CN215428964U

CN215428964U - Take waste gas to collect reation kettle for production of methotrexate disodium salt of function

Info

Publication number: CN215428964U
Application number: CN202121483333.6U
Authority: CN
Inventors: 周杨; 张楠; 蔡利芳
Original assignee: HUZHOU ZHANWANG PHARMACEUTICAL CO Ltd
Current assignee: HUZHOU ZHANWANG PHARMACEUTICAL CO Ltd
Priority date: 2021-07-01
Filing date: 2021-07-01
Publication date: 2022-01-07
Anticipated expiration: 2031-07-01

Abstract

The utility model belongs to the technical field of reaction kettle equipment, and particularly relates to a reaction kettle with a waste gas collecting function for producing methotrexate disodium salt. According to the utility model, the waste gas of the reaction kettle in the production process of the methotrexate disodium salt can be effectively collected by arranging the gas outlet pipe, the waste gas air bag, the T-shaped pipe unit, the three-way valve unit and the bottom plate unit on the kettle body. The utility model has the following advantages: firstly, the two modes of air bag collection and pipeline collection on the reaction kettle are effective, and switching and selection are convenient; secondly, when the air bag collects waste gas, the waste gas is not easy to leak, and the air bag is convenient to transport and store after being bundled and sealed; thirdly, gasbag formula waste gas is collected easy operation high efficiency, and whole waste gas is collected position stability good, and inner structure compactness is high, make things convenient for the dismouting maintenance.

Description

Take waste gas to collect reation kettle for production of methotrexate disodium salt of function

Technical Field

The utility model belongs to the technical field of reaction kettle equipment, and particularly relates to a reaction kettle with a waste gas collecting function for producing methotrexate disodium salt.

Background

The disodium salt of methotrexate is an intermediate of methotrexate which is a drug, and the methotrexate is an antifolate antitumor drug, and the main production method is as follows: 2,4,5, 6-tetraaminopyrimidine and 2, 3-dibromo propionaldehyde are cyclized and then condensed with p-methylamino benzoyl glutamic acid, and in the production process, the chemical equipment mainly used is a reaction kettle.

On the other hand, in the case of producing the disodium salt of methotrexate by mixing in a reaction vessel, exhaust gas is generated, and the exhaust gas is not directly discharged and must be collected and disposed of.

In addition, the position is collected to waste gas on current reation kettle, and its structure mainly has two kinds, and the first kind is the pipeline formula, connects exhaust-gas treatment jar and receives the jar, and the second kind is the gasbag formula, directly collects waste gas, but structure is collected to current gasbag formula waste gas, mostly all has the inconvenient problem of taking off of certain degree, takes off the in-process promptly and can spill not few waste gas, and this is very dangerous.

Therefore, in view of the above, there is an urgent need for an air bag type exhaust gas collecting structure with convenient use and high efficiency, which is used in a reaction kettle for producing disodium methotrexate salt.

Patent publication number is CN 208786388U, and the china utility model patent that bulletins day is 2019.04.26 discloses a chemical industry reation kettle with exhaust-gas treatment function, including the cauldron body, agitator motor, U type pipe and hair-dryer, the agitator motor lower extreme fixedly connected with cauldron body, cauldron body up end left side is equipped with objective, cauldron body up end right side is equipped with the feeding lid, terminal surface central position department fixedly connected with mount about the internal portion of cauldron, the terminal surface is equipped with the ejection of compact lid under the cauldron body, terminal surface fixedly connected with support under the cauldron body, cauldron body right-hand member face top fixedly connected with U type pipe, cauldron body right-hand member face below fixedly connected with hair-dryer, the terminal surface is equipped with out the water plug under the U type pipe, and is equipped with into the water plug directly over going out the water plug.

But the chemical industry reation kettle exhaust-gas treatment structure in this utility model patent, it is inconvenient collects waste gas, and waste gas also leaks gas relatively easily in the collection process, finally can cause great harm to environmental safety and personal health.

SUMMERY OF THE UTILITY MODEL

The utility model provides a reaction kettle with a waste gas collecting function for producing methotrexate disodium salt, which can achieve the aim that the waste gas of the reaction kettle can be effectively collected in the production process of the methotrexate disodium salt in a mode of arranging an air outlet pipe, a waste gas air bag, a T-shaped pipe unit, a three-way valve unit and a bottom plate unit on a kettle body.

The technical scheme adopted by the utility model for solving the problems is as follows: the utility model provides a take waste gas to collect reation kettle for production of methotrexate disodium salt of function, includes the cauldron body, sets up outlet duct on the annular cauldron body board of cauldron body to and waste gas gasbag, still including setting up T type pipe unit that is used for outer exhaust gas piping that links on the outlet duct sets up on the T type pipe unit and be used for installing two waste gas gasbag's three-way valve unit, and set up and be in on the annular cauldron body board surface of cauldron body and be used for supporting two waste gas gasbag's bottom plate unit.

The further preferred technical scheme is as follows: the T-shaped pipe unit comprises a T-shaped pipe main body and a first cutoff valve, wherein one pipe opening of the T-shaped pipe main body is connected with the air outlet pipe, the other pipe opening of the T-shaped pipe main body is connected with the three-way valve unit, and the first cutoff valve is arranged on an open pipe opening of the T-shaped pipe main body and is used for being externally connected with an exhaust gas pipeline.

The further preferred technical scheme is as follows: the three-way valve unit comprises a three-way valve main body arranged on the T-shaped pipe main body and two connecting pipes which are arranged on the three-way valve main body and are respectively used for sleeving and installing two waste gas air bags.

The further preferred technical scheme is as follows: the three-way valve unit is also arranged on the connecting pipe and used for reducing the leakage of waste gas in the waste gas air bag in a mode of injecting air inwards when the waste gas air bag is taken down, and a second cut-off valve arranged on the inflation pipe.

The further preferred technical scheme is as follows: the three-way valve unit further comprises an annular groove which is arranged on the outer annular surface of the connecting pipe and is close to one side of the waste gas air bag, an elastic ring which is arranged on the outer side of the waste gas air bag connecting section and is used for pressing the waste gas air bag on the annular groove, and a binding rope which is arranged on the waste gas air bag connecting section and is used for binding the connecting pipe.

The further preferred technical scheme is as follows: the three-way valve unit further comprises a protruding plate arranged on the outer ring surface of the connecting pipe, a threaded hole arranged on the protruding plate, and a threaded column arranged on the threaded hole and used for connecting the bottom plate unit.

The further preferred technical scheme is as follows: the connection pipe is rotatably adjusted before installation to provide the protruding plate and the base plate unit in parallel.

The further preferred technical scheme is as follows: the bottom plate unit comprises a bottom plate main body arranged on the outer surface of the annular kettle body plate of the kettle body, three vertical plates arranged on the upper surface of the bottom plate main body and used for limiting and fixing two waste gas air bags, and a thread groove arranged on the upper surface of the bottom plate main body and used for inserting and installing the thread column.

The further preferred technical scheme is as follows: the bottom plate unit further comprises an arc-shaped opening which is arranged on the bottom plate main body and used for being attached to the outer surface of the annular kettle body plate of the kettle body.

The further preferred technical scheme is as follows: the bottom plate unit further comprises an arc-shaped plate which is arranged on the arc-shaped opening and used for being connected with the outer surface of the annular kettle body plate of the kettle body.

The utility model has the following advantages: firstly, the two modes of air bag collection and pipeline collection on the reaction kettle are effective, and switching and selection are convenient; secondly, when the air bag collects waste gas, the waste gas is not easy to leak, and the air bag is convenient to transport and store after being bundled and sealed; thirdly, gasbag formula waste gas is collected easy operation high efficiency, and whole waste gas is collected position stability good, and inner structure compactness is high, make things convenient for the dismouting maintenance.

Drawings

FIG. 1 is a schematic structural diagram of the present invention.

FIG. 2 is a schematic view of the position structure of the T-shaped pipe unit in the present invention from the top view.

Fig. 3 is a schematic view of the position structure of the three-way valve unit according to the present invention.

Fig. 4 is a schematic structural view of the base plate unit of the present invention.

Detailed Description

The following description is only a preferred embodiment of the present invention and is not intended to limit the scope of the present invention.

Example (b): as shown in fig. 1, 2,3 and 4, the reaction kettle with the waste gas collecting function for producing the methotrexate disodium salt comprises a kettle body 11, an outlet pipe 12 arranged on an annular kettle body plate of the kettle body 11, a waste gas air bag 13, a T-shaped pipe unit 1 arranged on the outlet pipe 12 and used for being externally connected with a waste gas pipeline, a three-way valve unit 2 arranged on the T-shaped pipe unit 1 and used for installing the two waste gas air bags 13, and a bottom plate unit 3 arranged on the outer surface of the annular kettle body plate of the kettle body 11 and used for supporting the two waste gas air bags 13.

In this embodiment, when the reaction kettle produces methotrexate disodium salt, the generated exhaust gas passes through the outlet pipe 12, the T-shaped pipe unit 1 and the three-way valve unit 2 in sequence, and finally enters the exhaust gas bag 13, so as to ensure a basically effective air bag type exhaust gas collection method, at this time, the T-shaped pipe unit 1 closes a side pipeline, and the three-way valve unit 2 selectively opens a side pipeline, so as to ensure that the two exhaust gas bags 13 can be effectively and alternately used.

On the other hand, when the pipelines on both sides of the three-way valve unit 2 are closed, the pipeline on the side edge is opened by the T-shaped pipe unit 1, and at the moment, the T-shaped pipe unit 1 is connected with an external waste gas pipeline, so that the pipeline type collecting method is effective, the pipeline can be subjected to a plurality of steps of reaction, filtration or recycling operation in the following process according to the mode of the prior art, and finally the emission is up to the standard.

Finally, the bottom plate unit 3 is used for reinforcing and installing the three-way valve unit 2 and supporting and fixing the exhaust gas bag 13.

The T-shaped pipe unit 1 comprises a T-shaped pipe main body 101 with one pipe orifice connected with the gas outlet pipe 12 and the other pipe orifice connected with the three-way valve unit 2, and a first cut-off valve 102 which is arranged on an open pipe orifice of the T-shaped pipe main body 101 and is used for externally connecting an exhaust gas pipeline.

In this embodiment, when the reaction kettle performs the airbag type exhaust gas collection, the first shut-off valve 102 is closed, the T-shaped pipe main body 101 performs a straight-through ventilation operation, and after the three-way valve unit 2 is closed, the first shut-off valve 102 is connected to the exhaust gas collection pipeline and then opened, so that the subsequent pipeline type exhaust gas treatment and collection operation can be performed.

The three-way valve unit 2 includes a three-way valve main body 201 disposed on the T-shaped pipe main body 101, and two connecting pipes 202 disposed on the three-way valve main body 201 and respectively used for mounting two exhaust gas bladders 13 in a sleeved manner.

In this embodiment, the three-way valve body 201 is a common three-way valve, i.e. has three use states: the three-way valve body 201 is configured with two connection pipes 202 and two exhaust gas bags 13, and the two connection pipes 202 and the two exhaust gas bags 13 are not opened, that is, the two connection pipes are opened corresponding to the first shut-off valve 102, so that the three-way valve body is switched to the pipe-type exhaust gas collecting operation.

The three-way valve unit 2 further comprises an inflation pipe 203 which is arranged on the connecting pipe 202 and is used for reducing the leakage of the exhaust gas in the exhaust gas bag 13 by injecting air inwards when the exhaust gas bag 13 is taken down, and a second block valve 204 which is arranged on the inflation pipe 203.

When the opening of the exhaust gas bag 13 is tightened and completely removed, the three-way valve main body 201 needs to be in a completely closed state, but at this time, no matter how fast the tightening action is, a part of harmful exhaust gas is liable to be leaked, so the charging pipe 203 is introduced in the embodiment, that is, in the whole process of tightening and completely removing the opening of the exhaust gas bag 13, air is charged into the charging pipe 203 all the time to prevent the exposure of the exhaust gas, and finally, the amount of the exposed exhaust gas is almost negligible, and of course, the air is charged all the time until the opening of the exhaust gas bag 13 is tightened, because the excessive air is leaked without harm.

On the other hand, when the exhaust gas bag 13 normally collects exhaust gas, the second cut-off valve 204 is in a normally closed state.

The three-way valve unit 2 further includes an annular groove 205 formed on an outer circumferential surface of the connection pipe 202 at a position close to the exhaust gas bag 13, an elastic ring 206 provided outside a connection section of the exhaust gas bag 13 and pressing the exhaust gas bag 13 against the annular groove 205, and a fastening string 207 provided on the connection section of the exhaust gas bag 13 and fastening the connection pipe 202.

In this embodiment, the elastic ring 206 is made of conventional middle elastic rubber, the binding string 207 is a conventional nylon string, the former ensures that the exhaust gas bag 13 does not easily fall off from the connecting pipe 202, the latter is an opening for binding the exhaust gas bag 13, and the annular groove 205 is used to further improve the sealing performance of the elastic binding at the elastic ring 206 to prevent air leakage during the exhaust gas collection process.

The three-way valve unit 2 further includes a protrusion plate 208 provided on an outer circumferential surface of the connection pipe 202, a screw hole 209 provided on the protrusion plate 208, and a screw post 210 provided on the screw hole 209 and connecting the bottom plate unit 3. The connection pipe 202 is rotatably adjusted before installation to arrange the projection plate 208 and the base unit 3 in parallel.

In this embodiment, the connection pipe 202 is screwed and fixed to the bottom plate unit 3 through the protruding plate 208 and the threaded column 210, so as to avoid the problem of skew between the connection pipe 202 and the three-way valve body 201, and ensure that the connection pipe 202 and the three-way valve body 201 can be connected in a high-strength sealing manner.

Before the connection pipe 202 is installed, the protruding plate 208 is always kept parallel to the base unit 3, otherwise the threaded post 210 is not screwed in alignment, and when the connection pipe 202 itself is installed, there is no angle requirement, and it is sufficient to seal with the existing sealing tape.

The bottom plate unit 3 comprises a bottom plate main body 301 arranged on the outer surface of the annular kettle body plate of the kettle body 11, three vertical plates 302 arranged on the upper surface of the bottom plate main body 301 and used for limiting and fixing two exhaust gas air bags 13, and a thread groove 303 arranged on the upper surface of the bottom plate main body 301 and used for inserting and installing the thread column 210. The bottom plate unit 3 further comprises an arc-shaped opening 304 which is arranged on the bottom plate main body 301 and is used for being attached to the outer surface of the annular kettle body plate of the kettle body 11. The bottom plate unit 3 further comprises an arc-shaped plate 305 arranged on the arc-shaped opening 304 and used for connecting the outer surface of the annular kettle body plate of the kettle body 11.

In this embodiment, the arc plate 305 is welded to the bottom plate body 301 as a whole, the arc plate 305 and the outer surface of the annular kettle body plate of the kettle body 11 may be screwed or welded, and the thread groove 303 is used for installing the thread post 210, so that the connection pipe 202 is not easily pulled to incline by the exhaust gas bag 13.

In addition, the three vertical plates 302 are used to sandwich the two exhaust gas bags 13, so as to ensure that the exhaust gas bags 13 have sufficient expansion space and do not fall down from the floor main body 301.

The embodiments of the present invention have been described in detail with reference to the accompanying drawings, but the present invention is not limited to the above embodiments, and various modifications can be made within the knowledge of those skilled in the art without departing from the gist of the present invention. These are non-inventive modifications, which are intended to be protected by patent laws within the scope of the claims appended hereto.

Claims

1. The utility model provides a take waste gas to collect reation kettle is used in methotrexate disodium salt production of function, includes the cauldron body (11), sets up outlet duct (12) on the cauldron body (11) annular cauldron body board to and waste gas gasbag (13), its characterized in that: the waste gas treatment kettle further comprises a T-shaped pipe unit (1) arranged on the gas outlet pipe (12) and used for being externally connected with a waste gas pipeline, a three-way valve unit (2) arranged on the T-shaped pipe unit (1) and used for installing two waste gas air bags (13), and a bottom plate unit (3) arranged on the outer surface of the annular kettle body plate of the kettle body (11) and used for supporting the two waste gas air bags (13).

2. The reaction kettle with the waste gas collecting function for producing the disodium salt of methotrexate according to claim 1, characterized in that: the T-shaped pipe unit (1) comprises a T-shaped pipe main body (101) and a first cut-off valve (102), wherein one pipe opening of the T-shaped pipe main body is connected with the air outlet pipe (12), the other pipe opening of the T-shaped pipe main body is connected with the three-way valve unit (2), and the first cut-off valve (102) is arranged on an open pipe opening of the T-shaped pipe main body (101) and is used for externally connecting an exhaust gas pipeline.

3. The reaction kettle with the waste gas collecting function for producing the disodium salt of methotrexate according to claim 2, wherein: the three-way valve unit (2) comprises a three-way valve main body (201) arranged on the T-shaped pipe main body (101) and two connecting pipes (202) which are arranged on the three-way valve main body (201) and are respectively used for sleeving and installing the two exhaust gas air bags (13).

4. The reaction kettle with the waste gas collecting function for producing the disodium salt of methotrexate according to claim 3, wherein: the three-way valve unit (2) further comprises an inflation pipe (203) which is arranged on the connecting pipe (202) and is used for reducing the leakage of the waste gas in the waste gas air bag (13) in an inward air injection mode when the waste gas air bag (13) is taken down, and a second cut-off valve (204) arranged on the inflation pipe (203).

5. The reaction kettle with the waste gas collecting function for producing the disodium salt of methotrexate according to claim 3, wherein: the three-way valve unit (2) further comprises an annular groove (205) which is arranged on the outer annular surface of the connecting pipe (202) and is close to one side of the exhaust gas air bag (13), an elastic ring (206) which is arranged on the outer side of the connecting section of the exhaust gas air bag (13) and is used for pressing the exhaust gas air bag (13) on the annular groove (205), and a binding rope (207) which is arranged on the connecting section of the exhaust gas air bag (13) and is used for binding the connecting pipe (202).

6. The reaction kettle with the waste gas collecting function for producing the disodium salt of methotrexate according to claim 3, wherein: the three-way valve unit (2) further comprises a protruding plate (208) arranged on the outer annular surface of the connecting pipe (202), a threaded hole (209) arranged on the protruding plate (208), and a threaded column (210) arranged on the threaded hole (209) and used for connecting the bottom plate unit (3).

7. The reaction kettle with the waste gas collecting function for producing the disodium salt of methotrexate according to claim 6, wherein: the connecting pipe (202) is rotationally adjusted before installation for arranging the projecting plate (208) and the base unit (3) in parallel.

8. The reaction kettle with the waste gas collecting function for producing the disodium salt of methotrexate according to claim 6, wherein: the bottom plate unit (3) comprises a bottom plate main body (301) arranged on the outer surface of the annular kettle body plate of the kettle body (11), three vertical plates (302) arranged on the upper surface of the bottom plate main body (301) and used for limiting and fixing two exhaust gas air bags (13), and a thread groove (303) arranged on the upper surface of the bottom plate main body (301) and used for inserting and installing the thread column (210).

9. The reaction kettle with the waste gas collecting function for producing the disodium salt of methotrexate according to claim 8, wherein: the bottom plate unit (3) further comprises an arc-shaped opening (304) which is arranged on the bottom plate main body (301) and used for being attached to the outer surface of the annular kettle body plate of the kettle body (11).

10. The reaction kettle with the waste gas collecting function for producing the disodium salt of methotrexate according to claim 9, wherein: the bottom plate unit (3) further comprises an arc-shaped plate (305) which is arranged on the arc-shaped opening (304) and is used for connecting the outer surface of the annular kettle body plate of the kettle body (11).