CN214810719U - High-flux solid-phase polypeptide synthesis device - Google Patents

Abstract

The utility model relates to a synthetic technical field of polypeptide specifically is a high flux solid phase polypeptide synthesizer, the device comprises a device main body, the device main part is including synthetic reaction unit, the slide rail has all been seted up to synthetic reaction unit's both sides, and the inside all sliding connection of slide rail has the guide block, and is two sets of the guide block is kept away from synthetic reaction unit's the all fixedly connected with pivot seat in one side, and the pivot seat one end of keeping away from the guide block all with safety cover fixed connection, two sets of the all fixedly connected with stop gear of dorsal part of guide block, stop gear includes sleeve, spacer pin and spacing spring, guide block and sleeve fixed connection, and telescopic inside sliding connection has the spacer pin, fixedly connected with spacing spring between sleeve and the spacer pin, and the back in the spacing hole of one end embedding of spacer pin. The utility model discloses better protectiveness and stability have to be convenient for open and close.

Description

High-flux solid-phase polypeptide synthesis device

Technical Field

The utility model relates to a polypeptide synthesis technical field specifically is a high flux solid phase polypeptide synthesizer.

Background

With the continuous development of biomacromolecule synthesis industry, polypeptide synthesis industry is also continuously developed, people utilize polypeptide synthesis devices to synthesize amino acids into polypeptides, and polypeptide chains with different lengths and properties can be synthesized according to different requirements, so that the existing polypeptide synthesis devices basically meet the use requirements of people, and the following problems still exist.

The polypeptide synthesis device has a large number of glassware inside, which may cause a large amount of damage when the device is bumped during storage, and when the device is toppled during use, the possibility of damage is high, and material leakage and a high risk occur, so a high-throughput solid-phase polypeptide synthesis device is needed to solve the above problems.

SUMMERY OF THE UTILITY MODEL

An object of the utility model is to provide a high flux solid phase polypeptide synthesizer to the device that provides receives the striking among the above-mentioned background art and causes the device to damage and take place to empty the device and can damage the problem that causes the material to leak.

In order to achieve the above object, the utility model provides a following technical scheme: the utility model provides a high flux solid phase polypeptide synthesizer, includes the device main part, the device main part is including synthetic reaction unit, the slide rail has all been seted up to synthetic reaction unit's both sides, and the inside sliding connection all of slide rail has the guide block, and is two sets of the guide block is kept away from synthetic reaction unit's one side all fixedly connected with pivot seat, and the pivot seat keep away from the one end of guide block all with safety cover fixed connection, and is two sets of the dorsal part all fixedly connected with stop gear of guide block, stop gear includes sleeve, spacer pin and spacing spring, guide block and sleeve fixed connection, and telescopic inside sliding connection have the spacer pin, fixedly connected with spacing spring between sleeve and the spacer pin, and the back in the spacing hole of the one end embedding of spacer pin, the surface at synthetic reaction unit is seted up in the spacing hole.

Preferably, the fixed surface of safety cover is connected with the bearing frame, and the one end fixed connection of bearing frame and connecting rod, the inside sliding connection of connecting rod has the kelly, and the kelly keeps away from the one end of bearing frame and has seted up the trompil, fixedly connected with reset spring between kelly and the connecting rod, and reset spring keeps away from the one end of bearing frame and inlays and have the gim peg, and fixedly connected with block spring between gim peg and the kelly, the inside of the one end embedding fixture block of kelly is kept away from to the gim peg, and fixture block fixed connection is in the front of safety cover.

Preferably, the bottom of two sets of safety cover all fixedly connected with supporting legs, and the supporting legs all sets up to the rubber material.

Preferably, one end of the limiting pin, which is far away from the synthesis reaction device, is fixedly connected with a pull ring, and a round hole is formed in the pull ring.

Preferably, the grooves formed in the surface of the limit pin are connected with the lugs in a sliding manner, and the lugs are fixedly connected to the inner wall of the sleeve.

Preferably, one end of the clamping bolt, which is far away from the clamping rod, is welded into an arc shape, and the grooves formed in the inner wall of the clamping block are all arc-shaped.

Compared with the prior art, the beneficial effects of the utility model are that:

1. this high flux solid phase polypeptide synthesizer is provided with safety cover and stop gear, utilize the safety cover can carry out effectual protection to the glassware of device inside at the in-process that the device deposited, and the safety cover is opened the back, pulling spacer pin and pull ring, remove the locking between guide block and the synthesis reaction unit, slide guide block and safety cover down, make safety cover bottom fixed connection's supporting legs and ground contact, can increase the area of contact on device and ground through such design, the effectual empting of avoiding the device, the protectiveness and the stability of device have been improved.

2. This high flux solid phase polypeptide synthesizer is provided with the bearing frame, through the pulling kelly for the draw-in bolt block is in the inside of fixture block, can be convenient with kelly and fixture block joint together, thereby be in the same place the convenient locking of two sets of safety covers, make opening and closing that the device can be convenient, improved the convenience and the practicality of device.

Drawings

Fig. 1 is a schematic structural front view of the open state of the present invention;

FIG. 2 is a schematic sectional view of the front view of the structure of the present invention;

FIG. 3 is a schematic side view of the structure of the present invention;

FIG. 4 is a schematic side view and sectional view of a part of the synthesis reaction apparatus and the position-limiting mechanism of the present invention;

fig. 5 is an enlarged schematic view of a portion of the structure in fig. 2.

In the figure: 100. a device main body; 110. a synthesis reaction device; 111. a slide rail; 112. a limiting hole; 210. a guide block; 211. a rotating shaft seat; 212. a protective cover; 213. supporting legs; 220. a limiting mechanism; 221. a sleeve; 222. a spacing pin; 223. a limiting spring; 224. a pull ring; 310. a bearing seat; 311. a connecting rod; 312. a clamping rod; 313. a return spring; 314. fastening a bolt; 315. a snap spring; 316. a clamping block; 317. and (6) hole drawing.

Detailed Description

The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.

Referring to fig. 1-5, the present invention provides an embodiment:

a high-flux solid-phase polypeptide synthesis device comprises a device main body 100, wherein the device main body 100 comprises a synthesis reaction device 110, two sides of the synthesis reaction device 110 are respectively provided with a slide rail 111, the insides of the slide rails 111 are respectively connected with a guide block 210 in a sliding manner, one sides of two groups of guide blocks 210 far away from the synthesis reaction device 110 are respectively and fixedly connected with a rotating shaft seat 211, one ends of the rotating shaft seats 211 far away from the guide blocks 210 are respectively and fixedly connected with a protective cover 212, the back sides of the two groups of guide blocks 210 are respectively and fixedly connected with a limiting mechanism 220, the limiting mechanism 220 comprises a sleeve 221, a limiting pin 222 and a limiting spring 223, the guide blocks 210 are fixedly connected with the sleeve 221, the inside of the sleeve 221 is connected with a limiting pin 222 in a sliding manner, the limiting spring 223 is fixedly connected between the sleeve 221 and the limiting pin 222, one end of the limiting pin 222 is embedded into the back of a limiting hole 112, the limiting hole 112 is arranged on the surface of the synthesis reaction device 110, through the design, the protective cover 212 can protect the device, and when the protective cover 212 is opened, the contact area between the device and the ground can be effectively increased, and the protection performance and the stability of the device are improved.

The fixed surface of safety cover 212 is connected with bearing frame 310, and the one end fixed connection of bearing frame 310 and connecting rod 311, the inside sliding connection of connecting rod 311 has kelly 312, and the one end that bearing frame 310 was kept away from to kelly 312 has seted up trompil 317, fixedly connected with reset spring 313 between kelly 312 and the connecting rod 311, and the one end that reset spring 313 kept away from bearing frame 310 is inlayed and is had cotter 314, and fixedly connected with block spring 315 between cotter 314 and the kelly 312, inside that the one end that cotter 312 was kept away from to cotter 314 imbeds fixture block 316, and fixture block 316 fixed connection is in the front of safety cover 212, through such design, make two sets of safety covers 212 can be by convenient opening and closing, the convenience of device has been improved.

The bottom ends of the two groups of protective covers 212 are fixedly connected with supporting legs 213, and the supporting legs 213 are all made of rubber, so that when the protective covers 212 are put down, the friction force between the device and the ground can be increased, and the stability of the device is improved.

One end of the limiting pin 222, which is far away from the synthesis reaction device 110, is fixedly connected with a pull ring 224, and a round hole is formed in the pull ring 224, so that the pull ring 224 can be used for conveniently pulling the protection cover 212, and the convenience of the device is improved.

All there is the lug in the recess that the surface of spacer pin 222 was seted up sliding connection, and lug fixed connection is at the inner wall of sleeve 221, through such design for spacer pin 222 can be more stable at the in-process that removes, makes the more smooth of device operation, has improved the stability and the practicality of device.

The end of the clamping bolt 314, which is far away from the clamping rod 312, is welded into a circular arc shape, and the grooves formed in the inner wall of the clamping block 316 are all formed into a circular arc shape.

The working principle is as follows: when the device needs to be used, the clamping rod 312 is pushed by the pulling hole 317, the clamping bolt 314 embedded in the clamping rod 312 is separated from the inside of the clamping block 316, the locking between the two groups of protective covers 212 is released, then the protective covers 212 are opened, the limiting pin 222 is pulled to separate from the inside of the limiting hole 112, the locking between the guide block 210 and the synthetic reaction device 110 is released, then the guide block 210 and the protective covers 212 slide downwards until the supporting legs 213 are contacted with the ground, at the moment, the limiting pin 222 is embedded in the inside of the other group of limiting holes 112 under the action of the limiting spring 223, at the moment, the contact area between the device and the ground is increased under the action of the protective covers 212 and the supporting legs 213, and the stability of the device is enhanced.

When the device needs to be stored, the limiting pin 222 is pulled firstly, the guide block 210 and the protective cover 212 are pushed upwards until the limiting pin 222 is embedded into the limiting hole 112 with the higher setting position, then the two groups of protective covers 212 are closed, the clamping rod 312 is pushed, the clamping bolt 314 is embedded into the clamping block 316, at the moment, the two groups of protective covers 212 are conveniently locked, and the operation is finished.

It is obvious to a person skilled in the art that the invention is not restricted to details of the above-described exemplary embodiments, but that it can be implemented in other specific forms without departing from the spirit or essential characteristics of the invention. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein. Any reference sign in a claim should not be construed as limiting the claim concerned.

Claims (6)

1. A high-throughput solid-phase polypeptide synthesis apparatus comprising an apparatus main body (100), characterized in that: the device main body (100) comprises a synthesis reaction device (110), slide rails (111) are arranged on two sides of the synthesis reaction device (110), guide blocks (210) are connected to the inside of the slide rails (111) in a sliding manner, two sets of guide blocks (210) are fixedly connected to one sides far away from the synthesis reaction device (110) through rotating shaft seats (211), one ends, far away from the guide blocks (210), of the rotating shaft seats (211) are fixedly connected with a protective cover (212), limiting mechanisms (220) are fixedly connected to the back sides of the two sets of guide blocks (210), each limiting mechanism (220) comprises a sleeve (221), a limiting pin (222) and a limiting spring (223), the guide blocks (210) are fixedly connected with the sleeve (221), the limiting pins (222) are connected to the inside of the sleeve (221) in a sliding manner, and the limiting springs (223) are fixedly connected between the sleeve (221) and the limiting pins (222), and one end of the limiting pin (222) is embedded into the back of the limiting hole (112), and the limiting hole (112) is arranged on the surface of the synthesis reaction device (110).

2. The apparatus for high-throughput solid-phase polypeptide synthesis according to claim 1, wherein: the fixed surface of safety cover (212) is connected with bearing frame (310), and the one end fixed connection of bearing frame (310) and connecting rod (311), the inside sliding connection of connecting rod (311) has kelly (312), and kelly (312) keep away from the one end of bearing frame (310) and seted up trompil (317), fixedly connected with reset spring (313) between kelly (312) and connecting rod (311), and reset spring (313) keep away from the one end of bearing frame (310) and inlay and have gim peg (314), and fixedly connected with block spring (315) between gim peg (314) and gim peg (312), the one end that gim peg (312) were kept away from in gim peg (314) imbeds the inside of fixture block (316), and fixture block (316) fixed connection is in the front of safety cover (212).

3. The apparatus for high-throughput solid-phase polypeptide synthesis according to claim 1, wherein: the bottom ends of the two groups of protective covers (212) are fixedly connected with supporting legs (213), and the supporting legs (213) are all made of rubber materials.

4. The apparatus for high-throughput solid-phase polypeptide synthesis according to claim 1, wherein: one end of the limiting pin (222), which is far away from the synthesis reaction device (110), is fixedly connected with a pull ring (224), and a round hole is formed in the pull ring (224).

5. The apparatus for high-throughput solid-phase polypeptide synthesis according to claim 1, wherein: the grooves formed in the surface of the limiting pin (222) are connected with bumps in a sliding mode, and the bumps are fixedly connected to the inner wall of the sleeve (221).

6. The apparatus for high-throughput solid-phase polypeptide synthesis according to claim 2, wherein: one end of the clamping bolt (314) far away from the clamping rod (312) is welded into an arc shape, and grooves formed in the inner wall of the clamping block (316) are all arc-shaped.

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