CN215538555U

CN215538555U - Vacuum crystallization device for preparing injection cephalosporin powder

Info

Publication number: CN215538555U
Application number: CN202121891629.1U
Authority: CN
Inventors: 付子仲
Original assignee: Jiangxi Guorenruixin Pharmaceutical Co ltd
Current assignee: Jiangxi Guorenruixin Pharmaceutical Co ltd
Priority date: 2021-08-13
Filing date: 2021-08-13
Publication date: 2022-01-18
Anticipated expiration: 2031-08-13

Abstract

The utility model discloses a vacuum crystallization device for preparing injection cephalosporin powder, which comprises a first support frame and a second support frame, wherein the top of the first support frame is fixedly connected with a concentration cylinder, the top of the second support frame is fixedly connected with a crystallization cylinder, a feed inlet at the top of the concentration cylinder is fixedly connected with a feed pipe, an exhaust outlet at the top of the concentration cylinder is fixedly connected with an exhaust pipe, the side wall of the concentration cylinder is provided with a heating cavity, and the inner wall of the heating cavity is fixedly connected with a plurality of heating plates. The waste of resources is reduced.

Description

Vacuum crystallization device for preparing injection cephalosporin powder

Technical Field

The utility model relates to the technical field of crystallization equipment, in particular to a vacuum crystallization device for preparing injection cephalosporin powder.

Background

The cephalosporin is a general name of cephalosporin antibacterial drugs, and the cephalosporin is an antibiotic obtained by semi-synthesizing and transforming a side chain of natural cephalosporin C obtained by culturing coronafosporium as a raw material. In the antibiotic market, cephalosporins occupy a large share, and related intermediates thereof also show considerable market potential in conjunction. The most marketable varieties of cephalosporin antibiotics include ceftriaxone sodium, cefazolin sodium, cefotaxime, ceftriaxone, cefoperazone, cefuroxime (ester), and the like, and the corresponding intermediates include 7-ACA, 7-ADCA, GCLE, aminothiazoly loximate, AE-active ester, triazine ring, tetrazoleacetic acid, methimazole, HO-EPCP, methoxyamine hydrochloride, furan amine Salt (SIMA), chlorosulfonic acid isocyanate, and the like. In the preparation process of the injection cephalosporin powder, a vacuum crystallization device is needed to carry out vacuum crystallization on the injection cephalosporin reagent.

However, when the injection cephalosporin reagent solution is subjected to vacuum crystallization, a certain amount of injection cephalosporin reagent is still contained in the residual solution, and the filtered reagent needs to be collected, concentrated and crystallized in order to avoid resource waste.

SUMMERY OF THE UTILITY MODEL

The utility model aims to provide a vacuum crystallization device for preparing injection cephalosporin powder, which aims to solve the problems in the background technology.

In order to achieve the purpose, the utility model provides the following technical scheme:

a vacuum crystallization device for preparing injection cephalosporin powder comprises a first support frame and a second support frame, wherein the top of the first support frame is fixedly connected with a concentration cylinder, the top of the second support frame is fixedly connected with a crystallization cylinder, a feed inlet at the top of the concentration cylinder is fixedly connected with a feed pipe, an exhaust outlet at the top of the concentration cylinder is fixedly connected with an exhaust pipe, the side wall of the concentration cylinder is provided with a heating cavity, the inner wall of the heating cavity is fixedly connected with a plurality of heating plates, a discharge outlet at the bottom of the concentration cylinder is fixedly connected with a first discharge pipe, the bottom of the first discharge pipe is fixedly connected with a feed pump, the feed pump is connected with the top of a bottom plate of the first support frame through a bolt, the output end of the feed pump is communicated with the crystallization cylinder through a feed pipe, the top of the crystallization cylinder is fixedly provided with a vacuum pump and a motor, and the connecting end of the vacuum pump is communicated with the crystallization cylinder through a guide pipe, the crystallizer comprises a crystallizer barrel, a crystallizer body, a crystallizer shell, a crystallizer, a water storage tank, a water pump, a water tank, a water outlet, a water inlet, a water outlet, a water tank, a water pump, a water tank, a refrigerator, a water tank, a water pump, a water outlet, a water tank, a water pump, a water tank and a water tank, wherein the water tank, the water tank and the water tank are fixedly connected with the input end of the refrigerator through a pipe, the output end of the refrigerator is connected with the input end of the water pump through a guide pipe, the output end of the water pump is connected with the water inlet through a water pipe, the water outlet is communicated with the water inlet end of the water tank through a water pipe, and the side wall of the second support frame is fixedly connected with a switch.

As a further scheme of the utility model: the filter mechanism comprises a frame, four walls of the inner side of the frame and a bottom fixedly connected screen plate are arranged on the inner side of the frame, a layer of filter membrane is arranged on the side wall of the screen plate in the frame, and two clamping strips are symmetrically arranged at the top of the frame and fixedly connected with the frame.

As a still further scheme of the utility model: the bottom of the connecting frame is provided with a sliding groove matched with the clamping strip, the clamping strip is arranged in the sliding groove, and the clamping strip is connected with the sliding groove in a sliding mode.

As a still further scheme of the utility model: the connecting frame completely covers the frame of the filter mechanism.

As a still further scheme of the utility model: the feeding pipe is provided with a first valve, the first discharging pipe is provided with a second valve, and the second discharging pipe is provided with a third valve.

As a still further scheme of the utility model: the switch passes through the wire respectively with feed pump, refrigerator, water pump, vacuum pump, motor and hot plate electric connection, feed pump, refrigerator, water pump, switch, vacuum pump, motor and hot plate pass through wire and external power supply electric connection.

Compared with the prior art, the utility model has the beneficial effects that:

1. According to the utility model, the reagent solution in the crystallization cylinder is crystallized through the crystallization cylinder, the third valve is opened, the crystallized solution is filtered through the filtering mechanism in the filtering box, the crystals are stored in the filtering mechanism, the filtered solution enters the concentration cylinder for evaporation and concentration again, and the concentrated solution is conveyed to the crystallization cylinder again through the feeding pump, so that the filtered solution is crystallized again, and the waste of resources is reduced.

2. According to the utility model, the cold water refrigerated by the refrigerator is conveyed to the water storage cavity of the crystallization cylinder through the water pump, so that the temperature in the crystallization cylinder is reduced, and the reagent solution to be crystallized is concentrated by the concentration cylinder and then conveyed to the crystallization cylinder through the feeding pump, so that the crystallization rate in the crystallization cylinder is improved, and the production efficiency of the injection cephalosporin powder is improved.

Drawings

Fig. 1 is a schematic structural diagram of a vacuum crystallization device for preparing an injection cephalosporin powder.

FIG. 2 is a sectional view of a concentrating cylinder in a vacuum crystallization device for preparing cephalosporin powder for injection.

FIG. 3 is a sectional view of a crystallization cylinder in a vacuum crystallization device for preparing cephalosporin powder for injection.

FIG. 4 is a sectional view of a filter box in a vacuum crystallization device for preparing cephalosporin powder for injection.

FIG. 5 is a sectional view of a filter mechanism in a vacuum crystallization device for preparing cephalosporin powder for injection.

In the figure: the device comprises a first support frame 1, a concentration barrel 2, an exhaust pipe 3, a feeding pipe 4, a first valve 5, a feeding pump 6, a second valve 7, a first discharging pipe 8, a second support frame 9, a refrigerator 10, a water tank 11, a water pump 12, a switch 13, a filter box 14, a second discharging pipe 15, a third valve 16, a water inlet 17, a crystallization barrel 18, a water outlet 19, a vacuum pump 20, a motor 21, a heating cavity 22, a heating plate 23, a connecting shaft 24, a water storage cavity 25, a stirring rod 26, a connecting frame 27, a filtering mechanism 28, a sliding chute 29, a frame 30, a screen plate 31, a filtering membrane 32 and a clamping strip 33.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Referring to fig. 1 to 5, in the embodiment of the present invention, a vacuum crystallization apparatus for preparing an injection cephalosporin powder includes a first support frame 1 and a second support frame 9, a concentration cylinder 2 is fixedly connected to the top of the first support frame 1, a crystallization cylinder 18 is fixedly connected to the top of the second support frame 9, a feed pipe 4 is fixedly connected to a feed inlet at the top of the concentration cylinder 2, an exhaust pipe 3 is fixedly connected to an exhaust port at the top of the concentration cylinder 2, a heating cavity 22 is formed in a side wall of the concentration cylinder 2, a plurality of heating plates 23 are fixedly connected to an inner wall of the heating cavity 22, a first discharge pipe 8 is fixedly connected to a discharge port at the bottom of the concentration cylinder 2, a feed pump 6 is fixedly connected to the bottom of the first support frame 1, an output end of the feed pump 6 is communicated with the crystallization cylinder 18 through a feed pipe, a vacuum pump 20 and a motor 21 are fixedly installed at the top of the crystallization cylinder 18, the connection end of a vacuum pump 20 is communicated with a crystallization cylinder 18 through a conduit, a connection shaft 24 is rotationally connected in the crystallization cylinder 18, the top end of the connection shaft 24 penetrates through the crystallization cylinder 18 and is fixedly connected with the output end of a motor 21, the side wall of the connection shaft 24 is fixedly connected with a plurality of stirring rods 26 uniformly according to the circumference, the side wall of the crystallization cylinder 18 is provided with a water storage cavity 25, the side wall of the crystallization cylinder 18 is provided with a water inlet 17 and a water outlet 19, the water inlet 17 and the water outlet 19 are communicated with the water storage cavity 25, the discharge hole at the bottom of the crystallization cylinder 18 is fixedly connected with a second discharge pipe 15, the bottom of the second discharge pipe 15 is fixedly connected with a filter box 14, the inner wall of the filter box 14 is fixedly connected with a connection frame 27, the bottom of the connection frame 27 is slidably connected with a filter mechanism 28, the discharge hole at the bottom of the filter box 14 is communicated with a concentration cylinder 2 through a conduit, the top of a bottom plate of a second support frame 9 is fixedly connected with a water tank 11 and a refrigerator 10, and the top of the water tank 11 is fixedly connected with a water pump 12, the water outlet of the water tank 11 is connected with the input end of the refrigerator 10 through a guide pipe, the output end of the refrigerator 10 is connected with the input end of the water pump 12 through a guide pipe, the output end of the water pump 12 is connected with the water inlet 17 through a water pipe, the water outlet 19 is communicated with the water inlet end of the water tank 11 through a water pipe, and the side wall of the second support frame 9 is fixedly connected with a switch 13.

The filtering mechanism 28 comprises a frame 30, wherein the four walls and the bottom of the inner side of the frame 30 are fixedly connected with a screen plate 31, a layer of filtering membrane 32 is arranged on the side wall of the screen plate 31 in the frame 30, and two clamping strips 33 are symmetrically and fixedly connected to the top of the frame 30.

The bottom of the connecting frame 27 is provided with a sliding groove 29 matched with the clamping strip 33, the clamping strip 33 is arranged in the sliding groove 29, and the clamping strip 33 is connected with the sliding groove 29 in a sliding manner.

The connecting frame 27 completely covers the frame 30 of the filter mechanism 28.

The feeding pipe 4 is provided with a first valve 5, the first discharging pipe 8 is provided with a second valve 7, and the second discharging pipe 15 is provided with a third valve 16.

The switch 13 is respectively electrically connected with the feeding pump 6, the refrigerator 10, the water pump 12, the vacuum pump 20, the motor 21 and the heating plate 23 through leads, and the feeding pump 6, the refrigerator 10, the water pump 12, the switch 13, the vacuum pump 20, the motor 21 and the heating plate 23 are electrically connected with an external power supply through leads.

The working principle of the utility model is as follows:

when in use, the solution to be crystallized is conveyed into the concentration cylinder 2 through the feeding pipe 4, the switch 13 controls the heating plate 23 in the heating cavity 22 in the concentration cylinder 2 to work, the solution in the concentration cylinder 2 is evaporated and concentrated, the first valve 5 on the first discharging pipe 8 is opened, the concentrated solution is conveyed into the crystallization cylinder 18 through the feeding pump 6, the refrigerator 10, the water pump 12, the vacuum pump 20 and the motor 21 are controlled to work through the switch 13, the water pump 12 conveys the cold water refrigerated by the refrigerator 10 into the water storage cavity 25 of the crystallization cylinder 18, the temperature in the crystallization cylinder 18 is reduced, the output end of the motor 21 drives the stirring rod 26 through the connecting shaft 24 to stir the crystallization solution, the crystal blocks are prevented from being too large and from being accumulated on the inner wall of the crystallization cylinder 18, the crystallization rate in the crystallization cylinder 18 is improved, the production efficiency of the injection type cephalosporin powder is improved, the third valve 16 is opened, the crystallized solution is filtered by the filtering mechanism 28 in the filtering box 14, the crystals are stored in the filtering mechanism 28, the filtered solution enters the concentration cylinder 2 for evaporation concentration again, and the concentrated solution is conveyed to the crystallization cylinder 18 again by the feeding pump 6, so that the filtered solution is crystallized again, and the waste of resources is reduced.

Although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that various changes in the embodiments and/or modifications of the utility model can be made, and equivalents and modifications of some features of the utility model can be made without departing from the spirit and scope of the utility model.

Claims

1. The utility model provides a vacuum crystallization device that injection type cephalo class powder preparation was used, includes first support frame (1) and second support frame (9), its characterized in that: the utility model discloses a crystallization device, including first support frame (1) top fixedly connected with concentrated section of thick bamboo (2), second support frame (9) top fixedly connected with crystallization section of thick bamboo (18), feed inlet fixedly connected with inlet pipe (4) at concentrated section of thick bamboo (2) top, gas vent fixedly connected with blast pipe (3) at concentrated section of thick bamboo (2) top, heating chamber (22) have been seted up to the lateral wall of concentrated section of thick bamboo (2), the inner wall fixedly connected with a plurality of hot plate (23) of heating chamber (22), the first discharging pipe (8) of discharge gate fixedly connected with of concentrated section of thick bamboo (2) bottom, first discharging pipe (8) bottom fixedly connected with feed pump (6), feed pump (6) pass through the bottom plate top of bolt with first support frame (1), the output of feed pump (6) is linked together through feed pipe and crystallization section of thick bamboo (18), crystallization section of thick bamboo (18) top fixed mounting has vacuum pump (20) and motor (21), the vacuum pump is characterized in that a connecting end of the vacuum pump (20) is communicated with a crystallization cylinder (18) through a guide pipe, a connecting shaft (24) is rotationally connected in the crystallization cylinder (18), the top end of the connecting shaft (24) penetrates through the crystallization cylinder (18) and is fixedly connected with the output end of a motor (21), a plurality of stirring rods (26) are fixedly connected with the side wall of the connecting shaft (24) uniformly according to the circumference, a water storage cavity (25) is formed in the side wall of the crystallization cylinder (18), a water inlet (17) and a water outlet (19) are formed in the side wall of the crystallization cylinder (18), the water inlet (17) and the water outlet (19) are communicated with the water storage cavity (25), a second discharging pipe (15) is fixedly connected to a discharging port at the bottom of the crystallization cylinder (18), a filtering box (14) is fixedly connected to the bottom of the second discharging pipe (15), a connecting frame (27) is fixedly connected to the inner wall of the filtering box (14), and a filtering mechanism (28) is slidably connected to the bottom of the connecting frame (27), the discharge gate of rose box (14) bottom is linked together through pipe and concentrated section of thick bamboo (2), the bottom plate top fixedly connected with water tank (11) and refrigerator (10) of second support frame (9), water tank (11) top fixedly connected with water pump (12), the delivery port of water tank (11) is connected with the input of refrigerator (10) through the pipe, the output of refrigerator (10) is connected with water pump (12) input through the pipe, water pump (12) output leads to pipe to be connected with water inlet (17), and delivery port (19) leads to pipe to be linked together with the end of intaking of water tank (11), the lateral wall fixedly connected with switch (13) of second support frame (9).

2. The vacuum crystallization device for preparing cephalo-type powder for injection of claim 1, characterized in that: filtering mechanism (28) includes frame (30), frame (30) inboard four walls and bottom fixedly connected with otter board (31), otter board (31) lateral wall is provided with one deck filtration membrane (32) in frame (30), two card strips (33) of fixedly connected with of frame (30) top symmetry.

3. The vacuum crystallization device for preparing cephalo-type powder for injection of claim 2, characterized in that: the bottom of the connecting frame (27) is provided with a sliding groove (29) matched with the clamping strip (33), the clamping strip (33) is arranged in the sliding groove (29), and the clamping strip (33) is in sliding connection with the sliding groove (29).

4. The vacuum crystallization device for preparing cephalo-type powder for injection of claim 1, characterized in that: the connecting frame (27) completely covers the frame (30) of the filter mechanism (28).

5. The vacuum crystallization device for preparing cephalo-type powder for injection of claim 1, characterized in that: be provided with first valve (5) on inlet pipe (4), be provided with second valve (7) on first discharging pipe (8), be provided with third valve (16) on second discharging pipe (15).

6. The vacuum crystallization device for preparing cephalo-type powder for injection of claim 1, characterized in that: switch (13) pass through the wire respectively with feed pump (6), refrigerator (10), water pump (12), vacuum pump (20), motor (21) and hot plate (23) electric connection, feed pump (6), refrigerator (10), water pump (12), switch (13), vacuum pump (20), motor (21) and hot plate (23) pass through wire and external power supply electric connection.