CN215162267U - Production system of N- (4-fluoroaniline) -2-hydroxy-N-isopropylacetamide - Google Patents
Production system of N- (4-fluoroaniline) -2-hydroxy-N-isopropylacetamide Download PDFInfo
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- CN215162267U CN215162267U CN202121180238.9U CN202121180238U CN215162267U CN 215162267 U CN215162267 U CN 215162267U CN 202121180238 U CN202121180238 U CN 202121180238U CN 215162267 U CN215162267 U CN 215162267U
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- isopropylacetamide
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Abstract
The utility model relates to the technical field of chemical equipment, in particular to a production system of N- (4-fluoroaniline) -2-hydroxyl-N-isopropyl acetamide. The utility model discloses a high pressure reactor, the high pressure reactor top is equipped with the powder dog-house, the pipe connection filter is passed through to the high pressure reactor bottom, and the filter is connected with the reactor through the pipeline, and the reactor is connected with the regulation jar through the pipeline, and the regulation tank deck portion is connected equipment such as through pipeline and extractor, provides one kind and can be applied to the system of production N- (4-fluoroaniline) -2-hydroxy- -N-isopropylacetamide, and the product yield of production is high.
Description
Technical Field
The utility model relates to the technical field of chemical equipment, in particular to a production system of N- (4-fluoroaniline) -2-hydroxyl-N-isopropyl acetamide.
Background
The synthesis of N-aryl-N-isopropyl-2-hydroxyacetamide is an important medical intermediate, but at present, a production system capable of preparing N-aryl-N-isopropyl-2-hydroxyacetamide does not exist.
Disclosure of Invention
The utility model discloses the main technical problem who solves: aiming at the defects, the production system of the N- (4-fluoroaniline) -2-hydroxy-N-isopropylacetamide is provided.
In order to solve the technical problem, the utility model discloses the technical scheme who adopts:
a production system of N- (4-fluoroaniline) -2-hydroxy-N-isopropylacetamide comprises a high-pressure reactor, wherein a powder feeding port is arranged at the top of the high-pressure reactor, the bottom of the high-pressure reactor is connected with a filter through a pipeline, the filter is connected with the reactor through a pipeline, the reactor is connected with an adjusting tank through a pipeline, the top of the adjusting tank is connected with an extractor through a pipeline, the adjusting tank is connected with a secondary reactor through a pipeline, one side of the extractor is connected with the pipeline connecting the adjusting tank with the secondary reactor through a pipeline, the secondary reactor is connected with a delayer through a pipeline, the delayer is connected with a tertiary reactor through a pipeline, the bottom of the tertiary reactor is connected with a distillation tower through a pipeline, the top of the distillation tower is provided with a gas pipe, the gas pipe passes and is equipped with the condenser and is connected with the inlet pipe on the tertiary reactor, the distillation column below is connected with the washing jar through the pipeline, and the washing jar is connected with the atmospheric distillation tower through the pipeline, and atmospheric distillation tower bottom is connected with the vacuum distillation tower through the pipeline.
The high-pressure reactor is provided with a feeding pipe and an air inlet pipe.
And a feeding pipe is arranged on the reactor.
The adjusting tank is connected with an alkali liquor pipe, and the extractor is connected with a toluene pipe.
The layering device is provided with a water inlet pipe, and the washing tank is provided with a water inlet pipe.
The utility model has the advantages that:
the utility model provides a system which can be applied to the production of N- (4-fluoroaniline) -2-hydroxyl-N-isopropyl acetamide and has high yield of the produced product.
Drawings
FIG. 1 is a block diagram of the present invention;
wherein, 1, a high-pressure reactor; 2. a filter; 3. a reactor; 4. a conditioning tank; 5. a secondary reactor; 6.
a delayer; 7. a tertiary reactor; 8. a distillation column; 9. a water washing tank; 10. an atmospheric distillation column; 11. a vacuum distillation column; 12. a powder feeding port; 13. an extractor; 14. a condenser.
Detailed Description
Reference will now be made in detail to the embodiments of the present invention, examples of which are illustrated in the accompanying drawings, wherein like reference numerals refer to the same or similar elements or elements having the same or similar functions throughout. The embodiments described below by referring to the drawings are exemplary and intended to explain the present invention, and should not be construed as limiting the present invention.
As shown in figure 1, the production system of N- (4-fluoroaniline) -2-hydroxy-N-isopropylacetamide comprises a high-pressure reactor 1, wherein a powder feeding port 12 is arranged at the top of the high-pressure reactor 1, the bottom of the high-pressure reactor 1 is connected with a filter 2 through a pipeline, the filter is connected with a reactor 3 through a pipeline, the reactor 3 is connected with a regulating tank 4 through a pipeline, the top of the regulating tank is connected with an extractor 13 through a pipeline, the regulating tank 4 is connected with a secondary reactor 5 through a pipeline, one side of the extractor 13 is connected with the regulating tank 4 and the pipeline of the secondary reactor 5 through a pipeline, the secondary reactor 5 is connected with a delayer 6 through a pipeline, the delayer 6 is connected with a tertiary reactor 7 through a pipeline, the bottom of the tertiary reactor 7 is connected with a distillation tower 8 through a pipeline, the top of the distillation tower 8 is provided with a gas pipe, the gas pipe passes through a feeding pipe which is provided with a condenser 14 and connected with the three-stage reactor 7, the lower part of the distillation tower 8 is connected with a washing tank 9 through a pipeline, the washing tank is connected with an atmospheric distillation tower 10 through a pipeline, and the bottom of the atmospheric distillation tower is connected with a vacuum distillation tower 11 through a pipeline.
The high-pressure reactor 1 is provided with a feeding pipe and an air inlet pipe.
And a feeding pipe is arranged on the reactor 3.
The adjusting tank 4 is connected with an alkali liquor pipe, and the extractor 13 is connected with a toluene pipe.
The layering device 6 is provided with a water inlet pipe, and the washing tank 9 is provided with a water inlet pipe.
The utility model discloses when using, add high pressure reactor with powder raw materials through the powder dog-house, add liquid raw materials through the inlet pipe, then rush into hydrogen through the intake pipe, pressurize to 1.0 ~ 1.2MPa, after the reaction, filter through the filter, the filtrating gets into the reactor, add the reactant through the filling tube, after the reaction, get into the surge tank, add alkali lye through the alkali liquor pipe, the while is stood the layering, the water layer gets into the extractor through the pipeline and is extracted through toluene, the extract liquid gets into the secondary reactor, the organic phase in the surge tank gets into the secondary reactor simultaneously, the secondary reactor feeds in raw materials through the inlet pipe, after through the reaction, get into the layering ware, add into water, carry out the layering, the organic layer gets into the tertiary reactor, the reactant gets into the distillation column and distills, gas passes through the condensation of condenser through the outlet duct on upper portion, and (3) re-entering a three-stage reactor for use, enabling the distillate to enter a water washing tank, dissolving the solid by using water, standing for layering, enabling an organic layer to enter a normal-pressure distillation tower, then entering a vacuum distillation tower, obtaining a light yellow liquid product, and solidifying the light brown crystal at normal temperature.
Although embodiments of the present invention have been shown and described, it is to be understood that the above embodiments are exemplary and should not be construed as limiting the present invention, and that changes, modifications, substitutions and alterations can be made to the above embodiments by those of ordinary skill in the art without departing from the principles and spirit of the present invention.
Claims (5)
1. A production system of N- (4-fluoroaniline) -2-hydroxy-N-isopropylacetamide comprises a high-pressure reactor (1) and is characterized in that a powder feeding port (12) is arranged at the top of the high-pressure reactor (1), the bottom of the high-pressure reactor (1) is connected with a filter (2) through a pipeline, the filter is connected with a reactor (3) through a pipeline, the reactor (3) is connected with an adjusting tank (4) through a pipeline, the top of the adjusting tank is connected with an extractor (13) through a pipeline, the adjusting tank (4) is connected with a secondary reactor (5) through a pipeline, one side of the extractor (13) is connected with a pipeline connecting the adjusting tank (4) and the secondary reactor (5) through a pipeline, the secondary reactor (5) is connected with a delayer (6) through a pipeline, delayer (6) are connected through pipeline and tertiary reactor (7), and tertiary reactor (7) bottom is connected with distillation column (8) through the pipeline, and distillation column (8) top is equipped with the gas pipe, and the gas pipe passes and is equipped with the condenser and is connected with the inlet pipe on tertiary reactor (7), distillation column (8) below is connected through pipeline and washing jar (9), and the washing jar is connected through pipeline and atmospheric distillation tower (10), and atmospheric distillation tower bottom is connected through pipeline and vacuum distillation tower (11).
2. The production system of N- (4-fluoroaniline) -2-hydroxy-N-isopropylacetamide according to claim 1, characterized in that the high-pressure reactor (1) is provided with a feed pipe and an air inlet pipe.
3. The system for the production of N- (4-fluoroaniline) -2-hydroxy-N-isopropylacetamide according to claim 1, characterized in that the reactor (3) is provided with a feed line.
4. The system for producing N- (4-fluoroaniline) -2-hydroxy-N-isopropylacetamide according to claim 1, characterized in that the adjusting tank (4) is connected with a lye pipe, and the extractor (13) is connected with a toluene pipe.
5. The system for producing N- (4-fluoroaniline) -2-hydroxy-N-isopropylacetamide according to claim 1, characterized in that a water inlet pipe is arranged on the delayer (6) and a water inlet pipe is arranged on the water washing tank (9).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202121180238.9U CN215162267U (en) | 2021-05-30 | 2021-05-30 | Production system of N- (4-fluoroaniline) -2-hydroxy-N-isopropylacetamide |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202121180238.9U CN215162267U (en) | 2021-05-30 | 2021-05-30 | Production system of N- (4-fluoroaniline) -2-hydroxy-N-isopropylacetamide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN215162267U true CN215162267U (en) | 2021-12-14 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202121180238.9U Active CN215162267U (en) | 2021-05-30 | 2021-05-30 | Production system of N- (4-fluoroaniline) -2-hydroxy-N-isopropylacetamide |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN215162267U (en) |
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2021
- 2021-05-30 CN CN202121180238.9U patent/CN215162267U/en active Active
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