CN214794824U

CN214794824U - Clamping mechanism for multi-channel immunofluorescence analyzer and incubation device

Info

Publication number: CN214794824U
Application number: CN202120518202.0U
Authority: CN
Inventors: 孙海滨; 彭建康; 陈卫民
Original assignee: Nanjing Norman Biotechnology Co ltd
Current assignee: Nanjing Norman Biotechnology Co ltd
Priority date: 2021-03-11
Filing date: 2021-03-11
Publication date: 2021-11-19
Anticipated expiration: 2031-03-11

Abstract

The utility model discloses a fixture and incubation device for multichannel immunofluorescence analysis appearance belongs to the medical equipment field. The clamping mechanism comprises a clamping main body, a clamping pressure plate and an elastic element. The clamping main body is provided with an insertion groove and a through groove. The elastic element includes an elastic portion. The elastic part is upwards arc-shaped and convex along the through groove and forms an elastic clamping space with the clamping pressing plate in the vertical direction. The reagent strip is inserted from the insertion groove, and the elastic part of the elastic element presses the reagent strip to the clamping pressing plate to prevent the reagent strip from vibrating, so that the incubation uniformity and consistency are ensured; simultaneously, can also reduce the distance between reagent strip and the detection device to be convenient for detection device carries out accurately detecting the reagent strip from the detection through-hole on the centre gripping clamp plate. Compared with the prior art, the incubation device provided by the application can not only meet the requirement of compressing and clamping the reagent strip, but also ensure the uniformity and consistency of incubation; meanwhile, the reagent strip can be accurately detected by the detection device conveniently.

Description

Clamping mechanism for multi-channel immunofluorescence analyzer and incubation device

Technical Field

The utility model belongs to the field of medical equipment, especially, a fixture and incubation device for multichannel immunofluorescence analysis appearance.

Background

The chemiluminescence immunoassay technology is widely applied to the field of in vitro diagnosis by integrating the advantages of sensitive chemiluminescence analysis and specific antigen-antibody immunoassay. Wherein, the detection reagent strip is incubated according to the detection items. After incubation is finished, fluorescence detection is needed, and the detection device is close to the reagent strip as much as possible to ensure the accuracy of the result.

In order to facilitate the detection device to be close to the reagent strip as much as possible, the installation space of the pressing plate can be greatly limited, so that the structure of the pressing plate is thin, and the requirement for pressing the reagent strip is difficult to meet. And when the reagent strip compresses tightly not enough, the motion of mechanical parts can produce the air current in the device inside and make the reagent strip vibrate, and then makes the reagent strip be heated unevenly, influences incubated homogeneity and uniformity.

SUMMERY OF THE UTILITY MODEL

The utility model provides a fixture and incubation device for multichannel immunofluorescence analysis appearance to solve the problem that exists among the prior art.

In order to achieve the above purpose, the utility model adopts the following technical scheme:

a clamping mechanism for a multi-channel immunofluorescence analyzer, comprising:

the clamping body comprises an insertion groove formed by sinking downwards from the top surface of the clamping body by a preset distance and at least one through groove which is formed downwards from the bottom surface of the insertion groove and penetrates through the clamping body; the insertion groove extends to the front end face of the clamping main body along the width direction of the clamping main body;

the clamping pressing plate is fixed on the top surface of the clamping main body;

elastic element, including the fixed part of being connected with the bottom of centre gripping main part and the elastic part of being connected with one end and fixed part, the elastic part is followed logical groove arc arch that makes progress, the summit of elastic part is higher than the tank bottom surface of insertion groove, the elastic part with the centre gripping clamp plate forms elastic centre gripping space in vertical direction.

In a further embodiment, the through slots comprise a first through slot and a second through slot starting side by side in the width direction of the clamping body; the elastic elements are arranged in pairs and correspond to the first through grooves and the second through grooves one to one.

In a further embodiment, the clamping mechanism further comprises a positioning element fixed on one side of the rear end face of the clamping body, and the detection end of the positioning element horizontally extends to the position below the elastic element close to one side of the rear end face of the clamping body.

In a further embodiment, one side of the clamping pressure plate close to the front end face of the clamping main body comprises a right-angle flanging which is formed by bending upwards.

An incubation device for a multi-channel immunofluorescent analyzer comprising the clamping mechanism described in the above embodiment, the clamping platen starting from the top surface downwards with at least one detection through-hole running through the clamping platen.

In a further embodiment, the clamp further comprises a heating plate fixed to the bottom of the clamp body.

In a further embodiment, a temperature sensor for detecting the temperature of the heating plate is further included.

In a further embodiment, the clamping device further comprises an over-temperature protection switch embedded in the clamping main body.

Has the advantages that: the utility model provides an incubation device for multichannel immunofluorescence analysis appearance includes fixture. The clamping mechanism comprises a clamping main body, a clamping pressure plate and an elastic element. The clamping main body is provided with an insertion groove and a through groove. The elastic element comprises a fixed part and an elastic part. The elastic part is upwards arc-shaped and convex along the through groove and forms an elastic clamping space with the clamping pressing plate in the vertical direction. The reagent strip is inserted from the insertion groove, and the elastic part of the elastic element presses the reagent strip to the clamping pressing plate, so that the reagent strip is tightly attached to the clamping pressing plate, the reagent strip is prevented from vibrating, and the incubation uniformity and consistency are further ensured; simultaneously, can also reduce the distance between reagent strip and the detection device to be convenient for detection device carries out accurately detecting the reagent strip from the detection through-hole on the centre gripping clamp plate. Compared with the prior art, the incubation device provided by the application can not only meet the requirement of compressing and clamping the reagent strip, but also ensure the uniformity and consistency of incubation; meanwhile, the reagent strip can be accurately detected by the detection device conveniently.

Drawings

FIG. 1 is a schematic diagram of the structure of the incubation device for a multi-channel immunofluorescence analyzer according to the present invention.

FIG. 2 is a cross-sectional view of the incubation device.

Fig. 3 is a cross-sectional view of the clamping mechanism.

Fig. 4 is a side view of the elastic member.

FIG. 5 is a partial cross-sectional view of an incubation device

Each of the figures is labeled as: the clamping mechanism 1, the clamping main body 11, the insertion groove 111, the through groove 112, the clamping pressure plate 12, the detection through hole 121, the right-angle flange 122, the elastic element 13, the fixing part 131, the elastic part 132, the positioning element 14, the heating plate 2, the temperature sensor 3 and the over-temperature protection switch 4.

Detailed Description

The technical solution of the present invention will be described clearly and completely with reference to the accompanying drawings and embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without any creative effort belong to the protection scope of the present invention.

Research shows that when an immunofluorescence analyzer is utilized, a detection reagent strip needs to be incubated according to detection items, after incubation is completed, fluorescence detection needs to be carried out, and in order to guarantee accuracy of detection results, a detection device should be close to the reagent strip as much as possible. This can greatly restrict the installation space of clamp plate, leads to the structure of clamp plate to be thinner, is difficult to satisfy the requirement of compressing tightly the reagent strip. And when the reagent strip compresses tightly not enough, the motion of mechanical parts can produce the air current in the device inside and make the reagent strip vibrate, and then makes the reagent strip be heated unevenly, influences incubated homogeneity and uniformity.

In order to solve the above problems, as shown in fig. 1, the present invention provides an incubation device for a multi-channel immunofluorescence analyzer. The incubation device comprises a holding mechanism 1 for a multi-channel immunofluorescence analyzer.

Specifically, referring to fig. 1 to 4, the clamping mechanism 1 includes a clamping body 11, a clamping pressure plate 12, and an elastic element 13. Wherein, the top surface of the clamping main body 11 is recessed downwards by a preset distance to form an insertion groove 111, and the insertion groove 111 extends to the front end surface of the clamping main body 11 along the width direction of the clamping main body 11 to form an opening for inserting a reagent strip. The predetermined distance should be adapted to the thickness of the reagent strip. The predetermined distance cannot be too large, which may cause the reagent strip to be difficult to compress; meanwhile, the preset distance cannot be too small because it may cause difficulty in inserting the reagent strip into the insertion slot 111. Meanwhile, at least one through groove 112 is formed downwards in the bottom surface of the inserted groove, and the through groove 112 penetrates through the clamping main body 11. The clamping pressure plate 12 is fixed to the top surface of the clamping body 11. The holding pressure plate 12 is provided with at least one detection through hole 121 which penetrates through the holding pressure plate 12 from the top surface downward. The elastic member 13 includes a fixing portion 131 and an elastic portion 132. Wherein, the fixing portion 131 is fixedly connected with the bottom of the clamping body 11. One end of the elastic part 132 is integrally connected to the fixing part 131. The elastic portion 132 extends into the through slot 112 and is upwardly curved and convex along the through slot 112. The top of the elastic part 132 is higher than the bottom of the insertion slot 111, so that the elastic part 132 and the clamping platen 12 form a clamping space slightly smaller than the thickness of the reagent strip in the vertical direction. When the reagent strip is inserted from the insertion slot 111, the elastic member 13 is pressed by the reagent strip and deformed downward. Meanwhile, the elastic part 132 of the elastic element 13 applies a reverse elastic force to the reagent strip to press the reagent strip against the clamping platen 12, so that the reagent strip is tightly attached to the clamping platen 12. This prevents the strip from rattling, ensuring uniformity and consistency of incubation. The reagent strip is tightly attached to the clamping pressing plate 12, so that the distance between the reagent strip and the detection device can be reduced, and the detection device can accurately detect the reagent strip from the detection through hole 121 on the clamping pressing plate 12. Meanwhile, in order to improve the strength of the clamping pressure plate 12, an upward bending right-angle flange 122 is provided on the side of the clamping pressure plate 12 close to the front end face of the clamping main body 11. The right angle flanges 122 can act as reinforcing ribs and provide strength support in the thickness direction of the clamping platen 12.

With reference to fig. 2 and 5, the incubation device further comprises a heating plate 2, a temperature sensor 3 and an over-temperature protection switch 4. Wherein the heating plate 2 is fixed to the bottom of the clamping body 11 for heating. The temperature sensor 3 is connected with the heating plate 2 and used for detecting the heating temperature of the heating plate 2 in real time. The over-temperature protection switch 4 is embedded in the clamping main body 11 and electrically connected with the heating plate 2. When the temperature of the heating plate 2 is too high, the over-temperature protection switch 4 is automatically powered off, so that the heating plate 2 stops heating, and the incubation device is protected.

In order to promote the degree of compressing tightly of reagent strips, this embodiment compresses tightly the reagent strips from head and the tail both ends. Specifically, the through slots 112 include a first through slot 112 and a second through slot 112. The first through groove 112 and the second through groove 112 are arranged in parallel in the width direction of the clamp body 11; also, the first through groove 112 and the second through groove 112 are respectively close to the front end surface and the rear end surface of the clamp body 11. Meanwhile, the elastic elements 13 are also arranged in pairs, and the elastic elements 13 arranged in pairs correspond to the first through grooves 112 and the second through grooves 112 one to one, respectively. The elastic parts 132 of the elastic elements 13 extend from the first through grooves 112 and the second through grooves 112 respectively to apply elastic extrusion force to the head end and the tail end of the reagent strip, so that the compression effect of the reagent strip is improved.

In order to confirm whether the reagent strip is inserted in place, the holding mechanism 1 in this embodiment is further provided with a positioning element 14. The positioning member 14 is fixed to one side of the rear end surface of the clamp body 11. And the detecting end of the positioning member 14 extends horizontally below the elastic member 13 on the side close to the rear end face of the holding body 11. When the reagent strip is inserted into position, the elastic element 13 on the side close to the rear end face of the clamping main body 11 is pressed by the reagent strip to deform downwards and is abutted against the detection end of the positioning element 14. The positioning unit detects the pressure and confirms that the reagent strip is inserted in place. In particular, the positioning element 14 may be a pressure sensor.

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims

1. A clamping mechanism for a multi-channel immunofluorescence analyzer, comprising:

2. The clamping mechanism of claim 1, wherein the through slots include a first through slot and a second through slot beginning side-by-side in a width direction of the clamping body; the elastic elements are arranged in pairs and correspond to the first through grooves and the second through grooves one to one.

3. The clamping mechanism as claimed in claim 2, further comprising a positioning member fixed to a rear end face side of the clamping body, wherein the detection end of the positioning member extends horizontally below the elastic member near the rear end face side of the clamping body.

4. The clamping mechanism as claimed in claim 1, wherein the clamping pressure plate includes a right-angled flange bent upward on a side thereof adjacent to the front end surface of the clamping body.

5. An incubation device for a multi-channel immunofluorescent analyzer, comprising the holding mechanism of any one of claims 1 to 4, wherein the holding platen has at least one detection through-hole extending therethrough from the top surface downward.

6. The incubation device of claim 5, further comprising a heating plate affixed to the bottom of the clamping body.

7. The incubation device of claim 6, further comprising a temperature sensor for detecting the temperature of the heating plate.

8. The incubation device of claim 7, further comprising an over-temperature protection switch embedded in the clamp body.