CN214749621U - Device for on-line detecting integrity of radioactive drug filter membrane - Google Patents
Device for on-line detecting integrity of radioactive drug filter membrane Download PDFInfo
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- CN214749621U CN214749621U CN202023198171.XU CN202023198171U CN214749621U CN 214749621 U CN214749621 U CN 214749621U CN 202023198171 U CN202023198171 U CN 202023198171U CN 214749621 U CN214749621 U CN 214749621U
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- radiopharmaceutical
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Abstract
The utility model relates to a device of on-line measuring radiopharmaceutical filter membrane integrality, including hot chamber (1), filter membrane integrality tester (2), still include three-way valve (3), this three-way valve (3) include knob (31), valve rod (32) and valve body (33), knob (31) be located outside hot chamber (1), valve body (33) are located hot chamber (1), knob (31) and valve body (33) are connected in valve rod (32), valve body (33) on be equipped with liquid inlet (331), liquid outlet (332) and gas inlet (333), wherein be equipped with filter (4) on liquid outlet (332), filter membrane integrality tester (2) is connected in gas inlet (33). Compared with the prior art, the utility model has the advantages of safety, high efficiency, etc.
Description
Technical Field
The utility model relates to a radiopharmaceutical detects, especially relates to a device of on-line measuring radiopharmaceutical filter membrane integrality.
Background
Radiopharmaceuticals have a strong radiation and production requires operations within a shielded enclosure, known as a hot room. Due to the short half-life of radionuclides, production is generally performed fully automatically in dedicated synthesis modules. The method for producing the radioactive drug by adopting the hot chamber comprises the steps of placing the synthesis module in the hot chamber, filling raw material consumables such as chemical reagents and the like into the automatic synthesis module, closing the shielding door, injecting radioactive raw materials into the automatic synthesis module through a special shielding pipeline and starting production, and conveying the product to a product bottle for subpackaging and using after full-automatic synthesis. After production is finished, the nuclide decays to the state that the shielding door can be opened (generally, the operation is carried out after 10 half-lives), equipment cleaning is carried out, and the next production is carried out.
Carry the product bottle at the product and carry out the partial shipment before using, need filter the product, nevertheless at the in-process of long-term filtration radiopharmaceutical, filtration membrane often can damage the inefficacy, and often need shut down, dismantles out with filtration membrane and detects its integrality, has influenced production efficiency greatly.
Disclosure of Invention
The utility model aims at providing a safe and efficient device for online detection of integrity of a radiopharmaceutical filter membrane, which aims to overcome the defects of the prior art.
The purpose of the utility model can be realized through the following technical scheme: the utility model provides a device of on-line measuring radiopharmaceutical filter membrane integrality, includes hot chamber, filter membrane integrality tester, still includes the three-way valve, and this three-way valve includes knob, valve rod and valve body, the knob be located hot outdoor, the valve body is located hot indoor, knob and valve body are connected to the valve rod, the valve body on be equipped with liquid inlet, liquid outlet and gas inlet, wherein be equipped with the filter on the liquid outlet, gas inlet connects the filter membrane integrality tester.
The hot chamber is provided with a hole, the size of the hole is matched with that of the valve rod, and a sealing gasket is arranged between the hole and the valve rod.
The knob covers a radiation shield which is mounted around the opening of the hot chamber.
The radiation shield consists of a base and a shield door, wherein the base is welded on the hot chamber.
The radiation shield is made of lead or a material with the same shielding effect.
The liquid inlet is connected with a product outlet of the radiopharmaceutical synthesis module.
The liquid outlet is connected with a collecting bottle.
The valve rod passes through the hole on the hot chamber and is detachably connected with the valve body.
The valve body is fixed in the hot chamber.
The filter is a flat plate type filter and is detachably arranged at the liquid outlet.
Compared with the prior art, the utility model discloses following beneficial effect has:
1. the utility model discloses an add a special construction's three-way valve in conventional radiopharmaceutical synthesis module, install this three-way valve before radiopharmaceutical product receiving flask, and install the filter on an interface of three-way valve, with valve rod and the independent dismouting of valve body, the valve rod is elongated and is passed thick heat chamber lateral wall and be connected with the indoor valve body of heat, be connected the radiopharmaceutical collection system in the heat chamber with the outdoor filter membrane integrality check out test set of heat chamber through the three-way valve, through rotating the outdoor three-way valve knob of heat chamber, adjust the communicating line of three-way valve, when carrying out the radiopharmaceutical synthesis, three-way valve intercommunication liquid medicine input tube and receiving flask, input trachea end is in the closed state, can close the radiation protection casing simultaneously, prevent that the ray from leaking from the hole; after the liquid medicine is collected and taken away, the radiation protective cover is opened, the external valve is controlled to enable the input air pipe connecting end to be communicated with the collecting bottle end, and then the integrity test of the filter membrane can be started. The problem of protection of the radiopharmaceutical in the process of filter membrane integrity test operation is solved, the filter membrane does not need to be taken out, the filter membrane integrity test operation can be completed under the condition of reducing radioactive radiation, and the radiation dose of an operator is reduced.
2. The utility model discloses the device need not to dismantle the filter in the testing process, can carry out on-line measuring, has improved production efficiency.
Drawings
Fig. 1 is a schematic structural diagram of the device of the present invention.
Detailed Description
The present invention will be described in detail below with reference to the accompanying drawings and specific embodiments.
The utility model discloses in the radiopharmaceutical synthesis module that relates to be current radiopharmaceutical synthesis module, the filter membrane integrality tester is current tester, like Integtest V4.0 filter membrane integrality tester.
Examples
As shown in figure 1, the device for on-line detection of integrity of the radioactive drug filter membrane comprises a hot chamber 1, a filter membrane integrity tester 2 and a three-way valve 3, wherein the three-way valve 3 comprises a knob 31, a valve rod 32 and a valve body 33, the knob 31 is positioned outside the hot chamber 1, the valve body 33 is positioned in the hot chamber 1, a hole is formed in the hot chamber 1, the hole is matched with the valve rod 32 in size, and a sealing gasket 5 is arranged between the hole and the valve rod 32. The valve body 33 is fixed in the hot chamber. The valve stem 32 is removably connected at one end to the valve body 33 by passing through a hole in the thermal chamber and at the other end to a knob 31 outside the thermal chamber, the knob 31 covering the radiation shield 7, the radiation shield 7 being mounted around the opening of the thermal chamber 1. The radiation protection hood 7 consists of a base and a hood door, wherein the base is welded on the hot chamber. The radiation protection cover 7 is made of lead or a material with the same shielding effect.
The valve body 33 is provided with a liquid inlet 331, a liquid outlet 332 and a gas inlet 333, wherein the liquid outlet 332 is provided with a filter 4, the filter 4 is a flat plate type filter and is detachably arranged at the liquid outlet 332, and the gas inlet 33 is connected with the filter membrane integrity tester 2. The liquid inlet 331 is connected to the product outlet of the radiopharmaceutical synthesis module, and the liquid outlet 332 is connected to the collection vial 6.
When the radioactive drug synthesis is carried out, the three-way valve 3 is communicated with a liquid medicine input pipe of the radioactive drug synthesis module and the collecting bottle 6, the end of an input gas pipe (a gas inlet 333) is in a closed state, and meanwhile, the radiation protective cover 7 can be closed to prevent rays from leaking out of pores; after the liquid medicine is collected and taken away, the radiation protective cover 7 is opened, the knob 31 of the three-way valve 3 is rotated, the liquid outlet 332 on the valve body is communicated with the gas inlet 333, the connecting end of the input air pipe is communicated with the collecting bottle end, and the integrity test of the filter membrane can be started.
Claims (10)
1. The utility model provides a device of on-line measuring radiopharmaceutical filter membrane integrality, includes hot chamber (1), filter membrane integrality tester (2), its characterized in that still includes three-way valve (3), and this three-way valve (3) include knob (31), valve rod (32) and valve body (33), knob (31) be located outside hot chamber (1), valve body (33) are located hot chamber (1), knob (31) and valve body (33) are connected in valve rod (32), valve body (33) on be equipped with liquid inlet (331), liquid outlet (332) and gaseous inlet (333), wherein be equipped with filter (4) on liquid outlet (332), gaseous inlet (333) are connected filter membrane integrality tester (2).
2. The device for on-line testing the integrity of a radiopharmaceutical filter as defined in claim 1, wherein the hot chamber (1) is provided with an aperture matching the size of the valve stem (32) and a sealing gasket (5) is provided between the aperture and the valve stem (32).
3. An apparatus for on-line testing the integrity of radiopharmaceutical filters as defined in claim 1 wherein the knob (31) covers a radiation shield (7), the radiation shield (7) being mounted around the opening of the hot chamber (1).
4. The device for the on-line detection of the integrity of radiopharmaceutical filters as defined in claim 3, wherein the radiation protection shield (7) consists of a base and a shield door, wherein the base is welded to the hot chamber.
5. The device for on-line testing the integrity of radiopharmaceutical filters as defined in claim 3, wherein the radiation protection shield (7) is made of lead or a material with equivalent shielding effect.
6. The device for on-line testing the integrity of a radiopharmaceutical filter of claim 1 wherein the fluid inlet (331) is connected to the product outlet of a radiopharmaceutical synthesis module.
7. The device for on-line testing the integrity of a radiopharmaceutical filter of claim 1 wherein the fluid outlet (332) is connected to a collection vial (6).
8. An apparatus for on-line testing the integrity of a radiopharmaceutical filter as defined in claim 1 wherein the valve stem (32) is removably connected to the valve body (33) through an aperture in the hot chamber.
9. The device for on-line testing the integrity of a radiopharmaceutical filter of claim 1 wherein the valve body (33) is fixed in a hot chamber.
10. The device for on-line testing the integrity of a radiopharmaceutical filter membrane of claim 1 wherein the filter (4) is a flat filter removably mounted at the liquid outlet (332).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202023198171.XU CN214749621U (en) | 2020-12-24 | 2020-12-24 | Device for on-line detecting integrity of radioactive drug filter membrane |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202023198171.XU CN214749621U (en) | 2020-12-24 | 2020-12-24 | Device for on-line detecting integrity of radioactive drug filter membrane |
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| Publication Number | Publication Date |
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| CN214749621U true CN214749621U (en) | 2021-11-16 |
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| CN202023198171.XU Active CN214749621U (en) | 2020-12-24 | 2020-12-24 | Device for on-line detecting integrity of radioactive drug filter membrane |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114674719A (en) * | 2020-12-24 | 2022-06-28 | 上海原子科兴药业有限公司 | Device for on-line detecting integrity of radiopharmaceutical filter membrane |
| CN114713037A (en) * | 2022-06-10 | 2022-07-08 | 北京先通国际医药科技股份有限公司 | Online filter membrane integrity testing device and method and application thereof |
| CN114713036A (en) * | 2022-06-10 | 2022-07-08 | 北京先通国际医药科技股份有限公司 | Online filter membrane integrity testing device and method and application thereof |
-
2020
- 2020-12-24 CN CN202023198171.XU patent/CN214749621U/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114674719A (en) * | 2020-12-24 | 2022-06-28 | 上海原子科兴药业有限公司 | Device for on-line detecting integrity of radiopharmaceutical filter membrane |
| CN114713037A (en) * | 2022-06-10 | 2022-07-08 | 北京先通国际医药科技股份有限公司 | Online filter membrane integrity testing device and method and application thereof |
| CN114713036A (en) * | 2022-06-10 | 2022-07-08 | 北京先通国际医药科技股份有限公司 | Online filter membrane integrity testing device and method and application thereof |
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