CN214751494U - Bioreactor data management and remote control system - Google Patents
Bioreactor data management and remote control system Download PDFInfo
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- CN214751494U CN214751494U CN202120930232.2U CN202120930232U CN214751494U CN 214751494 U CN214751494 U CN 214751494U CN 202120930232 U CN202120930232 U CN 202120930232U CN 214751494 U CN214751494 U CN 214751494U
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Abstract
The utility model relates to the field of information technology, in particular to bioreactor data management and remote control system, include: the system comprises a bioreactor, a master control PLC, a single board controller, a local upper computer, a cloud server and a remote upper computer, wherein a fermentation data acquisition unit is arranged on the bioreactor, the master control PLC is connected with the fermentation data acquisition unit, the single board controller is connected with the master control PLC, the local upper computer is in communication connection with the single board controller, the cloud server is in communication connection with the single board controller, and the remote upper computer is in communication connection with the cloud server. The first Web server built on the single board control machine can use the local upper computer to access and check the state and process parameters of the equipment and operate the equipment. And the second Web server built on the cloud server can use the remote upper computer to access and check the state and the process parameters of the equipment and operate the equipment.
Description
Technical Field
The utility model relates to the technical field of information, in particular to bioreactor data management and remote control system.
Background
The fermentation technology has been developed from the earliest manual workshop-type production to the current large-scale industrialized integrated production for thousands of years. With the continuous updating and development of the bioreactor and the increasing number of detectable parameters, the data generated in the fermentation process is increased in an explosive manner. In the early stage, paper documents are adopted to record data, and manual data sorting and analysis are adopted, so that the efficiency is low, the data is easy to lose, and a large amount of precious original data cannot be effectively managed and utilized. Thus, bioreactor manufacturing enterprises have developed fermentation data management and control systems.
At present, developed fermentation data management and control systems are all installed on a local upper computer, are connected with a bioreactor master control PLC through a local area network, and can receive data generated by the PLC and store the data on the local upper computer. Meanwhile, an upper computer can send an instruction to the PLC, so that the local upper computer can control the bioreactor. However, this control method has the following problems: (1) data display and control instruction sending can only be completed on a local upper computer, and remote data calling and control instruction sending cannot be realized, which requires that an operator must continuously watch on a production site for 24 hours; (2) the software installation process of the upper computer is complex, many professional computer software knowledge is involved, and common users cannot perform competence, so that the popularization is difficult; (3) all control functions of the existing control system are fixed, and the control functions are difficult to modify or expand at the later stage of a client.
SUMMERY OF THE UTILITY MODEL
The utility model discloses an at least, solve one of the above-mentioned problem that proposes, for realizing the utility model discloses a purpose, the utility model discloses a following technical scheme: a bioreactor data management and remote control system comprising: the device comprises a bioreactor, a master control PLC, a single board controller, a local upper computer, a cloud server and a remote upper computer, wherein a fermentation data acquisition unit is arranged on the bioreactor, the master control PLC is connected with the bioreactor and used for acquiring equipment state information and controlling the operation of the bioreactor, the master control PLC is connected with the fermentation data acquisition unit and used for acquiring process parameters of the bioreactor, the single board controller is connected with the master control PLC and used for acquiring the equipment state information and the process parameters of the bioreactor and controlling the bioreactor through the master control PLC, the local upper computer is in communication connection with the single board controller, the cloud server is in communication connection with the single board controller, and the remote upper computer is in communication connection with the cloud server.
In a further improvement, the single board controller is provided with a local database, and the single board controller stores the obtained device status information and the process parameters in the local database.
The further improvement is that the single board controller is built with a first Web server, and the local upper computer accesses the first Web server on the single board controller through a local area network to call the data stored in the local database.
The further improvement is that the first Web server is provided with a first control system, and the first control system is used for directly sending a control instruction to the master control PLC so as to realize local control on the bioreactor.
The system is further improved in that the cloud server is provided with a cloud database, the single board controller is provided with an internet of things terminal device client for pushing device state information and process parameters to the cloud server at certain time intervals, and the cloud server stores the obtained device state information and the obtained process parameters in the cloud database.
The cloud server is further improved in that a second Web server is built in the cloud server, and the remote upper computer accesses the second Web server on the cloud server through the Internet and calls the data stored in the cloud database.
The further improvement is that the second Web server is provided with a second control system, and the second control system is used for pushing a control instruction to the single board controller by using an MQTT protocol and sending the control instruction to the master control PLC through the Ethernet so as to realize the remote control of the bioreactor.
In a further refinement, the fermentation data acquisition unit comprises a plurality of sensors.
The remote control system is further improved in that the local upper computer and the remote upper computer are any one of a PC (personal computer), a mobile phone and a tablet computer.
The further improvement is that the single Board controller is any one of raspberry, on Omega2+, NVIDIA Jetson Nano Developer Kit, ASUS Tinker Board S.
The utility model has the advantages that:
(1) the utility model discloses a bioreactor data management and remote control system, communication parameter between veneer controller and the master control PLC can be according to the nimble configuration of administrator user's page of a Web server, realizes the seamless butt joint between veneer controller and all kinds of equipment that come from different manufacturers.
(2) The utility model discloses a bioreactor data management and remote control system builds the first Web server on the single board control machine, can use the Web browser on this host computer, visits through the LAN, can look over the state and the process parameter of equipment. The method is different from traditional C/S architecture fermentation upper computer software, the software requires a user to install a client program and database management software which are completely deployed on a PC, the software installation process requires that an operator has higher basic knowledge of the computer software, and common users obviously cannot meet the requirement, so that the popularization efficiency of the C/S architecture upper computer software is severely restricted. And the utility model discloses a bioreactor data management and remote control system can effectively avoid this problem, reduces the threshold that end user used software.
(3) The utility model discloses a bioreactor data management and remote control system uses Python language development thing networking terminal equipment customer end on the single board control machine, according to certain time interval to high in the clouds Broker propelling movement equipment state information and process parameter. In the traditional data management system, data is stored in a hard disk of an upper computer, and only the original data can be deleted or hardware can be amplified after the hard disk is full, so that time and labor are wasted. Meanwhile, the mode of cloud database storage can realize that a remote upper computer can access and call data at any time, which cannot be realized by traditional hard disk storage data.
Drawings
FIG. 1 is a schematic diagram of a data management and remote control system for a bioreactor according to the present invention.
Detailed Description
The drawings are for illustrative purposes only and are not to be construed as limiting the patent; for the purpose of better illustrating the embodiments, certain features of the drawings may be omitted, enlarged or reduced, and do not represent the size of an actual product; it will be understood by those skilled in the art that certain well-known structures in the drawings and descriptions thereof may be omitted.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. The nomenclature used in this specification may be used to describe various components, but these components are not limited by these nomenclature. These terms are used only for the purpose of distinguishing one constituent element from other constituent elements.
In the description of the present invention, it is to be noted that, unless otherwise explicitly specified or limited, the terms "mounted" and "connected" are to be interpreted broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, so to speak, as communicating between the two elements. The specific meaning of the above terms in the present invention can be understood in specific cases for those skilled in the art. The technical solution of the present invention will be further explained with reference to the accompanying drawings and examples.
Referring to fig. 1, an embodiment of the present invention provides a bioreactor data management and remote control system, including: the device comprises a bioreactor, a master control PLC, a single board controller, a local upper computer, a cloud server and a remote upper computer, wherein a fermentation data acquisition unit is arranged on the bioreactor, the master control PLC is connected with the bioreactor and used for acquiring equipment state information and controlling the operation of the bioreactor, the master control PLC is connected with the fermentation data acquisition unit and used for acquiring process parameters of the bioreactor, the single board controller is connected with the master control PLC and used for acquiring the equipment state information and the process parameters of the bioreactor and controlling the bioreactor through the master control PLC, the local upper computer is in communication connection with the single board controller, the cloud server is in communication connection with the single board controller, and the remote upper computer is in communication connection with the cloud server.
Specifically, the single Board control machine is preferably a raspberry group, in other embodiments of the present invention, can also be any one of similar products such as one Omega2+, NVIDIA Jetson Nano device Kit, ASUS Tinker Board S, of course, the present invention is not limited to the single Board control machine above, as long as it can realize the same function of the present invention.
Specifically, in this embodiment, the CPU module of the master PLC connected to the bioreactor is connected to the board controller via ethernet, the PLC communication program is written in Python language on the board controller, and the snap7 software module is used to implement the communication connection between the board controller and the master PLC.
Specifically, in this embodiment, the board controller is provided with a local database, and the board controller stores the obtained device status information and the obtained process parameters in the local database. The single board controller is built with a first Web server, the local upper computer accesses the first Web server on the single board controller through a local area network, and calls the data stored in the local database, so as to check the equipment state information and analyze the process parameters.
Preferably, the first Web server is built on a single board controller using Python language. The basic data analysis function provided by the Web page of the first Web server mainly comprises: monitoring and comparing parameter curves of real-time batches, comparing multi-parameter curves of historical batches, analyzing difference among fermentation batches, analyzing key parameters of the fermentation process and the like.
Specifically, the monitoring and comparing of the parameter curves of the real-time batches comprises: multiple parameters of a single real-time fermentation batch are displayed in the same curve graph, and an operator judges the fermentation state through observing the parameter change rule, so that the reasonable operation is implemented on the fermentation process, the same key parameter of different real-time fermentation batches is displayed in the same curve graph, and the operator is helped to master the influence of the key parameter on the fermentation performance.
Specifically, the analysis of key parameters of the fermentation process comprises the following steps: the sensitivity of the fermentation performance to different process parameters is analyzed to determine the process parameter that has the greatest impact on the fermentation performance, i.e. the key parameter.
Specifically, the comparison of the multi-parameter curves of the historical batches and the analysis of the difference between fermentation batches comprise the following steps: the same key parameters of a plurality of historical batches are displayed in the same curve graph, and a more reasonable parameter control level is sought by comparing the relation between the change rule of one or a group of key parameters and the fermentation performance difference of each batch, so that the fermentation performance is improved.
Specifically, in this embodiment, the first Web server is provided with a first control system, and the first control system is configured to directly send a control instruction to the master PLC, so as to implement local control on the bioreactor.
Specifically, the communication parameters between the board controller and the master PLC may be flexibly configured through the administrator user page of the first Web server, so as to implement seamless docking between the board controller and various devices from different manufacturers, and the selectable communication parameters may include variable data types, register partitions and addresses corresponding to variables, and DB block numbers and addresses corresponding to variables.
Specifically, in this embodiment, the cloud server is provided with a cloud database, the single board controller is provided with an internet of things terminal device client built in Python language, and the internet of things terminal device client is used for pushing device state information and process parameters to the cloud server at certain time intervals, and the cloud server stores the obtained device state information and process parameters in the cloud database. Specifically, the device state information and the process parameters are pushed to a cloud Broker of the cloud server.
Specifically, the structures of the local database and the cloud database are designed according to the characteristics of fermentation data (such as dissolved oxygen concentration, temperature, respiratory quotient, cell concentration and the like), a function of storing data according to fermentation batches is provided, and a user can retrieve the data according to the characteristics of the fermentation batches, so that data meeting certain requirements can be quickly acquired from mass data for subsequent data analysis.
Specifically, in this embodiment, the cloud server is built with a second Web server in Python language, and the remote upper computer accesses the second Web server on the cloud server through the internet to retrieve the data stored in the cloud database.
Specifically, the second Web server adopts the same webpage design as the first Web server, adopts a response type layout, can automatically adjust the page layout according to the size of the display, and is suitable for accessing different types of upper computer equipment. The Web page of the second Web server also provides the same basic data analysis function as the first Web server, and a user can remotely call and analyze data.
Specifically, in this embodiment, the second Web server is provided with a second control system, and the second control system is configured to push a control instruction to the board controller by using an MQTT protocol, and send the control instruction to the master PLC through an ethernet, so as to implement remote control of the bioreactor.
Specifically, in a preferred embodiment of this embodiment, the control modes of the first control system and the second control system mainly include manual input of control parameters and an automatic control program written according to a fermentation commonality rule. The fermentation commonness rule refers to a rule possessed by most fermentation processes, such as positive correlation between carbon source consumption rate and heat production, positive correlation between respiratory quotient and TCA circulating metabolic flux, simultaneous increase of pH value and dissolved oxygen concentration of fermentation liquor caused by carbon source deficiency, and the like.
Specifically, in the present embodiment, the fermentation data acquisition unit includes a plurality of sensors. The sensors are used for collecting process parameters, and the specific types of the sensors can be set according to actual fermentation conditions, and can comprise a temperature sensor, a pH sensor, a dissolved oxygen concentration sensor and the like.
Specifically, in this embodiment, the local upper computer and the remote upper computer are any one of a PC, a mobile phone, and a tablet computer.
The technical features of the above embodiments can be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the above embodiments are not described, but should be considered as the scope of the present specification as long as there is no contradiction between the combinations of the technical features.
The above-mentioned embodiments only express the specific embodiments of the present invention, and the description thereof is specific and detailed, but not construed as limiting the scope of the present invention. It should be noted that, for those skilled in the art, without departing from the spirit of the present invention, several variations and modifications can be made, which are within the scope of the present invention.
Claims (10)
1. A bioreactor data management and remote control system, comprising: the device comprises a bioreactor, a master control PLC, a single board controller, a local upper computer, a cloud server and a remote upper computer, wherein a fermentation data acquisition unit is arranged on the bioreactor, the master control PLC is connected with the bioreactor and used for acquiring equipment state information and controlling the operation of the bioreactor, the master control PLC is connected with the fermentation data acquisition unit and used for acquiring process parameters of the bioreactor, the single board controller is connected with the master control PLC and used for acquiring the equipment state information and the process parameters of the bioreactor and controlling the bioreactor through the master control PLC, the local upper computer is in communication connection with the single board controller, the cloud server is in communication connection with the single board controller, and the remote upper computer is in communication connection with the cloud server.
2. The bioreactor data management and remote control system according to claim 1, wherein the single board controller is provided with a local database, and the single board controller stores the obtained equipment status information and process parameters in the local database.
3. The bioreactor data management and remote control system according to claim 2, wherein the single board controller is configured with a first Web server, and the local host computer accesses the first Web server on the single board controller via a local area network to retrieve the data stored in the local database.
4. The bioreactor data management and remote control system according to claim 3, wherein the first Web server is provided with a first control system, and the first control system is used for directly sending control instructions to the master PLC to realize local control of the bioreactor.
5. The bioreactor data management and remote control system according to any one of claims 1 to 4, wherein the cloud server is provided with a cloud database, the single board controller is provided with an internet of things terminal device client for pushing device status information and process parameters to the cloud server at certain time intervals, and the cloud server stores the obtained device status information and process parameters in the cloud database.
6. The bioreactor data management and remote control system according to claim 5, wherein the cloud server is provided with a second Web server, and the remote host computer accesses the second Web server on the cloud server through the Internet to retrieve the data stored in the cloud database.
7. The bioreactor data management and remote control system according to claim 6, wherein the second Web server is provided with a second control system, the second control system is configured to push a control command to the single-board controller by using MQTT protocol, and then send the control command to the master PLC through ethernet to realize remote control of the bioreactor.
8. The bioreactor data management and remote control system of claim 1, wherein the fermentation data collection unit comprises a plurality of sensors.
9. The bioreactor data management and remote control system according to claim 1, wherein the local upper computer and the remote upper computer are any one of a PC, a mobile phone and a tablet computer.
10. The bioreactor data management and remote control system as claimed in claim 1, wherein the single Board controller is any one of raspberry pi, on Omega2+, NVIDIA Jetson Nano Developer Kit, ASUS Tinker Board S.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202120930232.2U CN214751494U (en) | 2021-04-30 | 2021-04-30 | Bioreactor data management and remote control system |
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| CN202120930232.2U CN214751494U (en) | 2021-04-30 | 2021-04-30 | Bioreactor data management and remote control system |
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| CN214751494U true CN214751494U (en) | 2021-11-16 |
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| CN202120930232.2U Active CN214751494U (en) | 2021-04-30 | 2021-04-30 | Bioreactor data management and remote control system |
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| TR01 | Transfer of patent right |
Effective date of registration: 20230418 Address after: 2296, Building D2, No. 2009, Lihu Avenue, Wuxi City, Jiangsu Province, 214071 Patentee after: Wuxi Fate Lemon Biotechnology Co.,Ltd. Address before: 224403 No.5 Jingxi Road, Funing high tech Industrial Development Zone, Yancheng City, Jiangsu Province Patentee before: Yancheng baijianxing Biotechnology Co.,Ltd. |
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