CN214374163U - Sample loading sleeve and combined tube for rare cell flow detection - Google Patents
Sample loading sleeve and combined tube for rare cell flow detection Download PDFInfo
- Publication number
- CN214374163U CN214374163U CN202120219484.4U CN202120219484U CN214374163U CN 214374163 U CN214374163 U CN 214374163U CN 202120219484 U CN202120219484 U CN 202120219484U CN 214374163 U CN214374163 U CN 214374163U
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- Prior art keywords
- clamping device
- iron sheet
- sleeve pipe
- spring
- filter screen
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- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims abstract description 82
- 229910052742 iron Inorganic materials 0.000 claims abstract description 41
- 238000001914 filtration Methods 0.000 claims abstract description 7
- 239000011148 porous material Substances 0.000 claims abstract description 6
- 239000007787 solid Substances 0.000 claims description 10
- 238000003556 assay Methods 0.000 claims description 3
- 239000002131 composite material Substances 0.000 abstract description 3
- 230000007704 transition Effects 0.000 abstract description 2
- 210000004027 cell Anatomy 0.000 description 20
- 239000000523 sample Substances 0.000 description 16
- 238000000684 flow cytometry Methods 0.000 description 6
- 238000000034 method Methods 0.000 description 6
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- 238000004445 quantitative analysis Methods 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
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- 238000003759 clinical diagnosis Methods 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
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- 238000010586 diagram Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
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- 238000002474 experimental method Methods 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 238000011134 hematopoietic stem cell transplantation Methods 0.000 description 1
- 230000008588 hemolysis Effects 0.000 description 1
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Abstract
The utility model discloses a go up appearance sleeve pipe and composite tube for rare cell flow detects, including the sleeve pipe device body, the sleeve pipe device body includes support frame and sleeve pipe, the support frame includes the base, the telescopic link, fixed ring shape platform and clamping device, be equipped with the block on the sleeve pipe, be equipped with the rubber supporting legs on the bottom of base, the telescopic link includes telescopic link one and telescopic link two, sheathed tube inside is equipped with filter screen one and filter screen two, all be equipped with the filtration pore on filter screen one and the filter screen two, the upper portion of telescopic link is equipped with fixed ring shape platform, the middle part of fixed ring shape platform is equipped with fixed through hole one, the inside of fixed through hole one is equipped with elasticity iron sheet clamping device and spring clamping device, elasticity iron sheet clamping device and spring clamping device all are equipped with 4 at least. The utility model discloses a set up support frame, elasticity iron sheet clamping device and spring clamping device, solved the effective transition problem of sleeve pipe with the combination pipe for sleeve pipe and combination pipe place more convenient.
Description
Technical Field
The utility model belongs to the technical field of the biological medicine, concretely relates to a sample loading sleeve pipe and combination pipe for rare cell flow detects.
Background
Flow Cytometry (FCM) is a detection means capable of realizing quantitative analysis of a single cell, has the advantages of rapidness, high precision, multiple parameters and the like, and is one of the most advanced cell quantitative analysis methods at present. FCM plays an important role in clinical and scientific research fields, has been widely and deeply applied particularly in clinical in vitro diagnosis, and becomes one of the most mainstream detection means, and the clinical application thereof comprises: immunology, hematology, clinical oncology, hematopoietic stem cell transplantation, and the like; at present, the method is the gold standard for clinical diagnosis of malignant diseases such as leukemia, lymphoma and the like.
The biological sample used for the FCM on-machine detection is generally peripheral blood, bone marrow, cerebrospinal fluid, or other tissue samples. Before FCM is tested on a computer, a series of pretreatment operations such as antibody incubation, hemolysis, centrifugation, washing, transfer and the like are required to be carried out on a biological sample. Whether these operations are performed properly or not may directly affect the test results and even the diagnosis and further medical treatment protocols. For example, for a sample with a certain value such as cerebrospinal fluid, it is important to improve the cell recovery rate during the operation process to ensure the accuracy of the test result; in the case of Minimal Residual Disease (MRD), it is desirable to avoid losing diseased cells during the treatment procedure as much as possible, leading to false negative diagnosis.
The current flow cytometry detection has the following problems:
1) the situation that clamping is unstable often exists when the sleeve and the pointed-bottom centrifugal tube are used for sampling;
2) when the pointed-bottom centrifugal tube is used for sampling more, the sample can be deposited inside the sleeve.
SUMMERY OF THE UTILITY MODEL
The utility model provides a go up appearance sleeve pipe and combination pipe for rare cell flow detects has solved the effective transition problem of sleeve pipe and combination pipe through setting up support frame, elasticity iron sheet clamping device and spring clamping device for sleeve pipe and combination pipe are placed more conveniently.
The technical scheme of the utility model is realized like this:
the utility model provides a sample loading sleeve pipe for rare cell flow detects, its includes the sleeve pipe device body, a serial communication port, the sleeve pipe device body includes support frame and sleeve pipe, the support frame includes base, telescopic link, solid fixed ring shape platform and clamping device, be equipped with the block on the sleeve pipe, be equipped with the rubber supporting legs on the bottom of base, the telescopic link includes telescopic link one and telescopic link two, sheathed tube inside is equipped with filter screen one and filter screen two, all be equipped with the filtration pore on filter screen one and the filter screen two, the upper portion of telescopic link is equipped with solid fixed ring shape platform, the middle part of solid fixed ring shape platform is equipped with solid fixed through hole one, the inside of solid fixed through hole one is equipped with elasticity iron sheet clamping device and spring clamping device, elasticity iron sheet clamping device and spring clamping device all are equipped with 4 at least.
The utility model discloses an in the sample loading sleeve pipe for rare cell flow detects, telescopic link one and telescopic link two all are equipped with flexible section and canned paragraph, be equipped with fastening bolt on the canned paragraph, be equipped with the arc recess on the base top surface between telescopic link one and the telescopic link two.
The utility model discloses an in the sample loading sleeve pipe for rare cell flow detects, elasticity iron sheet clamping device is equipped with elasticity iron sheet clamping device one and elasticity iron sheet clamping device two, elasticity iron sheet clamping device one and elasticity iron sheet clamping device two all include elasticity iron sheet and elastic rubber circle, the elastic rubber circle sets up the outside at the elasticity iron sheet.
The utility model discloses an in the sample loading sleeve pipe for rare cell flow detects, spring clamping device is equipped with spring clamping device one and spring clamping device two, spring clamping device one and spring clamping device two all include base, spring and baffle, be equipped with flexible component on the top surface of baffle, the one end of spring is fixed on the base, and the other end is connected with the baffle.
The utility model discloses an in the sleeve pipe that takes a sample for rare cell flow detects, elasticity iron sheet clamping device sets up the middle part at fixed through hole one, spring clamping device sets up the bottom at fixed through hole one, clamping device includes down tube one, down tube two and horizontal pole one, be equipped with flexible component on the inboard of horizontal pole one.
The utility model discloses an in the sleeve pipe of drawing a design for rare cell flow detects, the one end of down tube one and down tube two is fixed at the fixed ring shape bench, the side swing joint of the other end and horizontal pole one, the filtration pore diameter on the filter screen one is greater than the filtration pore diameter on the filter screen two.
The utility model discloses an among the sheathed tube combination tube of going up appearance for rare cell flow detects, including sharp end centrifuging tube, place on the arc recess on the base bottom of sharp end centrifuging tube, the diameter of sharp end centrifuging tube is greater than sheathed tube diameter, the inside of sharp end centrifuging tube is inserted to sheathed tube bottom, sharp end centrifuging tube is fixed by spring clamping device, the centre gripping is fixed by elasticity iron sheet clamping device to the sheathed tube side.
Implement the utility model discloses a sample loading sleeve pipe and composite tube for rare cell flow assay has following beneficial effect: the present case sets up the support frame, sleeve pipe and combination tube, and be equipped with the inside of support frame a plurality of different clamping device, different sleeve pipes and combination tube are fixed respectively to every clamping device, also can set up the arc recess on the base, this problem that traditional centre gripping is unstable has just been solved, the influence that personnel's fatigue caused the experiment has been prevented, the setting up of telescopic link makes when taking a sample more unlikely to deposit at the intraductal portion of cover, artificial control cell flow detects the overall process of sample like this, the device is operated very portably, the detection of especially adapted cell flow is used.
Drawings
FIG. 1 is a schematic diagram of a sample loading sleeve and a combination tube for rare cell flow assay according to the present invention;
FIG. 2 is an enlarged view of a portion of FIG. 1 at A;
FIG. 3 is an enlarged view of a portion of FIG. 1 at B;
FIG. 4 is a schematic cross-sectional view at C-C of FIG. 1;
FIG. 5 is a schematic cross-sectional view taken at D-D in FIG. 1;
FIG. 6 is an enlarged partial view of E in FIG. 1;
fig. 7 is a partially enlarged schematic view of F in fig. 1.
In the figure: the device comprises a sleeve device body 1, a support frame 2, a sleeve 3, a base 4, a fixed annular table 5, a clamping device 6, a cover cap 7, a rubber supporting foot 8, a first telescopic rod 9, a second telescopic rod 10, a first filter screen 11, a second filter screen 12, a filter hole 13, a first fixing through hole 14, a telescopic section 15, a fixed section 16, a fastening bolt 17, an arc-shaped groove 18, a first elastic iron sheet clamping device 19, a second elastic iron sheet clamping device 20, an elastic iron sheet 21, an elastic rubber ring 22, a first spring clamping device 23, a second spring clamping device 24, a base 25, a spring 26, a baffle 27, a flexible part 28, a first inclined rod 29, a second inclined rod 30, a first cross rod 31 and a flexible part 32.
Detailed Description
The technical solution in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention.
The utility model discloses a kind of sample loading sleeve pipe and composite tube for rare cell flow detection as shown in fig. 1-7, it includes sleeve pipe device body 1, sleeve pipe device body 1 includes support frame 2 and sleeve pipe 3, support frame 2 includes base 4, telescopic link, fixed ring platform 5 and clamping device 6, be equipped with block 7 on the sleeve pipe 3, be equipped with rubber supporting legs 8 on the bottom of base 4, the telescopic link includes telescopic link one 9 and telescopic link two 10, the setting of telescopic link one 9 and telescopic link two 10 has satisfied the adjustability of sleeve pipe 3's height, the inside of sleeve pipe 3 is equipped with filter screen one 11 and filter screen two 12, filter screen one 11 and filter screen two 12 are all equipped with filtration pore 13, the upper portion of telescopic link is equipped with fixed ring platform 5, the middle part of fixed ring platform 5 is equipped with fixed through-hole one 14, the inside of fixed through-hole one 14 is equipped with elasticity iron sheet clamping device and spring clamping device, the elastic iron sheet clamping device and the spring clamping device are at least provided with 4, the first telescopic rod 9 and the second telescopic rod 10 are both provided with a telescopic section 15 and a fixed section 16, the fixed section 16 is provided with a fastening bolt 17, the top surface of the base between the first telescopic rod 9 and the second telescopic rod 10 is provided with an arc-shaped groove 18, the elastic iron sheet clamping device is provided with a first elastic iron sheet clamping device 19 and a second elastic iron sheet clamping device 20, the clamping stability of the sleeve 3 is ensured, the first elastic iron sheet clamping device 19 and the second elastic iron sheet clamping device 20 both comprise an elastic iron sheet 21 and an elastic rubber ring 22, the elastic rubber ring 22 is arranged on the outer side of the elastic iron sheet 21, the spring clamping device is provided with a first spring clamping device 23 and a second spring clamping device 24, the first spring clamping device 23 and the second spring clamping device 24 both comprise a base 25, a spring 26 and a baffle 27, and the top surface of the baffle 27 is provided with a flexible component 28, one end of a spring 26 is fixed on the base 25, the other end is connected with the baffle 27, an elastic iron sheet clamping device is arranged in the middle of the first fixing through hole 14, the spring clamping device is arranged at the bottom of the first fixing through hole 14, the clamping device comprises a first inclined rod 29, a second inclined rod 30 and a first cross rod 31, a flexible part 32 is arranged on the inner side of the first cross rod 31, the flexible part 32 is arranged to prevent the damage of a sleeve, one ends of the first inclined rod 29 and the second inclined rod 30 are fixed on the fixed annular table 5, the other end of the first inclined rod is movably connected with the side of the first cross rod 31, the diameter of a filter hole on the first filter screen 11 is larger than the diameter of a filter hole 13 on the second filter screen 12, and the filtering effect is better.
The utility model provides a combination tube that is used for rare cell flow to detect's sample loading sheathed tube, includes sharp end centrifuging tube 33, places on arc recess 18 on base 4 bottom of sharp end centrifuging tube 33, and the diameter of sharp end centrifuging tube 33 is greater than sleeve 3's diameter, and the inside of sharp end centrifuging tube 33 is inserted to sleeve 3's bottom, and sharp end centrifuging tube 33 is fixed by spring clamping device, and the centre gripping is fixed by elastic iron sheet clamping device to sleeve 3's side.
The utility model discloses a theory of operation does: at first, according to the capacity requirement of sample, adjust telescopic link one and telescopic link two on the support frame for satisfy the needs that use, then pass through fixing hole one with sharp end centrifuging tube inside, fix sharp end centrifuging tube through spring clamping device, after fixed, place sheathed tube bottom in sharp end centrifuging tube, then fix sheathed tube middle part through clamping device, sheathed tube bottom is fixed through elasticity iron sheet clamping device, has guaranteed the stability of whole process, so far, the utility model discloses a purpose can be accomplished.
The above description is only a preferred embodiment of the present invention, and should not be taken as limiting the invention, and any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (7)
1. The utility model provides a sample loading sleeve pipe for rare cell flow detects, includes the sleeve pipe device body, its characterized in that, the sleeve pipe device body includes support frame and sleeve pipe, the support frame includes base, telescopic link, solid fixed ring shape platform and clamping device, be equipped with the block on the sleeve pipe, be equipped with the rubber supporting legs on the bottom of base, the telescopic link includes telescopic link one and telescopic link two, sheathed tube inside is equipped with filter screen one and filter screen two, all be equipped with the filtration pore on filter screen one and the filter screen two, the upper portion of telescopic link is equipped with solid fixed ring shape platform, the middle part of solid fixed ring shape platform is equipped with solid fixed through hole one, the inside of solid fixed through hole one is equipped with elasticity iron sheet clamping device and spring clamping device, elasticity iron sheet clamping device and spring clamping device all are equipped with 4 at least.
2. The sample loading sleeve for rare cell flow detection according to claim 1, wherein the first telescopic rod and the second telescopic rod are both provided with a telescopic section and a fixed section, the fixed section is provided with a fastening bolt, and an arc-shaped groove is formed in the top surface of the base between the first telescopic rod and the second telescopic rod.
3. The sample loading sleeve for rare cell flow detection according to claim 1, wherein the elastic iron sheet clamping device is provided with a first elastic iron sheet clamping device and a second elastic iron sheet clamping device, each of the first elastic iron sheet clamping device and the second elastic iron sheet clamping device comprises an elastic iron sheet and an elastic rubber ring, and the elastic rubber ring is arranged on the outer side of the elastic iron sheet.
4. The loading sleeve for rare cell flow detection as claimed in claim 1, wherein the spring clamping device is provided with a first spring clamping device and a second spring clamping device, the first spring clamping device and the second spring clamping device both comprise a base, a spring and a baffle, a flexible component is arranged on the top surface of the baffle, one end of the spring is fixed on the base, and the other end of the spring is connected with the baffle.
5. The sample loading sleeve for rare cell flow detection according to claim 1, wherein the elastic iron sheet clamping device is arranged in the middle of the first fixing through hole, the spring clamping device is arranged at the bottom of the first fixing through hole, the clamping device comprises a first inclined rod, a second inclined rod and a first cross rod, and a flexible part is arranged on the inner side of the first cross rod.
6. The loading sleeve for rare cell flow assay as claimed in claim 5, wherein one end of the first diagonal bar and the second diagonal bar is fixed on the fixed annular table, the other end is movably connected with the side edge of the first cross bar, and the diameter of the filter hole on the first filter screen is larger than that of the filter hole on the second filter screen.
7. A combination tube comprising the sample loading thimble and the coned-bottom centrifuge tube of any one of claims 1-6, wherein the bottom of the coned-bottom centrifuge tube is placed on an arc-shaped groove on a base, the diameter of the coned-bottom centrifuge tube is greater than the diameter of the thimble, the bottom of the thimble is inserted into the interior of the coned-bottom centrifuge tube, the coned-bottom centrifuge tube is fixed by a spring clamping device, and the side of the thimble is fixedly clamped by an elastic iron sheet clamping device.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202120219484.4U CN214374163U (en) | 2021-01-27 | 2021-01-27 | Sample loading sleeve and combined tube for rare cell flow detection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202120219484.4U CN214374163U (en) | 2021-01-27 | 2021-01-27 | Sample loading sleeve and combined tube for rare cell flow detection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN214374163U true CN214374163U (en) | 2021-10-08 |
Family
ID=77961240
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202120219484.4U Expired - Fee Related CN214374163U (en) | 2021-01-27 | 2021-01-27 | Sample loading sleeve and combined tube for rare cell flow detection |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN214374163U (en) |
-
2021
- 2021-01-27 CN CN202120219484.4U patent/CN214374163U/en not_active Expired - Fee Related
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| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20211008 |
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| CF01 | Termination of patent right due to non-payment of annual fee |