CN214750029U - Small-volume high-efficiency online static mixer suitable for ultra-high performance liquid chromatography system - Google Patents

Abstract

The small-volume high-efficiency online static mixer suitable for the ultra-high performance liquid chromatography system comprises a plurality of columnar inner cores, wherein axial liquid inlet holes and liquid outlet holes are respectively formed in the middles of the upper end surface and the lower end surface of each inner core, a certain number of first connecting holes and second connecting holes which are radially distributed are respectively formed in the upper position and the lower position of the side wall of each inner core, the inner ends of the first connecting holes are communicated with the inner ends of the liquid inlet holes, the inner ends of the second connecting holes are communicated with the inner ends of the liquid outlet holes, a first annular groove is formed in the side wall of the inner core where the outer end of each first connecting hole is located, a second annular groove is formed in the side wall of the inner core where the outer end of each second connecting hole is located, and a certain number of connecting grooves are formed in the side wall of the inner core between the first annular groove and the second annular groove. The utility model discloses a blender is small, compromises binary high pressure gradient system (radially mixing) and low pressure gradient system (mix before the time back), can be applicable to HPLC system and UHPLC system simultaneously.

Description

Small-volume high-efficiency online static mixer suitable for ultra-high performance liquid chromatography system

Technical Field

The utility model relates to a blender technical field especially relates to a high-efficient online static mixer of little volume suitable for ultra performance liquid chromatography system.

Background

At present, both High Performance Liquid Chromatography (HPLC) and Ultra High Performance Liquid Chromatography (UHPLC) which are common contain isocratic mode and gradient mode.

In isocratic mode, the infusion system is responsible for delivering only a single component mobile phase, whereas in gradient mode, the infusion system needs to transport two or more mobile phases, and the composition ratio of each mobile phase needs to change over time during use. In order to ensure the separation and analysis effect, the various mobile phases need to be mixed sufficiently before entering the chromatographic column so as not to affect the peak shape and reproducibility of the sample peak.

However, whether a binary high pressure gradient system using two sets of infusion pumps or a quaternary low pressure gradient system using proportional valves for initial mixing, the different mobile phases are placed in different solvent bottles before entering the system. That is, for the gradient system, an in-line mixer is required to fully mix the mobile phase before entering the chromatographic column between the liquid feeding system and the sample feeding system, and for the real-time performance of the ratio change, the in-line mixer has to be small enough in volume on the premise of ensuring the mixing effect, because the liquid in the mixer needs to be replaced firstly after the mobile phase composition changes to reach the chromatographic column.

The common analysis flow rate of HPLC is 1000-2000 mu L/min, the common flow rate of UHPLC system is below 500 mu L/min, most of chromatographic columns used by the UHPLC system have smaller volume, and the sample peak-off time is shorter. The volume of a mixer of an HPLC system in the market is generally 1000-3000 mu L, the hysteresis volume of the mixer is acceptable on the HPLC system, but the mixer is not suitable for an UHPLC system, and a sample peak is already appeared when the composition of a mobile phase is changed and a chromatographic column is not reached in gradient sample injection, so that the volume of the mixer suitable for the UHPLC must be further reduced on the basis of the current HPLC mixer.

Furthermore, from fluid mechanics, the best way to improve the efficiency of liquid mixing is to bring the mobile phase into a turbulent state. The tube diameter of the HPLC tube is 0.5 mm; the common pipe diameter of UHPLC is 0.25mm, and the UHPLC belongs to a micro-channel. In the micro-channel, the liquid viscosity plays a leading role, and the Reynolds number is very small. By way of example, calculation under conditions customary for HPLC (pure water, 20 ℃, flow 1000. mu.L/min, tube diameter 0.5 mm) gives a Reynolds number Re = 42; calculated according to the common conditions of UHPLC (pure water, 20 ℃, the flow rate of 430 mu L/min and the pipe diameter of 0.25 mm), the Reynolds number Re =36 is obtained. Are less than the critical value for turbulence. The fluid state in the liquid chromatography system tube can be considered substantially laminar.

The mixing of different mobile phases depends mainly on intermolecular diffusion in a laminar flow state. Therefore, for improving the mixing effect of the fluid in a laminar flow state, on one hand, the contact area among different mobile phases needs to be increased, namely, the mobile phases are subjected to multiple shunting and converging; on the other hand, special mixing conditions such as impact, baffling, spiral coil and the like need to be manufactured to enhance local mixing effects.

Finally, in the binary high-pressure gradient system and the quaternary low-pressure gradient system, the distribution modes of different mobile phases in the pipeline are different. The binary high-pressure system uses two separate infusion pumps (also, there are ternary and quaternary high-pressure systems, which are not described herein) to deliver different mobile phases, and the outlet of each pump is connected to a premixer (the binary system generally uses a tee) to make all the mobile phases converge into the same flow path. That is, in a binary high pressure system, two different mobile phases are present at the same time in the cross section of the merged pipe at a certain time. However, in the case of a quaternary low-pressure gradient system (the same applies to other systems using proportional solenoid valves), only one infusion pump is used, different mobile phases enter the system at different times by switching the solenoid valves, and only one mobile phase exists in the section of the pipeline at the outlet of the infusion pump at a certain time.

SUMMERY OF THE UTILITY MODEL

The invention aims to solve the defects of the existing device, consider a binary high-pressure gradient system and a low-pressure gradient system and provide a small-volume high-efficiency online static mixer suitable for an ultra-high performance liquid chromatography system.

In order to achieve the above purpose, the utility model adopts the following technical scheme:

the small-volume high-efficiency online static mixer suitable for the ultra-high performance liquid chromatography system comprises a plurality of columnar inner cores, wherein axial liquid inlet holes and liquid outlet holes are respectively formed in the middles of the upper end surface and the lower end surface of each inner core, a certain number of first connecting holes and second connecting holes which are radially distributed are respectively formed in the upper position and the lower position of the side wall of each inner core, the inner ends of the first connecting holes are communicated with the inner ends of the liquid inlet holes, the inner ends of the second connecting holes are communicated with the inner ends of the liquid outlet holes, a first annular groove is formed in the side wall of the inner core where the outer end of each first connecting hole is located, a second annular groove is formed in the side wall of the inner core where the outer end of each second connecting hole is located, and a certain number of connecting grooves are formed in the side wall of the inner core between the first annular groove and the second annular groove. The liquid is divided into a plurality of parts from the liquid inlet hole to the first connecting hole for the first time, then the liquid enters the first ring groove, the liquid which is divided when entering the first ring groove is divided again, the liquid of each path of the first connecting hole is divided into two parts, the converging flow of the first ring groove enters the connecting groove, then the liquid enters the second ring groove flow path, the liquid is divided when entering the second ring groove, then the liquid enters the second connecting hole, the liquid is converged when entering the second connecting hole, and finally the liquid is converged again and enters the liquid outlet hole. The liquid in the mixer core, from the inlet to the outlet, was subjected to a total of 9 splits and 9 merges with 9T-hits.

Preferably, the number of the first connection holes and the second connection holes is even and the first connection holes and the second connection holes are distributed at equal intervals. The number of the first connection holes and the second connection holes may be 4, 6, or 8, etc.

Preferably, the number of the first connection holes, the second connection holes and the connection grooves is the same.

Preferably, the cross sections of the liquid inlet hole, the liquid outlet hole, the first connecting hole and the second connecting hole are circular, and the cross sections of the first ring groove, the second ring groove and the connecting groove are semicircular.

Preferably, the connecting groove is an axial straight groove or an inclined or curved inclined groove. If the connecting groove is an axial straight groove, when entering the connecting groove from the first ring groove, the connecting groove can be similar to a T-shaped groove, the 90-degree direction is an outlet, different mobile phases are impacted for 180 degrees in a T-shaped structure, and the impacted mobile phases face to the fluid exchange cross-section molecules, so that the impact mixing effect is far higher than that of common confluence due to the opposite speed direction of the two colliding fluids. If the connecting groove is an inclined or curved (such as a spiral line) chute, the intaglio flow path naturally has curvature, so that centrifugal force exists when liquid flows on the surface of the inner core, secondary flow perpendicular to the flow direction of the main body is generated, the radial mixing effect of the flowing phase is improved, originally, the secondary flow only exists in the annular groove, and after the connecting groove is changed into the chute, the secondary flow also exists on the chute, the existence time of the secondary flow is prolonged, and the radial mixing of the fluid in the pipeline is facilitated.

Preferably, the inner core is made of a resin material, such as PEEK.

Preferably, the mixer comprises a stainless steel shell, two inner cores which are connected in series and distributed up and down are arranged in the stainless steel shell, the upper end and the lower end of the stainless steel shell are respectively provided with a connecting end cover, and the connecting end covers are provided with connecting holes. The PEEK inner core is arranged in the stainless steel outer sleeve at low temperature (minus 40 ℃), and the normal temperature is recovered after the PEEK inner core is arranged, so that the PEEK inner core is expanded to be completely attached to the stainless steel outer sleeve.

Preferably, a sealing gasket is arranged between the connecting end cover and the stainless steel shell, and a partition plate with a hole is arranged between the two inner cores. The baffle can be as an organic whole structure with the stainless steel shell, and the stainless steel overcoat is inside to be punched, both ends are sealed, reduce the weeping point.

Preferably, the mixer further comprises a stainless steel shell, at least two inner cores which are distributed in series are arranged in the stainless steel shell, a connecting end cover is arranged at the upper end of the stainless steel shell, and a connecting hole is formed in the lower end of the stainless steel shell.

Preferably, a spacer with holes is arranged between the inner cores. The shock insulator is made of elastic materials (PTFE, PEEK and the like), so that the processing difficulty of the flow path is reduced, different inner cores can be combined more conveniently, and different mixing requirements can be met.

Preferably, the mixer further comprises a stainless steel shell, a certain number of accommodating holes are formed in the upper end face of the stainless steel shell, inner cores are arranged in the accommodating holes respectively, and the end portions of the accommodating holes are provided with connecting end covers with sealing gaskets. The inner cores of the mixer are connected in parallel, the number of the inner cores is two or more, and the inner cores are connected in parallel, so that on one hand, the linear velocity of a mobile phase entering the inner cores can be reduced, and the molecular diffusion time can be prolonged; on the other hand, the mixed liquid is divided into smaller volume units, so that the specific surface area can be increased, and the mixing effect of intermolecular diffusion can be improved. If the parallel method uses inner cores with different flow path volumes but the same resistance, the phase difference can be produced, and the front and the back can be mixed. And because the inlet is divided into a plurality of parts, compared with a series connection mode, the volume difference required for manufacturing the equivalent phase difference is smaller, and the reduction of the whole volume of the mixer is facilitated.

Preferably, the number of the connecting end covers is one, the bottom of each connecting end cover is provided with a certain number of upper connecting holes communicated with the accommodating holes, the upper connecting holes incline towards the middle and are overlapped on the top surface, the stainless steel shell at the bottom of each accommodating hole is respectively provided with lower connecting holes, and the lower connecting holes incline towards the middle and are overlapped on the bottom surface.

Preferably, the outer end of the upper connecting hole of the connecting end cover and the outer end of the lower connecting hole of the stainless steel shell are respectively welded with a stainless steel pipe. The stainless steel pipe is used for communicating with a transfusion system, and the outlet pipeline and the inlet pipeline are welded, so that the use of an external pipeline joint can be reduced, namely, the leakage point is reduced.

Preferably, the number of the connecting end covers is one or more, the connecting end covers are provided with axial upper connecting holes communicated with the accommodating holes, and the stainless steel shells at the bottoms of the accommodating holes are respectively provided with axial lower connecting holes. The upper connecting hole and the lower connecting hole are communicated with the transfusion system through a multi-way pipeline with one added to the number of the upper connecting hole and the lower connecting hole.

The beneficial effects of the utility model reside in that: 1. the mixer of the utility model has small volume, takes into account a binary high-pressure gradient system (radial mixing) and a low-pressure gradient system (mixing before and after time), and can be simultaneously suitable for an HPLC system and an UHPLC system;

2. the flow path is carved on the surface of the inner core cylinder, centrifugal force exists during flowing, secondary flow is generated, radial mixing can be performed, the mixing of different mobile phase systems (typically a binary high-pressure gradient system) existing at the cross section of the pipeline at the same time is facilitated, one implementation mode is that the surface connecting flow path is prolonged, the pipeline becomes a spiral line, the existence time of the secondary flow is prolonged, and the radial mixing effect is enhanced;

3. the fluid is divided and merged for a plurality of times in the core body, and the structure of the typical example (embodiment one) is divided for 9 times and merged for 9 times;

4. t-shaped notches are adopted, two paths of liquid impact oppositely, and the mixing effect is enhanced;

5. the PEEK inner core diameter and the nick radius can be independently changed, for example, the connecting nicks between the upper layer circumference and the lower layer circumference adopt nicks with different inner diameters, lengths and shapes, so that the volumes of the flow paths are unequal. When the outlets converge, the liquid generates a time phase difference, and the mobile phases are mixed in front and back, so that the mixing effect of different mobile phases in the flow direction (such as a low-pressure gradient system) is facilitated;

6. the PEEK inner core and the stainless steel outer sleeve are combined, the length and the number of the inner cores can be increased or decreased, a series connection mode or a parallel connection mode can be used, and the flexibility is high;

7. under some circumstances, use the welding method when parallelly connected, use the sealing washer sealed when establishing ties, reduce the quantity that external stainless steel connects, also reduce the weeping point of system promptly, have better pressure retaining nature under the high pressure.

8. Small volume, single mixer core volume of only 20 μ L when all flow paths are scored with d =0.5 mm (R =0.25 mm), fully applicable to UHPLC systems.

Drawings

Fig. 1 is a perspective view of a first embodiment of the present invention;

fig. 2 is a front view of a first embodiment of the present invention;

FIG. 3 is a cross-sectional view taken along line A-A of FIG. 2;

FIG. 4 is a cross-sectional view taken along line B-B of FIG. 2;

fig. 5 is a flow chart illustration of a first embodiment of the present invention;

fig. 6 is a perspective view of a second embodiment of the present invention;

fig. 7 is a front view of a second embodiment of the present invention;

fig. 8 is a perspective view of a third embodiment of the present invention;

fig. 9 is a front view of a third embodiment of the present invention;

FIG. 10 is a cross-sectional view taken along line C-C of FIG. 9;

fig. 11 is an exploded view of a third embodiment of the present invention;

fig. 12 is a perspective view of a fourth embodiment of the present invention;

fig. 13 is a front view of a fourth embodiment of the present invention;

FIG. 14 is a cross-sectional view taken along line D-D of FIG. 13;

fig. 15 is an exploded view of a fourth embodiment of the present invention;

fig. 16 is a perspective view of a fifth embodiment of the present invention;

fig. 17 is a front view of a fifth embodiment of the present invention;

FIG. 18 is a sectional view taken along line E-E in FIG. 17;

fig. 19 is an exploded view of a fifth embodiment of the present invention.

The main elements in the figures are symbolically illustrated: 10. an inner core; 11. a liquid inlet hole; 12. a liquid outlet hole; 13. a first connection hole; 14. a second connection hole; 15. a first ring groove; 16. a second ring groove; 17. connecting grooves; 18. a chute; 20. a stainless steel housing; 21. connecting holes; 30. connecting an end cover; 40. a gasket; 50. a spacer; 60. stainless steel tubes.

Detailed Description

The invention will be further explained by means of the following description and the attached drawings.

The first embodiment is as follows: as shown in fig. 1-4, the small-volume high-efficiency online static mixer suitable for an ultra-high performance liquid chromatography system includes a plurality of columnar inner cores 10 made of resin (such as PEEK), axial liquid inlet holes 11 and liquid outlet holes 12 are respectively formed in the middle of the upper and lower end surfaces of the inner core 10, 4 first connecting holes 13 and second connecting holes 14 radially distributed are respectively formed in the upper and lower positions of the side wall of the inner core 10, the inner ends of the first connecting holes 13 are communicated with the inner ends of the liquid inlet holes 11, the inner ends of the second connecting holes 14 are communicated with the inner ends of the liquid outlet holes 12, a first annular groove 15 is formed in the side wall of the inner core 10 where the outer ends of the first connecting holes 13 are located, a second annular groove 16 is formed in the side wall of the inner core 10 where the outer ends of the second connecting holes 14 are located, and 4 connecting grooves 17 are formed in the side wall of the inner core 10 between the first annular groove 15 and the second annular groove 16. Wherein, the cross-section of income liquid hole 11, play liquid hole 12, first connecting hole 13 and second connecting hole 14 is circular, and the cross-section of first annular 15, second annular 16 and connecting groove 17 is semicircular to connecting groove 17 is axial straight flute.

Referring to fig. 5, the liquid flows from the inlet to the outlet of the core 10, and 9 times of flow splitting and 9 times of flow merging are performed in total, and 9 times of T-shaped impact are performed.

The liquid flow paths are all engraved on the core 10. The diameter and the score radius of the inner core 10 can be changed independently, for example, the connecting flow path between the upper layer circumference and the lower layer circumference adopts scores with different inner diameters, lengths and shapes, so that the mobile phases when the outlets are combined have time phase difference, and the aim of mixing the mobile phases in front and back is fulfilled. The forward and backward mixing is mainly suitable for the quaternary low-pressure gradient, because the quaternary low-pressure gradient is in a mode of opening corresponding electromagnetic valves with different flows, different mobile phases enter the system at different time periods, and the mixing uniformity at the moment is more dependent on the forward and backward mixing.

In this embodiment, the number of the first connection holes 13 and the second connection holes 14 may be other even numbers, and the number of the first connection holes 13, the second connection holes 14, and the connection grooves 17 is the same and is distributed at equal intervals.

Example two: as shown in fig. 6 to 7, the difference from the first embodiment is that the connecting groove 17 is an inclined or curved inclined groove 18. Originally, the secondary flow only exists in the first annular groove 15 and the second annular groove 16, and after the connecting groove 17 is changed into the chute 18, the secondary flow also exists on the chute 18, so that the existence time of the secondary flow is prolonged, and the radial mixing of the fluid in the pipeline is facilitated.

Example three: as shown in fig. 8-11, the mixer core 10 is suitable for the case that only two mixer cores 10 need to be connected in series, and includes a stainless steel outer shell 20, two inner cores 10 are arranged in the stainless steel outer shell 20 in series, and the upper and lower ends are respectively provided with a connecting end cap 30. A sealing gasket 40 is arranged between the connecting end cover 30 and the stainless steel shell 20, and a partition plate with holes is arranged between the two inner cores 10. The stainless steel shell 20 is directly punched, and two ends of the stainless steel shell are sealed, so that liquid leakage points are reduced, and the reliability of the system is improved.

Example four: as shown in fig. 12-15, the mixer core 10 is suitable for the case of connecting more than two mixer cores 10 in series, and comprises a stainless steel outer shell 20, at least two inner cores 10 distributed in series are arranged in the stainless steel outer shell 20, a connecting end cover 30 is arranged at the upper end of the stainless steel outer shell 20, a connecting hole 21 is arranged at the lower end of the stainless steel outer shell, and a spacer 50 with holes is arranged between the inner cores 10. The spacer 50 is made of an elastic material (PTFE, PEEK, etc.).

When the inner core 10 is pressed into the stainless steel outer shell 20, a certain force is applied to deform the spacer 50, and the gap between the two inner cores is eliminated. For the installation of the plurality of inner cores 10, the inner cores 10 → the spacers 50 → … … → the spacers 50 → the inner cores 10 are sequentially installed in the stainless steel outer case 20, and finally the connecting end cap 30 is installed.

If the traditional mode of installation, n inner cores 10 are established ties, need 2n pipeline connection positions, and according to the scheme shown in this embodiment, only need 2 pipeline connection positions, show and reduce system's weeping point, improve system reliability.

Example five: as shown in fig. 16-19, the mixer is suitable for the case of connecting a plurality of mixer cores 10 in parallel, and comprises a stainless steel outer shell 20, wherein a certain number of accommodating holes are formed in the upper end surface of the stainless steel outer shell 20, the inner cores 10 are respectively arranged in the accommodating holes, and the end parts of the stainless steel outer shell are provided with connecting end covers 30 with sealing gaskets 40.

The number of the connecting end covers 30 is one, the bottom of the connecting end covers is provided with a certain number of upper connecting holes communicated with the accommodating holes, the upper connecting holes incline towards the middle and are overlapped on the top surface, the stainless steel shell 20 at the bottom of the accommodating holes is respectively provided with lower connecting holes, and the lower connecting holes incline towards the middle and are overlapped on the bottom surface. Stainless steel pipes 60 are welded to the outer ends of the upper connecting holes of the connecting end cover 30 and the outer ends of the lower connecting holes of the stainless steel shell 20 respectively, so that the number of external pipeline joints is reduced, and sealing points, namely liquid leakage points, can be reduced.

It should be noted that the stainless steel tube 60 may not be provided, the number of the connecting end covers 30 is one or more, an axial upper connecting hole communicated with the accommodating hole is formed on the connecting end covers, the stainless steel shell 20 at the bottom of the accommodating hole is respectively provided with an axial lower connecting hole, and the upper connecting hole and the lower connecting hole are communicated with the infusion system through a multi-way pipeline with one added to the number of the upper connecting hole and the lower connecting hole.

On one hand, the parallel connection mode can reduce the linear flow velocity of the mobile phase entering each mixer, increase the contact time of different mobile phase molecules and improve the mixing effect; on the other hand, since the mixed liquid is divided into smaller volume units, the specific surface area can be increased, and the mixing effect of intermolecular diffusion can be improved. If the parallel connection method adopts four inner cores 10 with different fluid volumes and the same resistance, the phase difference can be manufactured, and the front and the back can be mixed. Compared with a series connection mode, the mixer has the advantages that the volume difference required for manufacturing the equivalent phase difference is smaller due to the fact that the inlets are divided into a plurality of inlets, and the overall volume of the mixer is reduced. In the figure, only one is drawn for four times for convenience of illustration, and actually, the flow path can be divided into two and eight times, and any number of flow paths can be divided as long as the structure allows.

The above description is only the specific embodiments of the present invention, but the structural features of the present invention are not limited thereto, the present invention can be used in similar products, and any person skilled in the art is in the field of the present invention, and all the changes or modifications made are covered by the claims of the present invention.

Claims (14)

1. A small-volume high-efficiency online static mixer suitable for an ultra-high performance liquid chromatography system comprises a plurality of columnar inner cores (10), and is characterized in that: axial income liquid hole (11) and play liquid hole (12) have been seted up respectively in the centre of terminal surface about inner core (10), first connecting hole (13) and second connecting hole (14) that certain quantity radial distribution were seted up respectively to the upper and lower position of inner core (10) lateral wall, the inner of first connecting hole (13) communicates with each other with the inner of income liquid hole (11), the inner of second connecting hole (14) communicates with each other with the inner of going out liquid hole (12), first annular (15) have been seted up on inner core (10) lateral wall at first connecting hole (13) outer end place, second annular (16) have been seted up on inner core (10) lateral wall at second connecting hole (14) outer end place, set up on inner core (10) lateral wall between first annular (15) and second annular (16) connecting groove (17) of certain quantity.

2. The small-volume high-performance in-line static mixer suitable for use in an ultra-high performance liquid chromatography system according to claim 1, wherein: the number of the first connecting holes (13) and the second connecting holes (14) is even and are distributed at equal intervals.

3. The small-volume high-performance in-line static mixer suitable for the ultra-high performance liquid chromatography system according to claim 2, wherein: the number of the first connecting holes (13), the second connecting holes (14) and the connecting grooves (17) is the same.

4. The small-volume high-performance in-line static mixer suitable for use in an ultra-high performance liquid chromatography system according to claim 1, wherein: the cross-section of income liquid hole (11), play liquid hole (12), first connecting hole (13) and second connecting hole (14) is circular, the cross-section semicircular in shape of first annular (15), second annular (16) and spread groove (17).

5. The small-volume high-performance in-line static mixer suitable for use in an ultra-high performance liquid chromatography system according to claim 1, wherein: the connecting groove (17) is an axial straight groove or an inclined or bent inclined groove (18).

6. The small-volume high-performance in-line static mixer suitable for use in an ultra-high performance liquid chromatography system according to claim 1, wherein: the inner core (10) is made of resin.

7. A small-volume high-performance in-line static mixer suitable for use in an ultra-high performance liquid chromatography system according to any one of claims 1 to 6, wherein: the stainless steel core-pulling device is characterized by further comprising a stainless steel shell (20), wherein two inner cores (10) which are distributed in series up and down are arranged in the stainless steel shell (20), and connecting end covers (30) are respectively arranged at the upper end and the lower end.

8. The small-volume high-performance in-line static mixer suitable for use in an ultra-high performance liquid chromatography system according to claim 7, wherein: a sealing gasket (40) is arranged between the connecting end cover (30) and the stainless steel shell (20), and a partition plate with a hole is arranged between the two inner cores (10).

9. A small-volume high-performance in-line static mixer suitable for use in an ultra-high performance liquid chromatography system according to any one of claims 1 to 6, wherein: the stainless steel shell structure is characterized by further comprising a stainless steel shell (20), wherein at least two inner cores (10) which are distributed in series are arranged in the stainless steel shell (20), a connecting end cover (30) is arranged at the upper end of the stainless steel shell (20), and a connecting hole (21) is formed in the lower end of the stainless steel shell.

10. A small volume high performance in-line static mixer suitable for use in an ultra high performance liquid chromatography system according to claim 9, wherein: and a spacer (50) with holes is arranged between the inner cores (10).

11. A small-volume high-performance in-line static mixer suitable for use in an ultra-high performance liquid chromatography system according to any one of claims 1 to 6, wherein: the stainless steel shell structure is characterized by further comprising a stainless steel shell (20), a certain number of accommodating holes are formed in the upper end face of the stainless steel shell (20), inner cores (10) are arranged in the accommodating holes respectively, and connecting end covers (30) with sealing gaskets (40) are arranged at the end portions of the accommodating holes.

12. A small volume high performance in-line static mixer suitable for use in an ultra high performance liquid chromatography system according to claim 11, wherein: the stainless steel shell (20) at the bottom of the accommodating hole is respectively provided with a lower connecting hole, and the lower connecting holes are inclined towards the middle and overlapped at the bottom surface.

13. A small volume high performance in-line static mixer suitable for use in an ultra high performance liquid chromatography system according to claim 12, wherein: and stainless steel pipes (60) are welded at the outer ends of the upper connecting holes of the connecting end cover (30) and the outer ends of the lower connecting holes of the stainless steel shell (20) respectively.

14. A small volume high performance in-line static mixer suitable for use in an ultra high performance liquid chromatography system according to claim 11, wherein: the number of the connecting end covers (30) is one or more, axial upper connecting holes communicated with the accommodating holes are formed in the connecting end covers, and axial lower connecting holes are formed in the stainless steel shell (20) at the bottom of the accommodating holes respectively.

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