CN214485744U - Immunoaffinity column - Google Patents
Immunoaffinity column Download PDFInfo
- Publication number
- CN214485744U CN214485744U CN202120520507.5U CN202120520507U CN214485744U CN 214485744 U CN214485744 U CN 214485744U CN 202120520507 U CN202120520507 U CN 202120520507U CN 214485744 U CN214485744 U CN 214485744U
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- China
- Prior art keywords
- plate
- bottom end
- sleeve
- guide
- guide plate
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 239000000945 filler Substances 0.000 claims abstract description 8
- 230000001105 regulatory effect Effects 0.000 abstract description 9
- 239000007788 liquid Substances 0.000 description 9
- 230000000694 effects Effects 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 230000033001 locomotion Effects 0.000 description 2
- 231100000678 Mycotoxin Toxicity 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000002636 mycotoxin Substances 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 239000013076 target substance Substances 0.000 description 1
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- Treatment Of Liquids With Adsorbents In General (AREA)
Abstract
The utility model discloses an immunoaffinity column, the inside of a column tube is provided with an upper sieve plate and a lower sieve plate, filler is filled between the two sieve plates, the bottom end of the column tube is provided with a bottom plate, a circular truncated cone type through hole is arranged on the bottom plate, the column tube is connected with a sleeve through threads, the inside of the sleeve is provided with a guide plate, a circular truncated cone type regulating block is arranged on the guide plate, a guide hole is arranged on the guide plate, the bottom end of the sleeve is connected with a guide pipe, the outer side wall of the column tube is also provided with a support plate, the bottom end of the support plate is provided with an annular chute, a slide seat is arranged in the annular chute, the bottom end of the slide seat is provided with a limiting pipe, the inner side wall of the limiting pipe is provided with a chute, a guide plate is connected in the chute, the top end of the guide plate is fixedly provided with a spring, the top end of the spring is fixedly connected with the bottom end of the sleeve side wall; generally, the utility model has the advantages of adjust the velocity of flow, easy and simple to handle swiftly, work efficiency is high.
Description
Technical Field
The utility model belongs to the technical field of detect, concretely relates to immunoaffinity column.
Background
The immunoaffinity purifying column utilizes the high specificity and high affinity of antigen-antibody reaction, combines the specific antibody on a solid phase carrier by a proper method so as to effectively separate and purify a target substance, has the advantages of high selectivity, strong enrichment capacity and the like, is used for sample pretreatment of mycotoxin detection, can better eliminate influencing factors, reduces matrix effect and reduces the occurrence of false positive and false negative.
In the use process, for different operation procedures, different liquid flow rates are required to be used for achieving a better use effect, and the existing immunoaffinity column cannot adjust the flow rate, so that the use effect is influenced.
Therefore, in order to solve the above problems, it is necessary to develop an immunoaffinity column.
SUMMERY OF THE UTILITY MODEL
The utility model aims at overcoming prior art not enough, and provide an immunoaffinity post, can be according to the different processes regulation liquid flow rate of operation when the operation, easy operation, the procedure is controllable, effectively improves work efficiency.
The purpose of the utility model is realized like this: an immunoaffinity column comprises a column tube, sieve plates, a filler, a bottom plate, through holes, a sleeve, a guide plate, an adjusting block, guide holes, a guide tube, a support plate, an annular chute, a slide seat, a limiting tube, a chute, a guide plate, a spring and a guide rod, wherein the inside of the column tube is provided with an upper sieve plate and a lower sieve plate, the filler is filled between the two sieve plates, the bottom end of the column tube is provided with the bottom plate, the bottom plate is provided with a circular table-shaped through hole communicated with the inside of the column tube, the bottom end of the outer side wall of the column tube is connected with the sleeve through a thread, the guide plate is arranged inside the sleeve and below the bottom plate, the guide plate is provided with a circular table-shaped adjusting block matched with the through holes, the guide holes are also arranged on the guide plate and positioned between the adjusting block and the side wall of the sleeve, the bottom end of the sleeve is connected with the guide tube, the outer side wall of the column tube is also provided with the annular support plate, the utility model discloses a spacing pipe of spring, including backup pad, spout, spring top fixed connection slide bottom, the backup pad bottom is provided with annular spout, the slidable is provided with the slide in the annular spout, the slide bottom is provided with spacing pipe, be provided with the spout on the lateral wall in the spacing pipe, slidable connection has the deflector from top to bottom in the spout, the fixed spring that is provided with in deflector top, spring top fixed connection slide bottom, the fixed guide bar that is provided with in deflector bottom, spacing pipe fixed connection sleeve pipe lateral wall top is stretched out to the guide bar bottom.
The sleeve is connected with the delivery pipe through an inverted cone-shaped pipe.
The bottom end of the sliding groove is provided with a limiting block.
An upper cover is arranged at the top end of the column tube.
And the bottom cover is arranged at the bottom end of the delivery pipe.
The bottom end of the adjusting block is rotatably connected with the guide plate through a rotating shaft and a rotating bearing.
The utility model has the advantages that: in the utility model, the through hole of the circular truncated cone shape and the circular truncated cone shape adjusting block matched with the through hole are arranged at the bottom end of the column tube, the adjusting block can be driven to move up and down by the rotation of the sleeve to realize the purpose of plugging or opening the through hole by the adjusting block, and meanwhile, the flow velocity can be adjusted by adjusting the size of the flow guide channel formed between the adjusting block and the through hole; the annular sliding groove, the sliding seat, the limiting pipe, the spring, the sliding groove, the guide plate and the guide rod are arranged between the sleeve and the support plate, so that the up-and-down movement of the sleeve is limited while the normal rotation of the sleeve is not influenced, the sleeve is prevented from slipping off the column pipe, and the normal use is further influenced; generally, the utility model has the advantages of adjust the velocity of flow, easy and simple to handle swiftly, work efficiency is high.
Drawings
Fig. 1 is a schematic view of the structure of the present invention.
Fig. 2 is an enlarged schematic view of a portion a in fig. 1.
In the figure: 1. the device comprises a column tube 2, a sieve plate 3, a filler 4, a bottom plate 5, a through hole 6, a sleeve 7, a guide plate 8, an adjusting block 9, a guide hole 10, a guide tube 11, a support plate 12, an annular sliding groove 13, a sliding seat 14, a limiting tube 15, a sliding groove 16, a guide plate 17, a spring 18, a guide rod 19, an inverted conical tube 20, a limiting block 21, an upper cover 22 and a bottom cover.
Detailed Description
The technical scheme of the utility model is further explained in detail with the attached drawings.
As shown in fig. 1 and 2, an immunoaffinity column comprises a column tube 1, a sieve plate 2, a filler 3, a bottom plate 4, a through hole 5, a sleeve 6, a guide plate 7, an adjusting block 8, a guide hole 9, a guide tube 10, a support plate 11, an annular sliding groove 12, a sliding seat 13, a limiting tube 14, a sliding groove 15, a guide plate 16, a spring 17 and a guide rod 18.
Wherein, the top of the column tube 1 is provided with an upper cover 21, the column tube 1 is internally provided with an upper sieve plate 2 and a lower sieve plate 2, a filler 3 is filled between the two sieve plates 2, the bottom of the column tube 1 is provided with a bottom plate 4, the bottom plate 4 is provided with a circular truncated cone-shaped through hole 5 communicated with the inside of the column tube 1, the bottom of the outer side wall of the column tube 1 is connected with a sleeve 6 through a thread, the inside of the sleeve 6 is provided with a guide plate 7 below the bottom plate 4, the guide plate 7 is provided with a circular truncated cone-shaped adjusting block 8 matched with the through hole 5, preferably, the bottom of the adjusting block 8 is rotatably connected with the guide plate 7 through a rotating shaft and a rotating bearing, the adjusting block 8 can move up and down along with the sleeve 6 without circular motion, the use is more convenient and reliable, and a plurality of guide holes 9 are also arranged between the adjusting block 8 and the side wall of the sleeve 6 on the guide plate 7, the bottom end of the sleeve 6 is connected with a delivery tube 10, the sleeve 6 is connected with the delivery tube 10 through an inverted cone type tube 19, so that liquid flows out more smoothly and is not easy to remain, the bottom end of the delivery tube 10 is provided with a bottom cover 22, the outer side wall of the column tube 1 is also provided with an annular support plate 11, the bottom end of the support plate 11 is provided with an annular sliding groove 12, a sliding seat 13 is slidably arranged in the annular sliding groove 12, the bottom end of the sliding seat 13 is provided with a limit tube 14, the inner side wall of the limit tube 14 is provided with a sliding groove 15, a guide plate 16 is slidably connected in the sliding groove 15 up and down, the bottom end of the sliding groove 15 is provided with a limit block 20, the guide plate 16 can be limited when sliding in the sliding groove, the guide plate 16 is prevented from slipping from the sliding groove 15, so as to cause inconvenience, the top end of the guide plate 16 is fixedly provided with a spring 17, and the top end of the spring 17 is fixedly connected with the bottom end of the sliding seat 13, the bottom end of the guide plate 16 is fixedly provided with a guide rod 18, and the bottom end of the guide rod 18 extends out of the top end of the side wall of the connecting sleeve 6 and fixedly connected with the limiting pipe 14.
The utility model discloses during the implementation, through rotating sleeve 6, sleeve 6 reciprocates on column tube 1 lateral wall under the effect of screw thread, and then drive the inside regulating block 8 of sleeve 6 and reciprocate, make the liquid channel that forms between regulating block 8 and through-hole 5 follow the reciprocating of regulating block 8 and adjust, when the required velocity of flow is too fast, move sleeve 6 and regulating block 8 downwards, the liquid channel that forms between regulating block 8 and the through-hole 5 lateral wall becomes big, the liquid velocity of flow also becomes thereupon, otherwise, move sleeve 6 and regulating block 8 upwards, the liquid channel that forms between regulating block 8 and the through-hole 5 lateral wall diminishes, the liquid velocity of flow then diminishes thereupon, until regulating block 8 and through-hole 5 lateral wall hug closely connect, close the liquid channel shutoff; in the process of rotating the sleeve 6, through the transmission effect of guide bar 18, deflector 16, spout 15 and spacing pipe 14 for slide 13 follows the rotation of sleeve 6 and slides in annular spout 12, and simultaneously, under the effect of spring 17, deflector 16, spout 15 and guide bar 18, sleeve 6 can normally reciprocate, carries on spacingly to sleeve 6 simultaneously, prevents that it from slipping on post pipe 1, uses safe and reliable more.
The above description is only a preferred embodiment of the present invention, and is not intended to limit the present invention, and any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present invention should be included within the protection scope of the present invention.
Claims (6)
1. An immunoaffinity column, comprising: comprises a column tube (1), sieve plates (2), a filler (3), a bottom plate (4), through holes (5), a sleeve (6), a guide plate (7), an adjusting block (8), a guide hole (9), a delivery pipe (10), a support plate (11), an annular sliding groove (12), a sliding seat (13), a limiting pipe (14), a sliding groove (15), a guide plate (16), a spring (17) and a guide rod (18), wherein the column tube (1) is internally provided with an upper sieve plate and a lower sieve plate (2), the filler (3) is filled between the two sieve plates (2), the bottom end of the column tube (1) is provided with the bottom plate (4), the bottom plate (4) is provided with a circular truncated cone-shaped through hole (5) communicated with the interior of the column tube (1), the bottom end of the outer side wall of the column tube (1) is connected with the sleeve (6) through threads, and the guide plate (7) is arranged below the bottom plate (4) in the sleeve (6), the guide plate (7) is provided with a circular truncated cone type adjusting block (8) matched with the through hole (5), a plurality of guide holes (9) are further formed between the adjusting block (8) and the side wall of the sleeve (6) on the guide plate (7), the bottom end of the sleeve (6) is connected with a guide pipe (10), the outer side wall of the column tube (1) is further provided with an annular supporting plate (11), the bottom end of the supporting plate (11) is provided with an annular sliding groove (12), a sliding seat (13) is slidably arranged in the annular sliding groove (12), the bottom end of the sliding seat (13) is provided with a limiting pipe (14), the inner side wall of the limiting pipe (14) is provided with a sliding groove (15), the sliding groove (15) is internally and vertically slidably connected with a guide plate (16), the top end of the guide plate (16) is fixedly provided with a spring (17), and the top end of the spring (17) is fixedly connected with the bottom end of the sliding seat (13), the bottom end of the guide plate (16) is fixedly provided with a guide rod (18), and the bottom end of the guide rod (18) extends out of the top end of the side wall of the limiting pipe (14) and is fixedly connected with the top end of the sleeve (6).
2. An immunoaffinity column according to claim 1, wherein: the sleeve (6) is connected with the delivery pipe (10) through an inverted cone-shaped pipe (19).
3. An immunoaffinity column according to claim 1, wherein: the bottom end of the sliding groove (15) is provided with a limiting block (20).
4. An immunoaffinity column according to claim 1, wherein: an upper cover (21) is arranged at the top end of the column tube (1).
5. An immunoaffinity column according to claim 1, wherein: the bottom end of the delivery pipe (10) is provided with a bottom cover (22).
6. An immunoaffinity column according to claim 1, wherein: the bottom end of the adjusting block (8) is rotatably connected with the guide plate (7) through a rotating shaft and a rotating bearing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202120520507.5U CN214485744U (en) | 2021-03-12 | 2021-03-12 | Immunoaffinity column |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202120520507.5U CN214485744U (en) | 2021-03-12 | 2021-03-12 | Immunoaffinity column |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN214485744U true CN214485744U (en) | 2021-10-26 |
Family
ID=78198369
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202120520507.5U Expired - Fee Related CN214485744U (en) | 2021-03-12 | 2021-03-12 | Immunoaffinity column |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN214485744U (en) |
-
2021
- 2021-03-12 CN CN202120520507.5U patent/CN214485744U/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20211026 |