracting andrographolide according to claim 2, wherein: mix the subassembly and include hybrid motor (6), mixing shaft (7) and a plurality of puddler, the right side of hybrid motor (6) and the left side fixed mounting of mixing box (3), the left end of mixing shaft (7) and the right-hand member fixed mounting of hybrid motor (6) output shaft, mixing shaft (7) rotate and install the inside in mixing box (3), and a plurality of puddlers are fixed mounting respectively has the top and the bottom of mixing shaft (7), sealed intercommunication has ethanol addition pipe (8) on the right side inner wall of mixing box (3), and the right-hand member of ethanol addition pipe (8) extends to the right side of casing (2).
4. The apparatus for producing and extracting andrographolide according to claim 1, wherein: draw sealed intercommunication on the bottom inner wall of water bath (10) have filter residue passageway (20), and filter residue passageway (20) are provided with two, and two filter residue passageways (20) are located the left end and the right-hand member of filter screen (12) respectively, and the outside of two filter residue passageways (20) all is provided with the solenoid valve, and the bottom of two filter residue passageways (20) runs through the left side inner wall and the right side inner wall of casing (2) respectively and is located same vertical line with the left side and the right side of casing (2) respectively.
5. The apparatus for producing and extracting andrographolide according to claim 1, wherein: the right side fixed mounting of casing (2) has suction filtration pump (23), and the sealed intercommunication of input of suction filtration pump (23) has the chimney filter, and the left end of chimney filter and the inside seal of mixing water bath (22) are linked together, the sealed intercommunication of output of suction filtration pump (23) has concentrate tank (24), and the top fixed mounting of the bottom of concentrate tank (24) and base (1).
6. The apparatus for producing and extracting andrographolide according to claim 1, wherein: the sealed intercommunication in top of mixing box (3) has the andrographis paniculata powder to advance pipe (4), and the outside that the andrographis paniculata powder advances pipe (4) is provided with control valve (5), the top that the andrographis paniculata powder advances pipe (4) extends to the top of casing (2), fixed mounting has PLC control panel (25) on the left side inner wall of casing (2), PLC control panel (25) and the equal electric connection of mixed water bath (22), suction filtration pump (23), slagging-off motor (15), control valve, supersound extractor (11), hybrid motor (6) and control valve (5).
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CN202121669873.3U CN215538579U (en) | 2021-07-22 | 2021-07-22 | Andrographolide production extraction element |
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CN202121669873.3U CN215538579U (en) | 2021-07-22 | 2021-07-22 | Andrographolide production extraction element |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN114522440A (en) * | 2022-03-01 | 2022-05-24 | 昆明理工大学 | Full-automatic hot melt tank |
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2021
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN114522440A (en) * | 2022-03-01 | 2022-05-24 | 昆明理工大学 | Full-automatic hot melt tank |
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Granted publication date: 20220118 |