CN215464396U - Reaction device for oxazole medical intermediate - Google Patents
Reaction device for oxazole medical intermediate Download PDFInfo
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- CN215464396U CN215464396U CN202121535386.8U CN202121535386U CN215464396U CN 215464396 U CN215464396 U CN 215464396U CN 202121535386 U CN202121535386 U CN 202121535386U CN 215464396 U CN215464396 U CN 215464396U
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Abstract
The utility model discloses a reaction device for oxazole medical intermediates, which comprises a reaction kettle, wherein the reaction kettle comprises a kettle body and a kettle cover, a first feed inlet is arranged on the kettle cover, an upper hopper is connected above the first feed inlet, a feed inlet is arranged at the upper edge of the feed hopper far away from a protrusion, a spiral stirring shaft is arranged in the feed hopper, the feeding is convenient, solid raw materials can be uniformly added into reaction liquid, the practicability is good, and the reaction uniformity is improved; a heating cavity is formed between the kettle body and the heat preservation shell, the air inlet pipe is arranged in the heating cavity, nitrogen enters the heat preservation pipe from the second air inlet, enters the nitrogen generator after being preheated by a heating medium in the heating cavity through the heat preservation pipe, and is discharged into reaction liquid, so that the temperature difference between the nitrogen and the reaction liquid is reduced, the reaction stability is improved, and the product quality is improved; the reaction device has the advantages of simple operation, convenient feeding and uniform feeding, and nitrogen is simultaneously introduced into the reaction liquid and the reaction liquid, so that the stability of the whole reaction is improved, the reaction is uniform, and the quality and the yield of the product are improved.
Description
Technical Field
The utility model relates to the technical field of oxazole medical intermediate production, in particular to a reaction device for an oxazole medical intermediate.
Background
Oxazole compounds are a kind of important heterocyclic compounds, some compounds with oxazole ring have biological activity, have effects of fungicide, antibacterial, antiviral, oxazole medical intermediate has extensive application at the same time, in the preparation process of oxazole medical intermediate, the reaction apparatus is indispensable, existing reaction apparatus nitrogen is let into from reaction liquid top mostly, can't enter the reaction system, to needing to carry on the reaction of nitrogen protection below the liquid level of reaction, can't realize, to can carry on the reaction apparatus of nitrogen protection below the liquid level of reaction, nitrogen is let into the reaction system directly, the temperature difference of nitrogen temperature and reaction liquid temperature is large, will cause the local supercooling, thus influence the reaction, make the product quality decline, the yield is low, etc.; the solid component feeding of the existing reaction device is carried out by manual feeding, the feeding uniformity is poor, the reaction is not uniform, and the reaction rate is unstable.
Disclosure of Invention
In order to solve the problems, the utility model discloses a reaction device for an oxazole medical intermediate, which is uniform in feeding, and nitrogen is introduced into reaction liquid from top to bottom simultaneously, so that the whole reaction is uniform, the reaction stability is improved, and the product quality and the yield are improved.
In order to achieve the purpose, the utility model provides a reaction device for an oxazole medical intermediate, which comprises a reaction kettle, wherein the reaction kettle comprises a kettle body and a kettle cover, a first stirring motor is arranged in the middle of the kettle cover, the first stirring motor is vertically connected with a stirring shaft, the stirring shaft penetrates through the kettle cover and is arranged in the kettle body, a plurality of stirring paddles are arranged on the stirring shaft, a nitrogen generator is fixedly arranged at the bottom of the stirring shaft, a second stirring motor is arranged beside the first stirring motor, the second stirring motor is connected with a spiral stirring shaft, the spiral stirring shaft is suspended in a feeding hopper, a first feeding hole is connected below the feeding hopper, the first feeding hole is arranged on the kettle cover, and a second feeding hole, a first air inlet, a first air outlet and a pressure gauge are further arranged on the kettle cover; the kettle cover is arranged on the kettle body, a discharge port is formed in the bottom of the kettle body, a heat preservation shell is arranged outside the kettle body, a heating cavity is formed between the kettle body and the heat preservation shell, a medium inlet is formed in the bottom of the heat preservation shell, a medium outlet is formed in the upper portion of the side face of the heat preservation shell, a second air inlet is formed in the lower portion of the side face of the heat preservation shell and connected with one end of an air inlet pipe, the air inlet pipe is arranged in the heating cavity, the other end of the air inlet pipe is connected with a support in the bottom of the nitrogen generator, the nitrogen generator is arranged above the discharge port, and the nitrogen generator is fixed to the bottom of the kettle body through a plurality of supports.
Furthermore, the upper edge of the feeding hopper is provided with a feeding opening in a protruding mode far away from the direction of the first stirring motor, the bottom surface of the feeding opening is an inclined plane, feeding is facilitated, and practicability is good.
Further, the nitrogen cylinder is all connected to first air inlet and second air inlet, be equipped with first solenoid valve on the connecting pipeline of first air inlet and nitrogen cylinder, be equipped with the second solenoid valve on the connecting pipeline of second air inlet and nitrogen cylinder, lead to nitrogen gas from reation kettle bottom and upper portion simultaneously, provide more stable reaction environment, improve product quality and efficiency.
Further, the first air outlet is connected with a vacuum pump, a third electromagnetic valve is arranged on a pipeline connecting the first air outlet and the vacuum pump, and the reaction kettle is vacuumized before reaction according to the reaction conditions to discharge air in the kettle.
Furthermore, the nitrogen generator comprises a limiting block and a fixed disk, the limiting block is fixedly connected to the bottom end of the stirring shaft, the limiting block is arranged in a groove in the fixed disk, an annular sealing ring is arranged between the stirring shaft and the fixed disk, an annular groove is formed around the side surface of the groove, a plurality of convex blocks are arranged on the side surface of the limiting block and arranged in the annular groove, a plurality of guide grooves are radially and outwards arranged in the annular groove along the annular groove, sealing rods are arranged in the guide grooves, vertical through holes are formed in the sealing rods, a reset spring is arranged at one ends of the sealing rods, close to the depths of the guide grooves, and a guide block is arranged at one ends of the sealing rods, far away from the depths of the guide grooves and arranged in the annular groove; the upper surface of the guide groove is provided with an upper channel, the lower surface of the guide groove is provided with a lower channel, the upper channel and the lower channel are matched with the through hole, a main channel is arranged in one support connected with the air inlet pipe, the lower channel is connected with the main channel, and the main channel is connected with the air inlet pipe; the stopper rotates along with the (mixing) shaft, and the lug of stopper side rotates thereupon and leads the slider contact, then will lead the slider and outwards promote, and the through-hole moves to between last passageway and lower passageway, and nitrogen gas loops through intake pipe, main entrance, lower passageway, through-hole, last passageway, and simple mechanical structure realizes the switch of nitrogen gas.
Further, go up the passageway top and connect the blast pipe, the blast pipe side is equipped with a plurality of first ventholes, be equipped with the cushion chamber outside the blast pipe, the cushion chamber top is equipped with the second venthole, the second venthole is with cushion chamber and the internal intercommunication of cauldron, and the setting of cushion chamber avoids reaction liquid to get into in the blast pipe.
Compared with the prior art, the utility model has the following advantages and beneficial effects:
the reaction device for the oxazole medical intermediate comprises a reaction kettle, the reaction kettle comprises a kettle body and a kettle cover, a first feeding hole is formed in the kettle cover, an upper connecting hopper is connected above the first feeding hole, a feeding hole is formed in the upper edge of the feeding hopper far away from a protrusion, the bottom surface of the feeding hole is an inclined surface, a second stirring motor is arranged above the feeding hopper and connected with a spiral stirring shaft, feeding is convenient, solid raw materials can be uniformly added into reaction liquid, the practicability is good, and the reaction uniformity is improved.
A heating cavity is formed between the kettle body and the heat preservation shell, the air inlet pipe is arranged in the heating cavity, nitrogen enters the heat preservation pipe from the second air inlet, enters the nitrogen generator after being preheated by a heating medium in the heating cavity through the heat preservation pipe, and is discharged into reaction liquid, so that the temperature difference between the nitrogen and the reaction liquid is reduced, the reaction stability is improved, and the product quality is improved.
The reaction device for the oxazole medical intermediate is simple to operate, convenient to feed and uniform in feeding, and nitrogen is simultaneously introduced into the reaction liquid and the reaction liquid, so that the stability of the whole reaction is improved, the reaction is uniform, and the quality and the yield of the product are improved.
Drawings
FIG. 1 is a schematic structural view of the present invention;
FIG. 2 is a schematic structural diagram of a limiting block according to the present invention;
FIG. 3 is a schematic view of the structure of the guide slider and the seal bar of the present invention;
FIG. 4 is a schematic view of the nitrogen generator of the present invention;
FIG. 5 is a schematic top view of the nitrogen generator of the present invention;
FIG. 6 is a schematic cross-sectional view taken along line A-A of FIG. 4 in accordance with the present invention;
description of reference numerals:
1. a kettle body; 2. a heat preservation shell; 3. a kettle cover; 4. a first air outlet; 5. a vacuum pump; 6. a second feed port; 7. a pressure gauge; 8. a first stirring motor; 9. a second stirring motor; 10. feeding a hopper; 11. a feeding port; 12. a first feed port; 13. a first air inlet; 14. a media outlet; 15. a heating cavity; 16. a second air inlet; 17. an air inlet pipe; 18. a stirring shaft; 19. a stirring paddle; 20. a spiral stirring shaft; 21. a limiting block; 22. fixing the disc; 23. a support; 24. a discharge port; 25. a media inlet; 26. a sealing rod; 27. an upper channel; 28. a through hole; 29. an exhaust pipe; 30. a first exhaust port; 31. a second vent hole; 32. a bump; 33. a guide slider; 34. an annular seal ring.
Detailed Description
The technical solutions provided by the present invention will be described in detail below with reference to specific examples, and it should be understood that the following specific embodiments are only illustrative of the present invention and are not intended to limit the scope of the present invention. It should be noted that the terms "front," "back," "left," "right," "upper" and "lower" used in the following description refer to directions in the drawings, and the terms "inner" and "outer" refer to directions toward and away from, respectively, the geometric center of a particular component.
Example (b): as shown in fig. 1 to 6, a reaction device for oxazole pharmaceutical intermediates comprises a reaction kettle, the reaction kettle comprises a kettle body 1 and a kettle cover 3, a first stirring motor 8 is arranged in the middle of the kettle cover 3, the first stirring motor 8 is vertically connected with a stirring shaft 18, the stirring shaft 18 penetrates through the kettle cover 3 and is arranged in the kettle body 1, a plurality of stirring paddles 19 are arranged on the stirring shaft 18, a nitrogen generator is fixedly arranged at the bottom of the stirring shaft 18, a second stirring motor 9 is arranged beside the first stirring motor 8, the second stirring motor 9 is connected with a spiral stirring shaft 20, the spiral stirring shaft 20 is suspended in a feeding hopper 10, a feeding port 11 is arranged on the upper edge of the feeding hopper 10 in a protruding manner far from the first stirring motor 8, the bottom surface of the feeding port 11 is an inclined surface, a first feeding port 12 is connected below the feeding hopper 10, the first feeding port 12 is arranged on the kettle cover 3, a second feeding port 6 and a first air inlet 13 are further arranged on the kettle cover 3, A first air outlet 4 and a pressure gauge 7; the kettle cover 3 is arranged on the kettle body 1, a discharge hole 24 is formed in the bottom of the kettle body 1, a heat preservation shell 2 is arranged outside the kettle body 1, a heating cavity 15 is formed between the kettle body 1 and the heat preservation shell 2, a medium inlet 25 is formed in the bottom of the heat preservation shell 2, a medium outlet 14 is formed in the upper portion of the side face of the heat preservation shell 2, a second air inlet 16 is formed in the lower portion of the side face of the heat preservation shell 2, the second air inlet 16 is connected with one end of an air inlet pipe 17, the air inlet pipe 17 is arranged in the heating cavity 15, the other end of the air inlet pipe 17 is connected with a support 23 at the bottom of the nitrogen generator, the nitrogen generator is arranged above the discharge hole 24, and the nitrogen generator is fixed at the bottom of the kettle body 1 through a plurality of supports 23.
The first air inlet 13 and the second air inlet 16 are both connected with a nitrogen cylinder, a first electromagnetic valve is arranged on a connecting pipeline of the first air inlet 13 and the nitrogen cylinder, a second electromagnetic valve is arranged on a connecting pipeline of the second air inlet 16 and the nitrogen cylinder, and nitrogen can be introduced from the bottom and the upper part of the reaction kettle.
The first air outlet 4 is connected with a vacuum pump 5, and a third electromagnetic valve is arranged on a pipeline connecting the first air outlet 4 and the vacuum pump 5.
The nitrogen generator comprises a limiting block 21 and a fixed disk 22, the limiting block 21 is fixedly connected to the bottom end of a stirring shaft 18, the limiting block 21 is arranged in a groove in the fixed disk 22, an annular sealing ring 34 is arranged between the stirring shaft 18 and the fixed disk 22, an annular groove is formed around the side surface of the groove, a plurality of convex blocks 32 are arranged on the side surface of the limiting block 21, the convex blocks 32 are arranged in the annular groove, a plurality of guide grooves are radially and outwards arranged in the annular groove along the annular groove, sealing rods 26 are arranged in the guide grooves, vertical through holes 28 are formed in the sealing rods 26, a reset spring is arranged at one end, close to the depths of the guide grooves, of each sealing rod 26, a guide block 33 is arranged at one end, far away from the depths of the guide grooves, of each sealing rod 26, and the guide block 33 is arranged in the annular groove; the upper surface of the guide groove is provided with an upper channel 27, the lower surface of the guide groove is provided with a lower channel, the upper channel 27 and the lower channel are matched with the through hole 28, a main channel is arranged in a support 23 connected with the air inlet pipe 17, the channel is connected with the main channel, and the main channel is connected with the air inlet pipe 17; the limiting block 21 rotates along with the stirring shaft 18, the convex block 32 on the side face of the limiting block 21 rotates along with the stirring shaft to be in contact with the guide sliding block 33, then the guide sliding block 33 is pushed outwards, the through hole 28 moves between the upper channel 27 and the lower channel, and nitrogen sequentially passes through the air inlet pipe 17, the main channel, the lower channel, the through hole 28 and the upper channel 27.
The exhaust pipe 29 is connected at the top of the upper channel 27, a plurality of first air outlets are arranged on the side surface of the exhaust pipe 29, a buffer cavity is arranged outside the exhaust pipe 29, a second air outlet is arranged at the top of the buffer cavity, and the buffer cavity is communicated with the inside of the kettle body 1 through the second air outlet.
The working principle is as follows: the utility model relates to a reaction device for oxazole medical intermediate, before feeding, a vacuum pump 5 is started to pump out air in a reaction kettle from a first air outlet 4, nitrogen is introduced from a first air inlet 13, liquid raw materials are fed from a second feed inlet 6 through a metering pump, a first stirring motor 8 is started to start stirring, a limiting block 21 at the bottom of a stirring shaft 18 rotates along with the stirring shaft 18, a lug 32 on the side surface of the limiting block 21 rotates to be contacted with a guide slide block 33, then the guide slide block 33 is pushed outwards, a through hole 28 moves to a position between an upper channel 27 and a lower channel, the nitrogen sequentially passes through an air inlet pipe 17, a main channel, the lower channel, a through hole 28, the upper channel 27 and an exhaust pipe 29 and is discharged from the first air outlet and the second air outlet, a heating medium with a certain temperature is introduced from a medium inlet according to reaction conditions, the solid raw materials are discharged from a medium outlet 14 and circularly flow, and are fed into an upper hopper 10 from an upper material inlet 11, the second stirring motor 9 drives the spiral stirring shaft 20 to rotate, solid raw materials are added, after a reaction end time, the reaction is finished, the discharge port 24 is opened, reaction liquid flows into the discharge port 24 from the space between the supports 23 and is then discharged, and the reaction is finished.
Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art will understand that various modifications can be made to the embodiments described in the foregoing embodiments, or some or all of the technical features of the embodiments can be equivalently replaced, and the modifications or the replacements do not make the essence of the corresponding technical solutions depart from the scope of the embodiments of the present invention.
Claims (6)
1. A reaction device for oxazole medical intermediates is characterized by comprising a reaction kettle, wherein the reaction kettle comprises a kettle body and a kettle cover, a first stirring motor is arranged in the middle of the kettle cover, the first stirring motor is vertically connected with a stirring shaft, the stirring shaft penetrates through the kettle cover and is arranged in the kettle body, a plurality of stirring paddles are arranged on the stirring shaft, a nitrogen generator is fixedly arranged at the bottom of the stirring shaft, a second stirring motor is arranged beside the first stirring motor, the second stirring motor is connected with a spiral stirring shaft, the spiral stirring shaft is suspended in a feeding hopper, a first feeding hole is connected below the feeding hopper, the first feeding hole is arranged on the kettle cover, and a second feeding hole, a first air inlet, a first air outlet and a pressure gauge are further arranged on the kettle cover; the kettle cover is arranged on the kettle body, a discharge port is formed in the bottom of the kettle body, a heat preservation shell is arranged outside the kettle body, a heating cavity is formed between the kettle body and the heat preservation shell, a medium inlet is formed in the bottom of the heat preservation shell, a medium outlet is formed in the upper portion of the side face of the heat preservation shell, a second air inlet is formed in the lower portion of the side face of the heat preservation shell and connected with one end of an air inlet pipe, the air inlet pipe is arranged in the heating cavity, the other end of the air inlet pipe is connected with a support in the bottom of the nitrogen generator, the nitrogen generator is arranged above the discharge port, and the nitrogen generator is fixed to the bottom of the kettle body through a plurality of supports.
2. The reaction device for oxazole medical intermediates according to claim 1, wherein a feeding port is provided at the upper edge of the feeding hopper in a protruding manner away from the first stirring motor, and the bottom surface of the feeding port is an inclined surface.
3. The reaction device for the oxazole medical intermediate according to claim 1, wherein the first gas inlet and the second gas inlet are both connected to a nitrogen cylinder, a first electromagnetic valve is arranged on a connecting pipeline between the first gas inlet and the nitrogen cylinder, and a second electromagnetic valve is arranged on a connecting pipeline between the second gas inlet and the nitrogen cylinder.
4. The reaction device for the oxazole medical intermediate according to claim 1, wherein the first gas outlet is connected to a vacuum pump, and a third electromagnetic valve is arranged on a pipeline connecting the first gas outlet and the vacuum pump.
5. The reaction device for oxazole medical intermediates according to claim 1, wherein the nitrogen generator comprises a stopper and a fixed disk, the stopper is fixedly connected to the bottom end of the stirring shaft, the stopper is disposed in a groove in the fixed disk, an annular seal ring is disposed between the stirring shaft and the fixed disk, an annular groove is disposed around the side surface of the groove, a plurality of protrusions are disposed on the side surface of the stopper, the protrusions are disposed in the annular groove, a plurality of guide grooves are radially outwardly disposed in the annular groove along the annular groove, sealing rods are disposed in the guide grooves, vertical through holes are disposed on the sealing rods, a return spring is disposed at one end of the sealing rods close to the depth of the guide grooves, a guide block is disposed at one end of the sealing rods far away from the depth of the guide grooves, and the guide block is disposed in the annular groove; the upper surface of guide slot is equipped with the passageway, the guide slot lower surface is equipped with the lower passageway, go up passageway, lower passageway and through-hole phase-match, with be equipped with the main entrance in intake-tube connection's a support, the main entrance is connected to the lower passageway, and the intake-tube is connected to the main entrance.
6. The reaction device for the pharmaceutical intermediate of oxazole according to claim 5, wherein the top of the upper channel is connected to an exhaust pipe, the side of the exhaust pipe is provided with a plurality of first air outlets, the outside of the exhaust pipe is provided with a buffer chamber, the top of the buffer chamber is provided with a second air outlet, and the buffer chamber is communicated with the inside of the kettle body through the second air outlet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202121535386.8U CN215464396U (en) | 2021-07-07 | 2021-07-07 | Reaction device for oxazole medical intermediate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202121535386.8U CN215464396U (en) | 2021-07-07 | 2021-07-07 | Reaction device for oxazole medical intermediate |
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| Publication Number | Publication Date |
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| CN215464396U true CN215464396U (en) | 2022-01-11 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202121535386.8U Active CN215464396U (en) | 2021-07-07 | 2021-07-07 | Reaction device for oxazole medical intermediate |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024000881A1 (en) * | 2022-06-30 | 2024-01-04 | 宜昌邦普循环科技有限公司 | Coating device and coating system for positive electrode material of lithium battery |
-
2021
- 2021-07-07 CN CN202121535386.8U patent/CN215464396U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024000881A1 (en) * | 2022-06-30 | 2024-01-04 | 宜昌邦普循环科技有限公司 | Coating device and coating system for positive electrode material of lithium battery |
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