CN214371329U - Continuous vacuum drying device suitable for serials polypeptide of ruilin - Google Patents

Abstract

A continuous vacuum drying device suitable for Ruelin series polypeptide comprises a feeding pipe, a drying box and a discharging pipe; the outer side wall of the drying box is also provided with a vacuum pump, a first motor, a moisture treatment box and a constant temperature box; an air inlet box is arranged in the center of the bottom of the drying box; the bottom end of the air inlet box is fixedly provided with a second motor, the output end of the second motor extends into the air inlet box and is fixedly provided with a rotary drum, the other end of the rotary drum extends into the drying box and is fixedly provided with a rotary disc, and the top of the rotary disc is at least provided with three groups of spray heads. By adopting the above drying cabinet, the utility model, can effectively pour into the carousel with outside dry gas into, again by the shower nozzle blowout for spun dry gas produces the vortex under the turning force of carousel, compares in traditional direct-blowing type drying, the utility model discloses a carousel rotates dry gas blowout, makes dry gas and wet product polypeptide fully contact, has promoted the drying efficiency of device.

Description

Continuous vacuum drying device suitable for serials polypeptide of ruilin

Technical Field

The utility model relates to a drying device technical field, in particular to continuous type vacuum drying device suitable for ruin forest series polypeptide.

Background

The present preparation process of polypeptide medicine is mainly characterized by that it utilizes solid-phase or liquid-phase synthesis method, cracking resin, then utilizes liquid-phase chromatography to make purification, separation and freeze-drying so as to obtain the invented polypeptide medicine. Due to the characteristic of thermal instability of the self attribute of the polypeptide drug, the polypeptide drug cannot be dried through a common drying process, so a freeze-drying method is mostly used for drying, but the freeze-drying technology has the defects of expensive equipment, long working time, high energy consumption and the like, so that the price of the polypeptide drug is high, and the method becomes a bottleneck in the preparation process.

The existing device for drying wet polypeptide mostly combines spray drying technology and nitrogen purging technology to realize the drying treatment of wet polypeptide. However, the existing spray drying mostly adopts direct-blowing type gas injection, the contact surface of drying gas and wet polypeptide cannot be enlarged, and the drying rate is low.

SUMMERY OF THE UTILITY MODEL

An object of the utility model is to provide a continuous type vacuum drying device suitable for ruin lin series polypeptide can effectively solve the problem that current drying device blows formula drying process directly, and drying rate is low.

In order to achieve the above object, the solution of the present invention is: a continuous vacuum drying device suitable for Ruelin series polypeptide comprises a feeding pipe, a drying box and a discharging pipe; the feeding pipe is positioned at the top of the drying box, and a sealing cover is arranged at the top of the feeding pipe; the discharge pipe is positioned at the bottom of the drying box; the outer side wall of the drying box is provided with a control panel, and the outer side wall of the drying box is also provided with a vacuum pump, a first motor, a moisture treatment box and a constant temperature box; the first motor is positioned right above the control panel; the vacuum pump and the moisture treatment box are symmetrically arranged around the first motor, the output end of the vacuum pump extends into the drying box, the top end of the moisture treatment box is connected with an exhaust pipe, and the other end of the exhaust pipe extends into the drying box; the constant temperature box is positioned between the vacuum pump and the moisture treatment box and is arranged opposite to the first motor; an air inlet box is arranged in the center of the bottom of the drying box, an air inlet pipe is arranged on the outer side of the air inlet box, and the air inlet pipe and the discharge pipe are arranged in an opposite mode; a second motor is fixed at the bottom end of the air inlet box, the output end of the second motor extends into the air inlet box and is fixed with a rotary drum, the other end of the rotary drum extends into the drying box and is fixed with a rotary disc, the rotary disc and the rotary drum are both of hollow structures, a through groove is arranged on the rotary drum in the air inlet box, and at least three groups of spray heads are arranged at the top of the rotary disc; a charging barrel is arranged at the top end inside the drying box, a feeding box is fixed on the inner wall of the drying box under the charging barrel, the top end of the feeding box is communicated with the charging barrel, an opening is arranged under a feeding pipe at the bottom of the feeding box, an auger is rotatably connected inside the feeding box, and one end of the auger penetrates through the side wall of the drying box and is fixedly connected with the output end of a first motor; an atomization mechanism is fixed in the drying box right below the opening; be equipped with the coil pipe on the inner wall of drying cabinet between atomizing mechanism and the carousel, the both ends of coil pipe all extend to the outside of drying cabinet and are linked together with the input and the output of thermostated container respectively.

Furthermore, a pressure gauge is arranged at the top of the drying box, and a fixing frame is connected to the outer side below the drying box; the inside of drying cabinet is equipped with temperature sensor, humidity transducer and pressure sensor, and temperature sensor, humidity transducer and pressure sensor all with control panel electric connection.

Further, the vacuum pump, the first motor and the second motor are all electrically connected with the control panel; the heating pipe is arranged in the constant temperature box and is electrically connected with the control panel.

Further, the discharge pipe is arranged obliquely downwards; the air inlet pipe is arranged obliquely upwards.

Furthermore, the output end of the vacuum pump, the discharge pipe, the exhaust pipe and the air inlet pipe are all provided with one-way electromagnetic valves, and the one-way electromagnetic valves are electrically connected with the control panel.

Furthermore, the number of each group of spray heads is at least 2, and the spray heads are arranged in a scattering manner along the radius of the rotary table by taking the center of the rotary table as the center of a circle.

Furthermore, at least three guide grooves are arranged on the top of the rotary table at equal intervals, the guide grooves are arranged in a scattering manner along the radius of the rotary table by taking the center of the rotary table as the center of a circle, and the guide grooves are arranged between two adjacent groups of spray heads.

Further, a sealing ring is arranged at the joint of the drying box and the air inlet box outside the rotary drum.

Compared with the prior art, the utility model has the advantages that: through adopting above-mentioned drying cabinet, can effectively pour into the air inlet box with outside dry gas through the intake pipe in to lead to the carousel through the logical groove of rotary drum, again by the shower nozzle blowout, make spun dry gas produce the vortex under the turning force of carousel, and then strike the wet product polypeptide after the atomizing, realize the low temperature freeze-drying of wet product polypeptide granule, compare in traditional direct-blowing drying, the utility model discloses a carousel rotates dry gas blowout for dry gas and wet product polypeptide fully contact, have increased the drying efficiency of device.

Drawings

Fig. 1 is the external structure schematic diagram of the drying box of the present invention.

Fig. 2 is a schematic cross-sectional view taken along line a-a of fig. 1 according to the present invention.

Fig. 3 is a schematic view of the structure of the turntable according to the present invention.

Reference numerals:

the device comprises a feeding pipe 1, a drying box 2, a vacuum pump 3, a control panel 4, a discharging pipe 5, an air inlet box 6, an exhaust pipe 7, a first motor 8, a moisture treatment box 9, a fixing frame 10, an air inlet pipe 11, a second motor 12, a feeding box 13, a constant temperature box 14, a coil pipe 15, a charging barrel 16, an auger 17, an atomizing mechanism 18, a rotary table 19, a rotary drum 20, a spray head 21 and a guide groove 22.

Detailed Description

Reference will now be made in detail to embodiments of the present invention, examples of which are illustrated in the accompanying drawings, wherein like reference numerals refer to the same or similar elements or elements having the same or similar function throughout. The embodiments described below with reference to the drawings are exemplary and intended to be used for explaining the present invention, and should not be construed as limiting the present invention.

The first embodiment is as follows:

as shown in fig. 1-3, a continuous vacuum drying apparatus for polypeptides in the relin series comprises a feeding pipe 1, a drying box 2 and a discharging pipe 5; the feeding pipe 1 is positioned at the top of the drying box 2, the sealing cover is arranged at the top of the feeding pipe 1, wet polypeptide can conveniently enter the drying box 2 through the feeding pipe 1, the feeding pipe 1 can be sealed through the sealing cover after the wet polypeptide is injected, the drying box 2 is ensured to be sealed and dried, and the influence of impurities in the environment on the quality of the wet polypeptide is reduced; the discharge pipe 5 is positioned at the bottom of the drying box 2; a control panel 4 is arranged on the outer side wall of the drying box 2, and in the embodiment, a pressure gauge is arranged at the top of the drying box 2 and used for sensing the internal pressure of the drying box 2; the outer side of the lower part of the drying box 2 is connected with a fixing frame 10 which is used for fixing the drying box 2 and keeping the stability of the drying box 2 when in use; a temperature sensor, a humidity sensor and a pressure sensor are arranged inside the drying box 2, and are electrically connected with the control panel 4, so that the temperature, the humidity and the pressure inside the drying box 2 can be sensed through the temperature sensor and the pressure sensor, and an electric signal is transmitted to the control panel 4 after the temperature, the humidity or the pressure inside the drying box 2 reaches a limit value;

the outer side wall of the drying box 2 is also provided with a vacuum pump 3, a first motor 8, a moisture treatment box 9 and a constant temperature box 14; the first motor 8 is positioned right above the control panel 4; the vacuum pump 3 and the moisture processing box 9 are symmetrically arranged about the first motor 8, the output end of the vacuum pump 3 extends to the inside of the drying box 2, the top end of the moisture processing box 9 is connected with an exhaust pipe 7, and the other end of the exhaust pipe 7 extends to the inside of the top end of the drying box 2; the constant temperature box 14 is positioned between the vacuum pump 3 and the moisture treatment box 9, and the constant temperature box 14 is arranged opposite to the first motor 8; in this embodiment, the vacuum pump 3, the first motor 8 and the second motor 12 are all electrically connected to the control panel 4, so that the vacuum pump 3, the first motor 8 and the second motor 12 can be controlled to work through the control panel 4; a heating pipe is arranged in the thermostat 14 and is electrically connected with the control panel 4, so that the heating pipe in the thermostat 14 can be controlled to be electrified and work through the control panel 4, and the temperature of the thermostat 14 can be changed;

an air inlet box 6 is arranged in the center of the bottom of the drying box 2, an air inlet pipe 11 is arranged on the outer side of the air inlet box 6, and the air inlet pipe 11 and the discharge pipe 5 are arranged in an opposite mode; in this embodiment, the discharge pipe 5 is arranged obliquely downward, so that dried polypeptide particles can be discharged through the discharge pipe 5 conveniently for centralized collection; the air inlet pipe 11 is arranged obliquely upwards, so that external dry air can be conveniently connected; in the embodiment, the filtered nitrogen is used as the drying gas to carry out low-temperature freeze drying on the wet polypeptide; in this embodiment, the output end of the vacuum pump 3, the discharge pipe 5, the exhaust pipe 7 and the intake pipe 11 are all provided with one-way electromagnetic valves, and the one-way electromagnetic valves are electrically connected with the control panel 4, so that the control panel 4 controls the corresponding one-way electromagnetic valves to be powered on and powered off to control the on and off of each pipeline, so that the corresponding fluid flows in each pipeline;

a second motor 12 is fixed at the bottom end of the air inlet box 6, the output end of the second motor 12 extends into the air inlet box 6 and is fixed with a rotary drum 20, the other end of the rotary drum 20 extends into the drying box 2 and is fixed with a rotary disc 19, the rotary disc 19 and the rotary drum 20 are both hollow structures, and a through groove is arranged on the rotary drum 20 in the air inlet box 6, in the embodiment, a sealing ring is arranged at the joint of the drying box 2 and the air inlet box 6 outside the rotary drum 20, so that the sealing performance in the drying box 2 in the rotation process of the rotary drum 20 is ensured, and the leakage of dried polypeptide powder is avoided;

six groups of spray heads 21 are arranged at the top of the rotary table 19; in this embodiment, the number of each group of the nozzles 21 is 3, and the nozzles 21 are arranged in a scattering manner along the radius of the turntable 19 with the center of the turntable 19 as the center of circle, so that in the rotation process of the turntable 19, the dry gas injected into the air inlet box 6 through the air inlet pipe 11 can be introduced into the turntable 19 through the through groove of the rotary drum 20, and then is sprayed out from the nozzles 21, so as to perform low-temperature freeze drying on the wet polypeptide; in this embodiment, six guide grooves 22 are arranged at equal intervals on the top of the rotating disc 19, the guide grooves 22 are arranged in a scattering manner along the radius of the rotating disc 19 with the center of the rotating disc 19 as the center of circle, and the guide grooves 22 are arranged between two adjacent groups of spray heads 21, so that the eddy current generated when the rotating disc 19 rotates is promoted through the guide grooves 22, the drying gas is fully contacted with the wet polypeptide, and the drying efficiency of the device is increased;

a charging barrel 16 is arranged at the top end inside the drying box 2, a feeding box 13 is fixed on the inner wall of the drying box 2 under the charging barrel 16, the top end of the feeding box 13 is communicated with the charging barrel 16, an opening is arranged under a feeding pipe 1 at the bottom of the feeding box 13, an auger 17 is rotatably connected inside the feeding box 13, and one end of the auger 17 penetrates through the side wall of the drying box 2 and is fixedly connected with the output end of a first motor 8; an atomization mechanism 18 is fixed in the drying box 2 right below the opening, so that wet product polypeptide sent out by the packing auger 17 can be conveniently atomized and sprayed out through the atomization mechanism 18, the size of the wet product polypeptide is reduced, the contact area of dry gas and the wet product polypeptide is increased, and the drying speed of the device is further increased; be equipped with coil pipe 15 on the inner wall of drying cabinet 2 between atomizing mechanism 18 and carousel 19, the both ends of coil pipe 15 all extend to the outside of drying cabinet 2 and are linked together with the input and the output of thermostated container 14 respectively, and the device of being convenient for adjusts the temperature of thermostated container 14 to 10-20 ℃ according to the dry demand, and the leading-in drying cabinet 2 of the fluid after with the inside constant temperature of thermostated container 14 is inside, keeps the ambient temperature of drying cabinet 2 drying process to guarantee the drying rate of wet goods polypeptide.

In this embodiment, the first motor 8 is a speed-adjustable motor, and the second motor 12 is a constant-speed motor, so as to meet different requirements of the device on the feeding speed of the wet polypeptide; in actual production, the number of the spray heads 21 and the guide grooves 22 can be increased or decreased as required to change the air-jet drying range of the rotary disc 19 so as to meet different drying requirements of wet polypeptide products.

The working principle is as follows: when the device is used, firstly, wet polypeptide is injected into the drying box 2 through the feeding pipe 1, the injected wet polypeptide can be accumulated in the charging barrel 16, the sealing cover at the top of the feeding pipe 1 is covered after the injection is finished, then the vacuum pump 3 is opened, the inside of the drying box 2 is pumped into a vacuum state, the air inlet pipe 11 is connected with an external dry gas pipeline, the feeding speed of the first motor 8 is adjusted, the limited temperature of the temperature sensor and the constant temperature of the constant temperature box 14 are adjusted, at the moment, the first motor 8 drives the packing auger 17 to rotate, the wet polypeptide is sent into the opening of the feeding box 13 from the charging barrel 16, is atomized by the atomizing mechanism 18 and then falls into the drying box 2, the injected external dry gas is injected into the air inlet box 6 through the air inlet pipe 11 and is guided into the rotating disk 19 through the through groove of the rotating cylinder 20 and then is sprayed out by the spray head 21, and the sprayed out dry gas generates vortex under the rotating force of the rotating disk 19, further impacting the atomized wet polypeptide to realize low-temperature freeze drying of the wet polypeptide particles; when the waste gas generated in the drying process causes the internal pressure of the drying box 2 to reach a limit value, the one-way electromagnetic valve on the exhaust pipe 7 is opened, and the waste gas is discharged into the moisture treatment box 9 through the exhaust pipe 7, filtered and discharged; after the inside humidity of drying cabinet 2 reaches the limit value, humidity transducer gives control panel 4 with signal transmission, and control panel 4 control vacuum pump 3 and first motor 8 stop work, and the one-way solenoid valve on discharging pipe 5, the blast pipe 7 is opened, and the one-way solenoid valve on the intake pipe 11 is closed, relieves vacuum state in the drying cabinet 2, and the polypeptide powder after the drying is accomplished can fall under the action of gravity, finally discharges through discharging pipe 5.

In the description of the present invention, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise" and the like indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, and are only for convenience of description of the present invention and to simplify the description, but do not indicate or imply that the device or element referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore should not be construed as limiting the present invention.

In the description herein, references to the description of the term "one embodiment," "some embodiments," "an example," "a specific example," or "some examples," etc., mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above should not be understood to necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples. Furthermore, various embodiments or examples described in this specification can be combined and combined by those skilled in the art.

Although embodiments of the present invention have been shown and described, it is understood that the above embodiments are exemplary and should not be construed as limiting the present invention, and that variations, modifications, substitutions and alterations can be made to the above embodiments by those of ordinary skill in the art without departing from the scope of the present invention.

Claims (8)

1. A continuous vacuum drying device suitable for Ruelin series polypeptide comprises a feeding pipe (1), a drying box (2) and a discharging pipe (5); the feeding pipe (1) is positioned at the top of the drying box (2), and a sealing cover is arranged at the top of the feeding pipe (1); the discharge pipe (5) is positioned at the bottom of the drying box (2); be equipped with control panel (4) on the lateral wall of drying cabinet (2), its characterized in that: the outer side wall of the drying box (2) is also provided with a vacuum pump (3), a first motor (8), a moisture treatment box (9) and a constant temperature box (14); the first motor (8) is positioned right above the control panel (4); the vacuum pump (3) and the moisture treatment box (9) are symmetrically arranged relative to the first motor (8), the output end of the vacuum pump (3) extends into the drying box (2), the top end of the moisture treatment box (9) is connected with an exhaust pipe (7), and the other end of the exhaust pipe (7) extends into the drying box (2); the constant temperature box (14) is positioned between the vacuum pump (3) and the moisture treatment box (9), and the constant temperature box (14) is arranged opposite to the first motor (8); an air inlet box (6) is arranged in the center of the bottom of the drying box (2), an air inlet pipe (11) is arranged on the outer side of the air inlet box (6), and the air inlet pipe (11) and the discharge pipe (5) are arranged in an opposite mode; a second motor (12) is fixed at the bottom end of the air inlet box (6), the output end of the second motor (12) extends into the air inlet box (6) and is fixed with a rotary drum (20), the other end of the rotary drum (20) extends into the drying box (2) and is fixed with a rotary disc (19), the rotary disc (19) and the rotary drum (20) are both of a hollow structure, a through groove is formed in the rotary drum (20) in the air inlet box (6), and at least three groups of spray heads (21) are arranged at the top of the rotary disc (19); a charging barrel (16) is arranged at the top end inside the drying box (2), a feeding box (13) is fixed on the inner wall of the drying box (2) under the charging barrel (16), the top end of the feeding box (13) is communicated with the charging barrel (16), an opening is arranged under a feeding pipe (1) at the bottom of the feeding box (13), an auger (17) is rotatably connected inside the feeding box (13), and one end of the auger (17) penetrates through the side wall of the drying box (2) and is fixedly connected with the output end of a first motor (8); an atomization mechanism (18) is fixed in the drying box (2) right below the opening; be equipped with coil pipe (15) on the inner wall of drying cabinet (2) between atomizing mechanism (18) and carousel (19), the both ends of coil pipe (15) all extend to the outside of drying cabinet (2) and are linked together with the input and the output of thermostated container (14) respectively.

2. The continuous vacuum drying device for the serin polypeptides according to claim 1, characterized in that: a pressure gauge is arranged at the top of the drying box (2), and a fixing frame (10) is connected to the outer side below the drying box (2); the inside of drying cabinet (2) is equipped with temperature sensor, humidity transducer and pressure sensor, and temperature sensor, humidity transducer and pressure sensor all with control panel (4) electric connection.

3. The continuous vacuum drying device for the serin polypeptides according to claim 1, characterized in that: the vacuum pump (3), the first motor (8) and the second motor (12) are electrically connected with the control panel (4); the heating pipe is arranged in the thermostat (14) and is electrically connected with the control panel (4).

4. The continuous vacuum drying device for the serin polypeptides according to claim 1, characterized in that: the discharge pipe (5) is arranged obliquely downwards; the air inlet pipe (11) is arranged obliquely upwards.

5. The continuous vacuum drying device for polypeptides of the relin series according to claim 1 or 4, wherein: and the output end of the vacuum pump (3), the discharge pipe (5), the exhaust pipe (7) and the air inlet pipe (11) are all provided with one-way electromagnetic valves, and the one-way electromagnetic valves are electrically connected with the control panel (4).

6. The continuous vacuum drying device for the serin polypeptides according to claim 1, characterized in that: the number of each group of spray heads (21) is at least 2, and the spray heads (21) are arranged in a scattering manner along the radius of the rotary table (19) by taking the center of the rotary table (19) as the center of a circle.

7. The continuous vacuum drying device for the serin polypeptides according to claim 6, characterized in that: the top of the rotary table (19) is provided with at least three guide grooves (22) at equal intervals, the guide grooves (22) are arranged in a scattering manner along the radius of the rotary table (19) by taking the center of the rotary table (19) as the center of a circle, and the guide grooves (22) are arranged between two adjacent groups of spray heads (21).

8. The continuous vacuum drying device for the serin polypeptides according to claim 1, characterized in that: and a sealing ring is arranged at the joint of the drying box (2) and the air inlet box (6) outside the rotary drum (20).

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