CN215019618U - Gingivitis pharmacology experiment animal model fixing device - Google Patents
Gingivitis pharmacology experiment animal model fixing device Download PDFInfo
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- CN215019618U CN215019618U CN202121327193.3U CN202121327193U CN215019618U CN 215019618 U CN215019618 U CN 215019618U CN 202121327193 U CN202121327193 U CN 202121327193U CN 215019618 U CN215019618 U CN 215019618U
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- Prior art keywords
- rod
- fixing
- gingivitis
- lifting rod
- experiment
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- 238000010171 animal model Methods 0.000 title claims abstract description 54
- 238000002474 experimental method Methods 0.000 title claims abstract description 35
- 208000007565 gingivitis Diseases 0.000 title claims abstract description 24
- 210000003141 lower extremity Anatomy 0.000 claims abstract description 25
- 210000003414 extremity Anatomy 0.000 claims abstract description 12
- 210000003194 forelimb Anatomy 0.000 claims abstract description 12
- 230000000144 pharmacologic effect Effects 0.000 claims abstract description 11
- 230000006835 compression Effects 0.000 claims description 4
- 238000007906 compression Methods 0.000 claims description 4
- 210000000214 mouth Anatomy 0.000 description 18
- 201000010099 disease Diseases 0.000 description 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 9
- 238000011160 research Methods 0.000 description 5
- 238000000034 method Methods 0.000 description 2
- 230000008093 supporting effect Effects 0.000 description 2
- 210000001364 upper extremity Anatomy 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 1
- 208000035977 Rare disease Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 210000004195 gingiva Anatomy 0.000 description 1
- 208000024693 gingival disease Diseases 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 238000010030 laminating Methods 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 230000003239 periodontal effect Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000011552 rat model Methods 0.000 description 1
- 230000010076 replication Effects 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 231100000041 toxicology testing Toxicity 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
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Abstract
The utility model discloses a gingivitis pharmacological experiment animal model fixing device, which comprises an experiment fixing plate, a forelimb fixing rod, a chute, a hindlimb fixing rod and an opening device; the front limb fixing rods are two in number and are respectively and fixedly arranged on two sides of the front end of the experiment fixing plate; the sliding chute is positioned in the rear end of the experiment fixing plate; the hind limb fixing rod is arranged in the sliding groove in a sliding manner; the opening device comprises a fixed rod arranged at the front end of the experiment fixed plate, a rotating ring movably sleeved at the top end of the fixed rod, a telescopic cross rod fixedly installed on the side face of the rotating ring, a lifting rod sleeve vertically installed below the far end of the telescopic cross rod, a lifting rod rotatably sleeved in the lifting rod sleeve, and an adjusting opener installed at the lower end of the lifting rod. In a word, the utility model has the advantages of novel structure, easy operation, fixed effectual.
Description
Technical Field
The utility model belongs to the technical field of the experimental apparatus, in particular to gingivitis pharmacology experiment animal model fixing device.
Background
The gingiva is one of the periodontal tissues, and gum disease is a lesion confined to the gingival tissue, of which gingivitis is the most common. The disease rate and the severity of the disease can be gradually increased along with the increase of the age of the children of 3-5 years old until the peak of the adolescence is reached. Gingivitis is slightly more prevalent in men than women in children. Developing countries and regions are higher than economically developed countries. The preclinical pharmacological study of gingivitis treatment drugs is usually performed by first using animal models, such as experimental rat models.
In preclinical research of new drugs, pharmacological and toxicological studies are generally carried out by adopting animal models. The animal model of human diseases is an animal experimental object and a material with human disease similarity expression established in biomedical scientific research, and compared with clinical research, the advantages of the animal model adopted in preclinical research are mainly represented by avoiding the ethical conflict and risk of human experiments, the replication of multiple rare disease species through the animal model, no human part of diseases, long incubation period, long disease course and low disease incidence, relatively controllable experimental conditions, and relatively simple and convenient experimental operation and sample collection. The animal model of human diseases is an extremely important experimental method and means in modern biomedical research, and is helpful for understanding the occurrence and development rules of human diseases and researching prevention and treatment measures more conveniently and effectively.
At present, though there is the fixing device who is used for experimental animals among the prior art, nevertheless do not have the device that opens the support to experimental animals's oral cavity when fixed experimental animals, so, the utility model designs a gingivitis pharmacology experiment animal model fixing device.
SUMMERY OF THE UTILITY MODEL
The utility model aims at providing a gingivitis pharmacology experiment animal model fixing device, the utility model relates to a rationally, novel structure, it is not high to the operating requirement moreover, can realize carrying out opening of experimental animals oral cavity and supporting in fixed experimental animals, very convenient in pharmacology experiment and observation.
The technical scheme of the utility model is that: a gingivitis pharmacology experiment animal model fixing device comprises:
an experiment fixing plate;
the front limb fixing rods are two in total and are respectively and fixedly arranged on two sides of the front end of the experiment fixing plate;
the sliding chute is positioned inside the rear end of the experiment fixing plate;
the hind limb fixing rod is arranged in the sliding groove in a sliding manner;
the opening device comprises a fixed rod arranged at the front end of an experiment fixed plate, a rotating ring movably sleeved at the top end of the fixed rod, a telescopic cross rod fixedly installed on the side face of the rotating ring, a lifting rod sleeve vertically installed below the far end of the telescopic cross rod, a lifting rod rotatably sleeved in the lifting rod sleeve, and an adjusting opener installed at the lower end of the lifting rod.
Furthermore, fixed sleeves are sleeved on the front limb fixing rod and the rear limb fixing rod in a sliding mode and used for binding and fixing four limbs of the experimental animal, and the distance of the fixed position can be adjusted.
Further, forelimb dead lever, hind limb dead lever all can be folded to with experiment fixed plate edge laminating, convenient storage does not take up an area of, and avoids being broken.
Furthermore, the hind limb fixing rod comprises a sliding rod positioned in the sliding groove and side fixing rods connected to two ends of the sliding rod, the diameter of each side fixing rod is larger than the height of the sliding groove, and the hind limb fixing rods are prevented from falling off from the sliding grooves.
Furthermore, a rack is arranged on the side face of the lifting rod, a gear meshed with the rack is arranged inside the lifting rod sleeve, and a knob used for rotating the gear is further arranged outside the lifting rod sleeve and used for rotating the gear to drive the lifting rod to move up and down, so that the height of the lifting rod is mechanically adjusted, and the operation is convenient.
Furthermore, adjust the mouth gag including installing the control tube of lifter lower extreme and articulate the X type crotch in the control tube inside, be connected with compression spring between two poles of X type crotch upper end, it is equipped with adjust knob to run through on the control tube lateral wall, adjust knob is used for adjusting the angle of opening and shutting of X type crotch, struts experimental animals's oral cavity through X type crotch, conveniently carries out gingivitis pharmacology experiment.
Furthermore, flaring gaskets are respectively arranged on the outer sides of the ends of the two rods at the lower end of the X-shaped fork frame, so that the oral cavity of the experimental animal is prevented from being injured.
The utility model discloses a working method: an experimental animal for gingivitis pharmacological experiment is anesthetized and placed on an experimental fixing plate in a supine position, forelimbs of the experimental animal are respectively bound and fixed on a fixing sleeve of a forelimb fixing rod, then the position of the hind limb fixing rod in the chute is adjusted according to the position of the hind limb of the experimental animal, the hind limb of the experimental animal is respectively fixed on the hind limb fixing rod with the adjusted position, then the rotating ring of the opening device is rotated, the length of the telescopic cross rod is adjusted, the opening adjuster is moved to the upper part of the oral cavity of the experimental animal, the knob of the lifting rod sleeve is rotated, the gear rotates to drive the lifting rod to move up and down, the opening regulator is sent to the inside of the oral cavity of the experimental animal, then the adjusting knob of the mouth gag is adjusted in a rotating mode, so that the opening and closing angle of the X-shaped fork frame is increased, the lower end of the X-shaped fork frame is utilized to prop open the oral cavity of the experimental animal, and therefore gingivitis pharmacological experiments are conveniently carried out.
Compared with the prior art, the beneficial effects of the utility model reside in that: set up the forelimb dead lever of fixed position and the hind limb dead lever that can the adjusting position, can be used for the experimental animals of different sizes to use, and set up fixed cover that can slide on forelimb dead lever and hind limb dead lever, the experimental animals limbs of convenient different limbs length are fixed, and set up can be from top to bottom, the opening device of front and back regulation, will adjust the oral cavity that the mouth gag was put into experimental animals through flexible horizontal pole and lifter, then the support that opens and shuts through the angle of opening and shutting of adjusting X type crotch carries out the oral cavity of experimental animals, easy operation and supporting effect are good, can directly carry out gingivitis pharmacology experiment to experimental animals, and can the visual observation experimental animals gum, need not the oral cavity of repeated experimental animals that opens and shuts. In a word, the utility model has the advantages of novel structure, easy operation, fixed effectual.
Drawings
Fig. 1 is a schematic view of the overall structure of the present invention;
fig. 2 is a top view of the present invention;
fig. 3 is a schematic structural view of the hind limb fixing rod of the present invention;
FIG. 4 is a schematic view of the connection structure of the lifter sleeve and the lifter of the present invention;
fig. 5 is a schematic structural view of the adjustable mouth gag of the present invention.
The device comprises an experimental fixing plate 1, a front limb fixing rod 2, a sliding chute 3, a rear limb fixing rod 4, a sliding rod 41, a side fixing rod 42, a 5-opening device, a fixing rod 51, a rotating ring 52, a telescopic cross rod 53, a lifting rod sleeve 54, a gear 541, a knob 542, a lifting rod 55, a rack 551, an adjustable mouth gag 56, an adjustable tube 561, a fork arm 562-X, a 5621 flaring gasket, a 563 compression spring, an adjustable knob 564 and a fixed sleeve 6.
Detailed Description
The following detailed description of the present invention is provided in conjunction with the accompanying drawings, but it should be understood that the scope of the present invention is not limited by the following detailed description.
Example (b): as shown in fig. 1, a gingivitis pharmacological experiment animal model fixing device comprises: the device comprises an experimental fixing plate 1, a forelimb fixing rod 2, a sliding chute 3, a hindlimb fixing rod 4 and an opening device 5. Wherein, the number of the forelimb fixing rods 2 is two, and the forelimb fixing rods are respectively and fixedly arranged at two sides of the front end of the experiment fixing plate 1; the sliding chute 3 is positioned in the rear end of the experiment fixing plate 1; the hind limb fixing rod 4 is arranged in the sliding chute 3 in a sliding way, the hind limb fixing rod 4 comprises a sliding rod 41 positioned in the sliding chute 3 and side fixing rods 42 connected to two ends of the sliding rod 41, and the diameter of each side fixing rod 42 is larger than the height of the sliding chute 3; the forelimb fixing rod 2 and the hindlimb fixing rod 4 are sleeved with fixing sleeves 6 in a sliding manner and used for binding and fixing four limbs of the experimental animal, and the forelimb fixing rod 2 and the hindlimb fixing rod 4 can be folded to be attached to the edge of the experimental fixing plate 1; the opening device 5 comprises a fixed rod 51 arranged at the front end of the experimental fixed plate 1, a rotating ring 52 movably sleeved at the top end of the fixed rod 51, a telescopic cross rod 53 fixedly arranged on the side surface of the rotating ring 52, a lifting rod sleeve 54 vertically arranged below the far end of the telescopic cross rod 53, a lifting rod 55 rotatably sleeved in the lifting rod sleeve 54, an adjusting opener 56 arranged at the lower end of the lifting rod 55, a rack 551 arranged on the side surface of the lifting rod 55, a gear 541 meshed with the rack 551 arranged in the lifting rod sleeve 54, a knob 542 used for rotating the gear 541 and used for driving the lifting rod 55 to move up and down by rotating the gear 541, the adjusting opener 56 comprises an adjusting pipe 561 arranged at the lower end of the lifting rod 55 and an X-shaped fork frame 562 hinged in the adjusting pipe 561, a compression spring 563 is connected between two rods at the upper end of the X-shaped fork frame 562, and an adjusting knob 564 is arranged on the side wall of the adjusting pipe 561 in a penetrating manner, the adjusting knob 564 is used for adjusting the opening and closing angle of the X-shaped fork 562, and flaring gaskets 5621 are respectively arranged on the outer sides of two rod ends at the lower end of the X-shaped fork 562.
The working method of the above embodiment is as follows: the experimental animal used for gingivitis pharmacological experiment is anesthetized and placed on the experimental fixing plate 1 in a supine position, forelimbs of the experimental animal are respectively bound and fixed on a fixing sleeve 6 of a forelimb fixing rod 2, then the position of the hindlimb fixing rod 4 in a sliding groove 3 is adjusted according to the position of the hindlimb of the experimental animal, hindlimb of the experimental animal is respectively fixed on the hindlimb fixing rod 4 with the adjusted position, the experimental animal can be used for experimental animals with different body types, then a rotating ring 52 of an opening device 5 is rotated, the length of a telescopic cross rod 53 is adjusted, an opening adjuster 56 is moved to the upper part of the oral cavity of the experimental animal, a knob 542 of a lifting rod sleeve 54 is rotated, a lifting rod 55 is driven to move up and down through a gear 541, the opening adjuster 56 is sent to the inside of the oral cavity of the experimental animal, an adjusting knob 564 of the opening adjuster 56 is rotated, so that the opening angle of an X-shaped fork 562 is enlarged, the lower end of the X-shaped fork 562 is utilized to prop open the oral cavity of the experimental animal, thereby facilitating the gingivitis pharmacological experiment.
The concrete model of above-mentioned part is not specially appointed, all can choose for use the ordinary product of market, as long as can satisfy the utility model discloses a user demand can.
The above-mentioned embodiments further illustrate the objects, technical solutions and advantages of the present invention in detail, and it should be understood that the above-mentioned embodiments are only examples of the present invention, and do not limit the present invention, and any modifications, equivalent substitutions, improvements and the like made within the spirit and principle of the present invention are all included in the scope of the present invention.
Claims (7)
1. A gingivitis pharmacology experiment animal model fixing device is characterized by comprising:
an experimental fixing plate (1);
the front limb fixing rods (2) are two in total and are respectively and fixedly arranged on two sides of the front end of the experiment fixing plate (1);
the sliding chute (3) is positioned inside the rear end of the experiment fixing plate (1);
the hind limb fixing rod (4) is arranged in the sliding groove (3) in a sliding manner;
the opening device (5) comprises a fixing rod (51) arranged at the front end of the experiment fixing plate (1), a rotating ring (52) movably sleeved at the top end of the fixing rod (51), a telescopic cross rod (53) fixedly installed on the side face of the rotating ring (52), a lifting rod sleeve (54) vertically installed below the far end of the telescopic cross rod (53), a lifting rod (55) rotatably sleeved in the lifting rod sleeve (54), and an adjusting opener (56) installed at the lower end of the lifting rod (55).
2. The animal model fixing device for gingivitis pharmacological experiment as claimed in claim 1, wherein the fixing rods (2, 4) are slidably sleeved with fixing sleeves (6) for binding and fixing the limbs of the experimental animal.
3. The gingivitis pharmacology experimental animal model fixing device as claimed in claim 1, wherein the forelimb fixing rod (2) and the hindlimb fixing rod (4) can be folded to be attached to the edge of the experimental fixing plate (1).
4. The animal model fixing device for gingivitis pharmacological experiment according to claim 1, wherein the hind limb fixing rod (4) comprises a sliding rod (41) located in the sliding groove (3) and side fixing rods (42) connected to both ends of the sliding rod (41), and the diameter of the side fixing rods (42) is larger than the height of the sliding groove (3).
5. The animal model fixing device for gingivitis pharmacological experiment according to claim 1, wherein a rack (551) is arranged on the side surface of the lifting rod (55), a gear (541) engaged with the rack (551) is arranged inside the lifting rod sleeve (54), and a knob (542) for rotating the gear (541) is further arranged outside the lifting rod sleeve (54) and is used for rotating the gear (541) to drive the lifting rod (55) to move up and down.
6. The gingivitis pharmacology experimental animal model fixing device as claimed in claim 1, wherein the adjusting mouth gag (56) comprises an adjusting tube (561) installed at the lower end of the lifting rod (55) and an X-shaped fork (562) hinged inside the adjusting tube (561), a compression spring (563) is connected between two rods at the upper end of the X-shaped fork (562), an adjusting knob (564) penetrates through the side wall of the adjusting tube (561), and the adjusting knob (564) is used for adjusting the opening and closing angle of the X-shaped fork (562).
7. The gingivitis pharmacology experimental animal model fixing device as claimed in claim 6, wherein flaring gaskets (5621) are respectively arranged on the outer sides of the two rod ends at the lower end of the X-shaped fork (562).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202121327193.3U CN215019618U (en) | 2021-06-15 | 2021-06-15 | Gingivitis pharmacology experiment animal model fixing device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202121327193.3U CN215019618U (en) | 2021-06-15 | 2021-06-15 | Gingivitis pharmacology experiment animal model fixing device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN215019618U true CN215019618U (en) | 2021-12-07 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202121327193.3U Expired - Fee Related CN215019618U (en) | 2021-06-15 | 2021-06-15 | Gingivitis pharmacology experiment animal model fixing device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN215019618U (en) |
-
2021
- 2021-06-15 CN CN202121327193.3U patent/CN215019618U/en not_active Expired - Fee Related
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| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20211207 |