CN214844822U - Large-area-array liquid drop detection optical system - Google Patents
Large-area-array liquid drop detection optical system Download PDFInfo
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- CN214844822U CN214844822U CN202121113373.1U CN202121113373U CN214844822U CN 214844822 U CN214844822 U CN 214844822U CN 202121113373 U CN202121113373 U CN 202121113373U CN 214844822 U CN214844822 U CN 214844822U
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Abstract
The utility model discloses a large-area array liquid drop detection optical system, which comprises an illuminating mechanism arranged below a chip to be detected, a light source switching mechanism arranged above the chip to be detected and an imaging mechanism positioned above the light source switching mechanism; the light source switching mechanism is also provided with a spectroscope module and an exciting light module, and light emitted by the illuminating mechanism is used for irradiating an imaging area on the chip and sequentially enters the imaging mechanism through the chip and the spectroscope module so as to image micro liquid drops on the chip. The utility model relates to a rationally, compact structure, convenient to use can be used to carry out the formation of image for the liquid drop after amplification and by exciting light irradiation and handles to obtain relevant concentration data, in order to provide the guarantee to the accurate quantitative analysis of sample.
Description
Technical Field
The utility model relates to a digital PCR technical field especially relates to a big area array liquid drop detection optical system.
Background
The digital PCR instrument is a medical scientific research instrument applied to the fields of preventive medicine and public health, and mainly provides accurate quantitative analysis for samples. Digital PCR instruments generally include the following modules: the device comprises a chip conveying module, a liquid drop generating module, an amplifying module, a detecting module, an optical module, a computer control module and the like. The optical module is used for imaging liquid drops in the chip, at present, the field of the droplet digital PCR instrument is mainly divided into two types of flow type and imaging type, and the actual structure of the droplet digital PCR instrument is changed greatly due to different chip structures, so that new challenges are brought to the optical imaging module.
SUMMERY OF THE UTILITY MODEL
The utility model aims at providing a big area array liquid drop detects optical system for the liquid drop through the augmentation and after being shone by the exciting light carries out the formation of image processing to obtain relevant concentration data, provide the guarantee for the accurate quantitative analysis of sample.
In order to realize the purpose, the following technical scheme is adopted:
a large-area-array liquid drop detection optical system comprises an illuminating mechanism arranged below a chip to be detected, a light source switching mechanism arranged above the chip to be detected and an imaging mechanism positioned above the light source switching mechanism; the light source switching mechanism is also provided with a spectroscope module and an exciting light module, and light emitted by the illuminating mechanism is used for irradiating an imaging area on the chip and sequentially enters the imaging mechanism through the chip and the spectroscope module so as to image micro-droplets on the chip; the light emitted by the exciting light module is reflected to an exciting area on the chip through the spectroscope module so that the micro-droplets in the chip emit fluorescence, and the fluorescence excited by the micro-droplets enters the imaging mechanism through the spectroscope module so as to perform fluorescence imaging on the micro-droplets on the chip.
Further, the light source switching mechanism comprises a fixed frame, a first slide rail module arranged at the top of the fixed frame along the length direction of the fixed frame, a light source switching frame arranged on the first slide rail module, and a first translation mechanism connected with the light source switching frame and used for driving the light source switching frame to slide along the first slide rail module; the spectroscope module is installed in one side of light source switching frame, and the exciting light module is installed in the one side that is relative with the spectroscope module on the light source switching frame.
Furthermore, the spectroscope module comprises a plurality of first optical filters and a plurality of spectroscope lenses; a plurality of first mounting holes are formed in the length direction of the top of one side of the light source switching frame at intervals, a first wedge-shaped surface is further arranged at the bottom of the side of the light source switching frame, and the first wedge-shaped surface is obliquely arranged towards the other side of the light source switching frame; a plurality of second mounting holes are formed in the first wedge-shaped surface at intervals in the length direction, and each second mounting hole is communicated with one first mounting hole; each first optical filter is arranged in a first mounting hole, and each light splitting lens is arranged in a second mounting hole.
Furthermore, the exciting light module comprises a focusing module, a plurality of second optical filters arranged on the other side of the light source switching frame, and a plurality of first LED light sources with different light source wavelengths; each LED light source is arranged corresponding to a second optical filter and a light splitting lens, the focusing module is arranged between the light splitting lens and the second optical filter, and light emitted by each first LED light source is incident on the light splitting lens through the second optical filter and the focusing module in sequence.
Further, the focusing module comprises a focusing connecting cylinder; one end of the focusing connecting cylinder, which is close to the second optical filter, is also connected with a front lens seat, and one end of the focusing connecting cylinder, which is close to the light splitting lens, is also connected with a rear lens seat; a plano-convex lens is embedded in the front lens seat, and a double cemented lens is embedded in the rear lens seat; the outer side of the rear lens seat is further sleeved with a fixed mounting clamp used for fixedly mounting the focusing module on the outside.
Further, the illumination mechanism comprises an illumination seat, a light source installation barrel arranged on one side of the illumination seat, and a second LED light source installed at the end part of the light source installation barrel; the top of the illuminating seat is also provided with a first lens, a first reflector is also arranged in the illuminating seat, and the first reflector is obliquely arranged; and a second lens is further installed in the light source installation cylinder, and light emitted by the second LED light source sequentially passes through the second lens, the first reflector and the first lens to irradiate the chip.
Furthermore, the imaging mechanism comprises an imaging cylinder module, a camera connecting cylinder arranged at one end of the imaging cylinder module, and an imaging camera arranged at the end part of the camera connecting cylinder; the other end of the imaging cylinder module is also provided with a reflector adjusting module, and the reflector adjusting module is also provided with a second reflector positioned in the imaging cylinder module; the bottom of the imaging cylinder module is also provided with a first notch, and the second transmitting mirror is used for reflecting light which is incident into the imaging cylinder module through the first notch into the imaging camera.
Furthermore, the reflector adjusting module comprises an adjusting seat, a fixed seat, a wedge block and a fine adjustment assembly; the cross section of the adjusting seat is of a U-shaped structure, and one U-shaped cross end of the adjusting seat is positioned above the imaging cylinder module and is fixedly connected with the top of the imaging cylinder module through a fixed seat; the other U-shaped transverse end of the adjusting seat extends into the imaging cylinder module and is connected with the wedge block through the fine adjustment assembly; the bottom of the wedge-shaped block is provided with a second wedge-shaped surface, and the second reflector is installed on the second wedge-shaped surface.
Furthermore, the fine adjustment assembly comprises a plurality of first fine adjustment screw assemblies arranged on the adjustment seat and a tension spring connected between the adjustment seat and the wedge block; a first through hole is further formed in one side of the wedge block and corresponds to the tension spring, and a pin shaft is further mounted in the first through hole.
Furthermore, a second notch is formed in the top of the fixed seat, and one U-shaped transverse end of the adjusting seat extends into the second notch; a plurality of fixed slide holes penetrating to the top of the imaging cylinder module are further formed in the top of one U-shaped transverse end of the adjusting seat, a second fine adjustment screw rod assembly is installed on one side of the fixed seat, and one end of the second fine adjustment screw rod assembly is in contact with the adjusting seat.
Adopt above-mentioned scheme, the beneficial effects of the utility model are that:
1) the device has the advantages of reasonable design, compact structure and convenient use, and can be used for carrying out imaging processing on the liquid drops after amplification and irradiation of exciting light, thereby obtaining related concentration data and guaranteeing accurate quantitative analysis of samples;
2) the device is provided with the illuminating mechanism, the spectroscope module and the exciting light module, so that the uniform light distribution and smooth illumination in the shot view field can be ensured, the shot view field is imaged at one time, image splicing is not needed, and the imaging efficiency is high;
3) the light source switching frame is driven to move through the first translation mechanism, so that the LED light sources with different wavelengths can be switched, the use is convenient, and meanwhile, the mounting position of the second reflector can be adjusted through the reflector adjusting module to ensure the imaging precision.
Drawings
Fig. 1 is a perspective view of the present invention;
fig. 2 is an exploded view of the lighting mechanism of the present invention;
FIG. 3 is a perspective view of the light source switching mechanism, the beam splitter module and the excitation light module of the present invention;
FIG. 4 is an exploded view of FIG. 3;
fig. 5 is a perspective view of the imaging mechanism of the present invention;
fig. 6 is a perspective view of the mirror adjusting module of the present invention;
FIG. 7 is a cross-sectional view of FIG. 6;
fig. 8 is an exploded view of the focusing module of the present invention;
wherein the figures identify the description:
1-an illumination mechanism; 2-light source switching mechanism;
3-an imaging mechanism; 4-a spectroscope module;
5, exciting the light module; 6-a focusing module;
7-chip; 11-an illumination seat;
12-a light source mounting cylinder; 13 — a second LED light source;
14-a first lens; 15 — a first mirror;
16-a second lens; 21-a fixing frame;
22-a first slide rail module; 23-light source switching frame;
24 — a first translation mechanism; 31-imaging cylinder module;
32-camera connection cartridge; 33-an imaging camera;
34-a reflector adjusting module; 35-a second mirror;
41-a first filter; 42-a spectroscopic lens;
51-a second filter; 52-first LED light source;
61-a focusing connector; 62-front lens holder;
63-rear lens holder; 64-plano-convex lens;
65-double cemented lens; 66-fixing the mounting clip;
71-an imaging area; 341-adjusting seat;
342-a fixed seat; 343-wedge block;
344 — a first trim screw assembly; 345-a tension spring;
346-pin roll; 347 — fixed slide hole;
348 — second fine adjustment screw assembly.
Detailed Description
The present invention will be described in detail below with reference to the accompanying drawings and specific embodiments.
Referring to fig. 1 to 8, the present invention provides a large-area array droplet detection optical system, which includes an illumination mechanism 1 disposed below a chip 7 to be detected, a light source switching mechanism 2 disposed above the chip 7 to be detected, and an imaging mechanism 3 disposed above the light source switching mechanism 2; the light source switching mechanism 2 is also provided with a spectroscope module 4 and an excitation light module 5, and light emitted by the illumination mechanism 1 is used for irradiating an imaging area 71 on the chip 7 and sequentially enters the imaging mechanism 3 through the chip 7 and the spectroscope module 4 so as to image micro-droplets on the chip 7; the light emitted by the excitation light module 5 is reflected to the excitation area on the chip 7 through the spectroscope module 4, so that the micro-droplets in the chip 7 emit fluorescence, and the fluorescence excited by the micro-droplets enters the imaging mechanism 3 through the spectroscope module 4, so as to perform fluorescence imaging on the micro-droplets on the chip 7.
The light source switching mechanism 2 comprises a fixed frame 21, a first slide rail module 22 arranged at the top of the fixed frame 21 along the length direction of the fixed frame, a light source switching frame 23 arranged on the first slide rail module 22, and a first translation mechanism 24 connected with the light source switching frame 23 and used for driving the light source switching frame 23 to slide along the first slide rail module 22; the spectroscope module 4 is arranged on one side of the light source switching frame 23, and the exciting light module 5 is arranged on one side of the light source switching frame 23, which is opposite to the spectroscope module 4; the spectroscope module 4 comprises a plurality of first optical filters 41 and a plurality of spectroscope lenses 42; a plurality of first mounting holes are formed in the length direction of the top of one side of the light source switching frame 23 at intervals, a first wedge-shaped surface is further arranged at the bottom of the side of the light source switching frame 23, and the first wedge-shaped surface is obliquely arranged towards the other side of the light source switching frame 23; a plurality of second mounting holes are formed in the first wedge-shaped surface at intervals in the length direction, and each second mounting hole is communicated with one first mounting hole; each first optical filter 41 is installed in a first installation hole, and each beam splitting lens 42 is installed in a second installation hole; the exciting light module 5 comprises a focusing module 6, a plurality of second optical filters 51 arranged on the other side of the light source switching frame 23, and a plurality of first LED light sources 52 with different light source wavelengths; each LED light source is disposed corresponding to a second optical filter 51 and a light splitting lens 42, the focusing module 6 is disposed between the light splitting lens 42 and the second optical filter 51, and light emitted by each first LED light source 52 is incident on the light splitting lens 42 through the second optical filter 51 and the focusing module 6 in sequence.
The focusing module 6 comprises a focusing connector 61; a front lens seat 62 is connected to one end of the gathering connecting cylinder 61 close to the second optical filter 51, and a rear lens seat 63 is connected to one end of the gathering connecting cylinder 61 close to the beam splitting lens 42; a plano-convex lens 64 is embedded in the front lens seat 62, and a double cemented lens 65 is embedded in the rear lens seat 63; a fixed mounting clamp 66 for fixedly mounting the focusing module 6 to the outside is further sleeved on the outer side of the rear lens seat 63; the illumination mechanism 1 comprises an illumination seat 11, a light source installation barrel 12 arranged on one side of the illumination seat 11, and a second LED light source 13 installed at the end part of the light source installation barrel 12; a first lens 14 is further installed at the top of the illumination seat 11, a first reflector 15 is further arranged in the illumination seat 11, and the first reflector 15 is obliquely arranged; a second lens 16 is further installed in the light source installation cylinder 12, and light emitted by the second LED light source 13 sequentially passes through the second lens 16, the first reflector 15 and the first lens 14 to irradiate on the chip 7; the imaging mechanism 3 comprises an imaging cylinder module 31, a camera connecting cylinder 32 arranged at one end of the imaging cylinder module 31, and an imaging camera 33 arranged at the end part of the camera connecting cylinder 32; the other end of the imaging cylinder module 31 is also provided with a reflector adjusting module 34, and the reflector adjusting module 34 is also provided with a second reflector 35 positioned in the imaging cylinder module 31; the bottom of the imaging cylinder module 31 is further provided with a first notch, and the second reflector is used for reflecting light incident into the imaging cylinder module 31 through the first notch into the imaging camera 33.
The reflector adjusting module 34 includes an adjusting base 341, a fixing base 342, a wedge 343, and a fine-tuning assembly; the cross section of the adjusting seat 341 is of a U-shaped structure, and one U-shaped cross end of the adjusting seat 341 is located above the imaging cylinder module 31 and is fixedly connected with the top of the imaging cylinder module 31 through the fixing seat 342; the other U-shaped transverse end of the adjusting base 341 extends into the imaging cylinder module 31 and is connected to the wedge block 343 through the fine adjustment assembly; a second wedge-shaped surface is arranged at the bottom of the wedge block 343, and the second reflector 35 is installed on the second wedge-shaped surface; the fine adjustment assembly comprises a plurality of first fine adjustment screw assemblies 344 mounted on the adjustment base 341 and a tension spring 345 connected between the adjustment base 341 and the wedge block 343; a first through hole is further formed in one side of the wedge block 343, which corresponds to the tension spring 345, and a pin 346 is further mounted in the first through hole; the top of the fixed seat 342 is further provided with a second notch, and one of the U-shaped transverse ends of the adjusting seat 341 extends into the second notch; the top of one of the U-shaped transverse ends of the adjusting base 341 is further provided with a plurality of fixed sliding holes 347 penetrating to the top of the imaging cylinder module 31, and one side of the fixed base 342 is provided with a second fine tuning screw assembly 348, and one end of the second fine tuning screw assembly 348 is in contact with the adjusting base 341.
The utility model discloses the theory of operation:
with reference to fig. 1 to 8, in this embodiment, the system further includes a system bottom plate (not shown in the drawings), a chip moving platform (not shown in the drawings) is disposed on the system bottom plate, and a chip tray (not shown in the drawings) and a translation driving mechanism (not shown in the drawings) for driving the chip tray to move are mounted on the chip moving platform; the chip 7 is arranged on the chip bracket, and the lighting mechanism 1 is arranged on the system bottom plate; in this embodiment, the fixing frame 21 of the light source switching mechanism 2 is disposed on the chip moving platform, the top of the fixing frame 21 is further provided with a lens mounting clip, and the imaging mechanism 3 is fixedly mounted on the fixing frame 21 through the lens mounting clip; the focusing module 6 is located between two sides of the light source switching frame 23, and the focusing module 6 is fixedly mounted on the imaging mechanism 3 through the fixing mounting clamp 66.
During operation, the chip 7 is firstly moved to the upper part of the illumination mechanism 1, and light emitted by the second LED light source 13 of the illumination mechanism 1 passes through the second lens 16 (plano-convex lens), the first reflector 15 and the first lens 14 (plano-convex lens) in sequence to uniformly irradiate on the chip 7 and cover the imaging area 71 (area to be imaged) of the chip; then, the light penetrates through the spectroscopic lens 42 (dichroic mirror) and the first optical filter 41, enters the imaging cylinder module 31 through the first notch, and is reflected to the imaging surface of the imaging camera 33 through the second reflecting mirror 35 to image the micro-droplets on the chip 7; the light source switching mechanism 2 is further provided with an excitation light module 5, when fluorescence imaging is required, light emitted by the first LED light source 52 is firstly incident into the focusing module 6 through the second optical filter 51, and then sequentially penetrates through the plano-convex lens and the double-cemented lens 65 in the focusing module 6 and then is incident into the light splitting lens 42, the light splitting lens 42 reflects the light to an excitation area (i.e., an imaging area 71) of the chip 7, so that the liquid droplets in the chip 7 emit fluorescence, and then the fluorescence excited by the liquid droplets sequentially penetrates through the light splitting lens 42 and the first optical filter 41 and is incident into the imaging cylinder module 31 through the first notch, and then is reflected to an imaging surface of the imaging camera 33 through the second reflector 35, so as to perform fluorescence imaging on the micro liquid droplets on the chip 7.
In this embodiment, the excitation light module 5 includes four first LED light sources 52 and four second optical filters 51, and the wavelengths of the four first LED light sources 52 are different, and the first translation mechanism 24 drives the light source switching frame 23 to move, so that the LED light sources with different wavelengths can be switched, which is simple and practical; the first translation mechanism 24 comprises a first motor and a first lead screw module in driving connection with the first motor, the light source switching frame 23 is connected with a nut on the first lead screw module, and the first motor drives the first lead screw module to operate so as to drive the light source switching frame 23 to slide along the first slide rail module 22 to switch light sources with different wavelengths; the position of the second reflector 35 can be adjusted by the reflector adjusting module 34, specifically, the distance between the wedge block 343 and the adjusting seat 341 can be adjusted by the first fine adjustment screw assembly 344, and the adjusted wedge block is limited and fixed by the pin 346; the fixed slide hole 347 is used for installing screws, and the distance between the inner walls of the second notches of the adjusting seat 341 and the fixing seat 342 can be adjusted through the second fine adjustment screw assembly 348, so that the screw fixing can be carried out simply and conveniently.
The above description is only exemplary of the present invention and should not be construed as limiting the present invention, and any modifications, equivalents and improvements made within the spirit and principles of the present invention are intended to be included within the scope of the present invention.
Claims (10)
1. A large-area-array liquid drop detection optical system is characterized by comprising an illuminating mechanism arranged below a chip to be detected, a light source switching mechanism arranged above the chip to be detected and an imaging mechanism positioned above the light source switching mechanism; the light source switching mechanism is also provided with a spectroscope module and an exciting light module, and light emitted by the illuminating mechanism is used for irradiating an imaging area on the chip and sequentially enters the imaging mechanism through the chip and the spectroscope module so as to image micro-droplets on the chip; the light emitted by the exciting light module is reflected to an exciting area on the chip through the spectroscope module so that the micro-droplets in the chip emit fluorescence, and the fluorescence excited by the micro-droplets enters the imaging mechanism through the spectroscope module so as to perform fluorescence imaging on the micro-droplets on the chip.
2. The optical system for large area droplet detection according to claim 1, wherein the light source switching mechanism comprises a fixed frame, a first slide rail module disposed at the top of the fixed frame along the length direction of the fixed frame, a light source switching frame disposed on the first slide rail module, and a first translation mechanism connected to the light source switching frame and configured to drive the light source switching frame to slide along the first slide rail module; the spectroscope module is installed in one side of light source switching frame, and the exciting light module is installed in the one side that is relative with the spectroscope module on the light source switching frame.
3. The optical system for large area droplet detection according to claim 2, wherein the beam splitter module comprises a plurality of first filters, a plurality of beam splitting lenses; a plurality of first mounting holes are formed in the length direction of the top of one side of the light source switching frame at intervals, a first wedge-shaped surface is further arranged at the bottom of the side of the light source switching frame, and the first wedge-shaped surface is obliquely arranged towards the other side of the light source switching frame; a plurality of second mounting holes are formed in the first wedge-shaped surface at intervals in the length direction, and each second mounting hole is communicated with one first mounting hole; each first optical filter is arranged in a first mounting hole, and each light splitting lens is arranged in a second mounting hole.
4. The optical system for large area droplet detection according to claim 3, wherein the excitation light module comprises a focusing module, a plurality of second filters installed on the other side of the light source switching frame, and a plurality of first LED light sources with different light source wavelengths; each LED light source is arranged corresponding to a second optical filter and a light splitting lens, the focusing module is arranged between the light splitting lens and the second optical filter, and light emitted by each first LED light source is incident on the light splitting lens through the second optical filter and the focusing module in sequence.
5. The large area array droplet detection optical system of claim 4, wherein the focusing module comprises a focusing connector; one end of the focusing connecting cylinder, which is close to the second optical filter, is also connected with a front lens seat, and one end of the focusing connecting cylinder, which is close to the light splitting lens, is also connected with a rear lens seat; a plano-convex lens is embedded in the front lens seat, and a double cemented lens is embedded in the rear lens seat; the outer side of the rear lens seat is further sleeved with a fixed mounting clamp used for fixedly mounting the focusing module on the outside.
6. The optical system for large area droplet detection according to claim 1, wherein the illumination mechanism includes an illumination base, a light source mounting cylinder disposed on one side of the illumination base, and a second LED light source mounted on an end portion of the light source mounting cylinder; the top of the illuminating seat is also provided with a first lens, a first reflector is also arranged in the illuminating seat, and the first reflector is obliquely arranged; and a second lens is further installed in the light source installation cylinder, and light emitted by the second LED light source sequentially passes through the second lens, the first reflector and the first lens to irradiate the chip.
7. The large area droplet detection optical system of claim 1, wherein the imaging mechanism comprises an imaging cylinder module, a camera interface cylinder mounted at one end of the imaging cylinder module, and an imaging camera mounted at an end of the camera interface cylinder; the other end of the imaging cylinder module is also provided with a reflector adjusting module, and the reflector adjusting module is also provided with a second reflector positioned in the imaging cylinder module; the bottom of the imaging cylinder module is also provided with a first notch, and the second transmitting mirror is used for reflecting light which is incident into the imaging cylinder module through the first notch into the imaging camera.
8. The optical system for large area droplet detection according to claim 7, wherein the mirror adjustment module comprises an adjustment seat, a fixing seat, a wedge block, and a fine adjustment assembly; the cross section of the adjusting seat is of a U-shaped structure, and one U-shaped cross end of the adjusting seat is positioned above the imaging cylinder module and is fixedly connected with the top of the imaging cylinder module through a fixed seat; the other U-shaped transverse end of the adjusting seat extends into the imaging cylinder module and is connected with the wedge block through the fine adjustment assembly; the bottom of the wedge-shaped block is provided with a second wedge-shaped surface, and the second reflector is installed on the second wedge-shaped surface.
9. The optical system for large area array droplet detection according to claim 8, wherein the fine tuning assembly comprises a plurality of first fine tuning screw assemblies mounted on the adjusting base, and a tension spring connected between the adjusting base and the wedge block; a first through hole is further formed in one side of the wedge block and corresponds to the tension spring, and a pin shaft is further mounted in the first through hole.
10. The optical system for large area array droplet detection according to claim 9, wherein the top of the fixing base further has a second notch, and one of the U-shaped lateral ends of the adjusting base extends into the second notch; a plurality of fixed slide holes penetrating to the top of the imaging cylinder module are further formed in the top of one U-shaped transverse end of the adjusting seat, a second fine adjustment screw rod assembly is installed on one side of the fixed seat, and one end of the second fine adjustment screw rod assembly is in contact with the adjusting seat.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202121113373.1U CN214844822U (en) | 2021-05-21 | 2021-05-21 | Large-area-array liquid drop detection optical system |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202121113373.1U CN214844822U (en) | 2021-05-21 | 2021-05-21 | Large-area-array liquid drop detection optical system |
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| Publication Number | Publication Date |
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| CN214844822U true CN214844822U (en) | 2021-11-23 |
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| CN202121113373.1U Active CN214844822U (en) | 2021-05-21 | 2021-05-21 | Large-area-array liquid drop detection optical system |
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- 2021-05-21 CN CN202121113373.1U patent/CN214844822U/en active Active
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