CN214937136U - Tenofovir accuse temperature production line - Google Patents
Tenofovir accuse temperature production line Download PDFInfo
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- CN214937136U CN214937136U CN202121145185.7U CN202121145185U CN214937136U CN 214937136 U CN214937136 U CN 214937136U CN 202121145185 U CN202121145185 U CN 202121145185U CN 214937136 U CN214937136 U CN 214937136U
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Abstract
A tenofovir temperature control production line comprises a first stirring device, a second stirring device and a third stirring device, wherein the first stirring device comprises a temperature control tank body (1), a first stirrer (2), a first thermometer (3) and a second thermometer (4), the top of the temperature control tank body (1) is coated with a cooling jacket (5), the top of the temperature control tank body (1) is provided with a gas adding pipeline (6) and a group of raw material adding pipelines (7), the bottom of the temperature control tank body (1) is provided with a first liquid outlet (8), the bottom of the temperature control tank body (1) is coated with a heating jacket (9), the first stirrer (2) is installed in the temperature control tank body (1), and the first thermometer (3) and the second thermometer (4) are installed on the tank wall of the temperature control tank body (1) in a mirror image distribution manner; the advantages are that: the temperature is adjusted quickly, and the tenofovir raw material reacts fully.
Description
Technical Field
The utility model relates to a pharmaceutical equipment field, concretely relates to tenofovir accuse temperature production line.
Background
At present, the temperature of reactants needs to be changed and kept within a specified range in the production of tenofovir, and the temperature regulation performance of the existing temperature control reaction device is poor, so that the production requirement of a factory cannot be met.
SUMMERY OF THE UTILITY MODEL
The utility model aims to provide a tenofovir temperature control production line aiming at the defects.
The utility model comprises a first stirring device, a second stirring device and a third stirring device,
the first stirring device comprises a temperature control tank body, a first stirrer, a first thermometer and a second thermometer,
the top of the temperature control tank body is coated with a cooling jacket, the top of the temperature control tank body is provided with a gas adding pipeline and a group of raw material adding pipelines, the bottom of the temperature control tank body is provided with a first liquid outlet, the bottom of the temperature control tank body is coated with a heating jacket, a first stirrer is arranged in the temperature control tank body, a first thermometer and a second thermometer are arranged on the tank wall of the temperature control tank body in a mirror image distribution mode, and the detection ends of the first thermometer and the second thermometer are both located in the temperature control tank body;
the second stirring device comprises a reaction kettle body, an eccentric stirrer, a cooling coil, a heating coil and a pair of third thermometers,
the top of the reaction kettle body is provided with an inflation pipeline and a group of feeding pipelines, the bottom of the reaction kettle body is provided with a discharging pipeline, the eccentric stirrer, the cooling coil and the heating coil are annularly and uniformly arranged in the reaction kettle body, the pair of third thermometers are arranged on the side wall of the reaction kettle body in a mirror image manner, and the detection ends of the pair of third thermometers are positioned in the reaction kettle body;
the third stirring device comprises a tank body, a second stirrer, a pair of tube array heat exchange devices and a pair of fourth thermometers,
a group of feeding pipelines are arranged at the top of the tank body, a discharging pipeline is arranged at the bottom of the tank body, a second stirrer is arranged in the tank body,
the tube array heat exchange device comprises a pair of tube plates, a group of heat transfer tubes and a pair of end sockets, wherein the tube plates are in an arc shape matched with the inner wall of the tank body, the group of heat transfer tubes are sequentially arranged and installed between the pair of tube plates, an L-shaped medium conveying pipeline is arranged at the inlet end of the end sockets, the outlet end of the L-shaped medium conveying pipeline is positioned outside the tank body, the pair of end sockets are respectively installed on the corresponding tube plates, a pair of fourth thermometers are arranged on the outer wall of the tank body in a mirror image mode, and the detection ends of the fourth thermometers are both positioned in the tank body;
the first liquid outlet of the temperature control tank body is communicated with one of the feeding pipelines through a pipeline, and the discharging pipeline is communicated with one of the feeding pipelines.
The top of the cooling jacket is provided with a pipeline avoiding groove, a group of raw material adding pipelines are all positioned in the pipeline avoiding groove, the top of the temperature control tank body is provided with a first breather valve, and the first thermometer and the second thermometer are electric contact thermometers.
The cooling jacket is internally filled with water, the cooling jacket is internally provided with a refrigeration evaporator coil, the heating jacket is internally filled with heat-conducting oil, the heating jacket is internally provided with a resistance wire, and the resistance wire is coated with an insulating sleeve.
The temperature control tank body consists of a body and an upper cover, and the upper cover is connected with a flange at the top of the body.
Stop valves are respectively arranged on the gas adding pipeline, the group of raw material adding pipelines and the first liquid outlet.
The outer wall of the reaction kettle body is coated with a heat-insulating layer.
The cooling coil comprises a first spiral pipe and a first vertical liquid conveying pipe, the inlet end of the first vertical liquid conveying pipe is communicated with the outlet end of the bottom of the first spiral pipe, the outlet end of the first vertical liquid conveying pipe and the inlet end of the top of the first spiral pipe are arranged at the top of the reaction kettle body, the inlet end of the top of the first spiral pipe is a cold medium adding port, and the outlet end of the first vertical liquid conveying pipe is a cold medium outlet port;
the heating coil comprises a second spiral pipe and a second vertical liquid conveying pipe, the inlet end of the second vertical liquid conveying pipe is communicated with the bottom outlet end of the second spiral pipe, the outlet end of the second vertical liquid conveying pipe and the top inlet end of the second spiral pipe are arranged at the top of the reaction kettle body, the top inlet end of the second spiral pipe is a heat medium outlet, and the outlet end of the second vertical liquid conveying pipe is a heat medium inlet.
The center of the top of the reaction kettle body is provided with a second breather valve, the pair of third thermometers are electric contact thermometers, the reaction kettle body consists of a body and an upper cover, and the upper cover is connected with a flange at the top of the body; the inflation pipeline, the group of feeding pipelines and the discharging pipeline are respectively provided with a stop valve.
The second agitator is eccentric agitator, and second agitator and a pair of tubulation heat transfer device annular equipartition are installed in the jar internally, and the cladding has the heat preservation on the outer wall of the jar body, and a pair of fourth thermometer is electric contact thermometer, and the jar body comprises body and upper cover, upper cover and body top flange joint.
And the feeding pipeline and the discharging pipeline are respectively provided with a stop valve, one of the tube array heat exchange devices is a tube array cooling device, and the other tube array heat exchange device is a tube array heating device.
The utility model has the advantages that: the temperature is adjusted quickly, and the tenofovir raw material reacts fully.
Description of the drawings
Fig. 1 is a schematic sectional structural view of the first stirring device of the present invention.
Fig. 2 is a schematic structural diagram of the first stirring device of the present invention.
Fig. 3 is a schematic structural view of a second stirring device of the present invention.
Fig. 4 is a schematic sectional view of a second stirring device according to the present invention.
FIG. 5 is a schematic structural view of a reaction vessel body hidden by the second stirring device of the present invention.
Fig. 6 is a schematic sectional view of a third stirring device of the present invention.
Fig. 7 is a schematic structural view of a third stirring device of the present invention.
Fig. 8 is a schematic view of a partially hidden structure of a tank body of a third stirring device of the present invention.
Fig. 9 is a schematic top view of a third stirring device according to the present invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are some, but not all, embodiments of the present invention. The components of embodiments of the present invention generally described and illustrated in the figures herein may be arranged and designed in a wide variety of different configurations. Thus, the following detailed description of the embodiments of the present invention, presented in the figures, is not intended to limit the scope of the invention, as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention. It should be noted that: like reference numbers and letters refer to like items in the following figures, and thus, once an item is defined in one figure, it need not be further defined and explained in subsequent figures. In the description of the embodiments of the present invention, it should be noted that, if the terms "upper", "lower", "inside", "outside", etc. are used for indicating the orientations or positional relationships based on the orientations or positional relationships shown in the drawings or the orientations or positional relationships that the products of the present invention usually place when using, the present invention is only used for convenience of description and simplification of the description, but does not indicate or imply that the devices or elements indicated must have specific orientations, be constructed in specific orientations, and operate, and thus, the present invention should not be construed as being limited. Furthermore, the appearances of the terms "first," "second," and the like in the description of the present invention are only used for distinguishing between the descriptions and are not intended to indicate or imply relative importance. In the description of the embodiments of the present invention, it should be further noted that unless otherwise explicitly stated or limited, the terms "disposed" and "connected" should be interpreted broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.
As shown in the attached drawings, the utility model comprises a first stirring device, a second stirring device and a third stirring device,
the first stirring device comprises a temperature control tank body 1, a first stirrer 2, a first thermometer 3 and a second thermometer 4,
the top of the temperature control tank body 1 is coated with a cooling jacket 5, the top of the temperature control tank body 1 is provided with a gas adding pipeline 6 and a group of raw material adding pipelines 7, the bottom of the temperature control tank body 1 is provided with a first liquid outlet 8, the bottom of the temperature control tank body 1 is coated with a heating jacket 9, the first stirrer 2 is arranged in the temperature control tank body 1, the first thermometer 3 and the second thermometer 4 are arranged on the tank wall of the temperature control tank body 1 in a mirror image distribution mode, and the detection ends of the first thermometer 3 and the second thermometer 4 are both positioned in the temperature control tank body 1;
the second stirring device comprises a reaction kettle body 20, an eccentric stirrer 21, a cooling coil 22, a heating coil 23 and a pair of third thermometers 24,
an inflation pipeline 25 and a group of feeding pipelines 26 are arranged at the top of the reaction kettle body 20, a discharging pipeline 27 is arranged at the bottom of the reaction kettle body 20, the eccentric stirrer 21, the cooling coil 22 and the heating coil 23 are annularly and uniformly arranged in the reaction kettle body 20, a pair of third thermometers 24 are arranged on the side wall of the reaction kettle body 20 in a mirror image manner, and the detection ends of the third thermometers 24 are positioned in the reaction kettle body 20;
the third stirring device comprises a tank 30, a second stirrer 31, a pair of tube array heat exchange devices and a pair of fourth thermometers 32,
a group of feeding pipelines 36 are arranged at the top of the tank body 30, a discharging pipeline 37 is arranged at the bottom of the tank body 30, the second stirrer 31 is arranged in the tank body 30,
the tube array heat exchange device comprises a pair of tube plates 33, a group of heat transfer tubes 34 and a pair of end sockets 35, wherein the tube plates 33 are in an arc shape matched with the inner wall of the tank body 30, the group of heat transfer tubes 34 are sequentially arranged between the pair of tube plates 33, an L-shaped medium conveying pipeline is arranged at the inlet end of each end socket 35, the outlet end of each L-shaped medium conveying pipeline is positioned outside the tank body 30, the pair of end sockets 35 are respectively arranged on the corresponding tube plates 33, a pair of fourth thermometers 32 are arranged on the outer wall of the tank body 30 in a mirror image distribution mode, and the detection ends of the fourth thermometers 32 are positioned in the tank body 30;
the first liquid outlet 8 of the temperature-controlled tank 1 is communicated with one of the feeding pipelines 26 through a pipeline, and the discharging pipeline 27 is communicated with one of the feeding pipelines 36.
The top of the cooling jacket 5 is provided with a pipeline avoiding groove, a group of raw material adding pipelines 7 are all positioned in the pipeline avoiding groove, the top of the temperature control tank body 1 is provided with a first breather valve 10, and the first thermometer 3 and the second thermometer 4 are both electric contact thermometers.
The cooling jacket 5 is filled with water, the cooling jacket 5 is internally provided with a refrigeration evaporator coil 11, the heating jacket 9 is filled with heat-conducting oil, the heating jacket 9 is internally provided with a resistance wire, and the resistance wire is coated with an insulating sleeve.
The temperature control tank body 1 consists of a body and an upper cover, and the upper cover is connected with a flange at the top of the body.
Stop valves are respectively arranged on the gas adding pipeline 6, the group of raw material adding pipelines 7 and the first liquid outlet 8.
The outer wall of the reaction kettle body 20 is coated with a heat-insulating layer.
The cooling coil 22 comprises a first spiral pipe and a first vertical liquid conveying pipe, the inlet end of the first vertical liquid conveying pipe is communicated with the outlet end of the bottom of the first spiral pipe, the outlet end of the first vertical liquid conveying pipe and the inlet end of the top of the first spiral pipe are arranged at the top of the reaction kettle body 20, the inlet end of the top of the first spiral pipe is a cold medium adding port, and the outlet end of the first vertical liquid conveying pipe is a cold medium outlet port;
the heating coil 23 comprises a second spiral pipe and a second vertical liquid conveying pipe, the inlet end of the second vertical liquid conveying pipe is communicated with the outlet end of the bottom of the second spiral pipe, the outlet end of the second vertical liquid conveying pipe and the inlet end of the top of the second spiral pipe are arranged at the top of the reaction kettle body 20, the inlet end of the top of the second spiral pipe is a heat medium outlet, and the outlet end of the second vertical liquid conveying pipe is a heat medium inlet.
A second breather valve 28 is arranged at the center of the top of the reaction kettle body 20, the pair of third thermometers 24 are electric contact thermometers, and the reaction kettle body 20 consists of a body and an upper cover which is connected with a flange at the top of the body; the inflation pipeline 25, the group of feeding pipelines 26 and the discharging pipeline 27 are respectively provided with a stop valve.
The second stirrer 31 is an eccentric stirrer, the second stirrer 31 and the pair of tube array heat exchange devices are annularly and uniformly arranged in the tank body 30, the outer wall of the tank body 30 is coated with a heat insulation layer, the pair of fourth thermometers 32 are electric contact thermometers, the tank body 30 is composed of a body and an upper cover, and the upper cover is connected with the top of the body through a flange.
And a group of feeding pipelines 36 and discharging pipelines 37 are respectively provided with a stop valve, one of the tube array heat exchange devices is a tube array cooling device, and the other tube array heat exchange device is a tube array heating device.
The working mode and principle are as follows: a worker adds a first reaction raw material into the temperature control tank body 1 from a group of raw material adding pipelines 7, nitrogen is filled into the temperature control tank body through a gas adding pipeline 6, the first stirrer 2 is started to stir, the reaction is heated through the heating jacket 9, heating is stopped after the reaction is finished, and the cooling jacket 5 is started to cool the tank body until the tank body is completely cooled. Adding a second reaction raw material from a raw material adding pipeline 7, and stirring and reacting in a temperature control tank 1 to obtain the diethyl p-toluenesulfonyloxymethylphosphonate. The breather valve 10 plays a role in regulating the internal pressure of the temperature-controlled tank body 1.
The first reaction raw material is: diethyl phosphite, paraformaldehyde, triethylamine and toluene.
The second reaction raw material is: tosyl chloride and triethylamine.
Diethyl tosyloxymethyl phosphonate, (S) -glycidol, 5 percent palladium carbon, ethanol and sodium hydroxide aqueous solution are added into the reaction kettle body 20 through a group of feed pipes 26, the eccentric stirrer 21 is started to stir the raw materials in the reaction kettle body 20, a heat medium is filled into the heating coil 23 to heat the raw materials, and the reaction is accelerated. The nitrogen protective raw materials are added through the main pipe of the gas charging pipeline 25 for reaction. The branch gas inlet pipeline of the gas charging pipeline 25 is hydrogenated, the (R) -1, 2-propylene glycol is obtained by reaction, cooling medium is introduced into the cooling coil 22 after the reaction is finished, and the reaction can be finished by cooling the raw material. A pair of third thermometers 24 detect the temperature of the raw material in the reaction vessel body 20, one of which transmits heating data and the other transmits cooling data.
The cooling medium input by the cooling coil 22 flows from top to bottom, so that the cooling effect is better, and the heating medium of the heating coil 23 flows from bottom to top, so that the heating effect is better.
Adding the (R) -1, 2-propylene glycol obtained by the reaction into the tank body 30 through a feeding pipeline 36, and simultaneously adding diethyl carbonate and an ethanol solution of sodium ethoxide to react to obtain the (R) -1, 2-propylene glycol carbonate. Then (R) -1, 2-propylene glycol carbonate, adenine, diethyl p-toluenesulfonyloxymethylphosphonate and sodium hydroxide are dissolved in dimethylformamide to react to obtain (R) -9- [ 2- (diethylphosphonomethoxy) propyl ] adenine. In the reaction process, the reaction temperature of the raw materials in the tank body 30 is adjusted through a pair of tube array heat exchange devices, and the tube plate 33 is in an arc shape matched with the inner wall of the tank body 30, so that the volume occupied by the tank body 30 is reduced, and the heat transfer efficiency is improved. The second stirrer 31 is an eccentric stirrer, and can break the symmetry of a liquid circulation loop, effectively prevent circular motion and eliminate the phenomenon of liquid level depression. A pair of fourth thermometers 32 detect the temperature of the material in the vessel 30, one of which transmits heating data and the other transmits cooling data.
Claims (10)
1. A tenofovir temperature control production line is characterized by comprising a first stirring device, a second stirring device and a third stirring device,
the first stirring device comprises a temperature control tank body (1), a first stirrer (2), a first thermometer (3) and a second thermometer (4),
the top of the temperature control tank body (1) is wrapped with a cooling jacket (5), the top of the temperature control tank body (1) is provided with a gas adding pipeline (6) and a group of raw material adding pipelines (7), the bottom of the temperature control tank body (1) is provided with a first liquid outlet (8), the bottom of the temperature control tank body (1) is wrapped with a heating jacket (9), a first stirrer (2) is installed in the temperature control tank body (1), a first thermometer (3) and a second thermometer (4) are installed on the tank wall of the temperature control tank body (1) in a mirror image distribution mode, and the detection ends of the first thermometer (3) and the second thermometer (4) are both located in the temperature control tank body (1);
the second stirring device comprises a reaction kettle body (20), an eccentric stirrer (21), a cooling coil (22), a heating coil (23) and a pair of third thermometers (24),
an inflation pipeline (25) and a group of feeding pipelines (26) are arranged at the top of the reaction kettle body (20), a discharging pipeline (27) is arranged at the bottom of the reaction kettle body (20), an eccentric stirrer (21), a cooling coil (22) and a heating coil (23) are annularly and uniformly arranged in the reaction kettle body (20), a pair of third thermometers (24) are arranged on the side wall of the reaction kettle body (20) in a mirror image manner, and the detection ends of the third thermometers (24) are located in the reaction kettle body (20);
the third stirring device comprises a tank body (30), a second stirrer (31), a pair of tube array heat exchange devices and a pair of fourth thermometers (32),
a group of feeding pipelines (36) are arranged at the top of the tank body (30), a discharging pipeline (37) is arranged at the bottom of the tank body (30), a second stirrer (31) is arranged in the tank body (30),
the tube array heat exchange device comprises a pair of tube plates (33), a group of heat transfer tubes (34) and a pair of end sockets (35), wherein the tube plates (33) are arc-shaped and matched with the inner wall of the tank body (30), the group of heat transfer tubes (34) are sequentially arranged between the pair of tube plates (33), an L-shaped medium conveying pipeline is arranged at the inlet end of the end socket (35), the outlet end of the L-shaped medium conveying pipeline is positioned outside the tank body (30), the pair of end sockets (35) are respectively arranged on the corresponding tube plates (33), a pair of fourth thermometers (32) are arranged on the outer wall of the tank body (30) in a mirror image distribution mode, and the detection ends of the fourth thermometers (32) are positioned in the tank body (30);
the first liquid outlet (8) of the temperature control tank body (1) is communicated with one of the feeding pipelines (26) through a pipeline, and the discharging pipeline (27) is communicated with one of the feeding pipelines (36).
2. The tenofovir temperature control production line according to claim 1, characterized in that the top of the cooling jacket (5) is provided with a pipeline avoiding groove, a group of raw material adding pipelines (7) are all positioned in the pipeline avoiding groove, the top of the temperature control tank body (1) is provided with a first breather valve (10), and the first thermometer (3) and the second thermometer (4) are both electric contact thermometers.
3. The tenofovir temperature control production line according to claim 1, characterized in that the cooling jacket (5) is filled with water, the cooling jacket (5) is internally provided with a refrigeration evaporator coil (11), the heating jacket (9) is filled with heat transfer oil, the heating jacket (9) is internally provided with resistance wires, and the resistance wires are coated with insulating sleeves.
4. A tenofovir temperature control production line according to claim 1, characterized in that the temperature control tank body (1) is composed of a body and an upper cover, and the upper cover is connected with the top flange of the body.
5. The tenofovir temperature control production line according to claim 1, characterized in that the gas feeding pipe (6), the group of raw material feeding pipes (7) and the first liquid outlet (8) are respectively provided with a stop valve.
6. The tenofovir temperature control production line according to claim 1, characterized in that the outer wall of the reaction kettle body (20) is coated with an insulating layer.
7. The tenofovir temperature control production line according to claim 1, wherein the cooling coil (22) comprises a first spiral tube and a first vertical infusion tube, the inlet end of the first vertical infusion tube is communicated with the outlet end of the bottom of the first spiral tube, the outlet end of the first vertical infusion tube and the inlet end of the top of the first spiral tube are arranged at the top of the reaction kettle body (20), the inlet end of the top of the first spiral tube is a cold medium inlet, and the outlet end of the first vertical infusion tube is a cold medium outlet;
the heating coil (23) comprises a second spiral pipe and a second vertical liquid conveying pipe, the inlet end of the second vertical liquid conveying pipe is communicated with the outlet end of the bottom of the second spiral pipe, the outlet end of the second vertical liquid conveying pipe and the inlet end of the top of the second spiral pipe are arranged at the top of the reaction kettle body (20), the inlet end of the top of the second spiral pipe is a heat medium outlet, and the outlet end of the second vertical liquid conveying pipe is a heat medium inlet.
8. The tenofovir temperature control production line according to claim 1, characterized in that a second breather valve (28) is arranged at the center of the top of the reaction kettle body (20), the pair of third thermometers (24) are both electric contact thermometers, the reaction kettle body (20) is composed of a body and an upper cover, and the upper cover is connected with the top flange of the body; the inflation pipeline (25), the group of feeding pipelines (26) and the discharging pipeline (27) are respectively provided with a stop valve.
9. The tenofovir temperature control production line according to claim 1, characterized in that the second stirrer (31) is an eccentric stirrer, the second stirrer (31) and a pair of tube array heat exchange devices are uniformly arranged in the tank body (30) in an annular manner, the outer wall of the tank body (30) is coated with a heat insulation layer, the pair of fourth thermometers (32) are electric contact thermometers, the tank body (30) is composed of a body and an upper cover, and the upper cover is connected with a flange at the top of the body.
10. The tenofovir temperature control production line according to claim 1, characterized in that a group of feeding pipes (36) and discharging pipes (37) are respectively provided with a stop valve, one of the tube array heat exchange devices is a tube array cooling device, and the other tube array heat exchange device is a tube array heating device.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202121145185.7U CN214937136U (en) | 2021-05-26 | 2021-05-26 | Tenofovir accuse temperature production line |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202121145185.7U CN214937136U (en) | 2021-05-26 | 2021-05-26 | Tenofovir accuse temperature production line |
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| Publication Number | Publication Date |
|---|---|
| CN214937136U true CN214937136U (en) | 2021-11-30 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202121145185.7U Active CN214937136U (en) | 2021-05-26 | 2021-05-26 | Tenofovir accuse temperature production line |
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| Country | Link |
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| CN (1) | CN214937136U (en) |
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2021
- 2021-05-26 CN CN202121145185.7U patent/CN214937136U/en active Active
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