CN214553538U

CN214553538U - Special reation kettle of Suzuki coupling

Info

Publication number: CN214553538U
Application number: CN202120491334.9U
Authority: CN
Inventors: 孙开�; 舒倩; 程兴洋
Original assignee: Shanghai Haigao Technology Co ltd
Current assignee: Shanghai Haigao Technology Co ltd
Priority date: 2021-03-08
Filing date: 2021-03-08
Publication date: 2021-11-02
Anticipated expiration: 2031-03-08

Abstract

The utility model discloses a special reation kettle of Suzuki coupling belongs to the fine chemistry industry field. The Suzuki coupling special reaction kettle comprises a kettle body, wherein a first driving mechanism is arranged on the kettle body, a rotating shaft is connected in the kettle body in a rotating mode, the output end of the first driving mechanism is fixedly connected with the rotating shaft, a plurality of groups of stirring blades are fixedly connected onto the rotating shaft, a water pumping and draining mechanism is arranged on the kettle body, a second driving mechanism used for driving the water pumping and draining mechanism is arranged on the rotating shaft, a spiral pipe is arranged in the kettle body, a heating mechanism is arranged on the side wall of the kettle body, the input end of the water pumping and draining mechanism is connected into the spiral pipe, and the output end of the water pumping and draining mechanism is fixedly connected with the input end of the heating mechanism; the utility model discloses, be convenient for stir the internal solid-liquid mixture of cauldron through pivot, stirring vane's setting, be convenient for heat the water in the spiral pipe through taking out drainage mechanism, heating mechanism's setting, and then make the spiral pipe to the internal reaction liquid even heating of cauldron.

Description

Special reation kettle of Suzuki coupling

Technical Field

The utility model relates to a fine chemistry industry technical field especially relates to special reation kettle of Suzuki coupling.

Background

The Suzuki coupling reaction is one of the most common reactions in the field of medical intermediates, is used for connecting two molecular fragments under mild conditions, can tolerate the existence of various functional groups, is particularly used in the last steps of innovative drugs, and is prepared by coupling a heterocyclic bromide and a diboronic acid pinacol ester for most heterocyclic molecules.

In the coupling reaction, metallic palladium, inorganic base, coupling assistant and halide are usually adopted for reaction, and usually, the inorganic base in the reaction system is in an excess state, and the reaction system is in a suspension state or a two-phase system.

The existing Suzuki coupling reaction kettle generally directly heats reaction raw materials, the heating is uneven, the heating efficiency is low, and therefore, the number of dehalogenation byproducts is increased, the raw materials are excessive or the reaction speed is too slow.

SUMMERY OF THE UTILITY MODEL

The utility model aims at solving the problems of uneven heating, low heating efficiency and the special reaction kettle for Suzuki coupling in the prior art that the reaction raw materials are directly heated.

In order to achieve the above purpose, the utility model adopts the following technical scheme:

special reation kettle of Suzuki coupling, including the cauldron body, be equipped with first actuating mechanism on the cauldron body, the internal rotation of cauldron is connected with the pivot, first actuating mechanism's output and pivot fixed connection, fixedly connected with multiunit stirring vane in the pivot, be equipped with drainage mechanism in the cauldron body, be equipped with the second actuating mechanism that is used for the drive drainage mechanism in the pivot, the internal spiral pipe that is equipped with of cauldron, cauldron body side wall is equipped with heating mechanism, drainage mechanism's input inserts the spiral pipe, drainage mechanism's output and heating mechanism's input fixed connection take out, heating mechanism's output and spiral pipe fixed connection.

Preferably, the first driving mechanism comprises a motor base and a driving motor, the driving motor is fixedly connected to the motor base, and the output end of the driving motor is fixedly connected with the rotating shaft.

Preferably, second actuating mechanism includes crank, push rod, crank fixed connection is in the pivot, the push rod is connected with the crank rotation, drainage mechanism includes the suction bucket, sliding connection has the piston in the suction bucket, the one end that the crank was kept away from to the push rod is rotated with the piston and is connected, be connected with the inlet tube between suction bucket and the spiral pipe, fixedly connected with drain pipe between the input of suction bucket and heating mechanism, all be equipped with the check valve on inlet tube and the drain pipe.

Preferably, the heating mechanism comprises a heating box, a water guide pipe is connected between the heating box and the spiral pipe, and heating wires are arranged in the heating box.

Preferably, cauldron body bottom is equipped with the base, base bottom symmetry is equipped with the multiunit spout, sliding connection has the bracing piece in the spout, fixedly connected with spring between bracing piece and the spout, the one end fixedly connected with backup pad of spring is kept away from to the bracing piece.

Compared with the prior art, the utility model provides a special reation kettle of Suzuki coupling possesses following beneficial effect:

1. this special reation kettle of Suzuki coupling, it is internal that operating personnel follows the leading-in cauldron of inlet pipe with the reaction liquid, start first actuating mechanism and heating mechanism, first actuating mechanism drives the pivot and rotates, the pivot is passed through stirring vane and is stirred the mixture to the internal solid-liquid mixture of cauldron, meanwhile, the pivot is taken out the water of drainage mechanism in with the spiral pipe through the drive of second actuating mechanism and is taken out and put into heating mechanism internal heating, water after heating mechanism will heat is in the spiral pipe along the output, the water that gets into in the spiral pipe heats the internal reaction liquid of cauldron, the row of material edge cauldron body bottom of the raw materials after the reaction manages and discharges.

2. This special reation kettle of Suzuki coupling through driving motor's setting for the pivot rotates and provides power.

3. The Suzuki coupling special reaction kettle drives the piston to slide in the water pumping barrel in a reciprocating mode through the rotating shaft, the crank and the push rod, when the piston slides in the direction close to the crank, water in the spiral pipe enters the water pumping barrel along the water inlet pipe, and when the piston slides in the direction far away from the crank, water in the water pumping barrel enters the heating mechanism along the water outlet pipe.

4. This special reation kettle of Suzuki coupling is convenient for heat water through setting up of heating cabinet, heater strip.

5. This special reation kettle of Suzuki coupling is convenient for support the cauldron body through the setting of base, and the setting of spout, bracing piece, spring is convenient for carry out the shock attenuation to the cauldron body and supports, and the setting of backup pad is convenient for increase the support effect of bracing piece.

The part that does not relate to among the device all is the same with prior art or can adopt prior art to realize, the utility model discloses, be convenient for stir the internal solid-liquid mixture of cauldron through pivot, stirring vane's setting, be convenient for heat the water in the spiral pipe through taking out drainage mechanism, heating mechanism's setting, and then make the spiral pipe to the internal reaction liquid even heating of cauldron.

Drawings

FIG. 1 is a schematic structural diagram of a Suzuki coupling reaction kettle according to the present invention;

FIG. 2 is a schematic structural diagram of a part A of the Suzuki coupling reaction kettle of the present invention.

In the figure: 1. a kettle body; 2. a motor base; 201. a drive motor; 3. a rotating shaft; 301. a stirring blade; 302. a crank; 4. a water pumping barrel; 401. a piston; 402. a push rod; 403. a water inlet pipe; 404. a drain pipe; 5. a spiral tube; 6. a heating box; 601. heating wires; 602. a water conduit; 7. a base; 701. a chute; 702. a support bar; 703. a spring; 704. and a support plate.

Detailed Description

The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments.

In the description of the present invention, it is to be understood that the terms "upper", "lower", "front", "rear", "left", "right", "top", "bottom", "inner", "outer", and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and simplicity of description, and do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore, should not be construed as limiting the present invention.

Example 1:

referring to fig. 1-2, special reation kettle of Suzuki coupling, including the cauldron body 1, be equipped with first actuating mechanism on the cauldron body 1, cauldron body 1 internal rotation is connected with pivot 3, first actuating mechanism's output and pivot 3 fixed connection, fixedly connected with multiunit stirring vane 301 on the pivot 3, be equipped with drainage mechanism on the cauldron body 1, be equipped with the second actuating mechanism that is used for the drive drainage mechanism on the pivot 3, be equipped with spiral pipe 5 in the cauldron body 1, cauldron body 1 lateral wall is equipped with heating mechanism, drainage mechanism's input inserts spiral pipe 5, drainage mechanism's output and heating mechanism's input fixed connection, heating mechanism's output and spiral pipe 5 fixed connection.

An operator guides the reaction liquid into the kettle body 1 along the feeding pipe, starts the first driving mechanism and the heating mechanism, the first driving mechanism drives the rotating shaft 3 to rotate, the rotating shaft 3 stirs and mixes the solid-liquid mixture in the kettle body 1 through the stirring blade 301, meanwhile, the rotating shaft 3 drives the water pumping and draining mechanism to pump out water in the spiral pipe 5 through the second driving mechanism and discharge the water into the heating mechanism for heating, the heating mechanism discharges the heated water into the spiral pipe 5 along the output end, the water entering the spiral pipe 5 heats the reaction liquid in the kettle body 1, the reacted raw materials are discharged along the discharge pipe at the bottom of the kettle body 1, the solid-liquid mixture in the kettle body 1 is convenient to be stirred through the arrangement of the rotating shaft 3 and the stirring blades 301, the water in the spiral pipe 5 is convenient to heat through the arrangement of the pumping and drainage mechanism and the heating mechanism, and then the reaction liquid in the kettle body 1 is uniformly heated by the spiral pipe 5.

Example 2:

referring to fig. 1-2, a reactor dedicated for Suzuki coupling is substantially the same as that in embodiment 1, and further, the first driving mechanism includes a motor base 2 and a driving motor 201, the driving motor 201 is fixedly connected to the motor base 2, an output end of the driving motor 201 is fixedly connected to the rotating shaft 3, and the driving motor 201 is configured to provide power for the rotating shaft 3 to rotate.

Example 3:

referring to fig. 1-2, a Suzuki coupling special reaction kettle is substantially the same as that in embodiment 1, further, the second driving mechanism includes a crank 302 and a push rod 402, the crank 302 is fixedly connected to the rotating shaft 3, the push rod 402 is rotatably connected to the crank 302, the water pumping and draining mechanism includes a water pumping barrel 4, a piston 401 is slidably connected to the water pumping barrel 4, one end of the push rod 402 away from the crank 302 is rotatably connected to the piston 401, a water inlet pipe 403 is connected between the water pumping barrel 4 and the spiral pipe 5, a water draining pipe 404 is fixedly connected between the water pumping barrel 4 and the input end of the heating mechanism, one-way valves are respectively disposed on the water inlet pipe 403 and the water draining pipe 404, the rotating shaft 3 drives the piston 401 to slide in the water pumping barrel 4 through the crank 302 and the push rod 402, when the piston 401 slides in a direction close to the crank 302, water in the spiral pipe 5 enters the water pumping barrel 4 along the water inlet pipe 403, when the piston 401 slides in a direction away from the crank 302, the water in the water extraction tub 4 enters the heating mechanism along the drain pipe 404.

Example 4:

referring to fig. 1-2, a reactor dedicated for Suzuki coupling is substantially the same as that in embodiment 1, and further, the heating mechanism includes a heating box 6, a water conduit 602 is connected between the heating box 6 and the spiral pipe 5, a heating wire 601 is disposed in the heating box 6, and the heating box 6 and the heating wire 601 are disposed to facilitate heating water.

Example 5:

referring to fig. 1-2, a reactor dedicated for Suzuki coupling is substantially the same as that in embodiment 1, further, a base 7 is disposed at the bottom of the reactor body 1, a plurality of sets of chutes 701 are symmetrically disposed at the bottom of the base 7, a support rod 702 is slidably connected in the chute 701, a spring 703 is fixedly connected between the support rod 702 and the chute 701, a support plate 704 is fixedly connected to one end of the support rod 702 far away from the spring 703, the base 7 is disposed to support the reactor body 1, the chutes 701, the support rod 702, and the spring 703 are disposed to facilitate shock absorption support of the reactor body 1, and the support plate 704 is disposed to facilitate increase of support effect of the support rod 702.

The utility model discloses in, be convenient for stir the solid-liquid mixture in the cauldron body 1 through pivot 3, stirring vane 301's setting, be convenient for heat the water in the spiral pipe 5 through taking out drainage mechanism, heating mechanism's setting, and then make spiral pipe 5 evenly heat the reaction liquid in the cauldron body 1.

The above, only be the concrete implementation of the preferred embodiment of the present invention, but the protection scope of the present invention is not limited thereto, and any person skilled in the art is in the technical scope of the present invention, according to the technical solution of the present invention and the utility model, the concept of which is equivalent to replace or change, should be covered within the protection scope of the present invention.

Claims

The utility model provides a special reation kettle of Suzuki coupling, including the cauldron body (1), its characterized in that, be equipped with first actuating mechanism on the cauldron body (1), cauldron body (1) internal rotation is connected with pivot (3), first actuating mechanism's output and pivot (3) fixed connection, fixedly connected with multiunit stirring vane (301) are gone up in pivot (3), be equipped with drainage mechanism on the cauldron body (1), be equipped with the second actuating mechanism that is used for the drive drainage mechanism on pivot (3), be equipped with spiral pipe (5) in the cauldron body (1), cauldron body (1) lateral wall is equipped with heating mechanism, drainage mechanism's input inserts spiral pipe (5), drainage mechanism's output and heating mechanism's input fixed connection, heating mechanism's output and spiral pipe (5) fixed connection.
2. The Suzuki coupling special reaction kettle according to claim 1, wherein the first driving mechanism comprises a motor base (2) and a driving motor (201), the driving motor (201) is fixedly connected to the motor base (2), and an output end of the driving motor (201) is fixedly connected to the rotating shaft (3).
3. The special reaction kettle for Suzuki coupling according to claim 2, wherein the second driving mechanism comprises a crank (302) and a push rod (402), the crank (302) is fixedly connected to the rotating shaft (3), the push rod (402) is rotatably connected to the crank (302), the water pumping and draining mechanism comprises a water pumping bucket (4), a piston (401) is slidably connected to the water pumping bucket (4), one end of the push rod (402), which is far away from the crank (302), is rotatably connected to the piston (401), a water inlet pipe (403) is connected between the water pumping bucket (4) and the spiral pipe (5), a water draining pipe (404) is fixedly connected between the water pumping bucket (4) and the input end of the heating mechanism, and one-way valves are arranged on the water inlet pipe (403) and the water draining pipe (404).
4. The special reaction kettle for Suzuki coupling according to claim 1, wherein the heating mechanism comprises a heating box (6), a water conduit (602) is connected between the heating box (6) and the spiral pipe (5), and a heating wire (601) is arranged in the heating box (6).
5. The Suzuki coupling special reaction kettle according to claim 4, wherein a base (7) is arranged at the bottom of the kettle body (1), a plurality of groups of sliding grooves (701) are symmetrically arranged at the bottom of the base (7), a supporting rod (702) is slidably connected in the sliding grooves (701), a spring (703) is fixedly connected between the supporting rod (702) and the sliding grooves (701), and a supporting plate (704) is fixedly connected at one end of the supporting rod (702) far away from the spring (703).