CN214910632U - Clindamycin phosphate injection preparation facilities - Google Patents
Clindamycin phosphate injection preparation facilities Download PDFInfo
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- CN214910632U CN214910632U CN202120681163.6U CN202120681163U CN214910632U CN 214910632 U CN214910632 U CN 214910632U CN 202120681163 U CN202120681163 U CN 202120681163U CN 214910632 U CN214910632 U CN 214910632U
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- solution tank
- clindamycin phosphate
- injection
- filter membrane
- tank
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Abstract
The utility model discloses a clindamycin phosphate injection preparation device, which comprises a solution tank (1), wherein the solution tank (1) is arranged on a base (2), the upper end of the solution tank (1) is provided with a motor (3), a stirring rod (4) connected with the motor (3) is arranged inside the solution tank (1), and the tail end of the stirring rod (4) is provided with a stirring blade (5); a monitoring window (9) is arranged on the outer wall of the tank body of the solution tank (1); the liquid filter is characterized in that a liquid outlet pipe (10) is arranged at the lower end of the solution tank (1), and an electric valve I (11), a filter membrane I (12), a filter membrane II (13), sampling equipment (14), an electric valve II (15) and filling equipment (16) are sequentially arranged on the liquid outlet pipe (10) from one side close to the solution tank (1). The utility model discloses can improve the yield of clindamycin phosphate injection, reduction in production cost reduces patient's economic burden, more is fit for batch production.
Description
Technical Field
The utility model relates to an injection preparation technical field especially relates to a clindamycin phosphate injection preparation facilities.
Background
Clindamycin phosphate is a derivative of clindamycin, and is widely used for treating various infectious diseases caused by gram-positive bacteria and anaerobic bacteria. Clindamycin phosphate used clinically at present has oral preparations and injections. Clindamycin phosphate injection has strong penetrating power and high bioavailability, and can be widely distributed in tissues and body fluid, so the clindamycin phosphate injection is more favored clinically. However, the clindamycin phosphate aqueous solution has poor stability, and the heating sterilization of the injection in the preparation process causes high drug degradation rate and increased impurity content, which leads to more adverse reactions in clinical application.
The existing clindamycin phosphate injection adopts a high-temperature sterilization method for sterilization in the preparation process, and the existing preparation device of the clindamycin phosphate injection has the technical problems of serious raw material loss, environmental pollution, large inhalation amount of workers, incapability of operation and difficulty in batch production in the production process; the mode of activated carbon adsorption is adopted for removing the heat source, so that the yield of the prepared medicine is low, the production cost is increased, and the economic burden of a patient is increased.
SUMMERY OF THE UTILITY MODEL
The utility model provides a clindamycin phosphate injection preparation device aiming at the problems, which comprises a solution tank, wherein the solution tank is arranged on a base, the upper end of the solution tank is provided with a motor, a stirring rod connected with the motor is arranged inside the solution tank, and the tail end of the stirring rod is provided with a stirring blade; a monitoring window is arranged on the outer wall of the tank body of the solution tank; the lower end of the solution tank is provided with a liquid outlet pipe, and an electric valve I, a filter membrane II, sampling equipment, an electric valve II and filling equipment are sequentially arranged on the liquid outlet pipe from one side close to the solution tank.
Preferably, the upper end of the solution tank is provided with a water pipe for injection, one end of the water pipe for injection is arranged inside the solution tank, and the other end of the water pipe for injection is connected with water for injection.
Preferably, the solution tank upper end still is provided with the charging tank, the charging tank is connected with the solution tank through the filling tube, just inside the filling tube embedding solution tank.
Preferably, the monitoring window is made of glass materials, and scales are arranged on the monitoring window.
Preferably, the filling apparatus comprises a sterile reservoir and a filling needle.
Preferably, the filter membrane I is a 0.45 mu m microporous filter membrane.
Preferably, the filter membrane II is a 0.22 mu m microporous filter membrane.
The beneficial effects of the utility model reside in that: can improve the product yield, reduce the production cost, reduce the economic burden of patients and is more suitable for batch production.
Drawings
FIG. 1 is a schematic structural view of the present invention;
in the figure: 1-a solution tank, 2-a base, 3-a motor, 4-a stirring rod, 5-a stirring blade, 6-water for injection, 7-a water pipe for injection, 8-a feeding tank, 9-a monitoring window, 10-a liquid outlet pipe, 11-an electric valve I, 12-a filter membrane I, 13-a filter membrane II, 14-a sampling device, and 15-an electric valve II and 16-a filling device.
Detailed Description
Referring to fig. 1, the present invention provides an embodiment:
a clindamycin phosphate injection preparation device comprises a solution tank 1, wherein the solution tank 1 is arranged on a base 2, a motor 3 is arranged at the upper end of the solution tank 1, a stirring rod 4 connected with the motor 3 is arranged inside the solution tank 1, and the tail end of the stirring rod 4 is provided with a stirring blade 5; a monitoring window 9 is arranged on the outer wall of the tank body of the solution tank 1; the lower end of the solution tank 1 is provided with a liquid outlet pipe 10, and the liquid outlet pipe 10 is sequentially provided with an electric valve I11, a filter membrane I12, a filter membrane II 13, a sampling device 14, an electric valve II 15 and a filling device 16 from one side close to the solution tank 1.
Specifically, the upper end of the solution tank 1 is provided with an injection water pipe 7, one end of the injection water pipe 7 is arranged inside the solution tank 1, and the other end of the injection water pipe 7 is connected with injection water 6.
Specifically, solution tank 1 upper end still is provided with reinforced jar 8, reinforced jar 8 is connected with solution tank 1 through the filling tube, just inside filling tube embedding solution tank 1.
Specifically, the monitoring window 9 is made of glass, scales are arranged on the monitoring window 9, and the preparation condition of the clindamycin phosphate in the solution tank 1 can be observed through the monitoring window 9.
In particular, the filling device 16 comprises a sterile reservoir and a filling needle.
Specifically, the filter membrane I12 is a 0.45-micron microporous filter membrane.
Specifically, the stirring blade 5 is a semicircular stirring blade.
Specifically, the filter membrane II 13 is a 0.22 mu m microporous filter membrane.
Specifically, the sampling device 14 includes a sampling needle for detecting whether the clindamycin phosphate injection meets the standard, and the content of the clindamycin phosphate injection is detected according to the standard content and related substances of the clindamycin phosphate injection in the second edition of chinese pharmacopoeia 2015.
Specifically, the clindamycin phosphate injection can be prepared by referring to a patent application number of 201110086780.2: dissolving sodium hydroxide with corresponding fraction in injection water 6, injecting the sodium hydroxide solution into a solution tank 1, injecting clindamycin phosphate raw material with the weight part into the solution tank 1 through a feeding tank 8, starting a motor 3 to drive a stirring blade 5 to stir, injecting the injection water 6 with the corresponding weight part for dissolving, sterilizing through a filter membrane I12 and a filter membrane II 13, sampling by a sampling device 14, checking to be qualified, and finally filling by a filling device 16 to obtain the clindamycin phosphate injection.
It should be noted that the above mentioned embodiments are only preferred embodiments of the present invention, and the scope of the claims of the present invention should not be limited thereby, and that the modifications and variations of the present invention can be made by those skilled in the art without departing from the spirit and scope of the present invention.
Claims (7)
1. The preparation device of clindamycin phosphate injection is characterized by comprising a solution tank (1), wherein the solution tank (1) is arranged on a base (2), a motor (3) is arranged at the upper end of the solution tank (1), a stirring rod (4) connected with the motor (3) is arranged inside the solution tank (1), and the tail end of the stirring rod (4) is provided with a stirring blade (5); a monitoring window (9) is arranged on the outer wall of the tank body of the solution tank (1); the liquid filter is characterized in that a liquid outlet pipe (10) is arranged at the lower end of the solution tank (1), and an electric valve I (11), a filter membrane I (12), a filter membrane II (13), sampling equipment (14), an electric valve II (15) and filling equipment (16) are sequentially arranged on the liquid outlet pipe (10) from one side close to the solution tank (1).
2. The apparatus for preparing clindamycin phosphate injection according to claim 1, wherein the upper end of the solution tank (1) is provided with a water pipe (7) for injection, one end of the water pipe (7) for injection is arranged inside the solution tank (1), and the other end of the water pipe (7) for injection is connected with the water for injection (6).
3. The apparatus for preparing clindamycin phosphate injection according to claim 1, wherein a feeding tank (8) is further arranged at the upper end of the solution tank (1), the feeding tank (8) is connected with the solution tank (1) through a feeding pipe, and the feeding pipe is embedded inside the solution tank (1).
4. The apparatus for preparing clindamycin phosphate injection according to claim 1, wherein the monitoring window (9) is made of glass material, and the monitoring window (9) is provided with scales.
5. The apparatus for preparing clindamycin phosphate injection according to claim 1, wherein the filling equipment (16) comprises a sterile storage tank and a filling needle.
6. The apparatus for preparing clindamycin phosphate injection as claimed in claim 1, wherein the filter membrane I (12) is a 0.45 μm microporous filter membrane.
7. The apparatus for preparing clindamycin phosphate injection as claimed in claim 1, wherein the filter membrane II (13) is a 0.22 μm microporous filter membrane.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202120681163.6U CN214910632U (en) | 2021-04-02 | 2021-04-02 | Clindamycin phosphate injection preparation facilities |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202120681163.6U CN214910632U (en) | 2021-04-02 | 2021-04-02 | Clindamycin phosphate injection preparation facilities |
Publications (1)
Publication Number | Publication Date |
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CN214910632U true CN214910632U (en) | 2021-11-30 |
Family
ID=79047194
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN202120681163.6U Active CN214910632U (en) | 2021-04-02 | 2021-04-02 | Clindamycin phosphate injection preparation facilities |
Country Status (1)
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CN (1) | CN214910632U (en) |
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2021
- 2021-04-02 CN CN202120681163.6U patent/CN214910632U/en active Active
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