CN215462192U

CN215462192U - Column incubator temperature control system of protein purification system

Info

Publication number: CN215462192U
Application number: CN202121771096.3U
Authority: CN
Inventors: 刘诚; 刘鑫; 苏文敏
Original assignee: Tianjin Shengyuan Instrument Co ltd
Current assignee: Wuhan Paiwei Biotechnology Co.,Ltd.
Priority date: 2021-07-30
Filing date: 2021-07-30
Publication date: 2022-01-11
Anticipated expiration: 2031-07-30

Abstract

The application provides a protein purification system column incubator temperature control system belongs to protein detection analysis technical field. The temperature control system of the column incubator of the protein purification system comprises a refrigeration mechanism and a heating mechanism. The refrigerating mechanism comprises an insulation can, a motor, fan blades, a refrigerating system, a supporting plate, an adjusting component and a temperature sensor, wherein one side of the insulation can is of an open structure, the motor is connected to the inner wall of the insulation can, the fan blades are installed on the motor output shaft, and the refrigerating system and the temperature sensor are connected to the inner wall of the insulation can. This application is through the effect of second clamp splice, spring, threaded rod, I piece, support, first clamp splice, temperature sensor, refrigerating system, electric heat piece, motor and flabellum to reached the effectual purpose of temperature control system accuse temperature, through inside rapid heating up or cooling, the control rate who makes is fast, and the accuse temperature is accurate, and the external environment is difficult for influencing the change of chromatography column temperature, has improved protein purification's quality.

Description

Column incubator temperature control system of protein purification system

Technical Field

The application relates to the field of protein detection and analysis, in particular to a column incubator temperature control system of a protein purification system.

Background

The size, shape, charge, hydrophobicity, solubility and biological activity of each protein are different, the protein can be extracted from a mixture such as an escherichia coli lysate to obtain recombinant protein by utilizing the difference, the temperature control effect of a column temperature box temperature control system of the current protein purification system is poor, and the temperature of a chromatographic column is generally controlled by external refrigeration in production.

How to invent a temperature control system of a column incubator of a protein purification system to improve the problems becomes a problem to be solved urgently by the technical personnel in the field.

SUMMERY OF THE UTILITY MODEL

In order to make up for the above deficiency, the application provides a temperature control system of a column incubator of a protein purification system, aiming at improving the problem of poor temperature control effect of the temperature control system.

The embodiment of the application provides a column incubator temperature control system of a protein purification system, which comprises a refrigeration mechanism and a heating mechanism.

The refrigerating mechanism comprises an insulation can, a motor, fan blades, a refrigerating system, supporting plates, an adjusting component and a temperature sensor, wherein one side of the insulation can is of an open structure, the motor is connected with the inner wall of the insulation can, the fan blades are installed on the output shaft of the motor, the refrigerating system and the temperature sensor are connected with the inner wall of the insulation can, the two supporting plates are symmetrically installed on the inner wall of the insulation can, the adjusting component penetrates through the supporting plates in a threaded manner, the heating mechanism comprises a supporting plate, a sleeve, a clamping component, a chromatographic column body, an electric heating block and a stop block, the supporting plate is connected with the inner wall of the insulation can, the sleeve is installed on one side of the supporting plate, the inner wall of the sleeve is fixedly connected with a buffer cushion, the chromatographic column body is arranged on the buffer cushion, the clamping component is symmetrically connected with the inner wall of the sleeve, and the adjusting component and the clamping component are attached to the outer surface of the chromatographic column body, the electric heating blocks are connected to the other side of the support plate, and the two stop blocks are symmetrically arranged on the other side of the support plate.

In the above-mentioned realization in-process, the motor is used for driving the flabellum and rotates, make the flabellum produce from the bottom up blow, make the heat that the electric heat piece produced transmit whole insulation can fast, accelerate the programming rate of chromatography column body, refrigerating system is used for refrigerating, refrigerating system is located the insulation can top, because air conditioning density is big, can transmit downwards, can be full of whole insulation can with air conditioning fast, accelerate the cooling rate of chromatography column body, adjusting part is used for pressing from both sides tight chromatography column body, improve the stability of chromatography column body, temperature sensor is used for detecting the temperature of insulation can, the temperature of the real time monitoring chromatography column body of being convenient for, sleeve and clamping part are used for fixing a position the chromatography column body, make the chromatography column body be convenient for install, the dog is used for carrying out the water conservancy diversion to the hot-air, the hot-air of being convenient for upwards flows.

In a specific embodiment, one end of the refrigeration system penetrates and extends to the outside of the insulation can through a conduit.

In the above implementation, the conduit is used to communicate the refrigeration system with the outside atmosphere.

In a specific embodiment, the adjusting component comprises a threaded rod, an I-shaped block, a support, a first clamping block and a handle, wherein a threaded hole is formed in the inner surface of the support plate, threads of the threaded rod penetrate through the threaded hole, the I-shaped block is connected to one end of the threaded rod, the support is rotatably connected to the I-shaped block, the first clamping block is installed at one end of the support, and the handle is connected to the other end of the threaded rod.

In the implementation process, the handle is used for driving the threaded rod to rotate, the threaded rod drives the first clamping block to horizontally move through the I-shaped block and the support, so that the first clamping block cannot rotate, and the chromatographic column body is conveniently fixed.

In a specific embodiment, the bracket is of a U-shaped structure, the inner surface of the bracket is provided with a first through hole, and the i-shaped block is in clearance fit with the first through hole.

In the implementation process, the first through hole is used for enabling the I-shaped block to only drive the support to horizontally move in the rotating process and not to rotate.

In a specific embodiment, the first clamping blocks are arc-shaped structures, and two first clamping blocks are positioned on two sides of the chromatographic column body.

In a specific embodiment, the clamping assembly comprises a spring, a second clamping block, a round rod and a limiting rod, the spring is connected to two sides of the inner wall of the sleeve, the second clamping block is installed at one end of the spring, one end of the round rod is connected to one side of the second clamping block, a second through hole is formed in the inner surface of the sleeve, the round rod penetrates through the second through hole in a sliding mode, and the limiting rod is installed at the other end of the round rod.

In the above-mentioned realization process, the elasticity of spring passes through the bottom that the tight chromatography column body of second clamp splice clamp, when convenient location to the chromatography column body, improves the stability of chromatography column body, and the round bar is used for improving the stability of second clamp splice.

In a specific embodiment, the second clamping blocks are arc-shaped structures, and the two second clamping blocks are attached to two sides of the chromatographic column body.

In a specific embodiment, the electric heating block is a conical structure, and the inner surface of the support plate is provided with heat conduction holes which are positioned at two sides of the electric heating block.

In the implementation process, the conical structure and the heat conduction holes of the electric heating block facilitate the heat generated by the electric heating block to flow upwards along the blowing wind generated by the fan blades, so that the heating speed is increased.

In a specific embodiment, the opening side of the heat preservation box is rotatably connected with a box door, the box door and the opening side of the heat preservation box are provided with sealing gaskets, and one side of the box door is fixedly connected with a handle.

In the implementation process, the box door is used for sealing the opening side of the heat preservation box, so that the sealing performance of the heat preservation box is improved.

In a specific embodiment, one end of the heat preservation box is fixedly connected with four support legs.

Drawings

In order to more clearly explain the technical solutions of the embodiments of the present application, the drawings that are required to be used in the embodiments will be briefly described below, it should be understood that the following drawings only illustrate some embodiments of the present application and therefore should not be considered as limiting the scope, and that for those skilled in the art, other related drawings can be obtained from these drawings without inventive effort.

FIG. 1 is a schematic diagram of a temperature control system of a column oven of a protein purification system according to an embodiment of the present disclosure;

fig. 2 is a first perspective structural schematic view of a refrigeration mechanism according to an embodiment of the present disclosure;

fig. 3 is a schematic view of a second perspective structure of a refrigeration mechanism according to an embodiment of the present disclosure;

FIG. 4 is a schematic view of a first perspective structure of an adjustment assembly according to an embodiment of the present disclosure;

FIG. 5 is a schematic view of a second perspective structure of an adjustment assembly according to an embodiment of the present disclosure;

FIG. 6 is a schematic structural diagram of a heating mechanism provided in an embodiment of the present application;

FIG. 7 is a schematic view of a first perspective structure of a clamping assembly according to an embodiment of the present disclosure;

fig. 8 is a structural diagram of a second perspective view of a clamping assembly according to an embodiment of the present disclosure.

In the figure: 10-a refrigeration mechanism; 110-an incubator; 120-a motor; 130-fan blades; 140-a refrigeration system; 150-a pallet; 160-an adjustment assembly; 161-threaded rod; 162-an i-block; 163-a stent; 164-a first clamp block; 165-a handle; 170-temperature sensor; 180-support legs; 190-a box door; 20-a heating mechanism; 210-a support plate; 220-a sleeve; 230-a clamping assembly; 231-a spring; 232-a second clamp block; 233-round bar; 234-a stop lever; 240-a cushion; 250-a chromatography column body; 260-an electric heating block; 270-a stop block; 280-heat conduction holes.

Detailed Description

The technical solutions in the embodiments of the present application will be described below with reference to the drawings in the embodiments of the present application.

To make the objects, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions of the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application, and it is obvious that the described embodiments are some embodiments of the present application, but not all embodiments. All other embodiments obtained by a person of ordinary skill in the art without any inventive work based on the embodiments in the present application are within the scope of protection of the present application.

Thus, the following detailed description of the embodiments of the present application, as presented in the figures, is not intended to limit the scope of the claimed application, but is merely representative of selected embodiments of the application. All other embodiments obtained by a person of ordinary skill in the art without any inventive work based on the embodiments in the present application are within the scope of protection of the present application.

It should be noted that: like reference numbers and letters refer to like items in the following figures, and thus, once an item is defined in one figure, it need not be further defined and explained in subsequent figures.

In the description of the present application, it is to be understood that the terms "center," "longitudinal," "lateral," "length," "width," "thickness," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," "clockwise," "counterclockwise," and the like are used in the orientations and positional relationships indicated in the drawings for convenience in describing the present application and for simplicity in description, and are not intended to indicate or imply that the referenced device or element must have a particular orientation, be constructed in a particular orientation, and be operated in a particular manner, and thus should not be considered limiting.

Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of the present application, "a plurality" means two or more unless specifically limited otherwise.

In this application, unless expressly stated or limited otherwise, the terms "mounted," "connected," "secured," and the like are to be construed broadly and can include, for example, fixed connections, removable connections, or integral parts; either directly or indirectly through intervening media, either internally or in any other relationship. The specific meaning of the above terms in the present application can be understood by those of ordinary skill in the art as appropriate.

In this application, unless expressly stated or limited otherwise, the first feature "on" or "under" the second feature may comprise direct contact of the first and second features, or may comprise contact of the first and second features not directly but through another feature in between. Also, the first feature being "on," "above" and "over" the second feature includes the first feature being directly on and obliquely above the second feature, or merely indicating that the first feature is at a higher level than the second feature. A first feature being "under," "below," and "beneath" a second feature includes the first feature being directly under and obliquely below the second feature, or simply meaning that the first feature is at a lesser elevation than the second feature.

Referring to fig. 1, the present application provides a temperature control system for a column oven of a protein purification system, which includes a refrigeration mechanism 10 and a heating mechanism 20.

Wherein, heating mechanism 20 fixed connection is inside refrigerating mechanism 10, and refrigerating mechanism 10 is used for refrigerating, and heating mechanism 20 is used for heating to control the temperature of chromatographic column, improve the efficiency and the quality of protein purification.

Referring to fig. 1, 2 and 3, the refrigeration mechanism 10 includes an insulation can 110, a motor 120, fan blades 130, a refrigeration system 140, support plates 150, an adjusting assembly 160 and a temperature sensor 170, one side of the insulation can 110 is an open structure, the motor 120 is connected to the inner wall of the insulation can 110, specifically, the motor 120 is fixedly connected to the inner wall of the insulation can 110 through screws, the fan blades 130 are installed on the output shaft of the motor 120, specifically, the fan blades 130 are fixedly installed on the output shaft of the motor 120 through welding, the refrigeration system 140 and the temperature sensor 170 are connected to the inner wall of the insulation can 110, specifically, the refrigeration system 140 and the temperature sensor 170 are fixedly connected to the inner wall of the insulation can 110 through screws, the two support plates 150 are symmetrically installed on the inner wall of the insulation can 110, specifically, the two support plates 150 are symmetrically installed on the inner wall of the insulation can 110 through welding, threads of the adjusting assembly 160 penetrate through the support plates 150, and the motor 120 is used for driving the fan blades 130 to rotate, make flabellum 130 produce from the bottom up and blow, refrigerating system 140 is used for refrigerating, and refrigerating system 140 is located insulation can 110 top, because air conditioning density is big, can the downward transmission, can be full of whole insulation can 110 with air conditioning fast for the cooling rate of chromatography post, adjusting part 160 is used for pressing from both sides tight chromatography post, improves the stability of chromatography post, and temperature sensor 170 is used for detecting the temperature of insulation can 110, the real time monitoring chromatography post body 250's of being convenient for temperature.

In some specific embodiments, refrigerating system 140 one end runs through to extend to the insulation can 110 outside through the pipe, insulation can 110 opening side rotates and is connected with chamber door 190, specifically, insulation can 110 opening side rotates and is connected with chamber door 190 through the hinge, chamber door 190 and insulation can 110 opening side are provided with sealed the pad, specifically, sealed pad is the rubber pad, chamber door 190 one side fixedly connected with handle, insulation can 110 one end fixedly connected with supporting leg 180, supporting leg 180 sets up to four, chamber door 190 is used for the opening side of sealed insulation can 110, the leakproofness of improvement insulation can 110, the handle is used for people to conveniently open or close chamber door 190.

Referring to fig. 2, 4, 5, and 6, the adjusting assembly 160 includes a threaded rod 161, an i-shaped block 162, a bracket 163, a first clamping block 164, and a handle 165, a threaded hole is formed in the inner surface of the supporting plate 150, the threaded rod 161 is threaded through the threaded hole, the i-shaped block 162 is connected to one end of the threaded rod 161, specifically, the i-shaped block 162 is fixedly connected to one end of the threaded rod 161 by welding, the bracket 163 is rotatably connected to the i-shaped block 162, the first clamping block 164 is installed at one end of the bracket 163, specifically, the first clamping block 164 is fixedly installed at one end of the bracket 163 by welding, the handle 165 is connected to the other end of the threaded rod 161, and specifically, the handle 165 is fixedly connected to the other end of the threaded rod 161 by welding.

In some specific embodiments, the bracket 163 is a U-shaped structure, the inner surface of the bracket 163 is provided with a first through hole, the i-shaped block 162 is in clearance fit with the first through hole, the first clamping block 164 is an arc-shaped structure, the two first clamping blocks 164 are located at two sides of the chromatographic column body 250, the handle 165 is used for driving the threaded rod 161 to rotate, the threaded rod 161 drives the first clamping block 164 to rotate through the i-shaped block 162 and the bracket 163 in the horizontal movement process, so that the first clamping block 164 cannot rotate, the chromatographic column body 250 is conveniently fixed, and the first through hole is used for enabling the i-shaped block 162 to only drive the bracket 163 to horizontally move and not rotate in the rotation process.

Referring to fig. 1, 2 and 5, the heating mechanism 20 includes a support plate 210, a sleeve 220, a clamping assembly 230, a chromatography column body 250, an electric heating block 260 and two stoppers 270, the support plate 210 is connected to the inner wall of the thermal insulation box 110, specifically, the support plate 210 is fixedly connected to the inner wall of the thermal insulation box 110 by welding, the sleeve 220 is installed on one side of the support plate 210, specifically, the sleeve 220 is fixedly installed on one side of the support plate 210 by welding, the inner wall of the sleeve 220 is fixedly connected with a buffer 240, specifically, the buffer 240 is a rubber pad, the chromatography column body 250 is disposed on the buffer 240, the clamping assembly 230 is symmetrically connected to the inner wall of the sleeve 220, the adjusting assembly 160 and the clamping assembly 230 are attached to the outer surface of the chromatography column body 250, the electric heating block 260 is connected to the other side of the support plate 210, specifically, the electric heating block 260 is fixedly connected to the other side of the support plate 210 by screws, and the two stoppers 270 are symmetrically installed on the other side of the support plate 210, two dogs 270 pass through welded fastening symmetry and install in the extension board 210 opposite side, and sleeve 220 and clamping component 230 are used for fixing a position chromatography column body 250, make chromatography column body 250 be convenient for install, and dog 270 is used for leading the hot-air that produces electric heat piece 260 to flow, and the hot-air of being convenient for upwards flows for chromatography column body 250's programming rate.

Referring to fig. 6, 7 and 8, the clamping assembly 230 includes a spring 231, a second clamping block 232, a round bar 233 and a limiting rod 234, the spring 231 is connected to two sides of the inner wall of the sleeve 220, specifically, the spring 231 is connected to two sides of the inner wall of the sleeve 220 by welding, the second clamping block 232 is installed at one end of the spring 231, specifically, the second clamping block 232 is installed at one end of the spring 231 by welding, one end of the round bar 233 is connected to one side of the second clamping block 232, specifically, one end of the round bar 233 is connected to one side of the second clamping block 232 by welding, a second through hole is formed in the inner surface of the sleeve 220, the round bar 233 slidably penetrates through the second through hole, the limiting rod 234 is installed at the other end of the round bar 233, and specifically, the limiting rod 234 is installed at the other end of the round bar 233 by welding.

In some specific embodiments, the second clamping block 232 is an arc-shaped structure, two second clamping blocks 232 are attached to two sides of the chromatographic column body 250, the electric heating block 260 is a conical structure, the inner surface of the support plate 210 is provided with heat conduction holes 280, the heat conduction holes 280 are located on two sides of the electric heating block 260, the elastic force of the spring 231 clamps the bottom of the chromatographic column body 250 through the second clamping block 232, the chromatographic column body 250 is conveniently positioned, the stability of the chromatographic column body 250 is improved, the round bar 233 is used for improving the stability of the second clamping block 232, the conical structure of the electric heating block 260 and the heat conduction holes 280 facilitate the heat generated by the electric heating block 260 to flow to the upper side along with the blowing generated by the fan blade 130, and the heating speed is improved.

The working principle of the device is as follows: the box door 190 is opened, the second clamping block 232 is moved outwards, the bottom of the chromatographic column body 250 is placed on the buffer pad 240 in the sleeve 220, the second clamping block 232 is loosened, the bottom of the chromatographic column body 250 is clamped through the second clamping block 232 by the elastic force of the spring 231, then the handle 165 is screwed, the threaded rod 161 is driven to rotate by the handle 165, the threaded rod 161 drives the I-shaped block 162 to move through the threaded hole, the I-shaped block 162 drives the first clamping block 164 to move through the bracket 163, the upper portion of the chromatographic column body 250 is clamped by the first clamping block 164, the stability of the chromatographic column body 250 is improved, then the box door 190 is closed, the temperature in the incubator 110 is detected through the temperature sensor 170, when the temperature in the incubator 110 is higher than the set temperature, the refrigeration system 140 is opened, the density of cold air generated by the refrigeration system 140 is higher than the density of hot air, the cold air can rapidly flow from the top of the incubator 110 to the bottom of the incubator 110, and the chromatographic column body 250 is rapidly cooled, when the temperature is less than the set temperature in insulation can 110, open electric heat piece 260 and motor 120, electric heat piece 260 can produce the heat, motor 120 can drive flabellum 130 and rotate, produce the blowing from the bottom up, the heat that makes electric heat piece 260 produce flows to whole insulation can 110 in fast, heat chromatography column body 250, thereby reached the effectual purpose of temperature control system temperature control, through inside rapid heating up or cooling, the control speed of messenger is fast, the temperature control is accurate, the difficult change that influences the chromatography column temperature of external environment, the quality of protein purification has been improved.

It should be noted that the specific model specifications of the motor 120, the fan blade 130, the refrigeration system 140, the threaded rod 161, the i-shaped block 162, the first clamping block 164, the handle 165, the temperature sensor 170, the spring 231, the second clamping block 232, the chromatography column body 250, and the electric heating block 260 need to be determined by model selection according to the actual specification of the device, and the specific model selection calculation method adopts the prior art in the field, and therefore, detailed description is omitted.

The power supply and the principle of the motor 120, the refrigeration system 140, the temperature sensor 170 and the electric heating block 260 will be apparent to those skilled in the art and will not be described in detail herein.

The above description is only an example of the present application and is not intended to limit the scope of the present application, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, improvement and the like made within the spirit and principle of the present application shall be included in the protection scope of the present application. It should be noted that: like reference numbers and letters refer to like items in the following figures, and thus, once an item is defined in one figure, it need not be further defined and explained in subsequent figures.

The above description is only for the specific embodiments of the present application, but the scope of the present application is not limited thereto, and any person skilled in the art can easily conceive of the changes or substitutions within the technical scope of the present application, and shall be covered by the scope of the present application. Therefore, the protection scope of the present application shall be subject to the protection scope of the claims.

Claims

1. A temperature control system of a column incubator of a protein purification system is characterized by comprising

The refrigerating mechanism (10), the refrigerating mechanism (10) includes an insulation can (110), a motor (120), fan blades (130), a refrigerating system (140), supporting plates (150), an adjusting component (160) and a temperature sensor (170), one side of the insulation can (110) is of an open structure, the motor (120) is connected to the inner wall of the insulation can (110), the fan blades (130) are installed on an output shaft of the motor (120), the refrigerating system (140) and the temperature sensor (170) are connected to the inner wall of the insulation can (110), the two supporting plates (150) are symmetrically installed on the inner wall of the insulation can (110), and the adjusting component (160) penetrates through the supporting plates (150) in a threaded manner;

the heating mechanism (20), the heating mechanism (20) includes a support plate (210), a sleeve (220), a clamping assembly (230), a chromatographic column body (250), an electric heating block (260) and a stop block (270), the support plate (210) is connected to the inner wall of the heat preservation box (110), the sleeve (220) is installed on one side of the support plate (210), a cushion pad (240) is fixedly connected to the inner wall of the sleeve (220), the chromatographic column body (250) is arranged on the cushion pad (240), the clamping assembly (230) is symmetrically connected to the inner wall of the sleeve (220), the adjusting assembly (160) and the clamping assembly (230) are attached to the outer surface of the chromatographic column body (250), the electric heating block (260) is connected to the other side of the support plate (210), and the two stop blocks (270) are symmetrically installed on the other side of the support plate (210).

2. The column oven temperature control system of claim 1, wherein one end of the refrigeration system (140) extends through the conduit to the outside of the thermal insulation box (110).

3. The temperature control system of the column incubator of the protein purification system according to claim 1, wherein the adjusting assembly (160) comprises a threaded rod (161), an I-shaped block (162), a bracket (163), a first clamping block (164) and a handle (165), a threaded hole is formed in the inner surface of the supporting plate (150), the threaded rod (161) penetrates through the threaded hole, the I-shaped block (162) is connected to one end of the threaded rod (161), the bracket (163) is rotatably connected to the I-shaped block (162), the first clamping block (164) is installed at one end of the bracket (163), and the handle (165) is connected to the other end of the threaded rod (161).

4. The temperature control system of a column oven of a protein purification system as claimed in claim 3, wherein the bracket (163) is of a U-shaped structure, the inner surface of the bracket (163) is provided with a first through hole, and the I-shaped block (162) is in clearance fit with the first through hole.

5. The temperature control system according to claim 3, wherein the first clamping blocks (164) are arc-shaped, and two first clamping blocks (164) are located on two sides of the chromatography column body (250).

6. The temperature control system of the column incubator of the protein purification system according to claim 1, wherein the clamping assembly (230) comprises a spring (231), a second clamping block (232), a round rod (233) and a limiting rod (234), the spring (231) is connected to two sides of the inner wall of the sleeve (220), the second clamping block (232) is installed at one end of the spring (231), one end of the round rod (233) is connected to one side of the second clamping block (232), a second through hole is formed in the inner surface of the sleeve (220), the round rod (233) penetrates through the second through hole in a sliding manner, and the limiting rod (234) is installed at the other end of the round rod (233).

7. The temperature control system of the column incubator of the protein purification system as claimed in claim 6, wherein the second clamping blocks (232) are arc-shaped structures, and two of the second clamping blocks (232) are attached to two sides of the chromatography column body (250).

8. The column oven temperature control system of claim 1, wherein the electric heating block (260) has a conical structure, the support plate (210) has heat conduction holes (280) formed in the inner surface thereof, and the heat conduction holes (280) are disposed on both sides of the electric heating block (260).

9. The column oven temperature control system of claim 1, wherein a door (190) is rotatably connected to the open side of the thermal insulation box (110), the door (190) and the open side of the thermal insulation box (110) are provided with sealing gaskets, and a handle is fixedly connected to one side of the door (190).

10. The temperature control system of a column oven of a protein purification system according to claim 1, wherein one end of the heat preservation box (110) is fixedly connected with four support legs (180), and the number of the support legs (180) is four.