CN214539514U - Sample detection device for preparing 4-cyano-3-hydroxy ethyl butyrate - Google Patents
Sample detection device for preparing 4-cyano-3-hydroxy ethyl butyrate Download PDFInfo
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- CN214539514U CN214539514U CN202120767370.3U CN202120767370U CN214539514U CN 214539514 U CN214539514 U CN 214539514U CN 202120767370 U CN202120767370 U CN 202120767370U CN 214539514 U CN214539514 U CN 214539514U
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Abstract
The utility model belongs to the technical field of the detection device technique and specifically relates to a sample detection device is used in preparation of 4-cyano-3-hydroxybutyric acid ethyl ester places unstability, the poor problem of leakproofness to stock solution bottle among the prior art, now proposes following scheme, and it includes the base, its characterized in that, the sampling pump is installed at the top of base, the detector is installed at the top of sampling pump, the top of detector is installed and is placed the board, the top of placing the board is provided with multiunit placing mechanism, multiunit stock solution mechanism has all been placed to placing mechanism's inside. The utility model discloses rational in infrastructure, stable in structure, easy operation has not only realized detecting 4-cyano-3-hydroxy butyric acid ethyl ester sample, has effectually prevented to hold mobile stock solution bottle and has been overturned, has still realized sealing the stock solution bottle, prevents that mobility from volatilizing and causes the pollution to the environment, guarantees mobile accurate ratio, guarantees to detect the precision, easily uses widely.
Description
Technical Field
The utility model relates to a detection device field especially relates to a sample detection device is used in preparation of 4-cyano-3-hydroxybutyric acid ethyl ester.
Background
The 4-cyano-3-hydroxy ethyl butyrate is a medical intermediate, is a main raw material of a hypolipidemic drug atorvastatin calcium, a sample is often required to be detected in the preparation process of the 4-cyano-3-hydroxy ethyl butyrate, liquid chromatography is an important detection means for organic sample detection in a laboratory, the separation principle of the liquid chromatography is that the separation is carried out by utilizing the difference of affinity capacities such as distribution coefficient, adsorption capacity and the like of various substances to be separated in two phases (a fixed phase and a mobile phase), external force is used for leading the surface of the mobile phase containing the sample to be fixed, when a mixture carried in the mobile phase flows through the fixed phase, each component in the mixture interacts with the fixed phase, and the retention time of each component by the fixed phase is different due to the difference of the properties and the structures of each component in the mixture, thus, the components in the mixture are separated and detected by sequentially flowing out of the fixed phase according to a certain sequence.
The mobile phase of the liquid chromatograph often holds in the inside of stock solution bottle among the prior art, then will hold the stock solution bottle of mobile phase and place at the top of liquid chromatograph, the size and specification of stock solution bottle differs, the stock solution bottle often places comparatively unstably, be overturned easily, and all be doped with volatile organic liquid in most mobile phase at present, the stock solution bottle leakproofness is relatively poor, organic liquid in the mobility volatilizees, often can cause the pollution to the testing environment, threaten to operating personnel health, for this reason, this scheme has proposed a sample detection device is used in 4-cyano-3-hydroxybutyric acid ethyl ester preparation.
SUMMERY OF THE UTILITY MODEL
The utility model provides a sample detection device is used in preparation of 4-cyano-3-hydroxybutyric acid ethyl ester has solved the problem that the stock solution bottle was placed unstably among the prior art, the leakproofness is poor.
In order to achieve the above purpose, the utility model adopts the following technical scheme:
a sample detection device for preparing ethyl-cyano-hydroxybutyrate comprises a base, wherein a sample injection pump is mounted at the top of the base, a detector is mounted at the top of the sample injection pump, a placing plate is mounted at the top of the detector, a plurality of groups of placing mechanisms are arranged at the top of the placing plate, and liquid storage mechanisms are placed in the plurality of groups of placing mechanisms;
the placing mechanism comprises a placing opening formed in the top of the placing plate, a bottom plate movably mounted in the placing opening, and a plurality of groups of first springs fixedly connected to the bottom of the bottom plate, the bottoms of the plurality of groups of first springs are fixedly connected to the inner side bottom of the placing opening, the placing mechanism further comprises a placing groove formed in the placing plate, a lifting ring movably mounted in the placing groove, and a plurality of groups of transmission rods fixedly connected to the bottom of the lifting ring, the placing groove and the placing opening are concentric, the bottoms of the plurality of groups of transmission rods extend to the inside of the placing opening and are fixedly connected to the top of the bottom plate, the placing mechanism further comprises a plurality of groups of sliding rails fixedly connected to the inner side wall of the lifting ring, a plurality of groups of abutting blocks movably sleeved outside the sliding rails, and one ends of the plurality of groups of abutting blocks, which are close to each other, extend to the inside of the placing opening;
stock solution mechanism includes that stock solution bottle, screw thread cover establish at the drain pipe at the bottle lid at stock solution bottle top, fixed cover, the bottom of drain pipe extends to the inboard bottom of stock solution bottle, stock solution mechanism still includes that the rigid coupling overlaps at the sleeve pipe at drain pipe top, screw thread cover establishes at the inboard connecting pipe of sleeve pipe, is located the sealing mechanism of the inboard bottom of sleeve pipe, the other end of connecting pipe and the feed liquor end rigid coupling of sampling pump.
Preferably, sealing mechanism includes the sealing ring of rigid coupling in the inboard bottom of sleeve pipe, is located the sealed piece of sealing ring bottom, the connecting rod of rigid coupling at sealed piece top, the orifice plate of rigid coupling at the connecting rod top, sealed piece and sealing ring are mutually supported, the outside activity cover of connecting rod is equipped with the second spring, the top and the bottom of second spring respectively with the bottom of orifice plate and the top rigid coupling of sealing ring.
Preferably, a sealing gasket is fixedly connected to the top of the inner side of the bottle cap.
Preferably, the liquid outlet pipe is fixedly connected with a filter screen at the inner side of the bottom of the liquid storage bottle.
Preferably, the ends of the multiple groups of the abutting blocks, which are close to each other, are all in a semi-arc structure.
Preferably, the ends of the multiple groups of the abutting blocks, which are far away from each other, are all inclined planes.
The utility model has the advantages that:
1. through bottom plate, first spring, transfer line, lifter ring, butt piece, place the mouth etc. and mutually support, realize placing the stock solution bottle of different specifications, guarantee the stability that the stock solution bottle was placed, prevent that the stock solution bottle from being overturned.
2. Through mutually supporting such as sealing ring, sealed piece, connecting rod, orifice plate, the realization is sealed the stock solution bottle, prevents that the organic liquid component of mobile phase volatilizees in the stock solution bottle, causes the pollution to the detection ring border, guarantees the accuracy of mobile phase ratio in the stock solution bottle.
The utility model discloses rational in infrastructure, stable in structure, easy operation has not only realized detecting 4-cyano-3-hydroxy butyric acid ethyl ester sample, has effectually prevented to hold mobile stock solution bottle and has been overturned, has still realized sealing the stock solution bottle, prevents that mobility from volatilizing and causes the pollution to the environment, guarantees mobile accurate ratio, guarantees to detect the precision, easily uses widely.
Drawings
Fig. 1 is a front perspective view of the present invention.
Fig. 2 is a front sectional view of the placing board of the present invention.
Fig. 3 is an enlarged view of a point a of the present invention.
Fig. 4 is an enlarged view of the point B of the present invention.
Fig. 5 is a bottom view of the lifting ring of the present invention.
Fig. 6 is a top view of the placing board of the present invention.
Reference numbers in the figures: 1. a base; 2. a sample injection pump; 3. a detector; 4. placing the plate; 5. a placement port; 6. a base plate; 7. a first spring; 8. a placement groove; 9. a lifting ring; 10. a transmission rod; 11. a slide rail; 12. a butting block; 13. a liquid storage bottle; 14. a bottle cap; 15. a gasket; 16. a liquid outlet pipe; 17. a filter screen; 18. a sleeve; 19. a connecting pipe; 20. a seal ring; 21. a sealing block; 22. a connecting rod; 23. an orifice plate; 24. a second spring.
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments.
Referring to fig. 1-6, a sample detection device for preparing 4-cyano-3-hydroxy ethyl butyrate comprises a base 1, a sample injection pump 2 is installed on the top of the base 1, a detector 3 is installed on the top of the sample injection pump 2, a placing plate 4 is installed on the top of the detector 3, a plurality of groups of placing mechanisms are arranged on the top of the placing plate 4, liquid storage mechanisms are all placed inside the plurality of groups of placing mechanisms, each liquid storage mechanism comprises a liquid storage bottle 13, a bottle cap 14 is sleeved on the top of the liquid storage bottle 13 in a threaded manner, a sealing gasket 15 is fixedly connected to the top of the inner side of the bottle cap 14, a liquid outlet pipe 16 is fixedly sleeved on the top of the bottle cap 14, the bottom of the liquid outlet pipe 16 extends to the bottom of the inner side of the liquid storage bottle 13, a filter screen 17 is fixedly connected to the inner side of the bottom of the liquid storage bottle 13, a sleeve 18 is fixedly connected to the top of the liquid outlet pipe 16, a connecting pipe 19 is sleeved on the top of the inner side of the sleeve 18 in a threaded manner, the other end of the connecting pipe 19 is fixedly connected with the liquid inlet end of the sample pump 2, the bottom of the inner side of the sleeve 18 is provided with a sealing mechanism, the sealing mechanism comprises a sealing ring 20 fixedly connected with the bottom of the inner side of the sleeve 18, the bottom of the sealing ring 20 is provided with a sealing block 21, the top of the sealing block 21 is fixedly connected with a connecting rod 22, the top of the connecting rod 22 is fixedly connected with a pore plate 23, the sealing block 21 and the sealing ring 20 are matched with each other, the sealing block 21 and the sealing ring 20 are both made of tetrafluoro materials, the outer part of the connecting rod 22 is movably sleeved with a second spring 24, the top and the bottom of the second spring 24 are respectively fixedly connected with the bottom of the pore plate 23 and the top of the sealing ring 20, the configured flowing phase is contained in the liquid storage bottle 13, the bottle cap 14 is screwed, so that the sealing gasket 15 is extruded, the liquid storage bottle 13 is sealed, when the connecting pipe 19 is not inserted into the sleeve 18, the pore plate 23 is bounced under the elastic action of the second spring 24, and then make sealed piece 21 and sealing ring 20 laminating together, seal up liquid storage bottle 13, prevent that the inside mobility of liquid storage bottle 13 from volatilizing, cause the pollution to the testing environment, also guarantee the mobile ratio simultaneously, guarantee the accuracy that the sample detected, when connecting pipe 19 inserts inside sleeve 18, screw up connecting pipe 19 and sleeve 18, make connecting pipe 19 extrude orifice plate 23 to the inboard bottom of sleeve 18, and then make second spring 24 compressed, connecting rod 22 downstream, separate sealed piece 21 and sealing ring 20, sample injection pump 2 can be with inside mobility pump-in detector 3 of liquid storage bottle 13.
The placing mechanism comprises a placing opening 5 arranged at the top of a placing plate 4, a bottom plate 6 movably arranged at the bottom of the inner side of the placing opening 5, a plurality of groups of first springs 7 fixedly connected at the bottom of the bottom plate 6, the bottoms of the plurality of groups of first springs 7 are fixedly connected with the bottom of the inner side of the placing opening 5, a placing groove 8 is arranged inside the placing plate 4, the placing groove 8 is concentric with the placing opening 5, a lifting ring 9 is movably arranged inside the placing groove 8, a plurality of groups of transmission rods 10 are fixedly connected at the bottom of the lifting ring 9, the bottoms of the plurality of groups of transmission rods 10 extend to the inside of the placing opening 5 and are fixedly connected with the top of the bottom plate 6, a plurality of groups of sliding rails 11 fixedly connected with the inner side wall of the lifting ring 9 are movably sleeved with abutting blocks 12, one ends of the plurality of groups of abutting blocks 12, which are far away from each other, are inclined planes, the abutting blocks 12 are mutually matched with the lifting ring 9, one ends of the plurality of the abutting blocks 12, which are mutually close to extend to the inside of the placing opening 5, and the one end that multiunit butt joint piece 12 was close to each other is half circular arc-shaped structure, and bottom plate 6 descends, compresses multiunit first spring 7, and transfer line 10 drives the drop ring 9 downstream, and the vertical downstream of multiunit slide rail 11, and then makes multiunit butt joint piece 12 be pushed out the outside of standing groove 8, will be located the stock solution bottle 13 at bottom plate 6 top and carry out the centre gripping, prevents that stock solution bottle 13 from being overturned and topple over.
The working principle is as follows: when a sample is detected, the configured mobile phase is placed in the liquid storage bottle 13, then the bottle cap 14 is screwed to prevent the mobile phase in the liquid storage bottle 13 from volatilizing, the liquid storage bottle 13 filled with the mobile phase is placed in the placing opening 5, the liquid storage bottle 13 presses the bottom plate downwards under the action of gravity, so that the bottom plate 6 descends, the groups of first springs 7 are further compressed, the transmission rod 10 drives the lifting ring 9 to move downwards, the groups of sliding rails 11 vertically move downwards, so that the groups of abutting blocks 12 are pushed out of the placing groove 8, the liquid storage bottle 13 positioned at the top of the bottom plate 6 is clamped to prevent the liquid storage bottle 13 from being overturned and toppled over, then one end, far away from the sample injection pump 2, of the connecting pipe 19 is connected with the sleeve 18, the connecting pipe 19 is screwed with the sleeve 18, the bottom of the connecting pipe 19 abuts against the top of the pore plate 23, the connecting pipe 19 is pressed downwards to drive the connecting rod 22 to descend, the second spring 24 is compressed to separate the sealing block 21 from the sealing ring 20, the sample pump 2 can pump the fluidity inside the liquid storage bottle 13 into the detector 3, when the fluidity is changed, the connecting pipe 19 is screwed out, the orifice plate 23 is bounced under the elastic action of the second spring 24, the sealing block 21 is attached to the sealing ring 20 to seal the liquid storage bottle 13, the fluidity inside the liquid storage bottle 13 is prevented from volatilizing, the detection environment is polluted, meanwhile, the fluidity proportion is also ensured, the liquid storage bottle 13 is convenient to continue to be used next time, then the liquid storage bottle 13 is lifted upwards, the bottom plate 6 is lifted upwards under the elastic action of the multiple groups of the first springs 7, the multiple groups of the transmission rods 10 are lifted, the lifting rings 9 are lifted, the multiple groups of the sliding rails 11 are vertically moved upwards, the multiple groups of the abutting blocks 12 are contracted into the placing groove 8, and new flowing phases are replaced, the liquid storage bottle 13 containing the mobile phase is placed inside the placing opening 5, and the operation is repeated.
In the description of the present invention, it is to be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and to simplify the description, but do not indicate or imply that the device or element referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore should not be construed as limiting the present invention.
Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of the present invention, "a plurality" means two or more unless specifically limited otherwise.
The above, only be the concrete implementation of the preferred embodiment of the present invention, but the protection scope of the present invention is not limited thereto, and any person skilled in the art is in the technical scope of the present invention, according to the technical solution of the present invention and the utility model, the concept of which is equivalent to replace or change, should be covered within the protection scope of the present invention.
Claims (6)
1. The sample detection device for preparing the 4-cyano-3-hydroxy ethyl butyrate comprises a base (1) and is characterized in that a sample injection pump (2) is installed at the top of the base (1), a detector (3) is installed at the top of the sample injection pump (2), a placing plate (4) is installed at the top of the detector (3), a plurality of groups of placing mechanisms are arranged at the top of the placing plate (4), and liquid storage mechanisms are placed inside the placing mechanisms;
the placing mechanism comprises a placing opening (5) formed in the top of a placing plate (4), a bottom plate (6) movably mounted in the placing opening (5), a plurality of groups of first springs (7) fixedly connected to the bottom of the bottom plate (6), wherein the bottoms of the groups of first springs (7) are fixedly connected to the inner bottom of the placing opening (5), the placing mechanism further comprises a placing groove (8) formed in the placing plate (4), a lifting ring (9) movably mounted in the placing groove (8), a plurality of groups of transmission rods (10) fixedly connected to the bottom of the lifting ring (9), the placing groove (8) and the placing opening (5) are concentric, the bottoms of the plurality of groups of transmission rods (10) extend to the inside of the placing opening (5) and are fixedly connected to the top of the bottom plate (6), the placing mechanism further comprises a plurality of groups of sliding rails (11) fixedly connected to the inner side wall of the lifting ring (9), and a plurality of groups of abutting blocks (12) movably sleeved on the outside of the sliding rails (11), one ends of the abutting blocks (12) which are close to each other extend into the placing opening (5);
stock solution mechanism includes that liquid storage bottle (13), screw thread cover establish at bottle lid (14), the drain pipe (16) at bottle lid (14) top are established to fixed cover at liquid storage bottle (13) top, the bottom of drain pipe (16) extends to the inboard bottom of liquid storage bottle (13), stock solution mechanism still includes that the rigid coupling is established at sleeve pipe (18) at drain pipe (16) top, screw thread cover establish sleeve pipe (18) inboard connecting pipe (19), be located the sealing mechanism of sleeve pipe (18) inboard bottom, the inlet end rigid coupling of the other end of connecting pipe (19) and sampling pump (2).
2. The sample detection device for preparing ethyl 4-cyano-3-hydroxybutyrate according to claim 1, wherein the sealing mechanism comprises a sealing ring (20) fixedly connected to the bottom of the inner side of the sleeve (18), a sealing block (21) positioned at the bottom of the sealing ring (20), a connecting rod (22) fixedly connected to the top of the sealing block (21), and an orifice plate (23) fixedly connected to the top of the connecting rod (22), the sealing block (21) and the sealing ring (20) are matched with each other, a second spring (24) is movably sleeved outside the connecting rod (22), and the top and the bottom of the second spring (24) are respectively fixedly connected with the bottom of the orifice plate (23) and the top of the sealing ring (20).
3. The apparatus for detecting a sample for preparing ethyl 4-cyano-3-hydroxybutyrate according to claim 1, wherein the top of the inner side of the bottle cap (14) is fixedly connected with a sealing gasket (15).
4. The sample detection device for preparing ethyl 4-cyano-3-hydroxybutyrate according to claim 1, wherein the liquid outlet pipe (16) is fixedly connected with a filter screen (17) at the inner side of the bottom of the liquid storage bottle (13).
5. The apparatus for detecting a sample for preparing ethyl 4-cyano-3-hydroxybutyrate according to claim 1, wherein the ends of the abutting blocks (12) close to each other are semi-arc structures.
6. The apparatus for detecting a sample for the preparation of ethyl 4-cyano-3-hydroxybutyrate of claim 1, wherein the ends of the plurality of sets of the contact blocks (12) which are away from each other are all inclined surfaces.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202120767370.3U CN214539514U (en) | 2021-04-15 | 2021-04-15 | Sample detection device for preparing 4-cyano-3-hydroxy ethyl butyrate |
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| CN202120767370.3U CN214539514U (en) | 2021-04-15 | 2021-04-15 | Sample detection device for preparing 4-cyano-3-hydroxy ethyl butyrate |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117985357A (en) * | 2024-04-07 | 2024-05-07 | 山东利兴新材料科技股份有限公司 | Raw material storage equipment for producing propylene carbonate |
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2021
- 2021-04-15 CN CN202120767370.3U patent/CN214539514U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117985357A (en) * | 2024-04-07 | 2024-05-07 | 山东利兴新材料科技股份有限公司 | Raw material storage equipment for producing propylene carbonate |
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