CN215308924U - Blood purification device - Google Patents
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- CN215308924U CN215308924U CN202120142047.7U CN202120142047U CN215308924U CN 215308924 U CN215308924 U CN 215308924U CN 202120142047 U CN202120142047 U CN 202120142047U CN 215308924 U CN215308924 U CN 215308924U
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Abstract
The utility model protects a blood purification device, which comprises an oxygenation chamber and a hemofiltration chamber which are integrated into an integrated structure, wherein the oxygenation chamber and the hemofiltration chamber are mutually communicated through a connector, the oxygenation chamber at least comprises a hollow tubular oxygenation shell, a plurality of shunt channels are uniformly distributed on the inner wall of the oxygenation shell at intervals, and all the shunt channels are arranged along the axial direction of the oxygenation shell. The utility model can realize the functions of blood purification and blood carbon dioxide removal, and particularly integrates the oxygenation chamber and the blood filtration chamber into a whole, so that the pre-charging amount of the whole blood path is minimum, the oxygenation chamber and the blood filtration chamber are not required to be connected by a pipeline, the blood inlet and the blood outlet are both provided with threaded lock catches, and the threaded lock catches can realize sealed insertion and connection matched with the blood purification pipeline, so that the blood purification device can be directly combined with the blood purification machine without a transition pipeline, and the interface can be prevented from being pulled off.
Description
Technical Field
The utility model belongs to the field of medical instruments, and particularly relates to a blood purification device.
Background
When Continuous Renal Replacement Therapy (CRRT) is carried out on patients with new coronary pneumonia and similar diseases, particularly extensive metaplasia of both lungs is often accompanied by severe hypercapnia, the patient is found to have obvious carbon dioxide retention when sedating muscle relaxants and mechanical ventilation modes are fully applied, and if full volume balance adjustment, application of a respirator and prone position ventilation are carried out, the hypercapnia of the patient still cannot be improved, and the patient needs to be treated by an external carbon dioxide removal method (ECCO 2R).
At present, China has no blood purification device with the ECCO2R-CRRT function, and particularly has no oxygenation chamber component specially used for removing carbon dioxide. The clinical research on the mode of serially connecting a hemofilter and a membrane oxygenator currently used in cardiac surgery by a blood purification pipeline is going on, so as to achieve the above-mentioned therapeutic purpose, but the following disadvantages exist:
(1) the cardiac surgery membrane oxygenator is suitable for large blood flow and carries some blood path components which cannot be used in the treatment, the volume (pre-charging amount) of a blood path channel is large, and an extracorporeal blood circulation loop occupies a large amount of blood by adding a connecting pipeline;
(2) because the blood path has large volume, the local blood flow rate of the oxygenation chamber is extremely low when the oxygenation chamber is used for blood purification treatment, the utilization rate of the oxygen compression membrane is low, and thrombus is easy to generate;
(3) the interfaces of the cardiac surgical instrument and the blood purification instrument are not matched and need to be connected in a switching way, and the excessive pipeline connection points increase the risk of leakage and falling;
(4) the existing oxygenation chamber exhaust structure is not suitable for the atmospheric flow exhaust requirement of carbon dioxide removal treatment;
(5) assembly prior to use is time consuming.
SUMMERY OF THE UTILITY MODEL
The object of the present invention is to provide a blood purification device to overcome the above technical drawbacks.
In order to solve the technical problems, the utility model provides a blood purification device which comprises an oxygenation chamber and a blood filtration chamber which are integrated into an integrated structure, wherein the oxygenation chamber and the blood filtration chamber are communicated with each other through a connector, the oxygenation chamber at least comprises a hollow tubular oxygenation shell, a plurality of shunt channels are uniformly distributed on the inner wall of the oxygenation shell at intervals, and all the shunt channels are arranged along the axial direction of the oxygenation shell.
Furthermore, an upper cover is hermetically installed at an opening at the top of the oxygenation shell, an air inlet cover is connected to the center of a cover body of the upper cover, an air inlet nozzle is arranged on the air inlet cover, a connector is hermetically installed at an opening at the bottom of the oxygenation shell, an oxygen pressure membrane is arranged in a hollow cavity of the oxygenation shell, plugging glue is filled at the upper end and the lower end of the oxygen pressure membrane, a shell wall of the oxygenation shell close to the upper end plugging glue extends in the radial direction to form a tubular blood inlet, and an annular gap exists between the oxygenation shell where the blood inlet is located and the oxygen pressure membrane.
Preferably, the periphery of the blood inlet is provided with a first annular internal thread lock catch which can be screwed with the artery interface of the blood purification pipeline in a sealing manner, the central axis of the blood inlet is perpendicular to the central axis of the oxygenation housing, and the hollow cavity of the oxygenation housing is communicated with the blood inlet.
Furthermore, oxygenation room still includes inserts the occupy-place core of locating the hollow intracavity of oxygen pressure membrane, and the occupy-place core is hollow tubular structure, and the department that meets between oxygenation shells inner wall, oxygen pressure membrane, the occupy-place core outer wall of blood inlet top is filled to the upper end shutoff glue of oxygen pressure membrane, and wherein the bleed end of occupying-place core contracts to the closed water conservancy diversion awl that is used for the drainage, and the water conservancy diversion awl is just to the hemofiltration room.
Preferably, the air inlet cover is hung at the center of the cover body of the upper cover through a hook and can rotate 360 degrees around the upper cover, and a rubber sealing ring is sleeved at the joint of the upper cover and the air inlet cover.
Further, the connector comprises a drainage tube, the diameter of the drainage tube is divided into a first straight tube section, an expanding section and a second straight tube section along the blood flowing direction, wherein the first straight tube section is hermetically inserted at the bottom of the oxygenation shell, the diameter of the first straight tube section is larger than the outer diameter of the guide cone, and the second straight tube section is hermetically connected with the hemofiltration chamber;
the outer wall of the diameter expanding section extends upwards to form a shell, an annular space for containing carbon dioxide is formed between the shell and the drainage tube, and a plurality of exhaust holes for discharging the carbon dioxide are formed in the shell along the circumferential direction.
Preferably, the hemofiltration chamber at least comprises a hemofiltration shell with a hollow tubular structure, the top opening of the hemofiltration shell is hermetically screwed at the lower end of the connector, the bottom opening of the hemofiltration shell is hermetically provided with a funnel-shaped lower cover, the small-diameter end of the lower cover is used as a bleeding hole, the periphery of the bleeding hole is provided with a second annular internal thread lock catch which can be hermetically screwed with the vein interface of the blood purification pipeline, a hollow cavity of the hemofiltration shell is fully distributed with a cluster-shaped hemofiltration membrane, and the upper end part and the lower end part of the hemofiltration membrane are filled with plugging glue;
the walls of the blood filter housing extend radially to form a tubular filtrate outlet adjacent the connector.
Preferably, the inner wall of the hemofiltration shell is variable-diameter, the inner diameter of the inner wall is divided into an upper section inner diameter, a middle section inner diameter and a lower section inner diameter from top to bottom, the inner diameters of the two end parts are all larger than the inner diameter of the middle section, and the upper section inner diameter refers to the shell where the filtrate outlet is located and above.
Furthermore, the oxygenation shell, the occupation core, the connector, the hemofilter shell and the lower cover are all made of medical grade plastics, the oxygen pressure membrane is made of polypropylene or polymethylpentene or silicon rubber, and the hemofilter membrane is made of polysulfone or polyether sulfone.
The utility model also protects a blood purification method, which at least comprises a blood purification device and comprises the following steps:
clamping the blood purifying device on a blood purifying machine bracket;
connecting the blood inlet with the artery interface of the blood purification pipeline;
connecting the bleeding port with a vein interface of a blood purification pipeline;
connecting the air inlet nozzle with an air source;
starting a peristaltic pump of the blood purifier, enabling blood of a patient to enter an oxygenation chamber through a blood inlet, shunting the blood in a shunting groove of an oxygenation shell, filling the blood into a bundling tube gap of an oxygen compression membrane, enabling oxygen or air-oxygen mixed gas to flow into a hollow fiber capillary of the oxygen compression membrane through an air inlet nozzle, and enabling the blood to exchange oxygen and carbon dioxide on the surface of the oxygen compression membrane;
then the blood enters the hemofiltration chamber through the connector, the blood enters the hollow fiber capillary of the hemofiltration membrane, the excessive moisture and the small molecular solute form filtrate, the filtrate seeps out from the micropores on the wall of the hollow fiber capillary under the action of transmembrane pressure and is finally discharged from a filtrate outlet, and the blood is returned to the patient body through the blood outlet.
The utility model has the following beneficial effects:
(1) the oxygenation chamber and the hemofiltration chamber are integrated into a whole, so that the overall blood circuit precharge volume is minimum, and the pipeline connection is not needed;
(2) the inner wall of the oxygenation shell is provided with a plurality of shunting grooves, and the shunting grooves can enable blood to be uniformly distributed on a peripheral oxygen pressure membrane;
(3) the air inlet cover is hung at the center of the cover body of the upper cover through the hook, and the air inlet cover can rotate 360 degrees, so that the air inlet nozzle can adapt to the arrangement position of an air source in an intensive care unit, and the air inlet pipe is prevented from being folded;
(4) blood purification device's blood inlet and bleeding mouth all designs have the screw thread hasp, can realize through the screw thread hasp with the sealed grafting of blood purification pipeline complex, make blood purification device need not the transition pipeline on the one hand, can directly use with conventional blood purification machine, blood purification pipeline combination, on the other hand can also prevent that the interface from pulling off.
In order to make the aforementioned and other objects of the present invention comprehensible, preferred embodiments accompanied with figures are described in detail below.
Drawings
Fig. 1 is a schematic structural view of a blood purification apparatus.
Fig. 2 is a view from a-a of fig. 1.
Description of reference numerals:
1. an oxygenation chamber;
2. an upper cover;
3. an air intake cover; 3.1, hooking; 3.2 air inlet nozzles;
4. pressing the film with oxygen;
5. an oxygenation housing; 5.1 a first annular internal thread lock catch; 5.2 blood inlet; 5.3 a splitter box;
6. an placeholder core; 6.1 a flow guide cone;
7. plugging glue;
8. a connector; 8.1 exhaust hole; 8.2 a drainage tube;
9. a hemofiltration chamber; 9.1 a filtrate outlet; 9.2 process ports;
10. a blood filtration membrane;
11. a lower cover; 11.1 locking a second annular internal thread; 11.2 bleeding port;
12. a hemofilter housing.
Detailed Description
The following description of the embodiments of the present invention is provided for illustrative purposes, and other advantages and effects of the present invention will become apparent to those skilled in the art from the present disclosure.
In the present invention, the upper, lower, left, and right in the drawings are regarded as the upper, lower, left, and right of the blood purification apparatus described in the present specification.
The exemplary embodiments of the present invention will now be described with reference to the accompanying drawings, however, the present invention may be embodied in many different forms and is not limited to the embodiments described herein, which are provided for complete and complete disclosure of the present invention and to fully convey the scope of the present invention to those skilled in the art. The terminology used in the exemplary embodiments illustrated in the accompanying drawings is not intended to be limiting of the utility model. In the drawings, the same units/elements are denoted by the same reference numerals.
Unless otherwise defined, terms (including technical and scientific terms) used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Further, it will be understood that terms, such as those defined in commonly used dictionaries, should be interpreted as having a meaning that is consistent with their meaning in the context of the relevant art and will not be interpreted in an idealized or overly formal sense.
First embodiment
The embodiment relates to a blood purification device, referring to fig. 1, which comprises an oxygenation chamber 1 and a hemofiltration chamber 9 integrated into an integrated structure, wherein the oxygenation chamber 1 and the hemofiltration chamber are communicated with each other through a connector 8, the oxygenation chamber 1 at least comprises a hollow tubular oxygenation housing 5, a plurality of shunt channels 5.3 are uniformly distributed on the inner wall of the oxygenation housing 5 at intervals, and all the shunt channels 5.3 are arranged along the axial direction of the oxygenation housing 5.
As shown in fig. 1, the upper half part is an oxygenation chamber 1, the lower half part is a blood filter chamber 9, the oxygenation chamber 1 and the blood filter chamber are integrated through a connector 8, blood of a patient firstly enters the oxygenation chamber 1, the blood exchanges oxygen and carbon dioxide in the oxygenation chamber 1, then enters the blood filter chamber 9, and redundant moisture and small molecular substances are discharged under the action of transmembrane pressure, so that carbon dioxide removal and continuous kidney replacement therapy can be realized in the same device.
The working principle of the blood purification device is as follows:
clamping the blood purification device on a blood purification machine bracket, starting a peristaltic pump of the blood purification machine, enabling blood of a patient to enter an oxygenation chamber 1, enabling the blood to flow in a flow dividing groove 5.3, enabling oxygen and carbon dioxide to exchange in the oxygenation chamber 1, enabling the blood to enter a blood filtration chamber 9 through a connector 8, enabling the blood to exchange with filtrate in the blood filtration chamber 9, discharging the filtrate, and enabling the blood to be back transfused into the patient.
The blood exchanges oxygen and carbon dioxide in the oxygenation chamber 1 by the following mechanism:
oxygen enters the blood to be combined with the hemoglobin to form oxygenated hemoglobin, the oxygen partial pressure and oxygen saturation in the blood rise, carbon dioxide diffuses into the hollow fiber capillary from the blood and is discharged out of the oxygenation chamber 1 along with the air flow, the carbon dioxide partial pressure in the blood drops, and the pH value rises.
The structure of the shunt groove 5.3 refers to fig. 2, after entering the oxygenation chamber 1, the blood is fully distributed on the inner wall of the oxygenation housing 5, under the guide of the shunt groove 5.3, the blood is shunted and flows according to the shunt groove 5.3 shown in fig. 2, and as the shunt groove 5.3 is uniformly distributed in the oxygenation housing 5 at intervals, the shunt groove 5.3 can uniformly distribute the blood flow in the oxygen pressing film pad, reduce the blood path resistance and improve the utilization rate of the oxygen pressing film.
Second embodiment
The embodiment relates to a blood purification device, referring to fig. 1, which comprises an oxygenation chamber 1 and a hemofiltration chamber 9 integrated into an integrated structure, wherein the oxygenation chamber 1 and the hemofiltration chamber are communicated with each other through a connector 8, the oxygenation chamber 1 at least comprises a hollow tubular oxygenation housing 5, a plurality of shunt channels 5.3 are uniformly distributed on the inner wall of the oxygenation housing 5 at intervals, and all the shunt channels 5.3 are arranged along the axial direction of the oxygenation housing 5.
As shown in fig. 1, an upper cover 2 is hermetically installed at an opening at the top of an oxygenation housing 5, an air inlet cover 3 is connected to the center of the cover body of the upper cover 2, the air inlet cover 3 is provided with an air inlet nozzle 3.2, a connector 8 is hermetically installed at an opening at the bottom of the oxygenation housing 5, an oxygen pressing membrane 4 is arranged in a hollow cavity of the oxygenation housing 5, plugging glue 7 is filled at the upper end and the lower end of the oxygen pressing membrane 4, a shell wall of the oxygenation housing 5 close to the plugging glue 7 at the upper end extends in the radial direction to form a tubular blood inlet 5.2, and an annular gap exists between the oxygenation housing 5 where the blood inlet 5.2 is located and the oxygen pressing membrane 4.
The air inlet nozzle 3.2 can be firmly inserted into the air inlet hose.
The mechanism of the oxygen-pressed film 4 is as follows:
blood takes place the exchange of oxygen and carbon dioxide on the surface of oxygen pressing membrane 4, and oxygen gets into blood and combines with hemoglobin, forms oxyhemoglobin, and partial pressure of oxygen and oxygen saturation rise in the blood, and carbon dioxide disperses to the hollow fiber capillary from blood in, along with air current discharge oxygenation room 1, and partial pressure of carbon dioxide descends in the blood, and the pH value rises, and then reaches and dispels unnecessary carbon dioxide in the patient's blood, corrects the purpose of blood pH value.
The oxygen pressing film 4 is a multilayer structure film pad for gas exchange, which is formed by weaving a plurality of hollow fiber capillaries, the inside of the hollow fiber capillaries is a gas channel, the tiny gap between the adjacent hollow fiber capillaries is a blood channel, and the walls of the capillaries are fully distributed with nanometer micropores, so that gas can pass through, but water or blood can be blocked.
The oxygen-pressure film 4 may be made of polypropylene, polymethylpentene, or silicone rubber, but is not limited thereto.
The oxygen pressing film 4 is tightly attached to the oxygenation casing 5, and the function of the oxygen pressing film is to uniformly distribute blood in the oxygen pressing film 4.
As shown in fig. 1, the oxygen-containing membrane 4 has the same height as the oxygen-containing housing 5, the ends are flush, and the sealing gel 7 is filled in both ends to seal the blood channel and the gas channel and prevent the blood from leaking into the gas channel.
The blocking glue 7 is preferably a polyurethane blocking glue.
The periphery of the blood inlet 5.2 is provided with a first annular internal thread lock catch 5.1 which can be screwed with the artery interface of the blood purification pipeline in a sealing way, the central axis of the blood inlet 5.2 is vertical to the central axis of the oxygenation shell 5, and the hollow cavity of the oxygenation shell 5 is communicated with the blood inlet 5.2.
The blood inlet 5.2 can be inserted into an artery interface screwed on the blood purification pipeline through the first annular internal thread lock catch 5.1 to form sealing fit, it should be noted that the threads of the interfaces screwed with each other are matched, for example, the artery interface is a 6:100 internal cone interface, then the first annular internal thread lock catch 5.1 is an external cone interface with the outer wall inclination of 6:100, so that the design can prevent the interface from being pulled off on one hand, and on the other hand, the blood inlet can be directly used with the blood purification pipeline without a transition pipeline.
Referring to fig. 1, the oxygenation chamber 1 further comprises an occupying core 6 inserted in the hollow cavity of the oxygen pressing membrane 4, the occupying core 6 is a hollow tubular structure, an upper end plugging glue 7 of the oxygen pressing membrane 4 is filled in a joint between the inner wall of the oxygenation shell 5 above the blood inlet 5.2, the oxygen pressing membrane 4 and the outer wall of the occupying core 6, wherein a bleeding end of the occupying core 6 is contracted into a closed flow guide cone 6.1 for drainage, and the flow guide cone 6.1 is opposite to the hemofiltration chamber 9.
As a preferred configuration, the tubular end of the space-occupying core 6 is a closed hemispherical flow-guiding cone 6.1 for drainage, as shown in fig. 1, the flow-guiding cone 6.1 facing the hemofilter 9 for the purpose of guiding blood into the hemofilter 9.
The occupying core 6 is used for drainage and shunt, and the specific working principle is as follows:
the blood of a patient enters the oxygenation chamber 1 from the blood inlet 5.2, part of the blood is directly filled in the gap of the outer wall of the hollow fiber capillary tube of the oxygen pressing film 4, part of the blood enters the diversion channel 5.3, the structure of the diversion channel 5.3 is shown in fig. 2, the blood is divided into a plurality of strands to flow along the diversion channel 5.3, and the diversion channel 5.3 is tightly attached to the inner surface of the oxygen pressing film 4, so that the blood is uniformly distributed on the oxygen pressing film 4 through the diversion channel 5.3, meanwhile, oxygen or air-oxygen mixed gas flows into the hollow fiber capillary tube of the oxygen pressing film 4 from the air inlet nozzle 3.2, the blood exchanges oxygen and carbon dioxide on the surface of the oxygen pressing film 4, the blood which is oxygenated and removed with carbon dioxide enters the blood filter chamber 9, the circulation process is maintained, and the purpose of reducing the partial pressure of carbon dioxide in the whole blood of the patient is achieved.
The diameter that occupies 6 adjacent water conservancy diversion awl 6.1 one end of core reduces than the membrane pad internal diameter of oxygen pressure membrane 4, and the splitter box 5.3 makes the blood fluid evenly distributed of business turn over oxygen pressure membrane 4 membrane pad, improves the gas exchange area utilization ratio of oxygen pressure membrane 4 to make partial blood flow get into oxygen pressure membrane 4 membrane pad middle section fast, reduce the blood stream resistance, reduce the blood cell and destroy.
The joint of the upper cover 2 and the air inlet cover 3 is sleeved with a rubber sealing ring to avoid gas leakage.
The top of the oxygenation housing 5 is hermetically bonded with the upper cover 2.
The air intake cover 3 and the upper cover 2 are not limited to be hooked, and for example, the air intake cover 3 is fixed to the upper cover 2, or other forms.
The connector 8 is used for integrating the oxygenation chamber 1 and the hemofiltration chamber 9 into a whole, the connector 8 comprises a drainage tube 8.2, the diameter of the drainage tube 8.2 is divided into a first straight tube section, an expanding section and a second straight tube section along the blood flowing direction, the first straight tube section is hermetically inserted in the lower half section of the oxygenation shell 5, the diameter of the first straight tube section is larger than the outer diameter of the flow guide cone 6.1, and the second straight tube section is hermetically connected with the hemofiltration chamber 9.
The connector 8 is preferably, but not limited to, an inverted cone structure as shown in fig. 1.
The outer wall of the diameter expansion section of the drainage tube 8.2 extends upwards to form a shell, an annular space for containing carbon dioxide is formed between the shell and the drainage tube 8.2, and a plurality of exhaust holes 8.1 for discharging the carbon dioxide are formed in the shell along the circumferential direction.
As shown in fig. 1, the connector 8 is a double-layer shell structure, and the interlayer (annular space) is used for accommodating carbon dioxide, and the carbon dioxide in the interlayer can be discharged through the vent hole 8.1, so that the carbon dioxide in blood can be removed and discharged.
The blood enters the hemofilter chamber 9 along the guide cone 6.1 and the drainage tube 8.2.
Referring to fig. 1, the hemofiltration chamber 9 at least includes a hemofiltration casing 12 of a hollow tubular structure, the top opening of the hemofiltration casing 12 is hermetically screwed to the second straight tube section of the drainage tube 8.2, the bottom opening of the hemofiltration casing 12 is hermetically mounted with a funnel-shaped lower cover 11, the small diameter end of the lower cover 11 serves as a blood outlet 11.2, the periphery of the blood outlet 11.2 is provided with a second annular internal thread lock catch 11.1 which can be hermetically screwed to a vein interface of a blood purification pipeline, a hollow cavity of the hemofiltration casing 12 is fully distributed with a bunched hemofiltration membrane 10, the upper and lower end portions of the hemofiltration membrane 10 are both filled with plugging glue 6, the plugging glue 6 completely fills a membrane bundle gap of the section of hemofiltration membrane 10, and separates a filtrate channel outside the hemofiltration membrane 10 from an internal blood channel.
The blood outlet 11.2 can be inserted into a vein interface screwed to the blood purification pipeline through the second annular internal thread lock catch 11.1 to form sealing fit, it should be noted that the threads of the interfaces screwed to each other are matched, for example, the vein interface is a 6:100 internal cone interface, then the second annular internal thread lock catch 11.1 is an external cone interface with the outer wall inclination of 6:100, so that the design can prevent the interface from being pulled off on one hand, and on the other hand, the blood outlet can be directly combined with the blood purification pipeline without a transition pipeline.
The blood filter membrane 10 is a polysulfone hollow fiber capillary tube in a cluster shape, the interior of the blood filter membrane is a blood channel, the exterior of the blood filter membrane is a filtrate channel (or a dialysate channel), and the wall of the capillary tube is fully distributed with nano-scale micropores, so that small and medium molecular weight substances such as water, urea, creatinine, inulin, myoglobin and the like can pass through the capillary tube, but large molecular weight substances such as albumin and the like or blood cells can be prevented from passing through the capillary tube.
The walls of the hemofilter housing 12 extend radially to form a tubular filtrate outlet 9.1, the filtrate outlet 9.1 being adjacent the connector 8.
The filtrate outlet 9.1 is a hansen interface and can be firmly and hermetically connected with the quick pipeline interface.
The technical port 9.2 is used for ventilating and drying the filter membrane and is in a blocking state in the using process
The inner wall of the hemofiltration shell 12 is variable-diameter, the inner diameter of the inner wall is divided into an upper section inner diameter, a middle section inner diameter and a lower section inner diameter from top to bottom, the inner diameters of the two end parts are all larger than the inner diameter of the middle section, wherein the upper section inner diameter refers to the shell where the filtrate outlet 9.1 is located and above, and the inner wall of the middle section is tightly attached to the hemofiltration membrane 10.
The middle section inner wall of the hemofilter shell 12 extends towards both ends respectively, the upper end extension part and the upper section inner wall of the hemofilter shell 12 form a first annular groove, the lower end extension part and the lower section inner wall of the hemofilter shell 12 form a second annular groove, and the two annular grooves are used for discharging the filtrate more smoothly, so that the utilization rate of the hemofilter membrane 10 is improved.
Since the blood purification device is a medical instrument, the oxygenation housing 5, the space occupying core 6, the connector 8, the hemofiltration housing 12 and the lower cover 11 are all made of medical grade plastics, such as medical grade polycarbonate, the oxygen pressure membrane 4 is made of polypropylene or polymethylpentene or silicone rubber, and the hemofiltration membrane 10 is made of polysulfone or polyethersulfone, or is replaced by a dialysis membrane with only a dialysis function.
Third embodiment
The embodiment provides a blood purification method, which at least comprises a blood purification device and specifically comprises the following steps:
clamping the blood purifying device on a blood purifying machine bracket;
connecting the blood inlet 5.2 with the artery interface of the blood purification pipeline;
connecting the bleeding port 11.2 with a vein interface of a blood purification pipeline;
connecting the air inlet nozzle 3.2 with an air source;
starting a peristaltic pump of the blood purifier, enabling blood of a patient to enter an oxygenation chamber 1 through a blood inlet 5.2, enabling the blood to be shunted in a shunt groove 5.3 of an oxygenation shell 5, filling the blood into a bundling tube gap of an oxygen pressing film 4, enabling oxygen or air-oxygen mixed gas to flow into a hollow fiber capillary of the oxygen pressing film 4 through an air inlet nozzle 3.2, and enabling the blood to exchange oxygen and carbon dioxide on the surface of the oxygen pressing film 4;
then the blood enters the hemofiltration chamber 9 through the connector 8, the blood enters the hollow fiber capillary of the hemofiltration membrane 10, the excessive moisture and the micromolecule solute form filtrate, the filtrate is exuded from the micropores of the wall of the hollow fiber capillary under the action of transmembrane pressure and is finally discharged from the filtrate outlet 9.1, and the blood is returned to the patient body through the blood outlet 11.2.
When CRRT is the filtration therapy mode, the blood purification method is as follows:
B01.
the blood inlet 5.2 is connected with the artery interface of the blood purification pipeline, the blood outlet 11.2 is connected with the vein interface of the blood purification pipeline, the air inlet nozzle 3.2 is connected with an air source (oxygen or air-oxygen mixture), and the filtrate outlet 9.1 is connected with the filtrate pipeline, so that the blood purification device and the blood purification pipeline form a circulating system.
B02.
The blood purification device is clamped on the blood purification machine bracket, so that the movable and static vessels of the blood purification pipeline are connected with the blood vessel of a patient through the cannula after exhausting.
B03.
Blood of a patient enters the oxygenation chamber 1 from the blood inlet 5.2 under the driving of a peristaltic pump of a blood purifier, the blood is shunted in a shunt groove 5.3 of the oxygenation shell 5 and is filled in gaps on the outer surfaces of hollow fibers of the oxygen compression membrane 4, oxygen or air-oxygen mixture flows into hollow fiber capillaries of the oxygen compression membrane 4 through the air inlet nozzle 3.2, the blood exchanges oxygen and carbon dioxide on the surface of the oxygen compression membrane 4, the oxygen enters the blood and is combined with hemoglobin to form oxygenated hemoglobin, the oxygen partial pressure and oxygen saturation in the blood rise, the carbon dioxide diffuses into the hollow fiber capillaries from the blood and is discharged out of the oxygenation chamber 1 along with air flow, the carbon dioxide partial pressure in the blood drops, and the pH value rises.
B04.
Oxygenated and carbon dioxide removed blood passes from the oxygenation chamber 1 through the connector 8 into the hemofiltration chamber 9 where it enters the hollow fiber capillaries of the hemofiltration membrane 10.
B05.
The filtrate is driven by a peristaltic pump to flow outside the hollow fiber capillary of the blood filter membrane 10, the water and inflammatory media in the blood are transferred from the inside of the fiber membrane to the outside of the membrane through the convection action, the concentration of the inflammatory media is reduced, the redundant water is discharged, the tissue edema is eliminated, the treated blood is returned to the human body through the blood outlet 11.2, the circulation process is maintained, and the purposes of reducing the partial pressure of carbon dioxide in the whole blood of the patient and continuously purifying the blood are achieved.
Fig. 1 shows the oxygenation chamber 1 and the hemofilter chamber 9 assembled axially in series, but this is not limiting and parallel mounting arrangements may be used, or other arrangements may be used.
In summary, the blood purification method provided by the utility model can realize the blood purification function and the blood carbon dioxide removal function, and particularly integrates the oxygenation chamber and the blood filtration chamber into a whole, so that the overall blood circuit precharge volume is minimum, the oxygenation chamber and the blood filtration chamber do not need to be connected through a pipeline, the blood inlet and the blood outlet are both provided with threaded latches, and the threaded latches can realize the sealed insertion and connection matched with the blood purification pipeline, so that the blood purification device can be directly used with the blood purification device without a transition pipeline, and the interface can be prevented from being pulled off.
It will be understood by those of ordinary skill in the art that the foregoing embodiments are specific examples for carrying out the utility model, and that various changes in form and details may be made therein without departing from the spirit and scope of the utility model in practice.
Claims (9)
1. The blood purification device is characterized by comprising an oxygenation chamber (1) and a hemofiltration chamber (9) which are integrated into an integrated structure, wherein the oxygenation chamber (1) and the hemofiltration chamber are communicated with each other through a connector (8), the oxygenation chamber at least comprises a hollow tubular oxygenation shell (5), a plurality of shunt channels (5.3) are uniformly distributed on the inner wall of the oxygenation shell (5) at intervals, and all the shunt channels (5.3) are arranged along the axial direction of the oxygenation shell (5).
2. The blood purification device according to claim 1, wherein the top opening of the oxygenation housing (5) is hermetically provided with an upper cover (2), the center of the cover body of the upper cover (2) is connected with the air inlet cover (3), the air inlet cover (3) is provided with an air inlet nozzle (3.2), the bottom opening of the oxygenation housing (5) is hermetically provided with a connector (8), an oxygen pressure membrane (4) is arranged in the hollow cavity of the oxygenation housing (5), the upper end and the lower end of the oxygen pressure membrane (4) are both filled with plugging glue (7), the shell wall of the oxygenation housing (5) close to the upper end plugging glue (7) extends along the radial direction to form a tubular blood inlet (5.2), and an annular gap exists between the oxygenation housing (5) where the blood inlet (5.2) is located and the oxygen pressure membrane (4).
3. A blood purification device as claimed in claim 2, wherein the periphery of the blood inlet (5.2) is provided with a first annular internal thread lock catch (5.1) which can be screwed with the artery interface of the blood purification pipeline in a sealing way, the central axis of the blood inlet (5.2) is perpendicular to the central axis of the oxygenation housing (5), and the hollow cavity of the oxygenation housing (5) is communicated with the blood inlet (5.2).
4. The blood purification device according to claim 3, wherein the oxygenation chamber (1) further comprises an occupying core (6) inserted into the hollow cavity of the oxygen pressing membrane (4), the occupying core (6) is a hollow tubular structure, the upper end plugging glue (7) of the oxygen pressing membrane (4) is filled at the joint of the inner wall of the oxygenation housing (5) above the blood inlet (5.2), the oxygen pressing membrane (4) and the outer wall of the occupying core (6), the bleeding end of the occupying core (6) is contracted into a closed diversion cone (6.1) for drainage, and the diversion cone (6.1) is opposite to the blood filtering chamber (9).
5. The blood purification device according to claim 2, wherein the air inlet cover (3) is hung at the center of the cover body of the upper cover (2) through a hook (3.1), the air inlet cover (3) can rotate 360 degrees around the upper cover (2), and a rubber sealing ring is sleeved at the joint of the upper cover (2) and the air inlet cover (3).
6. A blood purification device according to claim 4, wherein the connector (8) comprises a drainage tube (8.2), and the diameter of the drainage tube (8.2) is divided into a first straight tube section, an expanded diameter section and a second straight tube section along the blood flowing direction, wherein the first straight tube section is inserted at the bottom of the oxygenation housing (5) in a sealing way, the diameter of the first straight tube section is larger than the outer diameter of the guide cone (6.1), and the second straight tube section is connected with the hemofiltration chamber (9) in a sealing way;
the outer wall of the diameter expanding section extends upwards to form a shell, an annular space for containing carbon dioxide is formed between the shell and the drainage tube (8.2), and a plurality of exhaust holes (8.1) for discharging the carbon dioxide are formed in the shell along the circumferential direction.
7. The blood purification device according to claim 6, wherein the blood filtering chamber (9) at least comprises a blood filtering housing (12) with a hollow tubular structure, the top opening of the blood filtering housing (12) is hermetically and rotatably connected to the lower end of the connector (8), the bottom opening of the blood filtering housing (12) is hermetically provided with a funnel-shaped lower cover (11), the small-diameter end of the lower cover (11) is used as a blood outlet (11.2), the periphery of the blood outlet (11.2) is provided with a second annular internal thread lock catch (11.1) which can be hermetically and rotatably connected with a vein interface of the blood purification pipeline, a hollow cavity of the blood filtering housing (12) is fully distributed with a bunchy blood filtering membrane (10), and the upper and lower end parts of the blood filtering membrane (10) are filled with plugging glue (7);
the wall of the hemofilter housing (12) extends radially to form a tubular filtrate outlet (9.1), the filtrate outlet (9.1) being adjacent to the connector (8).
8. A blood purification device according to claim 7, wherein the inner wall of the hemofilter housing (12) is tapered, the inner diameter of the inner wall is divided into an upper inner diameter, a middle inner diameter and a lower inner diameter from top to bottom, the inner diameters of the two end portions are larger than the inner diameter of the middle portion, and the upper inner diameter refers to the housing where the filtrate outlet (9.1) is located and above.
9. A blood purification device according to claim 7, wherein the oxygenation housing (5), the space occupying wick (6), the connector (8), the hemofilter housing (12) and the lower cover (11) are all made of medical grade plastic, the oxygen compression membrane (4) is made of polypropylene or polymethylpentene or silicone rubber, and the hemofilter membrane (10) is made of polysulfone or polyethersulfone.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202120142047.7U CN215308924U (en) | 2021-01-19 | 2021-01-19 | Blood purification device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202120142047.7U CN215308924U (en) | 2021-01-19 | 2021-01-19 | Blood purification device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN215308924U true CN215308924U (en) | 2021-12-28 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202120142047.7U Active CN215308924U (en) | 2021-01-19 | 2021-01-19 | Blood purification device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN215308924U (en) |
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2021
- 2021-01-19 CN CN202120142047.7U patent/CN215308924U/en active Active
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