CN215506824U - Digital microfluidic unit based on ultra-smooth technology and digital microfluidic system - Google Patents
Digital microfluidic unit based on ultra-smooth technology and digital microfluidic system Download PDFInfo
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- CN215506824U CN215506824U CN202121122511.2U CN202121122511U CN215506824U CN 215506824 U CN215506824 U CN 215506824U CN 202121122511 U CN202121122511 U CN 202121122511U CN 215506824 U CN215506824 U CN 215506824U
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Abstract
The utility model provides a digital microfluidic unit and a digital microfluidic system based on an ultra-sliding technology, which comprise a substrate, a driving part arranged in the substrate and a plurality of sliding parts arranged on the substrate, wherein each sliding part comprises an ultra-sliding sheet and a hydrophilic modification layer for adhering microfluid, the hydrophilic modification layer is arranged on the outer side of the ultra-sliding sheet, the contact surface of the ultra-sliding sheet and the substrate is an ultra-sliding surface, and the substrate and the ultra-sliding sheet are in ultra-sliding contact. The digital microfluidic control unit based on the ultra-sliding technology changes the contact interface between the microfluid and the substrate, and the ultra-sliding sheet and the substrate are in ultra-sliding contact, so that extremely-low friction and abrasion-free sliding can be realized, ultra-long-life quick driving can be realized, the digital microfluidic control unit is suitable for controlling micro liquid, the control of movement, separation, fusion, centrifugation and the like can be realized, and the application range of the digital microfluidic control system is expanded.
Description
Technical Field
The utility model relates to the technical field of structure ultra-lubricity, in particular to a digital microfluidic unit and a digital microfluidic system based on an ultra-lubricity technology.
Background
In the existing digital microfluidic system, common driving methods of microfluid include dielectric wetting driving, surface acoustic wave driving, magnetic driving, temperature gradient driving and the like. The size of the microfluid which can be controlled by the digital microfluidic system is generally millimeter and above, the demand for reactants is large, the speed of the traditional digital microfluidic system for controlling the movement of the microfluid is low, generally in the order of cm/s, and the time required by the reaction is greatly prolonged.
The reasons for the above phenomena are: when the microfluid is operated, the driving force of the microfluid comes from an external driving source, and the driving force F of the microfluidAThe characteristic length L of the micro-fluid is in a cubic relation, namely FAL3; while the resistance comes from the adhesion between the microfluidic and substrate interface, resistance FDThe characteristic length L of the micro-fluid is quadratic, namely FDL2. Therefore, when the characteristic length L becomes gradually smaller, the driving force FASpecific resistance FDDecreases more rapidly, driving force F when characteristic length L is sufficiently smallAIs insufficient to overcome the resistance FDThe micro-fluid cannot be driven, that is, the conventional driving method cannot drive the minute droplets.
In addition, the existing digital microfluidic system cannot drive tiny droplets, and can only realize simple operations such as movement, separation, temperature control, fusion and the like when the droplets are controlled. Centrifugation is an important and common operation in biochemical experiments, but the existing digital microfluidic system can not realize centrifugation operation because the operation of a single microfluidic is global and can not be locally controlled, thereby seriously limiting the popularization and application of the digital microfluidic system.
Therefore, there is an urgent need for a digital microfluidic platform that can perform rapid and multifunctional manipulation of small-scale microfluidics, especially micro-scale microfluidics.
Disclosure of Invention
The utility model aims to provide a digital microfluidic unit and a digital microfluidic system based on an ultra-smooth technology, and aims to solve the technical problem that a digital microfluidic platform in the prior art cannot perform quick and multifunctional control on small-scale microfluid.
In order to achieve the purpose, the utility model adopts the technical scheme that: the utility model provides a digital micro-fluidic unit based on super-sliding technology locates the top of basement and is used for controlling the microfluid motion, includes at least one sliding part, sliding part includes super gleitbretter and the hydrophilic modification layer that is used for adhesion microfluid, hydrophilic modification layer locates the outside of super gleitbretter, super gleitbretter with the contact surface of basement is the super glide plane, the basement with super gleitbretter is super-sliding contact.
Furthermore, the hydrophilic modification layer is located on the top surface of the super-slip sheet, and the surface of the hydrophilic modification layer is provided with hydrophilic patterned modification.
Furthermore, the sliding component further comprises an island cover arranged between the super-sliding sheet and the hydrophilic modification layer.
Furthermore, the number of the sliding parts is two or more, and all the sliding parts are arranged in an array and spliced into a whole.
Further, the length and width of the superclip range from 1 to 20 microns.
The utility model also discloses a digital microfluidic system based on the ultra-smooth technology, which comprises a substrate, a driving part and a plurality of digital microfluidic units based on the ultra-smooth technology, wherein the digital microfluidic units are arranged on the substrate and driven by the driving part to slide on the substrate.
Further, the number of the driving parts is one, and the driving parts simultaneously drive all the digital microfluidic units to move.
Furthermore, the substrate is provided with a plurality of stations, each station corresponds to one digital microfluidic unit, each station is internally provided with one driving part, and the driving parts drive the digital microfluidic units to move to the next station.
Furthermore, a plurality of stations are combined into at least one annular station array, and the annular station array is arranged in a layered mode.
Further, the digital microfluidic unit is not arranged on at least one station in the annular station array of each layer.
The digital microfluidic unit and the digital microfluidic system based on the ultra-slip technology have the beneficial effects that:
1. the contact interface between the microfluid and the substrate is altered. The microfluid is not in direct contact with the substrate, but forms a contact mode of 'microfluid-ultra-slide-substrate' with the ultra-slide, compared with the mode that the microfluid is in direct contact with the substrate in the prior art, the adhesion force is slightly smaller, and the microfluid can be synchronized with the movement of the sliding part, so that the microfluid can achieve rapid movement under the drive of the driving part without the limitation of the characteristic length of the microfluid. And the ultra-sliding sheet is in ultra-sliding contact with the substrate, so that extremely-low friction and abrasion-free sliding can be realized, and the ultra-long service life of the rapid driving can be realized.
2. The size of the ultra-sliding sheet is generally submicron to micron order, so that the size of the microfluid carried by the ultra-sliding sheet is submicron to micron order, the ultra-sliding sheet can be suitable for controlling micro liquid, a plurality of digital microfluidic units can be spliced and combined to form a large-scale microfluidic unit, the ultra-sliding sheet can be suitable for controlling large-size liquid, and the ultra-sliding sheet is wider in application area.
3. The control of moving, separating, fusing, centrifuging and the like can be realized through batch control of the digital microfluidic control units, the positions of the digital microfluidic control units only need to be adjusted and controlled, the control mode is simple, global control can be realized, local control can be performed on a single digital microfluidic control unit, and the application range of the digital microfluidic control system is expanded.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, and it is obvious that the drawings in the following description are some embodiments of the present invention, and other drawings can be obtained by those skilled in the art without creative efforts.
Fig. 1 is a schematic structural diagram of a digital microfluidic unit based on an ultra-slip technique according to an embodiment of the present invention;
fig. 2 is a schematic structural diagram of a digital microfluidic unit based on an ultra-slip technique according to an embodiment of the present invention;
fig. 3 is a schematic structural diagram of a digital microfluidic system based on the ultra-slippery technology according to an embodiment of the present invention.
Description of reference numerals:
1. a substrate; 2. a digital microfluidic cell; 3. microfluidics; 11. a station; 21. a sliding member; 211. a superclipper sheet; 212. a hydrophilic modification layer; 213. and an island cover.
Detailed Description
The technical solutions of the present invention will be described clearly and completely with reference to the accompanying drawings, and it should be understood that the described embodiments are some, but not all embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc., indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and simplicity of description, but do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be construed as limiting the present invention. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.
In the description of the present invention, it should be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.
Because the ultra-slip of a large scale cannot be realized for a long time, the phenomenon that the friction coefficient is in the order of thousandth or lower is often called as ultra-slip in documents for over ten years; the phenomenon that the initial friction and wear caused by the non-degree-of-concentricity contact are almost zero is called 'structural lubrication', and the 'ultra-lubricity' referred to in the utility model refers to the phenomenon that the friction and wear caused by the non-degree-of-concentricity contact are almost zero.
In addition, the technical features involved in the different embodiments of the present invention described below may be combined with each other as long as they do not conflict with each other.
Referring to fig. 1 and fig. 2, the digital microfluidic unit based on the ultra-slip technology provided by the present invention will now be described. The digital microfluidic system based on the ultra-smooth technology comprises a substrate 1, a driving part (not shown) arranged inside the substrate 1 and a digital microfluidic unit 2 arranged on the substrate 1, wherein the driving part can perform integral control or local control on the digital microfluidic unit 2.
Digital micro-fluidic unit 2 includes at least one slide part 21, slide part 21 includes super gleitbretter 211 and the hydrophilic modification layer 212 that is used for adhesion microfluid 3, hydrophilic modification layer 212 is located super gleitbretter 211's the outside, basement 1 has atomic level and levels the surface, just any face of super gleitbretter 211 has super gliding plane, basement 1 with super gleitbretter 211 is super smooth contact. The sliding member 21 can slide on the surface of the substrate 1 with extremely low friction without abrasion, and at the same time, adhesion failure due to charge accumulation on the electrodes and "electrostatic attraction" phenomenon do not occur, and an extremely long life can be achieved.
The super-slip sheet 211 is made of HOPG graphite sheet, and at least one surface of the super-slip sheet 211 is an atomically smooth surface. The ultra-sliding sheet 211 is a part of an ultra-sliding pair, the substrate 1 forms the other part of the ultra-sliding pair, the ultra-sliding surfaces of the two contact ultra-sliding pairs are in ultra-sliding contact, the friction force is almost zero when the ultra-sliding pairs slide relatively, the friction coefficient is less than one thousandth, and the abrasion is zero.
Preferably, the substrate 1 may further include an insulating layer (not shown), which is generally a hydrophobic insulating layer having an atomically flat surface, and the insulating layer and the super-slip sheet 211 may further form a super-slip pair, which is not limited herein.
Wherein, to hydrophilic modification layer 212, it sets up in the outer fringe of super slide 211, and the preferred setting is at the top of super slide 211, and microfluid 3 can adhere at the top of super slide 211, drives microfluid 3 by super slide 211 and realizes quick slip, and microfluid 3 can not follow the top landing of super slide 211.
Because the ultra-slip sheet 211 is generally made of HOPG graphite sheets, and the hydrophilic modification layer 212 is difficult to be constructed on the surface layer of graphite materials, an island cover 213 needs to be disposed on the top of the ultra-slip sheet 211, and the island cover 213 is generally made of silicon dioxide materials or metal materials. Preferably, the island cover 213 is made of a metal material, and in this case, a capacitor can be formed with the driving part when electric driving is used, so that rapid driving can be achieved.
For the hydrophilic treatment of hydrophilic modification layer 212, physical methods and chemical methods can be generally adopted:
1. the physical method is to construct a micro-nano scale structure on the surface of the island cover 213, and the micro-nano scale structure generally means that a concave-convex structure is formed on the surface of the island cover 213, so that the hydrophilic performance of the island cover is enhanced. For the processing method of the micro-nano scale structure, methods such as etching, self-assembly, sol-gel method, electrostatic spinning and the like are generally adopted.
2. The chemical method is to treat the island cover 213 by a chemical modification method, a plasma treatment method, a purple light irradiation treatment method or a hydrophilic silane treatment method, so that the upper surface of the island cover 213 has hydrophilic performance.
The dimension of the superslide sheet 211 is generally submicron to micron order, and the dimension range thereof is generally 1 to 20 microns, so that the dimension of the microfluid 3 carried by the superslide sheet 211 is also submicron to micron order, and the superslide sheet 211 can be suitable for the control of a tiny liquid. The shape of the ultra-slide sheet 211 is generally square, referring to fig. 2, a plurality of digital microfluidic units 2 can be spliced and combined to form a large-scale microfluidic unit, and the plurality of digital microfluidic units 2 jointly bear a large-size liquid, so that the ultra-slide sheet is suitable for fusion and reaction among the microfluids 3, and the application area of the ultra-slide sheet is wider.
The same substrate 1 is generally provided with a plurality of digital microfluidic units 2, the plurality of digital microfluidic units 2 can be controlled by one large driving part in a unified manner or by a plurality of small driving parts individually, and the driving parts are generally driven by electric charges, so that the sliding part 21 can move towards one direction under the driving of the pressure difference by forming the pressure difference on two sides of the sliding part 21.
Preferably, the number of the driving parts is plural, and the number of the driving parts is larger than that of the digital microfluidic unit 2. The substrate 1 is generally provided with a plurality of stations 11, each station 11 is internally provided with a driving part, the driving part generally comprises at least two electrodes, and the movement of the digital microfluidic unit 2 inside the station 11 is controlled by electrifying towards the two electrodes.
The stations 11 on the substrate 1 are generally arranged in an array, a plurality of stations 11 can be combined into a plurality of annular station arrays, and the size and the dimension of the plurality of annular station arrays can be the same, so that the plurality of annular station arrays are sequentially arranged on the substrate 1 in an array manner. The annular station arrays can also be different in size, the annular station arrays are sequentially arranged from large to small at the moment, the annular station array with the larger size is positioned at the outer side, the annular station array with the smaller size is positioned at the inner side, and the sizes of the annular station arrays from outside to inside are sequentially reduced.
For example: the arrangement may be a square array arrangement in n × n form, please refer to fig. 3, the arrangement in the figure is a 4 × 4 array arrangement, which includes station rings annularly arranged on both sides, wherein 101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, and 112 are a first level; 201. 202, 203 and 204 are second levels, wherein the first level and the second level respectively have a cavity, i.e. the digital microfluidic unit 2 is not arranged on the station 11, and the cavities can be formed when the first level and the second level rotate, such as the station 101 and the station 201. The driving part controls the digital microfluidic control unit 2 in the station 102 to move towards the station 101, the digital microfluidic control unit 2 in the station 103 to move towards the station 102, and the like, so that the first-level anticlockwise rotation can be realized; meanwhile, the digital microfluidic control unit 2 in the station 202 moves towards the station 201, the digital microfluidic control unit 2 in the station 203 moves towards the station 202, and the like, so that the anticlockwise rotation of the second level can be realized;
if the clockwise selection needs to be realized, the digital microfluidic control unit 2 in the station 112 is controlled by the driving part to move towards the station 101, the digital microfluidic control unit 2 in the station 111 moves towards the station 112, and the like, so that the clockwise rotation of the first level can be realized; meanwhile, the digital microfluidic control unit 2 in the station 204 moves towards the station 201, the digital microfluidic control unit 2 in the station 203 moves towards the station 204, and the like, so that the anticlockwise rotation of the second level can be realized.
The whole rotation and centrifugation of the whole digital microfluidic system can be realized by controlling the movement of the single digital microfluidic control unit 2, the control mode is simple, the control of movement, separation, fusion, centrifugation and the like can be realized, not only can the global control be realized, but also the local control can be carried out on the single digital microfluidic control unit 2, and the application range of the digital microfluidic control system is expanded.
As an alternative embodiment of the present invention, the island cover 213 may not be disposed between the super-slip sheet 211 and the hydrophilic modification layer 212, and the hydrophilic modification may be performed directly on the surface of the super-slip sheet 211, which is not limited herein.
As an alternative embodiment of the present invention, the shape of the superclip 211 may be not square, but may also be circular, triangular or other shapes, which is not limited herein.
As an alternative embodiment of the present invention, the sequence of the stations 11 on the substrate 1 may also be a non-square arrangement, which may also be a circular or other profile, and is not limited herein.
It should be understood that the above examples are only for clarity of illustration and are not intended to limit the embodiments. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. And are neither required nor exhaustive of all embodiments. And obvious variations or modifications therefrom are within the scope of the utility model.
Claims (10)
1. Digital micro-fluidic unit based on super-lubricity technique, locate the top of base and be used for controlling the microfluid motion, its characterized in that: including at least one sliding part, sliding part is including surpassing the gleitbretter and being used for the hydrophilic modification layer of adhesion microfluid, hydrophilic modification layer is located surpass the outside of gleitbretter, surpass the gleitbretter with the contact surface of basement is the super glide plane, the basement with surpass the gleitbretter and be the super glide contact.
2. The digital microfluidic cell based on ultra-smooth technology as claimed in claim 1, wherein: the hydrophilic modification layer is located on the top surface of the super-slip sheet, and the surface of the hydrophilic modification layer is provided with hydrophilic patterned modification.
3. The digital microfluidic cell based on ultra-smooth technology as claimed in claim 1, wherein: the sliding component further comprises an island cover arranged between the super-slip sheet and the hydrophilic modification layer.
4. The digital microfluidic cell based on ultra-slippery technology of any of claims 1 to 3, wherein: the number of the sliding parts is more than two, and all the sliding parts are arranged in an array and spliced into a whole.
5. The digital microfluidic cell based on ultra-slippery technology of any of claims 1 to 3, wherein: the length and width of the superclip range from 1 to 20 microns.
6. Digital micro-fluidic system based on super smooth technique, its characterized in that: the ultra-slide technology-based digital microfluidic control unit comprises a substrate, a driving part and a plurality of ultra-slide technology-based digital microfluidic control units arranged on the substrate, wherein the digital microfluidic control units are driven by the driving part to slide on the substrate.
7. The digital microfluidic system based on ultra-smooth technology of claim 6, wherein: the number of the driving parts is one, and the driving parts simultaneously drive all the digital microfluidic units to move.
8. The digital microfluidic system based on ultra-smooth technology of claim 6, wherein: the substrate is provided with a plurality of stations, each station corresponds to one digital microfluidic unit, one driving part is arranged in each station, and the driving parts drive the digital microfluidic units to move to the next station.
9. The digital microfluidic system based on ultra-smooth technology of claim 8, wherein: the plurality of stations are combined into at least one annular station array, and the annular station array is arranged in layers.
10. The digital microfluidic system based on ultra-smooth technology of claim 9, wherein: at least one station in the annular station array of each layer is not provided with the digital microfluidic unit.
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| CN113231115A (en) * | 2021-05-24 | 2021-08-10 | 清华大学 | Digital microfluidic unit based on ultra-smooth technology and digital microfluidic system |
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