CN214244464U - Coated antibody culture bag - Google Patents
Coated antibody culture bag Download PDFInfo
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- CN214244464U CN214244464U CN202022728057.7U CN202022728057U CN214244464U CN 214244464 U CN214244464 U CN 214244464U CN 202022728057 U CN202022728057 U CN 202022728057U CN 214244464 U CN214244464 U CN 214244464U
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Abstract
The utility model discloses a bag is cultivateed to peridium antibody, the bag body is cultivateed by FEP material or EVA material and is constituted, and the bag internal portion peridium CD3, CD28 or other monoclonal antibodies cultivate the bag and include liquid-taking pipe and spout, liquid-taking pipe sets up in bag body bottom middle part position, and bag body top both sides position on the left side installs the feed liquor pipe, the threaded rod runs through in the position on the right side of speed governing storehouse bottom, and has cup jointed the movable block on the threaded rod to the ejector pad is installed to movable block one side, install the dead lever on the inner wall of speed governing storehouse left side, and the dead lever right-hand member has cup jointed linkage block to linkage block left side both ends are connected with speed governing storehouse inner wall through the spring. This envelope antibody culture bag, the staff can stir the rotation handle for preceding splint and back splint coincide each other or separate, thereby adjust the volume in the culture bag, are favorable to controlling antibody cell culture volume, and can be divided into two with the bag body, have improved its practicality.
Description
Technical Field
The utility model relates to an antibody culture technical field specifically is a bag is cultivateed to peridium antibody.
Background
Tumor immune cell therapy is a therapeutic method which uses cell biology and molecular biology means to enhance the immune system of a patient body so as to achieve the purpose of inhibiting the growth of tumors and even eradicating the tumors. A large amount of basic and clinical research evidences prove that the biological treatment of the tumor is a safe and effective means for tumor patients, can improve the survival treatment of the patients, prolong the life cycle and even achieve the curative effect on some patients. The great success of the PD1 and PDL1 antibodies and the chimeric antigen receptor recognition T cells in the aspect of treating tumors shows the advantages of immunotherapy in the aspect of treating tumors, and the immunotherapy is bound to become an indispensable means for treating tumors.
The immune cell culture is an important and core link in cell gene therapy and plays a decisive role in the effect of cell therapy, wherein monoclonal antibodies such as CD3, CD28 and the like are particularly critical to T cell culture and the like, and a coated antibody culture bag is used in the existing industrialized cell culture process.
The common envelope antibody culture bag in the existing market is difficult to control the speed of transfusion when inputting the culture solution into the culture bag, and hinders the cell proliferation, and can not adjust the volume of the culture bag, and can not control the culture amount of antibody cells, aiming at the problems, the culture bag is innovatively designed on the basis of the original rice polished rice processing device.
SUMMERY OF THE UTILITY MODEL
An object of the utility model is to provide a peridium antibody culture bag to solve the common peridium antibody culture bag on the existing market that proposes in the above-mentioned background art, when inputing the culture solution in the culture bag, be difficult to control the speed of infusion, produce the hindrance to the cell proliferation, and can not adjust the culture bag volume, can't carry out the problem controlled to antibody cell culture volume.
In order to achieve the above object, the utility model provides a following technical scheme: a coated antibody culture bag comprises a liquid taking pipe and a sliding groove, wherein the liquid taking pipe is arranged in the middle of the bottom of a bag body, liquid inlet pipes are arranged on the positions on two sides of the upper portion of the bag body, the upper end of each liquid inlet pipe is connected with one end of a pipeline, the pipeline penetrates through a speed regulation bin, a threaded rod penetrates through the position on the right side of the bottom of the speed regulation bin, a movable block is sleeved on the threaded rod, a push block is arranged on one side of the movable block, a fixed rod is arranged on the inner wall of the left side of the speed regulation bin, a linkage block is sleeved at the right end of the fixed rod, the two ends of the left side of the linkage block are connected with the inner wall of the speed regulation bin through springs, the springs penetrate through the outer part of the fixed rod, a rear clamping plate is arranged on one side of the bag body, a straight connecting rod penetrates through the middle position of the rear clamping plate, a rotating handle is arranged at the left end of the straight connecting rod, the outer side of the rotating handle is attached to one side of a front clamping plate, the sliding grooves are formed in two ends of the front clamping plate, and the front clamping plate is arranged on the other side of the bag body.
Preferably, the liquid inlet pipe has two in bag top symmetric distribution, and the liquid taking pipe has two in bag below symmetric distribution to liquid inlet pipe and liquid taking pipe dislocation set.
Preferably, the front splint is U type structure, and three lug has been seted up to the front splint inboard equidistant, three recess has been seted up to back splint inner wall equidistant, and the vertical width of its recess is greater than the width of lug on the front splint.
Preferably, the sliding grooves are symmetrically formed in the upper end and the lower end of the front clamping plate, and the sliding grooves are connected with the upper end and the lower end of the rear clamping plate in a sliding mode.
Preferably, the threaded rod and the movable block form a spiral structure, the movable block and the push block are of an integrated structure, the push block is of a right-angle triangular structure, and meanwhile, the longitudinal length of the push block is greater than one half of the height of the speed regulation bin.
Preferably, the fixed rods are symmetrically distributed on two sides of the pipeline, and the outer wall of the pipeline is connected with the left side of the linkage block in an adhesion mode.
Preferably, the transverse width of the linkage block is the same as the width of the push block, the right side of the linkage block is of an inclined surface structure, and the angle of the inclined surface of the linkage block is the same as that of the inclined surface of the push block.
Compared with the prior art, the beneficial effects of the utility model are that: the coated antibody culture bag is characterized in that,
1. separately be provided with feed liquor pipe and liquid taking pipe in both ends about the bag body, can avoid the antibody cell to receive the pollution in the in-process of proliferating, and when input culture solution in to the culture bag, the staff can rotate the screw rod lower extreme to speed to the culture solution input is controlled and is adjusted, is favorable to the cladding antibody cell to carry out effective proliferation.
2. When needs are cultivateed the envelope antibody of different grade type or quantity, the staff can stir the rotation handle for preceding splint and back splint coincide each other or separate, thereby adjust the volume in the culture bag, be favorable to controlling antibody cell culture volume, and can be divided into two with the bag body, improved its practicality.
Drawings
FIG. 1 is a schematic view of the overall front view structure of the present invention;
FIG. 2 is a schematic side view of the rear and front splints of the present invention;
FIG. 3 is a schematic view of the internal structure of the speed regulation bin of the present invention;
FIG. 4 is a right-view structural diagram of the pipeline and the linkage block of the present invention;
fig. 5 is a left-side view structural diagram of the push block and the linkage block of the present invention.
In the figure: 1. a bag body; 2. a liquid taking pipe; 3. a liquid inlet pipe; 4. a pipeline; 5. a speed regulation bin; 6. a rear splint; 7. a straight connecting rod; 8. a front splint; 9. rotating the handle; 10. a chute; 11. a threaded rod; 12. a movable block; 13. a push block; 14. fixing the rod; 15. a linkage block; 16. a spring.
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.
Referring to fig. 1-5, the present invention provides a technical solution: a culture bag for coating antibody comprises a liquid taking pipe 2 and a chute 10, wherein the liquid taking pipe 2 is arranged in the middle of the bottom of a bag body 1, liquid inlet pipes 3 are arranged on two sides of the upper part of the bag body 1, the upper end of each liquid inlet pipe 3 is connected with one end of a pipeline 4, the pipeline 4 penetrates through a speed regulation bin 5, a threaded rod 11 penetrates through the right side of the bottom of the speed regulation bin 5, a movable block 12 is sleeved on the threaded rod 11, a push block 13 is arranged on one side of the movable block 12, a fixed rod 14 is arranged on the inner wall of the left side of the speed regulation bin 5, a linkage block 15 is sleeved on the right end of the fixed rod 14, two ends of the left side of the linkage block 15 are connected with the inner wall of the speed regulation bin 5 through springs 16, the springs 16 penetrate through the outer part of the fixed rod 14, the middle of the left side of the linkage block 15 is connected with the outer wall of the pipeline 4, a rear clamping plate 6 is arranged on one side of the bag body 1, and a straight connecting rod 7 penetrates through the middle of the rear clamping plate 6, and the left end of the straight connecting rod 7 is provided with a rotating handle 9, the outer side of the rotating handle 9 is attached to one side of the front clamping plate 8, the sliding grooves 10 are formed in two ends of the front clamping plate 8, and the front clamping plate 8 is arranged on the other side of the bag body 1.
Two liquid inlet pipes 3 are symmetrically distributed above the bag body 1, two liquid taking pipes 2 are symmetrically distributed below the bag body 1, and the liquid inlet pipes 3 and the liquid taking pipes 2 are arranged in a staggered manner, so that the antibody cells can be prevented from being polluted in the proliferation process;
the front clamping plate 8 is of a U-shaped structure, three convex blocks are arranged on the inner side of the front clamping plate 8 at equal intervals, three grooves are arranged on the inner wall of the rear clamping plate 6 at equal intervals, the longitudinal width of each groove is larger than the width of the convex block on the front clamping plate 8, the front clamping plate 8 and the rear clamping plate 6 can be clamped conveniently, and the inner parts of the bag body 1 are isolated from each other;
the sliding grooves 10 are symmetrically formed in the upper end and the lower end of the front clamping plate 8, the connecting mode of the sliding grooves 10 and the upper end and the lower end of the rear clamping plate 6 is sliding connection, and the straight connecting rod 7 drives the two ends of the rear clamping plate 6 to slide in the sliding grooves 10, so that the front clamping plate 8 and the rear clamping plate 6 can be conveniently superposed or separated from each other;
the threaded rod 11 and the movable block 12 form a spiral structure, the movable block 12 and the pushing block 13 are of an integrated structure, the pushing block 13 is of a right-angle triangular structure, meanwhile, the longitudinal length of the pushing block 13 is larger than one half of the height of the speed regulation bin 5, the threaded rod 11 rotates to drive the pushing block 13 to move up and down, and the pushing block 13 can be in contact with the linkage block 15 to push in the moving process, so that the infusion speed can be adjusted conveniently;
the fixed rods 14 are symmetrically distributed on two sides of the pipeline 4, the outer wall of the pipeline 4 is connected with the left side of the linkage block 15 in an adhesion mode, the linkage block 15 can fully extrude the pipeline 4, and the linkage block 15 moves rightwards to drive the pipeline 4 to expand, so that the pipeline 4 is prevented from being extruded and deformed to influence the infusion speed;
the transverse width of the linkage block 15 is the same as the width of the push block 13, the right side of the linkage block 15 is of an inclined surface structure, and the inclined surface angle of the linkage block is the same as that of the push block 13, so that the push block 13 and the linkage block 15 are conveniently and tightly attached, and the linkage block 15 is favorably pushed.
The working principle is as follows: according to the figures 1-5, firstly, when the coated antibody needs to be cultured, the culture solution can be input into the culture bag from the upper part of the bag body 1 by a worker through the liquid inlet pipe 3, and when the transfusion speed needs to be controlled, the worker can rotate one end of the threaded rod 11 below the speed regulation bin 5, the movable block 12 drives the push block 13 to move up and down, when the push block 13 moves upwards, the inclined surface of the push block 13 gradually contacts with the inclined surface of the linkage block 15 and pushes the linkage block 15 leftwards, so that the left side of the linkage block 15 slides on the fixed rod 14, the left side of the linkage block 15 extrudes the pipeline 4, the flow rate of the culture solution in the pipeline 4 is reduced, when the worker reverses the threaded rod 11 and the push block 13 moves downwards, the push block 13 is gradually separated from the linkage block 15, and the linkage block 15 resets rightwards under the action of the spring 16, and linkage block 15 drives pipeline 4 and expands, and the culture solution velocity of flow risees in the pipeline 4, has effectively avoided the condition of pipeline 4 extrusion deformation, is favorable to carrying out control regulation to culture solution input speed, and the cladding antibody cell of being convenient for effectively breeds, and usable liquid taking tube 2 takes out the liquid in the bag body 1 simultaneously, avoids the antibody cell to receive the pollution in carrying out the proliferation in-process.
In addition, when different types or quantities of envelope antibodies are required to be cultured, a worker can downwards stir the rotating handle 9, the straight connecting rod 7 drives the rear clamping plate 6 to extrude and close the middle position of the bag body 1, so that the front clamping plate 8 and the rear clamping plate 6 are mutually overlapped, the middle part of the bag body 1 is mutually isolated, the bag body 1 is divided into two parts, different cultures of the envelope antibodies are convenient to be respectively carried out, when a culture bag with larger volume is required, the worker can upwards stir the rotating handle 9, the straight connecting rod 7 drives the rear clamping plate 6 to move backwards, two ends of the upper end of the rear clamping plate 6 slide in the sliding groove 10, the front clamping plate 8 and the rear clamping plate 6 are mutually separated, the internal space of the bag body 1 is combined into one, so that the volume in the culture bag is enlarged, the internal space of the culture bag is convenient to be adjusted according to requirements, and the culture amount of antibody cells is favorably controlled, the practicability is improved. The above is the operation of the whole device, and the details which are not described in detail in this specification are well known to those skilled in the art.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (7)
1. A bag for culturing coated antibody, comprising a liquid taking tube (2) and a chute (10), characterized in that: the liquid taking pipe (2) is arranged at the middle position of the bottom of the bag body (1), liquid inlet pipes (3) are arranged at two side positions above the bag body (1) in a biased manner, the upper ends of the liquid inlet pipes (3) are connected with one end of a pipeline (4), the pipeline (4) penetrates through the speed regulation bin (5), a threaded rod (11) penetrates through the position of the speed regulation bin (5) in the biased manner, a movable block (12) is sleeved on the threaded rod (11), a push block (13) is arranged at one side of the movable block (12), a fixed rod (14) is arranged on the inner wall of the left side of the speed regulation bin (5), a linkage block (15) is sleeved at the right end of the fixed rod (14), the two ends of the left side of the linkage block (15) are connected with the inner wall of the speed regulation bin (5) through springs (16), the springs (16) penetrate through the outer part of the fixed rod (14), the middle position of the left side of the linkage block (15) is connected with the outer wall of the pipeline (4), the utility model discloses a bag body, including bag body (1), the bottom plate of bag body (6), the bottom plate of bag body (1) one side is provided with back splint (6), and back splint (6) middle part position runs through there is straight connecting rod (7) right-hand member to turning handle (9) are installed to straight connecting rod (7) left end, and the turning handle (9) outside is laminated with front splint (8) one side simultaneously mutually, slide groove (10) are seted up at front splint (8) both ends, and front splint (8) set up the opposite side at the bag body (1).
2. A coated antibody culture bag according to claim 1, wherein: the liquid inlet pipe (3) is symmetrically distributed with two parts above the bag body (1), the liquid taking pipe (2) is symmetrically distributed with two parts below the bag body (1), and the liquid inlet pipe (3) and the liquid taking pipe (2) are arranged in a staggered manner.
3. A coated antibody culture bag according to claim 1, wherein: the front splint (8) is U type structure, and three lug has been seted up to front splint (8) inboard equidistant, three recess has been seted up to back splint (6) inner wall equidistant, and the vertical width of its recess is greater than the width of lug on front splint (8).
4. A coated antibody culture bag according to claim 1, wherein: the sliding grooves (10) are symmetrically formed in the upper end and the lower end of the front clamping plate (8), and the sliding grooves (10) are connected with the upper end and the lower end of the rear clamping plate (6) in a sliding mode.
5. A coated antibody culture bag according to claim 1, wherein: threaded rod (11) and movable block (12) constitute helical structure, and movable block (12) and ejector pad (13) be the integral structure to ejector pad (13) are right angle triangle structure, and ejector pad (13) longitudinal length is greater than the half of speed governing storehouse (5) height simultaneously.
6. A coated antibody culture bag according to claim 1, wherein: the fixing rods (14) are symmetrically distributed on two sides of the pipeline (4), and the outer wall of the pipeline (4) is connected with the left side of the linkage block (15) in an adhesion mode.
7. A coated antibody culture bag according to claim 1, wherein: the transverse width of the linkage block (15) is the same as the width of the push block (13), the right side of the linkage block (15) is of an inclined plane structure, and the angle of the inclined plane of the linkage block is the same as that of the push block (13).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202022728057.7U CN214244464U (en) | 2020-11-23 | 2020-11-23 | Coated antibody culture bag |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202022728057.7U CN214244464U (en) | 2020-11-23 | 2020-11-23 | Coated antibody culture bag |
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| CN214244464U true CN214244464U (en) | 2021-09-21 |
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| CN202022728057.7U Active CN214244464U (en) | 2020-11-23 | 2020-11-23 | Coated antibody culture bag |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113855267A (en) * | 2021-11-05 | 2021-12-31 | 重庆市璧山区人民医院 | Skin expander convenient to adjust |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113855267A (en) * | 2021-11-05 | 2021-12-31 | 重庆市璧山区人民医院 | Skin expander convenient to adjust |
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Legal Events
| Date | Code | Title | Description |
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| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20220616 Address after: 361012 unit 431, floor 4, building C, Xiamen international shipping center, No. 93, Xiangyu Road, Xiamen area, China (Fujian) pilot Free Trade Zone, Xiamen, Fujian Patentee after: Xiamen Sany hematopoietic Technology Co.,Ltd. Address before: 350108 building 10, innovation park, Haixi Park, high tech Zone, Fuzhou City, Fujian Province Patentee before: FUJIAN STEMERY TECHNOLOGY CO.,LTD. |
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| TR01 | Transfer of patent right |