CN215103325U - Cell culture is with automatic liquid device that trades - Google Patents
Cell culture is with automatic liquid device that trades Download PDFInfo
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- CN215103325U CN215103325U CN202121308520.0U CN202121308520U CN215103325U CN 215103325 U CN215103325 U CN 215103325U CN 202121308520 U CN202121308520 U CN 202121308520U CN 215103325 U CN215103325 U CN 215103325U
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Abstract
The utility model provides a cell culture is with automatic liquid device that trades, including chassis and the culture bottle body of placing two rows of fixed distances on the chassis, the both sides of chassis are fixed with branch respectively, are fixed with the lateral adjustment frame between the top of two branches, and the activity is provided with the sideslip piece in the lateral adjustment frame, and the bottom mounting of sideslip piece has the connecting rod, and the bottom fixedly connected with steering mechanism of connecting rod, steering mechanism's bottom mounting have the extension board, and the bottom surface both sides of extension board are fixed with the spacing respectively, and vertical swing joint has a liquid section of thick bamboo of getting in the spacing. The utility model discloses in the use, utilize sideslip piece lateral shifting in the lateral adjustment frame, the adjustment extension board is in the top of the culture bottle body of different positions, then according to annotating the liquid or getting the operation of liquid, selects a suitable liquid section of thick bamboo of getting, utilizes steering mechanism to adjust its to culture bottle body top, then vertical electric putter descends and operates, utilizes the change of automatic control cell culture in-process cell liquid to get liquid process, economical and practical.
Description
Technical Field
The utility model belongs to the technical field of cell culture is with trading liquid device, concretely relates to cell culture is with automatic liquid device that trades.
Background
Cell culture methods can be roughly divided into two types: one is colony culture, a suspension containing a certain number of cells is placed in a culture bottle, the cells grow in an adherent manner, and a uniform single cell layer is formed after confluence; the other method is clone culture, wherein highly diluted free cell suspension is added into a culture flask, after the cells are attached to the wall, the cells are far away from each other, and each cell grows and proliferates to form a cell colony, which is called clone. All cells in one cell clone were derived from the same progenitor cell. In addition, a rotary drum culture method is designed for preparing cell products, a large-capacity round culture bottle is used, and the round culture bottle continuously rotates in the culture process, so that the cultured cells are always in a suspension state and do not adhere to the wall.
In the cell culture process, the cell sap in the culture flask body needs regular change, takes out old cell sap and pours into new cell sap into to do benefit to the culture of cell, but the cell culture in current laboratory often is that the manual work carries out the exchange of cell sap, and work efficiency is low, and exchange liquid measure control is not exquisite moreover, influences the quality of cell culture.
SUMMERY OF THE UTILITY MODEL
The utility model aims to solve the technical problem that to the not enough of above-mentioned prior art, provide an automatic liquid device that trades for cell culture to solve the problem that proposes in the above-mentioned background art.
In order to solve the technical problem, the utility model discloses a technical scheme is: the utility model provides a cell culture is with automatic liquid device that trades, includes chassis and the two rows of culture flask bodies of fixed distance of placing on the chassis, the both sides of chassis are fixed with branch respectively, two be fixed with the horizontal adjustment frame between the top of branch, the activity is provided with the sideslip piece in the horizontal adjustment frame, the bottom mounting of sideslip piece has the connecting rod, the bottom fixedly connected with steering mechanism of connecting rod, the bottom mounting of steering mechanism has the extension board, the bottom surface both sides of extension board are fixed with the spacing frame respectively, vertical swing joint has a liquid section of thick bamboo of getting in the spacing frame, still be fixed with vertical electric putter in the spacing frame place region in bottom surface of extension board, the telescopic shaft bottom end of vertical electric putter is fixed in the top of getting the liquid section of thick bamboo.
Preferably, the transverse adjusting frame comprises a rectangular frame, a lead screw and a driving motor, two ends of the rectangular frame are fixed between the top ends of the two supporting rods, the lead screw is rotatably connected in the rectangular frame through a bearing seat, the driving motor is fixed on the outer side of the rectangular frame, the driving motor is in transmission connection with the lead screw through a belt pulley and a belt ring, a transverse moving block is in threaded connection with the outer side of the lead screw, a connecting rod is fixed at the bottom end of the transverse moving block, the connecting rod is in sliding connection with the bottom side of the rectangular frame, and the bottom end of the connecting rod extends to the outer side of the rectangular frame.
Preferably, the driving motor is a micro servo motor.
Preferably, the steering mechanism comprises a T-shaped block, a connecting block and a steering motor, a T-shaped cavity is formed in the connecting rod, the T-shaped block is rotatably connected in the T-shaped cavity, the connecting block is fixed to the bottom end of the connecting rod, the steering motor is fixed to the side end of the connecting rod, a gear is fixed to the bottom end of a telescopic shaft of the steering motor, a ring of teeth are formed in the side face of the connecting block, the gear is meshed with the teeth, and the support plate is fixed to the bottom end of the connecting block.
Preferably, the liquid taking cylinder is a liquid taking cylinder capable of automatically extracting liquid.
Preferably, the length of the support plate is not less than the length of the distance between the centers of the circles of the two culture bottle bodies in the same row.
Compared with the prior art, the utility model has the following advantage:
the utility model discloses a be provided with the transverse adjustment frame on the chassis, utilize steering mechanism to be connected with the extension board below the transverse adjustment frame, be provided with two in the extension board and get a liquid section of thick bamboo, in the use, utilize sideslip piece lateral shifting in the transverse adjustment frame, the adjustment extension board is in the top of the culture flask body of different positions, then according to annotating the operation that liquid or got liquid, select the suitable liquid section of thick bamboo of getting, utilize steering mechanism to adjust it to the culture flask body top, then utilize vertical electric push rod to descend to the culture flask is internal to be operated, and is simple and convenient, utilize the change of automated control cell culture in-process cell liquid process of getting, and is economical and practical.
Drawings
FIG. 1 is a side view of the overall structure of the present invention;
FIG. 2 is a top view of the overall structure of the present invention;
FIG. 3 is a schematic view of the internal structure of the lateral adjustment frame of the present invention;
fig. 4 is a schematic view of the connection structure of the steering mechanism of the present invention.
Description of reference numerals:
1-a chassis; 2-a strut; 3-culturing the bottle body; 4-a transverse adjusting frame; 41-rectangular frame; 42-a lead screw; 43-a traverse block; 44-a connecting rod; 45-driving the motor; 5-a steering mechanism; a 51-T block; 52-connecting block; 53-steering motor; 54-gear wheel; 55-teeth; 6-a support plate; 61-vertical electric push rod; 62-a limiting frame; 7-liquid taking cylinder.
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.
As shown in fig. 1-4, the utility model provides a technical solution: the utility model provides a cell culture is with automatic liquid device that trades, includes chassis 1 and places two rows of certain distance's on chassis 1 culture flask 3, and 3 quantity of culture flask set up according to using quantity, and one is equipped with fresh culture solution in two culture flask 3 of one row in the outside, and another is used for collecting the waste liquid.
The both sides of chassis 1 are fixed with branch 2 respectively, two be fixed with horizontal alignment jig 4 between the top of branch 2, horizontal alignment jig 4 includes rectangular frame 41, lead screw 42 and driving motor 45, the both ends of rectangular frame 41 are fixed between the top of two branch 2, utilize branch 2 to install rectangular frame 41 in the culture flask body 3 top.
The inner side of the rectangular frame 41 is rotatably connected with a lead screw 42 through a bearing seat, the driving motor 45 is fixed on the outer side of the rectangular frame 41, the driving motor 45 is in transmission connection with the lead screw 42 through a belt pulley and a belt ring, the outer side of the lead screw 42 is in threaded connection with a transverse moving block 43, the bottom end of the transverse moving block 43 is fixed with a connecting rod 44, the connecting rod 44 is in sliding connection with the bottom side of the rectangular frame 41, the transverse moving block 43 can be driven to transversely move by utilizing the rotation of the lead screw 42, and the connecting rod 44 fixed below the transverse moving block 43 can be driven to transversely move in the transverse moving process of the transverse moving block 43.
In order to facilitate accurate control of the number of rotation turns of the lead screw 42, the moving distance of the transverse moving block 43 is controlled, the driving motor 45 is specifically a micro servo motor, the driving motor 45 is controlled to rotate by a controller, and then the transverse space position of the transverse moving block 43 can be accurately adjusted.
The bottom of connecting rod 44 extends to the outside of rectangular frame 41, the bottom fixedly connected with steering mechanism 5 of connecting rod 44, and steering mechanism 5 includes T type piece 51, connecting block 52 and steering motor 53, set up the T die cavity in the connecting rod 44, T type piece 51 rotates and connects in the T die cavity, the bottom mounting of connecting rod 44 has connecting block 52, steering motor 53 fixes the side at connecting rod 44, steering motor 53's telescopic shaft bottom mounting has gear 54, a circle of tooth 55 has been seted up to the side of connecting block 52, meshing connection between gear 54 and the tooth 55, the utilization turns to motor 53 and drives gear 54 and rotates to can drive the rotation of connecting block 52 rather than the meshing connection, accomplish the pivoted operation of connecting block 52.
The support plate 6 is fixed at the bottom end of the connecting block 52, the limiting frames 62 are respectively fixed on two sides of the bottom surface of the support plate 6, the liquid taking cylinders 7 are vertically and movably connected in the limiting frames 62, one of the two liquid taking cylinders is used for extracting fresh culture liquid, and the other is used for extracting waste liquid.
The area of the bottom surface limiting frame 62 of the support plate 6 is also fixed with a vertical electric push rod 61, the bottom end of a telescopic shaft of the vertical electric push rod 61 is fixed at the top end of the liquid taking cylinder 7, the liquid taking cylinder 7 can be driven by the electric push rod 61 to enter the culture bottle body 3, the culture liquid is extracted, the limiting frame 62 enables the liquid taking cylinder 7 to be stable in the up-and-down process, and the use stability of the device is improved.
Get a liquid section of thick bamboo 7 and specifically be the liquid section of thick bamboo of getting of automatic extraction liquid, get the liquid in-process and can also get liquid volume through its accurate control of controller, do benefit to the change effect of accurate control cell culture in-process culture solution.
In order to facilitate the liquid taking cylinders 7 on the two sides to complete the injection of fresh culture solution and the extraction of waste liquid in the culture bottle bodies 3 on the two sides, the length of the support plate 6 is not less than the length of the distance between the circle centers of the two culture bottle bodies 3 in the same row.
In summary, when the culture bottle 3 is used, the culture bottle 3 is cultured, the marking area outside the culture bottle 3 is marked, and the frequency and the quantity of fresh culture solution to be injected and the frequency and the quantity of waste solution to be extracted are preset in the controller according to the type of the cultured cells in the culture bottle 3;
during the operation, utilize sideslip piece 43 lateral shifting in the horizontal adjustment frame 4, adjust extension board 6 in the culture flask 3's of different positions top, then according to annotating the liquid or get the operation of liquid, select the suitable liquid section of thick bamboo of getting, utilize steering mechanism 5 to adjust it to culture flask 3 top, then utilize vertical electric putter 61 to descend and operate in culture flask 3, it is simple convenient, utilize the change of automated control cell culture in-process cell sap to get liquid process, economical and practical.
It is noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (6)
1. The utility model provides a cell culture is with automatic liquid device that trades, includes chassis (1) and places two rows of certain distance's on chassis (1) culture flask body (3), its characterized in that: the liquid taking device is characterized in that supporting rods (2) are fixed on two sides of the underframe (1) respectively, a transverse adjusting frame (4) is fixed between the top ends of the two supporting rods (2), a transverse moving block (43) is movably arranged in the transverse adjusting frame (4), a connecting rod (44) is fixed at the bottom end of the transverse moving block (43), a steering mechanism (5) is fixedly connected at the bottom end of the connecting rod (44), a supporting plate (6) is fixed at the bottom end of the steering mechanism (5), limiting frames (62) are fixed on two sides of the bottom surface of the supporting plate (6) respectively, a liquid taking barrel (7) is vertically and movably connected in the limiting frames (62), a vertical electric push rod (61) is further fixed in the area where the limiting frames (62) on the bottom surface of the supporting plate (6) are located, and the bottom end of a telescopic shaft of the vertical electric push rod (61) is fixed at the top end of the liquid taking barrel (7).
2. The automatic fluid changing device for cell culture according to claim 1, the transverse adjusting frame (4) comprises a rectangular frame (41), a screw rod (42) and a driving motor (45), two ends of the rectangular frame (41) are fixed between the top ends of the two support rods (2), a lead screw (42) is rotatably connected in the rectangular frame (41) through a bearing seat, the driving motor (45) is fixed on the outer side of the rectangular frame (41), and the driving motor (45) is in transmission connection with the lead screw (42) through the action of the belt pulley and the belt ring, the outer side of the screw rod (42) is in threaded connection with a transverse moving block (43), the bottom end of the transverse moving block (43) is fixed with a connecting rod (44), the connecting rod (44) is in sliding connection with the bottom side of the rectangular frame (41), and the bottom end of the connecting rod (44) extends to the outer side of the rectangular frame (41).
3. The automatic fluid changing device for cell culture according to claim 2, wherein the driving motor (45) is a micro servo motor.
4. The automatic liquid changing device for cell culture according to claim 1, wherein the steering mechanism (5) comprises a T-shaped block (51), a connecting block (52) and a steering motor (53), a T-shaped cavity is formed in the connecting rod (44), the T-shaped block (51) is rotatably connected in the T-shaped cavity, the connecting block (52) is fixed at the bottom end of the connecting rod (44), the steering motor (53) is fixed at the side end of the connecting rod (44), a gear (54) is fixed at the bottom end of a telescopic shaft of the steering motor (53), a ring of teeth (55) are formed in the side surface of the connecting block (52), the gear (54) is in meshing connection with the teeth (55), and the support plate (6) is fixed at the bottom end of the connecting block (52).
5. The automatic fluid changing device for cell culture according to claim 1, wherein the fluid taking cylinder (7) is a fluid taking cylinder for automatically drawing fluid.
6. The automatic liquid changing device for cell culture according to claim 1, wherein the length of the support plate (6) is not less than the distance between the centers of the circles of two culture flask bodies (3) in the same row.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202121308520.0U CN215103325U (en) | 2021-06-11 | 2021-06-11 | Cell culture is with automatic liquid device that trades |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202121308520.0U CN215103325U (en) | 2021-06-11 | 2021-06-11 | Cell culture is with automatic liquid device that trades |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN215103325U true CN215103325U (en) | 2021-12-10 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202121308520.0U Expired - Fee Related CN215103325U (en) | 2021-06-11 | 2021-06-11 | Cell culture is with automatic liquid device that trades |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN215103325U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114410451A (en) * | 2022-01-17 | 2022-04-29 | 罗志勇 | Tumor cell culture device for oncology department |
| CN116676173A (en) * | 2023-07-24 | 2023-09-01 | 哈尔滨学院 | Microorganism incubator integrating liquid exchange and sampling |
-
2021
- 2021-06-11 CN CN202121308520.0U patent/CN215103325U/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114410451A (en) * | 2022-01-17 | 2022-04-29 | 罗志勇 | Tumor cell culture device for oncology department |
| CN116676173A (en) * | 2023-07-24 | 2023-09-01 | 哈尔滨学院 | Microorganism incubator integrating liquid exchange and sampling |
| CN116676173B (en) * | 2023-07-24 | 2023-10-17 | 哈尔滨学院 | Microorganism incubator integrating liquid exchange and sampling |
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| Date | Code | Title | Description |
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| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20211210 |