CN215465222U - Micro-column centrifugal separation device for measuring encapsulation rate of micro-nano drug preparation - Google Patents
Micro-column centrifugal separation device for measuring encapsulation rate of micro-nano drug preparation Download PDFInfo
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- CN215465222U CN215465222U CN202120735066.0U CN202120735066U CN215465222U CN 215465222 U CN215465222 U CN 215465222U CN 202120735066 U CN202120735066 U CN 202120735066U CN 215465222 U CN215465222 U CN 215465222U
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- 238000000926 separation method Methods 0.000 title claims abstract description 81
- 239000003814 drug Substances 0.000 title claims abstract description 78
- 229940079593 drug Drugs 0.000 title claims abstract description 31
- 238000002360 preparation method Methods 0.000 title claims abstract description 18
- 238000005538 encapsulation Methods 0.000 title claims abstract description 16
- 239000000463 material Substances 0.000 claims description 4
- 125000003003 spiro group Chemical group 0.000 claims description 3
- 239000004698 Polyethylene Substances 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- -1 polyethylene Polymers 0.000 claims description 2
- 229920000573 polyethylene Polymers 0.000 claims description 2
- 238000003908 quality control method Methods 0.000 abstract description 3
- 238000007789 sealing Methods 0.000 description 3
- 238000012377 drug delivery Methods 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000004005 microsphere Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000002105 nanoparticle Substances 0.000 description 1
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Abstract
The utility model belongs to the technical field of micro-nano medicine preparation quality control, and particularly relates to a micro-column centrifugal separation device for measuring micro-nano medicine preparation encapsulation rate, which comprises a separation tube, wherein a cavity for medicine separation is formed in the separation tube, a collecting tube is arranged at the position, corresponding to the cavity, of the bottom of the separation tube, the collecting tube is fixed on the outer wall of the separation tube in a threaded manner and covers the bottom of the cavity, a baffle is fixedly connected to the bottom of the cavity, a first through hole communicated with the collecting tube is formed in the middle of the baffle, and the cavity is communicated with the collecting tube through the first through hole; can carry out spacingly with the filter plate centre gripping between baffle and spacing ring, avoid appearing the skew and leading to free medicine and enveloped the condition emergence that the medicine mixes from the gap between filter plate, the baffle because of the filter plate when the separator tube carries out centrifugal motion, improve the quality of drug separation, the practicality is strong.
Description
Technical Field
The utility model belongs to the technical field of micro-nano medicine preparation quality control, and particularly relates to a micro-column centrifugal separation device for measuring the encapsulation rate of a micro-nano medicine preparation.
Background
With the development of new materials and new technologies of micro-nano drug preparations, micro-nano drug delivery systems for encapsulating various drugs, such as liposomes, nanoparticles, microspheres, submicron emulsion and the like, are emerging continuously, and effective delivery can be realized if and only if the drugs are encapsulated in carriers, so that the encapsulation efficiency is an important index when the drug delivery systems are subjected to quality control.
Chinese patent publication No. CN210146251U discloses a microcolumn centrifugal separation device for measuring the encapsulation efficiency of micro-nano drug preparations, which can be used to fill different types of separation media, not only can realize the rapid separation of free drugs from encapsulated drugs, and improve the measurement efficiency, but also can realize the standardization of the microcolumn centrifugal separation device, so that the reliability of the measurement result is higher, but the device can not limit the position of the filter plate when the filter plates made of different separation materials are filled in the separation tube to perform centrifugal separation on the drugs, which can cause the filter plate to shift when the separation tube performs centrifugal motion, so that the situation that the free drugs and the encapsulated drugs are mixed from the gap is easy to occur, and the quality of drug separation is affected.
Therefore, the skilled person provides a micro-column centrifugal separation device for measuring the encapsulation efficiency of micro-nano drug preparations to solve the problems mentioned in the background art.
SUMMERY OF THE UTILITY MODEL
To solve the problems set forth in the background art described above. The utility model provides a micro-column centrifugal separation device for measuring the encapsulation efficiency of a micro-nano medicinal preparation, which has the characteristic of improving the medicament separation quality.
In order to achieve the purpose, the utility model provides the following technical scheme: a micro-column centrifugal separation device for measuring the encapsulation rate of micro-nano medicinal preparations comprises a separation tube, wherein a cavity for medicament separation is formed in the separation tube, a collecting tube is arranged at the position, corresponding to the cavity, of the bottom of the separation tube, the collecting tube is fixed on the outer wall of the separation tube in a screwed mode and covers the bottom of the cavity, a baffle is fixedly connected to the bottom of the cavity, a first through hole communicated with the collecting tube is formed in the middle of the baffle, the cavity is communicated with the collecting tube through the first through hole, a filter plate is placed on the upper end face of the baffle, a top cover is fixed to the position, corresponding to the cavity, of the top of the separation tube in a screwed mode, a feed port for placing medicaments is formed in the middle of the top cover, the feed port is communicated with the cavity, and a plug is fixedly clamped in the inner portion of the feed port, the bottom of top cap is located the equal fixedly connected with dead lever in both sides of feed inlet, two the dead lever is kept away from the one end of top cap all extends to the bottom of cavity, the dead lever is located the one end fixedly connected with spacing ring of cavity bottom, the bottom of spacing ring is hugged closely the up end of filter plate, just the second through-hole has been seted up to the inside of spacing ring, the second through-hole with cavity, first through-hole are linked together.
Preferably, the collecting pipe is provided with a second thread groove matched with the separating pipe, and the collecting pipe is fixed at the bottom of the outer wall of the separating pipe through the second thread groove in a threaded manner.
Preferably, the bottom of the top cover is located outside fixedly connected with an annular support lug of the fixed rod, a first thread groove matched with the annular support lug is formed in the inner wall of the cavity, and the annular support lug is fixed to the inner wall of the cavity through the first thread groove in a threaded connection mode.
Preferably, the upper end face of baffle the lower terminal surface of spacing ring is the fixedly connected with second sealed pad and first sealed pad respectively, second sealed pad, first sealed pad are kept away from the one end of spacing ring, baffle is hugged closely respectively the downward both ends of filter plate, the material of first sealed pad, second sealed pad is rubber.
Preferably, the separation pipe and the collection pipe are both made of transparent polyethylene.
Preferably, the outer wall of the separation tube is provided with a scale for measuring the volume of the liquid.
Compared with the prior art, the utility model has the beneficial effects that: according to the medicine separation device, the filter plate is placed on the upper end face of the baffle plate, the bottom of the limiting ring is tightly attached to the upper end face of the filter plate, when medicine is separated, a worker firstly puts the filter plate to be used into the cavity and covers the upper end face of the baffle plate, the top cover is fixed to the top of the separation tube in a threaded mode through the matching of the annular support lug and the first threaded groove, the limiting ring fixed below the top cover through the fixing rod extends into the cavity and is tightly attached to the upper end face of the filter plate, the filter plate can be clamped between the baffle plate and the limiting ring for limiting, the situation that free medicine and encapsulated medicine are mixed from gaps between the filter plate and the baffle plate due to the fact that the filter plate deflects when the separation tube carries out centrifugal motion is avoided, medicine separation quality is improved, and practicability is high.
Drawings
The accompanying drawings, which are included to provide a further understanding of the utility model and are incorporated in and constitute a part of this specification, illustrate embodiments of the utility model and together with the description serve to explain the principles of the utility model and not to limit the utility model. In the drawings:
FIG. 1 is a schematic structural view of the present invention;
FIG. 2 is a schematic cross-sectional view of the present invention;
FIG. 3 is a schematic structural view of a top cover according to the present invention;
fig. 4 is a schematic structural view of a baffle plate, a limiting ring and a filter plate in the utility model.
In the figure: 1. a separation tube; 101. a cavity; 102. a first thread groove; 11. a baffle plate; 111. a first through hole; 112. a first gasket; 12. filtering the plate; 13. a dial gauge; 2. a collection pipe; 201. a second thread groove; 3. a top cover; 301. a feed inlet; 31. fixing the rod; 32. a limiting ring; 321. a second through hole; 322. a second gasket; 33. a plug; 34. and (6) a ring-shaped support lug.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Referring to fig. 1-4, the present invention provides the following technical solutions: a micro-column centrifugal separation device for measuring the encapsulation rate of micro-nano medicinal preparations comprises a separation tube 1, a cavity 101 for medicament separation is formed in the separation tube 1, a collecting tube 2 is arranged at the position, corresponding to the cavity 101, of the bottom of the separation tube 1, the collecting tube 2 is fixed on the outer wall of the separation tube 1 in a threaded manner and covers the bottom of the cavity 101, a baffle plate 11 is fixedly connected to the bottom of the cavity 101, a first through hole 111 communicated with the collecting tube 2 is formed in the middle of the baffle plate 11, the cavity 101 is communicated with the collecting tube 2 through the first through hole 111, a filter plate 12 is placed on the upper end face of the baffle plate 11, a top cover 3 is fixed at the position, corresponding to the cavity 101, of the top of the separation tube 1 in a threaded manner, a feed port 301 for placing medicaments is formed in the middle of the top cover 3, the feed port 301 is communicated with the cavity 101, and a plug 33 is clamped and fixed inside the feed port 301, the bottom of top cap 3 is located the equal fixedly connected with dead lever 31 in both sides of feed inlet 301, and the one end that two dead levers 31 kept away from top cap 3 all extends to the bottom of cavity 101, and dead lever 31 is located the one end fixedly connected with spacing ring 32 of cavity 101 bottom, and the up end at filter plate 12 is hugged closely to the bottom of spacing ring 32, and the second through-hole 321 has been seted up to the inside of spacing ring 32, and second through-hole 321 is linked together with cavity 101, first through-hole 111.
In this embodiment: the cavity 101 for separating the medicines is formed in the separation tube 1, the collecting tube 2 is arranged at the position, corresponding to the cavity 101, of the bottom of the separation tube 1, the collecting tube 2 is fixed on the outer wall of the separation tube 1 in a threaded manner and covers the bottom of the cavity 101, when the separated medicines enter the collecting tube 2, the collecting tube 2 is fixed on the outer wall of the separation tube 1 in a threaded manner through the second thread groove 201, the medicines can directly fall into the collecting tube 2 and cannot enter the joint of the collecting tube 2 and the separation tube 1, the situation that the medicines enter the collecting tube 2 and are lost at the joint of the separation tube 1 due to the fact that the collecting tube 2 is fixed on the inner wall of the separation tube 1 in a threaded manner can be avoided, the medicine waste is reduced, the baffle 11 is fixedly connected to the bottom of the cavity 101, the first through hole 111 communicated with the collecting tube 2 is formed in the middle position of the baffle 11, and the cavity 101 is communicated with the collecting tube 2 through the first through hole 111, a filter plate 12 is placed on the upper end face of the baffle plate 11, a top cover 3 is fixed on the top of the separation tube 1 in a threaded manner at a position corresponding to the cavity 101, a feed inlet 301 for placing medicines is arranged at the middle position of the top cover 3, the feed inlet 301 is communicated with the cavity 101, a plug 33 is fixed in the feed inlet 301 in a clamped manner, fixing rods 31 are fixedly connected to both sides of the bottom of the top cover 3, which are positioned at the feed inlet 301, one ends of the two fixing rods 31, which are far away from the top cover 3, extend to the bottom of the cavity 101, a limiting ring 32 is fixedly connected to one end of the fixing rod 31, which is positioned at the bottom of the cavity 101, the bottom of the limiting ring 32 is tightly attached to the upper end face of the filter plate 12, a second through hole 321 is arranged in the limiting ring 32, the second through hole 321 is communicated with the cavity 101 and the first through hole 111, when medicines are separated, the filter plate 12 required to be used by a worker is firstly placed in the cavity 101 and covers the upper end face of the baffle plate 11, then the top cover 3 is fixed on the top of the separation tube 1 by the matching of the ring-shaped support lug 34 and the first thread groove 102, the limit ring 32 fixed under the top cover 3 by the fixing rod 31 extends to the inside of the cavity 101 and clings to the upper end surface of the filter plate 12, then the medicine is poured into the cavity 101 from the feed inlet 301, and the feed inlet 301 is sealed by the plug 33, finally, the worker carries out centrifugal operation on the separation tube 1, so that the medicine can be contacted with the filter plate 12 from the second through hole 321 and can be filtered by the filter plate 12, the separated medicine can enter the collecting tube 2 from the first through hole 111, so as to complete the separation of the medicine, the filter plate 12 can be clamped between the baffle plate 11 and the limit ring 32 for limiting, the condition that the free medicine and the encapsulated medicine are mixed from the gap between the filter plate 12 and the baffle plate 11 due to the deviation of the filter plate 12 when the separation tube 1 carries out centrifugal motion is avoided, improves the quality of medicine separation and has strong practicability.
In fig. 1, 2 and 3: when separating the medicine, the worker firstly puts the filter plate 12 to be used into the cavity 101 and covers the upper end face of the baffle plate 11, then the ring-shaped support lug 34 is matched with the first thread groove 102 to fix the top cover 3 on the top of the separation tube 1 in a screw joint manner, the limit ring 32 fixed below the top cover 3 through the fixing rod 31 extends into the cavity 101 and is tightly attached to the upper end face of the filter plate 12, then the medicine is poured into the cavity 101 from the feed inlet 301, the feed inlet 301 is sealed through the plug 33, finally, the worker carries out centrifugal operation on the separation tube 1, namely, the medicine can be contacted with the filter plate 12 from the second through hole 321 and is filtered through the filter plate 12, the separated medicine can enter the collecting tube 2 from the first through hole 111, so that the separation of the medicine is completed, and the filter plate 12 can be clamped between the baffle plate 11 and the limit ring 32 for limiting, avoided because of filter plate 12 the skew appears when separator tube 1 carries out centrifugal motion and lead to free medicine and from filter plate 12 by the medicine of being enveloped, the condition that gap department between baffle 11 mixes takes place, the quality of medicine separation has been improved, therefore, the clothes hanger is strong in practicability, and, when the medicine of isolating gets into collecting pipe 2, because collecting pipe 2 fixes the outer wall at separator tube 1 through second thread groove 201 spiro union, the medicine can directly fall into collecting pipe 2 and can not get into collecting pipe 2 and separator tube 1's junction, can avoid fixing the inner wall at separator tube 1 and lead to the medicine to get into collecting pipe 2 because of collecting pipe 2 spiro union, the junction of separator tube 1 causes the condition of medicine loss to take place, the waste of medicine has been reduced, the staff can also directly observe the medicine surplus after the separation in separator tube 1 through graduation apparatus 13.
In fig. 4: when the baffle plate 11 and the limiting ring 32 clamp and limit the filter plate 12, the first sealing gasket 112 and the second sealing gasket 322 are respectively tightly attached to the upper end and the lower end of the filter plate 12, so that the gaps between the filter plate 12 and the baffle plate 11 and between the filter plate 12 and the limiting ring 32 can be sealed, the situation that free medicines and encapsulated medicines are mixed from the gap between the filter plate 12 and the baffle plate 11 is avoided, and the sealing performance is high.
The working principle and the using process of the utility model are as follows: when separating the medicine, the worker firstly puts the filter plate 12 to be used into the cavity 101 and covers the upper end face of the baffle plate 11, then the ring-shaped support lug 34 is matched with the first thread groove 102 to fix the top cover 3 on the top of the separation tube 1 in a screw joint manner, the limit ring 32 fixed below the top cover 3 through the fixing rod 31 extends into the cavity 101 and is tightly attached to the upper end face of the filter plate 12, then the medicine is poured into the cavity 101 from the feed inlet 301, the feed inlet 301 is sealed through the plug 33, finally, the worker carries out centrifugal operation on the separation tube 1, namely, the medicine can be contacted with the filter plate 12 from the second through hole 321 and is filtered through the filter plate 12, the separated medicine can enter the collecting tube 2 from the first through hole 111, so that the separation of the medicine is completed, and the filter plate 12 can be clamped between the baffle plate 11 and the limit ring 32 for limiting, the condition that free medicines and encapsulated medicines are mixed from the gap between the filter plate 12 and the baffle plate 11 due to the fact that the filter plate 12 deflects when the separation tube 1 performs centrifugal motion is avoided, the quality of medicine separation is improved, and practicability is high.
Finally, it should be noted that: although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that changes may be made in the embodiments and/or equivalents thereof without departing from the spirit and scope of the utility model. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (6)
1. The utility model provides a little post centrifugal separation device for determining little nano-drug preparation encapsulation rate, includes separator tube (1), its characterized in that: the medicine separation device is characterized in that a cavity (101) for medicine separation is formed in the separation tube (1), a collecting tube (2) is arranged at the position, corresponding to the cavity (101), of the bottom of the separation tube (1), the collecting tube (2) is fixed to the outer wall of the separation tube (1) in a threaded mode and covers the bottom of the cavity (101), a baffle (11) is fixedly connected to the bottom of the cavity (101), a first through hole (111) communicated with the collecting tube (2) is formed in the middle of the baffle (11), the cavity (101) is communicated with the collecting tube (2) through the first through hole (111), a filter plate (12) is placed on the upper end face of the baffle (11), a top cover (3) is fixedly connected to the position, corresponding to the cavity (101), of the top of the separation tube (1) in a threaded mode, a feed inlet (301) for placing medicines is formed in the middle of the top cover (3), feed inlet (301) with cavity (101) are linked together, just the inside block of feed inlet (301) is fixed with end cap (33), the bottom of top cap (3) is located the equal fixedly connected with dead lever (31) in both sides of feed inlet (301), two dead lever (31) are kept away from the one end of top cap (3) all extends to the bottom of cavity (101), dead lever (31) are located the one end fixedly connected with spacing ring (32) of cavity (101) bottom, the bottom of spacing ring (32) is hugged closely the up end of filter plate (12), just second through-hole (321) have been seted up to the inside of spacing ring (32), second through-hole (321) with cavity (101), first through-hole (111) are linked together.
2. The micro-column centrifugal separation device for measuring the encapsulation efficiency of the micro-nano drug preparation according to claim 1, wherein: and a second thread groove (201) matched with the separation pipe (1) is formed in the collecting pipe (2), and the collecting pipe (2) is fixed to the bottom of the outer wall of the separation pipe (1) through the second thread groove (201) in a threaded mode.
3. The micro-column centrifugal separation device for measuring the encapsulation efficiency of the micro-nano drug preparation according to claim 1, wherein: the bottom of top cap (3) is located outside fixedly connected with annular journal stirrup (34) of dead lever (31), the inner wall of cavity (101) seted up with annular journal stirrup (34) matched with first thread groove (102), annular journal stirrup (34) pass through first thread groove (102) spiro union is fixed the inner wall of cavity (101).
4. The micro-column centrifugal separation device for measuring the encapsulation efficiency of the micro-nano drug preparation according to claim 1, wherein: the up end of baffle (11) the lower terminal surface of spacing ring (32) is the sealed pad of fixedly connected with second (322) and first sealed pad (112) respectively, the sealed pad of second (322), first sealed pad (112) are kept away from the one end of spacing ring (32), baffle (11) is hugged closely respectively the downward both ends of filter plate (12), the material that first sealed pad (112), second sealed pad (322) is rubber.
5. The micro-column centrifugal separation device for measuring the encapsulation efficiency of the micro-nano drug preparation according to claim 1, wherein: the separating pipe (1) and the collecting pipe (2) are made of transparent polyethylene.
6. The micro-column centrifugal separation device for measuring the encapsulation efficiency of the micro-nano drug preparation according to claim 1, wherein: the outer wall of the separation pipe (1) is provided with a dial gauge (13) for measuring the volume of the liquid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202120735066.0U CN215465222U (en) | 2021-04-12 | 2021-04-12 | Micro-column centrifugal separation device for measuring encapsulation rate of micro-nano drug preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202120735066.0U CN215465222U (en) | 2021-04-12 | 2021-04-12 | Micro-column centrifugal separation device for measuring encapsulation rate of micro-nano drug preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN215465222U true CN215465222U (en) | 2022-01-11 |
Family
ID=79774243
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202120735066.0U Expired - Fee Related CN215465222U (en) | 2021-04-12 | 2021-04-12 | Micro-column centrifugal separation device for measuring encapsulation rate of micro-nano drug preparation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN215465222U (en) |
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2021
- 2021-04-12 CN CN202120735066.0U patent/CN215465222U/en not_active Expired - Fee Related
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| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20220111 |
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| CF01 | Termination of patent right due to non-payment of annual fee |