CN214484721U

CN214484721U - Fixing device for continuously collecting cerebrospinal fluid of rat

Info

Publication number: CN214484721U
Application number: CN202022733592.1U
Authority: CN
Inventors: 彭娇娇; 杨德孝
Original assignee: Suzhou Shengsu New Drug Development Co ltd
Current assignee: Suzhou Shengsu New Drug Development Co ltd
Priority date: 2020-11-23
Filing date: 2020-11-23
Publication date: 2021-10-26
Anticipated expiration: 2030-11-23

Abstract

The utility model discloses a fixing device for continuously collecting rat cerebrospinal fluid, which comprises a bottom plate, an adjusting and fixing mechanism and an elastic fixing mechanism; the rear end of the upper surface of the bottom plate is provided with a groove plate, the interior of the groove plate is connected with a sliding block in a sliding manner, the upper surface of the groove plate is provided with a cover plate, the left side and the right side of the upper surface of the bottom plate are both provided with symmetrical sliding grooves, the outer side walls of the sliding grooves are both provided with threaded holes, the interior of each threaded hole is connected with an adjusting bolt in a threaded manner, the inner side end of each adjusting bolt is rotatably connected with a supporting block through a bearing, the supporting blocks are respectively connected with the corresponding sliding grooves in a sliding manner, and four corners of the upper surface of the bottom plate are both provided with mounting holes; the adjusting and fixing mechanisms are respectively and rotatably connected with the upper end surfaces of the corresponding supporting blocks; the elastic fixing mechanism is arranged on the bottom surface of the cover plate, and the lower end of the elastic fixing mechanism is fixedly connected with the sliding block. This fixing device of continuous collection rat cerebrospinal fluid is convenient for fix rat body and four limbs, is applicable to the fixed of different size rats.

Description

Fixing device for continuously collecting cerebrospinal fluid of rat

Technical Field

The utility model relates to a biological analysis experiment technical field specifically is a fixing device of continuous acquisition rat cerebrospinal fluid.

Background

Bioanalysis experiments are chromatography applied to downstream technologies of protein chemistry, proteomics and bioengineering, and currently, in the fields of life science research, application and production, various biochemical analysis technical methods, experimental principles, experimental design, operation techniques and related instruments, such as separation, purification, preparation, analysis, identification, data processing and the like of natural and gene recombinant biomolecules, can also be used for experiments of local students and researchers in the subjects of biopharmaceuticals, foods, medicines, medicine, clinical examination, environmental monitoring and the like, and can be used for social research and application of related biopharmaceutical enterprises and the like.

In biological experiments, the cerebrospinal fluid of a rat is usually required to be collected for experiments, the cerebrospinal fluid is transparent body fluid which fills a subarachnoid cavity between a skull and a cerebral cortex in a brain, is located between the arachnoid and the pia mater of the meninges, is pure physiological saline containing microglia cells, is mainly used for mechanical buffering of the cerebral cortex, and becomes one of important auxiliary means if the central nervous system is diseased.

At present, cerebrospinal fluid collection experiments are more and more, fixation is very difficult during collection, collection points are not accurate, pollution is easy, and sampling failure and sampling waste are caused. At the collection in-process to mouse cerebrospinal fluid, need use fixing device, current fixing device adopts the rubber tape to bind the four limbs of mouse more, has a lot of defects, is not convenient for fix rat body and four limbs, and fixed effect is poor, and fixed mode is complicated, and application scope is little, and collection efficiency is low. Therefore, a fixing device for continuously collecting the cerebrospinal fluid of a rat is provided.

SUMMERY OF THE UTILITY MODEL

The to-be-solved technical problem of the utility model is to overcome current defect, provide a fixing device of continuous collection rat cerebrospinal fluid, be convenient for fixed to rat body and four limbs, flexible centre gripping is fixed, and is fixed effectual, avoids gathering in-process rat position to take place the skew, is applicable to the fixed of different size rats, and application scope is wide, improves collection efficiency, can effectively solve the problem in the background art.

In order to achieve the above object, the utility model provides a following technical scheme: a fixing device for continuously collecting rat cerebrospinal fluid comprises a bottom plate, an adjusting fixing mechanism and an elastic fixing mechanism;

the rear end of the upper surface of the bottom plate is provided with a groove plate, a sliding block is connected inside the groove plate in a sliding mode, a cover plate is arranged on the upper surface of the groove plate, symmetrical sliding grooves are formed in the left side and the right side of the upper surface of the bottom plate, threaded holes are formed in the outer side walls of the sliding grooves, adjusting bolts are connected inside the threaded holes in a threaded mode, supporting blocks are rotatably connected to the inner side ends of the adjusting bolts through bearings, the supporting blocks are respectively connected with the corresponding sliding grooves in a sliding mode, and four corners of the upper surface of the bottom plate are provided with mounting holes;

the adjusting and fixing mechanisms are respectively and rotatably connected with the upper end surfaces of the corresponding supporting blocks;

the elastic fixing mechanism is arranged on the bottom surface of the cover plate, and the lower end of the elastic fixing mechanism is fixedly connected with the sliding block.

Furthermore, the adjusting and fixing mechanism comprises an arc-shaped groove plate, a top plate, a pressing block and an inserting plate; the bottom surface of arc frid all rotates through the bearing to be connected in the supporting shoe up end that corresponds, and equal activity grafting has the picture peg in the slot that the arc frid up end set up, and the up end of two picture pegs of grafting all with the bottom surface fixed connection of roof on the same arc frid, roof be four and bottom surface middle part all are equipped with the briquetting, are convenient for fixed to rat four limbs, and fixed effectual is applicable to the fixed of different size rats, and application scope is wide.

Furthermore, the width of the pressing block is smaller than the diameter of a circular groove formed in the middle of the upper end face of the arc-shaped groove plate, and the clamping range is enlarged.

Further, elastic fixation mechanism includes flexible post, spring, fixed plate and arc, flexible post sets up in the bottom surface of apron, the lower extreme of flexible post and the up end fixed connection of slider, and the outside cover of flexible post is equipped with the spring, the both sides end of spring respectively with the bottom surface of apron and the last fixed surface of slider be connected, the leading flank of slider is equipped with the fixed plate, the bottom surface of fixed plate is equipped with the arc, is convenient for fixed to the rat body, and flexible centre gripping is fixed, and is fixed effectual, avoids the too big death of rat atress, improves collection efficiency.

Furthermore, a rubber pad is arranged in the middle of the upper surface of the bottom plate to provide flexible support.

Compared with the prior art, the beneficial effects of the utility model are that:

1. the fixed plate is pulled upwards, the sliding block slides upwards along the groove plate, the telescopic column is contracted, the spring is compressed, the anesthetized rat is placed on the upper surface of the rubber pad, the fixed plate is loosened, the sliding block and the fixed plate are pushed to move downwards under the action of the elastic force of the spring, the arc-shaped plate is driven to move downwards and press the body of the rat, the rat body is fixed conveniently, the fixing effect is good due to flexible clamping and fixing, the rat is prevented from being stressed too much and dying, and the collection efficiency is improved;

2. the pulling roof, and then make picture peg and arc wall separation, and then take off roof and briquetting, rotation adjusting bolt, make the supporting shoe remove along the spout, transfer the supporting shoe to suitable position, rotate the arc wall, transfer the arc wall to suitable angle, and put the four limbs of rat respectively in the circular slot that arc wall up end middle part set up, insert the picture peg in the slot that arc wall up end set up, and then it is fixed with the four limbs of rat, and easy operation, it is fixed to rat four limbs to be convenient for, fixed effectual, be applicable to the fixed of different size rats, and wide application scope.

Drawings

Fig. 1 is a schematic structural diagram of the present invention.

In the figure: 1. the adjustable sliding block comprises a bottom plate, a groove plate 2, a cover plate 3, a sliding block 4, a sliding groove 5, a threaded hole 6, an adjusting and fixing mechanism 7, an arc-shaped groove plate 71, a top plate 72, a pressing block 73, a plug plate 74, an elastic fixing mechanism 8, a telescopic column 81, a spring 82, a fixing plate 83, an arc-shaped plate 84, an adjusting bolt 9, a supporting block 10, a rubber pad 11 and a mounting hole 12.

Detailed Description

The technical solution in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, rather than all embodiments, and all other embodiments obtained by a person of ordinary skill in the art without creative work belong to the protection scope of the present invention based on the embodiments of the present invention.

Referring to fig. 1, the fixing device for continuously collecting cerebrospinal fluid of a rat provided by the present invention comprises a bottom plate 1, an adjusting fixing mechanism 7 and an elastic fixing mechanism 8.

Wherein: the rear end of the upper surface of the bottom plate 1 is provided with a groove plate 2, a sliding block 4 is connected inside the groove plate 2 in a sliding manner, a cover plate 3 is arranged on the upper surface of the groove plate 2, symmetrical sliding grooves 5 are formed in the left side and the right side of the upper surface of the bottom plate 1 to provide sliding support, threaded holes 6 are formed in the outer side walls of the sliding grooves 5, adjusting bolts 9 are connected inside the threaded holes 6 in a threaded manner, supporting blocks 10 are rotatably connected to the ends of the inner sides of the adjusting bolts 9 through bearings, the supporting blocks 10 are respectively connected with the corresponding sliding grooves 5 in a sliding manner, and mounting holes 12 are formed in four corners of the upper surface of the bottom plate 1; the middle part of the upper surface of the bottom plate 1 is provided with a rubber pad 11 for providing flexible support.

Wherein: the adjusting and fixing mechanisms 7 are respectively and rotatably connected with the upper end faces of the corresponding supporting blocks 10, and each adjusting and fixing mechanism 7 comprises an arc-shaped groove plate 71, a top plate 72, a pressing block 73 and an inserting plate 74; the bottom surfaces of the arc-shaped groove plates 71 are rotatably connected to the upper end surfaces of the corresponding supporting blocks 10 through bearings, inserting plates 74 are movably inserted into the inserting grooves formed in the upper end surfaces of the arc-shaped groove plates 71, and the upper end surfaces of the two inserting plates 74 inserted into the same arc-shaped groove plate 71 are fixedly connected with the bottom surface of the top plate 72; the number of the top plates 72 is four, pressing blocks 73 are arranged in the middle of the bottom surface of each top plate, and the width of each pressing block 73 is smaller than the diameter of a circular groove formed in the middle of the upper end surface of the arc-shaped groove plate 71.

Wherein: the elastic fixing mechanism 8 is arranged on the bottom surface of the cover plate 3, the lower end of the elastic fixing mechanism 8 is fixedly connected with the sliding block 4, and the elastic fixing mechanism 8 comprises a telescopic column 81, a spring 82, a fixing plate 83 and an arc-shaped plate 84; the telescopic column 81 is arranged on the bottom surface of the cover plate 3, the lower end of the telescopic column 81 is fixedly connected with the upper end face of the sliding block 4, the spring 82 is sleeved outside the telescopic column 81, the ends of the two sides of the spring 82 are fixedly connected with the bottom surface of the cover plate 3 and the upper surface of the sliding block 4 respectively, the front side face of the sliding block 4 is provided with a fixing plate 83, and the bottom surface of the fixing plate 83 is provided with an arc-shaped plate 84.

The utility model discloses a theory of operation:

firstly, bolts penetrate through mounting holes 12 arranged at four corners of the upper surface of a bottom plate 1, the device is fixed on a workbench, a fixing plate 83 is pulled upwards, a sliding block 4 slides upwards along a groove plate 2, a telescopic column 81 is contracted, and a spring 82 is compressed;

the anesthetized rat is placed on the upper surface of the rubber pad 11, the fixing plate 83 is loosened, the sliding block 4 and the fixing plate 83 are pushed to move downwards under the action of the elastic force of the spring 82, and then the arc-shaped plate 84 is driven to move downwards and press the body of the rat, so that the body of the rat is conveniently fixed, the rat is flexibly clamped and fixed, the fixing effect is good, the rat is prevented from being stressed too much and dying, and the acquisition efficiency is improved;

pulling roof 72, and then make picture peg 74 and arc wall 71 separate, and then take off roof 72 and briquetting 73, rotation adjusting bolt 9, make supporting shoe 10 remove along spout 5, transfer suitable position with supporting shoe 10, rotate arc wall 71, transfer suitable angle with arc wall 71, and put the four limbs of rat respectively in the circular slot that arc wall 71 up end middle part set up, insert the slot that arc wall 71 up end set up with picture peg 74, and then it is fixed with the four limbs of rat, therefore, the operation is simple, it is convenient for to fix the rat four limbs, fixed effectual, be applicable to the fixed of different size rats, application scope is wide.

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims

1. The utility model provides a fixing device of continuous collection rat cerebrospinal fluid which characterized in that: comprises a bottom plate (1), an adjusting and fixing mechanism (7) and an elastic fixing mechanism (8);

the rear end of the upper surface of the bottom plate (1) is provided with a groove plate (2), the interior of the groove plate (2) is connected with a sliding block (4) in a sliding manner, the upper surface of the groove plate (2) is provided with a cover plate (3), the left side and the right side of the upper surface of the bottom plate (1) are respectively provided with a symmetrical sliding chute (5), the outer side wall of each sliding chute (5) is provided with a threaded hole (6), the interior of each threaded hole (6) is connected with an adjusting bolt (9) in a threaded manner, the end of the inner side of each adjusting bolt (9) is rotatably connected with a supporting block (10) through a bearing, the supporting blocks (10) are respectively connected with the corresponding sliding chutes (5) in a sliding manner, and four corners of the upper surface of the bottom plate (1) are respectively provided with mounting holes (12);

the adjusting and fixing mechanisms (7) are respectively and rotatably connected with the upper end faces of the corresponding supporting blocks (10);

the elastic fixing mechanism (8) is arranged on the bottom surface of the cover plate (3), and the lower end of the elastic fixing mechanism (8) is fixedly connected with the sliding block (4).

2. The fixing device for continuously collecting cerebrospinal fluid of a rat according to claim 1, wherein: the adjusting and fixing mechanism (7) comprises an arc-shaped groove plate (71), a top plate (72), a pressing block (73) and an inserting plate (74); the bottom surface of arc frid (71) all rotates through the bearing to be connected in corresponding supporting shoe (10) up end, equal activity is pegged graft in the slot that arc frid (71) up end set up has picture peg (74), it is same two of pegging graft on arc frid (71) the up end of picture peg (74) all with the bottom surface fixed connection of roof (72), roof (72) all are equipped with for four and bottom surface middle part briquetting (73).

3. The fixing device for continuously collecting cerebrospinal fluid of a rat according to claim 2, wherein: the width of the pressing block (73) is smaller than the diameter of a circular groove formed in the middle of the upper end face of the arc-shaped groove plate (71).

4. The fixing device for continuously collecting cerebrospinal fluid of a rat according to claim 1, wherein: the elastic fixing mechanism (8) comprises a telescopic column (81), a spring (82), a fixing plate (83) and an arc-shaped plate (84); flexible post (81) set up in the bottom surface of apron (3), the lower extreme of flexible post (81) and the up end fixed connection of slider (4), the outside cover of flexible post (81) is equipped with spring (82), the both sides end of spring (82) respectively with the bottom surface of apron (3) and the last fixed surface of slider (4) be connected, the leading flank of slider (4) is equipped with fixed plate (83), the bottom surface of fixed plate (83) is equipped with arc (84).

5. The fixing device for continuously collecting cerebrospinal fluid of a rat according to claim 1, wherein: and a rubber pad (11) is arranged in the middle of the upper surface of the bottom plate (1).