CN214794450U - Terahertz transmission type blood or urine detection chip - Google Patents
Terahertz transmission type blood or urine detection chip Download PDFInfo
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- CN214794450U CN214794450U CN202120807538.9U CN202120807538U CN214794450U CN 214794450 U CN214794450 U CN 214794450U CN 202120807538 U CN202120807538 U CN 202120807538U CN 214794450 U CN214794450 U CN 214794450U
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Abstract
The utility model relates to a terahertz transmission type blood or urine detection chip, which is of an upper and lower layer structure, wherein the lower layer is a rectangular transmission basal layer; the detection chip is of an upper-layer structure and a lower-layer structure, and the lower layer is a rectangular transmission basal layer; the upper layer is a metal layer with an array-arranged asymmetric open resonator structure, and the metal layer is made of metamaterial in a spatial integral manner. The detection sensitivity and accuracy of biomedical detection are effectively improved by adopting a resonance ring microstructure array combining terahertz with one-way response, and are improved by 1000 times compared with the traditional method; the method is simple to operate, and no complex pretreatment means is adopted, so that the biomedical detection speed is effectively increased, and the medical resource utilization rate is increased.
Description
Technical Field
The utility model relates to a detection technology, in particular to terahertz transmission-type blood or urine detection chip now.
Background
Terahertz waves, or terahertz rays, have been formally named in the middle and late 80 s of the last century. Terahertz waves are electromagnetic waves having a frequency in the range of 0.1 to 10THz, and have a wavelength in the range of approximately 0.03 to 3mm, which is between microwave and infrared. The terahertz spectrum detection technology has the excellent characteristics of unique fingerprint spectrum, high penetrability and the like due to the terahertz waves, and has wide application in the fields of physics, chemistry, biomedicine, security inspection and the like. Taking cancer detection as an example, the existing cancer detection usually adopts pathological section, and needs four stages of freezing, slicing, staining and microscopic observation, the process is complicated, the time consumption is long, and doctors need to wait for pathological results on an operating table at the same time, which causes great waste of medical resources, so that efficient, accurate and nondestructive biomedical detection becomes one of the most urgent social requirements. At present, the existing biomedical detection technical means mainly comprise a fluorescence analysis method, a high performance liquid chromatography, a gas chromatography and mass spectrometry combined method and the like, a sample is required to be lost in actual detection, secondary detection cannot be carried out, the time consumption is long, the pretreatment is complicated, and the cost is high. These methods cannot meet the requirements of modern biomedicine on efficient, accurate and nondestructive detection, and have great limitations.
Based on the terahertz time-domain spectroscopy detection technology, a more efficient and convenient method can be generated by combining a terahertz time-domain spectroscopy system and used for biomedical detection. Taking specific markers MI and GABA of brain glioma as an example, for MI and GABA which are two different substances, due to different dielectric constants of the substances, based on the capacitance-inductance effect, finally, the change of the equivalent capacitance-inductance of the metamaterial chip can generate different change trends according to the types of the substances, so that different capacitance-inductance resonance rules can be generated, the terahertz transmission type blood/urine detection chip can be used for distinguishing different substances, and the detection and identification of disease proteins in microgram-level blood/urine can be realized at present.
Disclosure of Invention
In order to improve the biomedical detection speed, a terahertz transmission type blood or urine detection chip is provided, and the requirements of high-efficiency, accurate and nondestructive detection on biomedical early detection are met.
The technical scheme of the utility model is that: a terahertz transmission type blood or urine detection chip is provided, wherein the detection chip is of an upper layer structure and a lower layer structure, and the lower layer is a rectangular transmission basal layer; the upper layer is a metal layer with asymmetric open resonator ring structures arranged in an array mode, the metal layer is integrally formed into a metamaterial in a space mode, and no metal layer is arranged on the recessed asymmetric open resonator ring structures.
Preferably, the transmissive base layer is fused silica having a high transmittance for terahertz waves.
Preferably, the metal layer is gold with good conductivity.
Preferably, in the terahertz transmission type blood or urine detection chip, terahertz waves are incident to the metamaterial metal layer, terahertz waves at the resonant frequency of the metamaterial metal layer penetrate through the metal layer to be detected, and terahertz waves at the non-resonant frequency of the metamaterial metal layer are reflected by the metal layer.
The beneficial effects of the utility model reside in that: the terahertz transmission type blood or urine detection chip of the utility model adopts a method of combining terahertz with a one-way response resonant ring structure, effectively improves the detection sensitivity and accuracy of biomedical detection, and improves 1000 times compared with the traditional method; the method is simple to operate, and no complex pretreatment means is adopted, so that the biomedical detection speed is effectively increased, and the medical resource utilization rate is increased.
Drawings
FIG. 1 is a schematic structural view of a terahertz transmission type blood or urine detection chip of the present invention;
fig. 2 is the electric field diagram of the terahertz transmission type blood or urine detection chip of the present invention.
Detailed Description
The present invention will be described in detail below with reference to the accompanying drawings and specific embodiments. The embodiment is implemented on the premise of the technical solution of the present invention, and a detailed implementation manner and a specific operation process are given, but the scope of the present invention is not limited to the following embodiments.
According to the structural schematic diagram of the terahertz transmission type blood or urine detection chip shown in fig. 1, the detection chip is of an upper layer structure and a lower layer structure, the lower layer structure is a rectangular transmission substrate layer, the upper layer structure is a metal layer with asymmetric open resonant ring structures arranged in an array, and the metal layer space integrally forms a metamaterial, wherein the asymmetric open resonant ring structures are sunken in the metamaterial and are not plated with metal, the inner circle diameter of the asymmetric open resonant ring is D1, the outer circle diameter is D2, the gap distance is D, the thickness of the substrate layer is T, and the resonant period of the metamaterial is P. And plating a metal layer on the other substrate layers except the asymmetrical open resonator ring structure, wherein the metal layer is preferably gold. The resonant ring is a microstructure, and the periodic array arrangement of the resonant ring enhances the response.
In the embodiment, the detection limit is improved by combining the terahertz spectroscopy and the metamaterial chip. The terahertz transmission type blood or urine detection chip comprises an upper layer and a lower layer, which are respectively as follows: the bottom integral substrate layer is made of fused quartz, so that better transmission of terahertz waves can be realized; the upper metal layer is made of gold and has good conductivity. When terahertz waves are incident on the surface of each resonant ring structure, the left part and the right part which are taken as axes along the direction of an electric field generate potential difference, a capacitance inductance effect is induced, an oscillation current is generated, and therefore the superstructure generates characteristic absorption. As shown in fig. 2, E is the direction of the electric field, and since the opening is formed on one side of the resonant ring, the resonant ring is of an asymmetric structure, the electric field intensities on the two sides of the resonant ring are significantly different, so that a potential difference is generated and an oscillating current is finally generated due to the periodicity of the electric field. Meanwhile, the terahertz transmission type blood or urine detection chip is different from the existing absorption type chip in design in that the chip is in a complementary graph structure, as shown in fig. 1, the part (white part) of the detection chip outside a resonance ring is filled with gold, no gold is arranged at the position (gray part) of the resonance ring, so that the chip is changed from a characteristic absorption terahertz wave structure into a characteristic transmission terahertz wave structure, and the terahertz waves at the resonance frequency can penetrate through a metamaterial metal layer, but at the non-resonance frequency, the terahertz waves are reflected by the metamaterial metal layer. The signal-to-noise ratio of the chip at the resonance frequency is highest, so that the identification accuracy is high compared with that of an absorption chip.
The principle of detecting substances by the chip is as follows: based on the capacitance inductance effect, when the sample covers the surface of the chip, the equivalent capacitance inductance of the metamaterial chip changes. Different substances have different dielectric constants, so that the equivalent capacitance and inductance of the metamaterial chip have different variation trends, and different capacitance and inductance resonance rules appear, so that different substances are detected and identified according to the resonance rules.
The metal layer of the terahertz transmission type blood or urine detection chip needs to be graphically designed into a resonant ring structure with unidirectional response. A blood or urine sample is dripped on the surface of the chip, the chip is placed in a drying system, water in the sample is removed, absorption of the water to terahertz waves is reduced, then the chip with the sample is placed in a terahertz time-domain spectroscopy system, when terahertz light irradiates the surface of the chip, the left part and the right part which are axial lines along the direction of an electric field generate potential difference, a capacitance inductance effect is induced, oscillation current is generated, and therefore the superstructure generates characteristic absorption. At the resonant frequency, terahertz waves can be transmitted through the metamaterial, while at the non-resonant frequency, terahertz waves are reflected by the metamaterial. Based on the capacitance inductance effect, the dielectric of the sample can be equivalent to a negative value, and finally the frequency spectrum of the sample has unimodal characteristics. Under the coverage of the sample, the equivalent capacitance and inductance of the chip are changed, so that the resonance frequency of the capacitance and inductance is changed. Meanwhile, for different reasons, the dielectric constants of the terahertz transmission type blood or urine detection chip are different, so that the change of the equivalent capacitance inductance of the terahertz transmission type blood or urine detection chip finally generates different change trends according to the types of substances, and different capacitance inductance resonance rules are generated. Based on the principle, the terahertz transmission type blood or urine detection chip can be used for biosensing test, and is simple to implement and rapid in detection.
The above-mentioned embodiments only represent some embodiments of the present invention, and the description thereof is specific and detailed, but not to be construed as limiting the scope of the present invention. It should be noted that, for those skilled in the art, without departing from the spirit of the present invention, several variations and modifications can be made, which are within the scope of the present invention. Therefore, the protection scope of the present invention should be subject to the appended claims.
Claims (4)
1. A terahertz transmission type blood or urine detection chip is characterized in that the detection chip is of an upper layer structure and a lower layer structure, and the lower layer is a rectangular transmission basal layer; the upper layer is a metal layer with asymmetric open resonator ring structures arranged in an array mode, the metal layer is integrally formed into a metamaterial in a space mode, and no metal layer is arranged on the recessed asymmetric open resonator ring structures.
2. The terahertz transmission type blood or urine detection chip according to claim 1, wherein the transmission substrate layer is fused quartz having high transmittance for terahertz waves.
3. The terahertz transmission type blood or urine detection chip as claimed in claim 1 or 2, wherein the metal layer is gold with good conductivity.
4. The terahertz transmission type blood or urine detection chip according to claim 3, wherein terahertz waves are incident on the metamaterial metal layer, terahertz waves at a resonant frequency of the metamaterial metal layer are detected by transmitting the metal layer, and terahertz waves at a non-resonant frequency of the metamaterial metal layer are reflected by the metal layer.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202120807538.9U CN214794450U (en) | 2021-04-20 | 2021-04-20 | Terahertz transmission type blood or urine detection chip |
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| CN202120807538.9U CN214794450U (en) | 2021-04-20 | 2021-04-20 | Terahertz transmission type blood or urine detection chip |
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| CN214794450U true CN214794450U (en) | 2021-11-19 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115598086A (en) * | 2022-09-20 | 2023-01-13 | 山东大学（Cn） | Terahertz metamaterial biosensor for evaluating postoperative curative effect of glioma and application |
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2021
- 2021-04-20 CN CN202120807538.9U patent/CN214794450U/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115598086A (en) * | 2022-09-20 | 2023-01-13 | 山东大学（Cn） | Terahertz metamaterial biosensor for evaluating postoperative curative effect of glioma and application |
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Granted publication date: 20211119 |